July, 2009

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Colorectal Cancer News in Brief: July 31

Cost_of_Care_CoverGet help managing the financial costs of your cancer care from an ASCO booklet or figure out how to deal with the Medicare prescription doughnut hole using an AARP online calculator.

In research, Lynch syndrome women have excellent survival after ovarian cancer, older patients have similar effectiveness and side effects from Avastin, and parents with advanced cancer often underestimate how upset their children are.  Long-term cancer survivors have no more depression than people without cancer. Continue reading…

Posted by Kate Murphy on July 31st, 2009
Posted in: Research & Treatment News | No Comments »
Tags: Avastin, cancer cost, depression, doughnut hole, Lynch syndrome, Medicare Part D

Trial of New Drug to Blocks Cell Changes Available at NIH Clinical Center

An oral drug that blocks activity of enzymes that change proteins in cells that leads to cancer is being tested at the National Institutes of Health.

R935788 or Fostamatinib, a protein kinase inhibitor, is in a Phase II clinical trial for patients with several types of advanced cancer, including colorectal cancer.  Patients whose cancer has gotten worse on previous treatment are eligible to participate.  The trial is being conducted at the NIH Clinical Center in Bethesda, Maryland. Continue reading…

Posted by Kate Murphy on July 30th, 2009
Posted in: Research & Treatment News | No Comments »
Tags: clinical trials, fostamatinib, NIH Clinical Center

Test of Vaccine Against Colon Cancer Underway

Scientists at the University of Pittsburgh are testing a vaccine to recognize a protein in colon polyps and trigger the immune system to destroy them.

MUC1 is a protein found in precancerous colorectal polyps and in colon cancer. The experimental vaccine causes the body’s immune system to develop antibodies against MUC1, killing tissue that contains it and potentially preventing polyps from returning. Continue reading…

Posted by Kate Murphy on July 29th, 2009
Posted in: Research & Treatment News | 2 Comments »
Tags: clinical trials, colorectal cancer prevention

Clinical Trials with Novel Compounds from Germany

I wanted to share with you another novel clinical trial using a compound targeting two receptors on tumor cells. Both receptors we know very well: one is HER2, the target for Herceptin, and the other one is EGFR, the target for Erbitux.

One compound targeting both receptors is on the market known as Tykerb® (lapatinib) which is approved for breast cancer patients in combination with Xeloda® (capecitabine). Continue reading…

Posted by Heinz-Josef Lenz, MD on July 28th, 2009
Posted in: From the Desk of Dr. Lenz | No Comments »
Tags: Knowing About Clinical Trials, lapatinib, Understanding Genetics, Xeloda

Two Colonoscopies Better at Predicting Future Polyp Risk

Results from two colonoscopies three years apart gave better information about whether a high-risk polyp would be found on a third exam than results from the second test alone.

Even if a second colonoscopy, done three years after the first, showed no adenomas at all, 8 in 100 study participants with high-risk polyps on their first exam had developed a high-risk polyp by six years when they had a third colonoscopy. Continue reading…

Posted by Kate Murphy on July 28th, 2009
Posted in: Research & Treatment News | No Comments »
Tags: adenomas, colonoscopy, colorectal cancer prevention

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