Posted by Kate Murphy on October 27th, 2011
Colorectal cancer patients in a phase III clinical trial who took the oral drug regorafenib lived longer than those who got the best supportive care along with a placebo.
In fact, when the independent Data Monitoring Committee analyzed the progress of the trial, they recommended it be unblinded so that patients who had been randomly assigned to supportive care and a placebo pill could receive the new medicine.
The survival benefit was statistically significant, although how much time was gained isn’t yet available. Overall survival benefits are expected to be reported at an upcoming scientific meeting.
Patients enrolled in the randomized Phase III CORRECT trial had already had their cancer get worse on all standard approved treatments. Read the rest of this entry »