FDA issues E.coli warning on Dole pre-packaged salads

Posted by Kate Murphy on October 6th, 2005

The FDA has warned consumers of the potential of E.coli illness from the use of certain brands and “use-by” dates of Dole pre-packaged salads. The nationwide health alert is based on an outbreak of E. coli O157:H7 in Minnesota.

Since people undergoing chemotherapy are at increased risk for any infection and those who have been treated for rectal or colon cancer may also experience increased diarrhea, colorectal cancer patients and their families should be particularly careful to check the brands and “use-by” dates for any pre-packaged salads. Although these salads should no longer be on store shelves, consumers may still have them in their refrigerators.

The alert covers the following products:

+ Classic Romaine – with a “best-if-used-by (BIUB)” date of September 23, 2005 and a production code beginning with “B250.”
+ American Blend – with a “best-if-used-by (BIUB)” date of September 23, 2005 and a production code beginning with “B250.”
+ Greener Selection – with a “best-if-used-by (BIUB)” date of September 22, 2005, and a production code beginning with “B250.”

The FDA warns consumers not to eat or serve salads from these batches. The “best used if” code date is located in the upper right-hand corner of the front of the bag. At this time the FDA does not believe that other DOLE products are affected, and they say that the DOLE company is working cooperatively with them and has recalled alll potentially dangerous salads.

The FDA believes that this warning is an urgent one because:

E. coli O157:H7 infection often causes severe bloody diarrhea and abdominal cramps; sometimes the infection causes non-bloody diarrhea or no symptoms. Usually little or no fever is present, and the illness resolves in five to ten days. Although most healthy adults can recover completely within a week, in some persons, particularly children under five years of age and the elderly, the infection can also cause a complication called hemolytic uremic syndrome (HUS). This condition can lead to serious kidney damage and even death.

The FDA recommends anyone who experienced any of these symptoms after eating pre-packaged salad contact their physician or their local health department.

Although these lettuces are washed prior to packaging, high risk individuals, especially those who might become dehydrated from diarrhea, should wash them again at home and keep them refrigerated.

“Lettuce is washed before it’s sold, but our research has shown the risks of food-borne illness can be greatly reduced by washing it again at home,” said Joe Frank, a food microbiologist with the University of Georgia Center for Food Safety in Griffin, Ga.

Frank found that E.coli clings to the “stomata” or tiny breathing holes in lettuce leaves. He also found increased levels of E. coli on the cut edges of lettuce and in bruised areas.

Although washing with a chlorine solution destroys E. coli on cut surfaces of lettuces, the scientists at the University of Georgia do not recommend this at home. Washing will reduce, but not eliminate risk of disease.

Not all strains of E. coli cause disease. In fact, the organism is part of the helpful bacteria in the healthy human intestinal tract. However, dangerous strains such as the E. coli O157:H7 found in the Minnesota outbreak can cause severe illness in people who are already battling other disease.

[FDA Nationalwide Health Alert](http://www.fda.gov/bbs/topics/news/2005/new01239.html)

[Recommendations from the Center for Food Safety at the University of Georgia](http://www.griffin.peachnet.edu/cfs/hottopics/lettuce.html)

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Move research out of the labs and into people!

Posted by Nancy Roach on October 6th, 2005

The process of developing cancer treatments, diagnostics and interventions can easily take 15 years or more:

* Ideas turn into lab experiments
* Lab experiments are moved to animals
* … and then to early research with people
* Good results mean large late-phase trials with large numbers of participants

The jump from lab experiments to large clinical trials is called TRANSLATIONAL RESEARCH –and without translational research, promising ideas may be stuck in labs and test tubes instead of moving to patients.

NCI’s SPORE program [Specialized Programs of Research Excellence](http://spores.nci.nih.gov/index.html) funds translational research. SPORE research has resulted in 210 clinical interventions for patients in the last 13 years, a remarkable record.

The SPORE program is being reviewed by NCI, and significant changes are proposed. There is concern about the changes in many quarters, [including Congress](http://www.c-three.org/pdf/lettertohhs.pdf) and [SPORE advocates](http://www.sporeadvocates.net/content/index.php?option=content&task=view&id=78&Itemid=2).

C3 urges NCI to be sure that changes are made thoughtfully in the context of scientific merit. [You can send the same message by asking your Congressional member to sign onto the Shaw-Harman letter before October 9. Click here to take action!](http://www.kintera.org/siteapps/advocacy/index.aspx?c=cgKJLROyEpH&b=437949)

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Comparing bowel preparation for colonoscopy — do you need a gallon?

Posted by Kate Murphy on October 4th, 2005

“The procedure was nothing at all . . . it was the prep that was awful.” A common response to colonoscopy which we hear many times.

Recent randomized research showed low volume sodium phosphate solution cleaned the bowel as effectively and was much higher in patient acceptance than the large volume PEG solutions.

In an effort to compare both effective bowel cleansing and patient acceptance, researchers randomized colonoscopy patients to prepare for the test with sodium phosphate solutions, polyethylene glycol,or senna solutions. Sodium phosphate solution is marketed in the US as Fleet’s PhosphoSoda. Polyethylene glycol or PEG is available as Colyte, Golytely, and Nulytely. Senna is an herbal preparation that is dissolved in clear liquid. Both sodium phosphate and senna require much less volume of liquid be drunk than PEG.

Body weight, blood pressure, and blood chemistry were measured before and after the bowel preparations. Patients completed a questionnaire after the colonoscopy listing side effects and rating their satisfaction with the method of bowel prep. Gastroenterologists rated each preparation as clean, suboptimal or dirty.

170 patients were randomized to 3 groups. Group 1 prepared with sodium phosphate solution, Group 2 with PEG, Group 3 with a senna solution.

There were no significant differences in body weight changes or laboratory tests among the three groups. Side effects during the prep were not sigificantly different except for more cramping in the senna group.

Overall cleansing was the same for the groups. However the senna-prepared group had the highest level of fecal contamination (17.8%).

When asked if they would like the same method of preparation again, more patients in the sodium phosphate group said yes (59%). The fewest senna-prepared patients agreed (6.8%).

A team of gastroenterologists from Turkey reported their results in the October, 2005 issue of *Digestive Endoscopy* (Volume 17 Issue 4 Page 290). They concluded:

When compared with respect to their efficacies in colon cleansing, safety of application, ease of usage, and side-effects, no significant differences were noted between sodium phosphate, polyethylene glycol and senna solutions. Nevertheless, due to its greater tolerability, requirement of a shorter period of time in colon cleansing, and lower cost, we recommend the use of sodium phosphate in bowel preparation prior to colonoscopy.

[Read an abstract of the study in *Digestive Endoscopy.*](http://www.blackwell-synergy.com/doi/abs/10.1111/j.1443-1661.2005.00547.x)

[Read a similar study done in India in 2002, not including senna](http://www.indianjgastro.com/article.asp?issn=0254-8860;year=2002;volume=21;issue=6;spage=219;epage=21;aulast=Reddy;type=0)

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Join the Tour of Hope by making its promise

Posted by Kate Murphy on September 28th, 2005

Encouraged by champion cyclist and cancer survivor Lance Armstrong, a [team of 24 bicyclists ](http://www.tourofhope.org/team/index.htm) will ride from San Diego to Washington D.C. to raise awareness of the importance of cancer research and cancer clinical trials. The ride begins on September 26 and will follow a [3,300 mile route](http://www.tourofhope.org/ride/2005_national_route/index.htm) across the United States.

[Lance Armstrong](http://www.tourofhope.org/lance/index.htm) will deliver the promises of hundreds of thousands of cancer survivors and supporters to Congress at the end of the ride. You can [add your own promise](http://www.tourofhope.org/promise/index.php) to learn about cancer and support cancer research. You can make the Promise in memory or honor of someone special.

According to the Tour of Hope team, you can help keep the Promise by:

+ Knowing your risks, geting screened and learning about cancer

+ Supporting your family and friends through their health care decisions

+ Advocating that cancer research become a national health care priority

+ And, if faced with the disease, discussing with your cancer care team the options available, including possible participation in a cancer research study (clinical trial).

The Grand Finale will be held [on the Ellipse in Washington](http://www.tourofhope.org/toh/2005_dc_finale/dc_ride_finale.htm) on October 8th.

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ASCO Foundation establishes fund to help cancer patients in need because of hurricanes

Posted by Kate Murphy on September 28th, 2005

Donations are being accepted by the ASCO Foundation to help cancer patients affected by hurricanes Katrina and Rita who are in need of critical services.

100% of all contributions to the **ASCO Foundation Hurricane Relief Fund** will be available through non-profit organizations that provide direct assistance to cancer patients, including *CancerCare*.

We realize that many cancer patients and their families who have been displaced are not only dealing with the challenges of their cancer diagnosis and treatment, but also with the trauma of uncertainty and temporary relocation. Funds will be made available through the end of 2006 to make sure this support reaches cancer patients as their individual situations and needs emerge over the coming year.

Donations may be made in memory of a loved one or in honor of a person living with cancer.

[More information on how to make a donation](http://www.ascofoundation.org/foundation/FoundationMain/1,2094,_12-003592-00_18-0042395-00_19-0042402-00_20-001,00.aspASC)

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