http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer We envision victory over colorectal cancer Fri, 18 May 2012 19:09:48 +0000 hourly 1 http://wordpress.org/?v=3.3.1 http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer/comment-page-1#comment-1919 Heinz-Josef Lenz Mon, 08 Jun 2009 17:05:55 +0000 http://fightcolorectalcancer.org/?p=4981#comment-1919 but probably two years..... but probably two years…..

]]> http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer/comment-page-1#comment-1918 Heinz-Josef Lenz Mon, 08 Jun 2009 17:05:32 +0000 http://fightcolorectalcancer.org/?p=4981#comment-1918 hopefully in one year HJL hopefully in one year HJL

]]> http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer/comment-page-1#comment-1917 j.d. Mon, 08 Jun 2009 16:59:57 +0000 http://fightcolorectalcancer.org/?p=4981#comment-1917 When will data become available on NO147? Are there any preliminary results? When will data become available on NO147? Are there any preliminary results?

]]> http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer/comment-page-1#comment-1916 Heinz-Josef Lenz Mon, 08 Jun 2009 13:43:34 +0000 http://fightcolorectalcancer.org/?p=4981#comment-1916 very well said. not that i dont use avastin but we need to know when and how. HJL very well said. not that i dont use avastin but we need to know when and how. HJL

]]> http://fightcolorectalcancer.org/dr_lenz/2009/06/avastin_in_stage_ii_and_iii_colon_cancer/comment-page-1#comment-1915 Maen Addassi Mon, 08 Jun 2009 13:03:06 +0000 http://fightcolorectalcancer.org/?p=4981#comment-1915 I think the Avastin is a big bubble should be finished for example: 1. Colorectal Cancer: with Oxaliplatin was not impressive. Only with Irinotecan also a negative result in early cancer 2. Breast cancer with old product called Paclitaxel was given a good result (only progression free survival not overall survival) but in the other hand with the newest & most common drug Docetaxel with a trial called Avado trial ; it seems the result was not so impressive they tried to promoted the Hazard ratio rather than a clinical result. The median time to disease progression was 8 months with docetaxel alone, compared with 8.7 months with docetaxel plus low-dose bevacizumab, and 8.8 months with docetaxel plus high-dose Bevacizumab it is 0.8 months = 24 days !!! 3. Lung cancer : at the beginning with Paclitaxel it was made a good survival a trial called E4599 by A Sandler published at 2006 at NEJM it is add 2 months for overall survival (from 10.2 to 12.2 ) with a double dose and of course a double cost. And at ATLAS study with Tarceva 1.3 Month more !!! 4. Renal cell carcinoma : same story; without any advantages regarding survival Kindly note the British health system was refused Avastin for CRC and/or other indications due to lack cost effectiveness. They approved Cetuximab rather than Avastin Is it worth this!!! I think the Avastin is a big bubble should be finished for example:
1. Colorectal Cancer: with Oxaliplatin was not impressive. Only with Irinotecan also a negative result in early cancer
2. Breast cancer with old product called Paclitaxel was given a good result (only progression free survival not overall survival) but in the other hand with the newest & most common drug Docetaxel with a trial called Avado trial ; it seems the result was not so impressive they tried to promoted the Hazard ratio rather than a clinical result. The median time to disease progression was 8 months with docetaxel alone, compared with 8.7 months with docetaxel plus low-dose bevacizumab, and 8.8 months with docetaxel plus high-dose Bevacizumab it is 0.8 months = 24 days !!!
3. Lung cancer : at the beginning with Paclitaxel it was made a good survival a trial called E4599 by A Sandler published at 2006 at NEJM it is add 2 months for overall survival (from 10.2 to 12.2 ) with a double dose and of course a double cost. And at ATLAS study with Tarceva 1.3 Month more !!!
4. Renal cell carcinoma : same story; without any advantages regarding survival
Kindly note the British health system was refused Avastin for CRC and/or other indications due to lack cost effectiveness. They approved Cetuximab rather than Avastin
Is it worth this!!!

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