Colorectal Cancer News in Brief: May 15

Despite more resources in large cities, patients were more often diagnosed with cancer at a late stage in cities in Illinois compared to rural areas. Phone calls and personalized diet and exercise plans helped long-term cancer survivors lose weight and gain strength, and scientists have found changes in the blood of family caregivers that promote inflammation and may lead to illness.

In other headlines, both patients and doctors liked virtual, computer videoconferencing visits, and the FDA reports that shortages of fentanyl patches have been resolved.

Research Reports

  • Finding cancer at a late stage is more common in Illinois cities than in rural areas. Colorectal, breast, prostate, and lung cancers — are more common in the most densely populated areas of Chicago and follow a pattern of reduced risk as the area population decreases. There was a small increased risk in the most remote rural areas. Researchers used data from Illinois State Cancer Registry from 1998 through 2002. Even after accounting for socioeconomic differences and access to nearby health care facilities, the disparities between city and rural remained. Writing in the early view edition of Cancer published May 11, 2009, geographer Sara McLafferty, Ph.D. said, “The observed pattern of urban disadvantage emphasized the need for more extensive urban-based cancer screening and education programs.”
  • Telephone calls and personally tailored printed diet and exercise information reduced the rate of functional decline in older, overweight long-term cancer survivors.  They lost weight and their physical activity, diet, and quality of life improved.  At the beginning of the year-long program both the group in the program and a control group had functional abilities averaging 75.7 on a 100 point scale.  During the year, overall scores declined 2.15 points for survivors in the program compared to a 4.84 loss for the control group.  Leg strength increased,while the control group’s leg function declined further. Program participants were over 65 and had survived cancer for more than five years. Miriam C. Morey, Ph.D. at Duke University reported the results of the study in the May 13, 2009 Journal of the American Medical Association.
  • The caregivers of cancer patients show very real changes over time in blood markers of inflammation — both those that promote inflammatory changes and those that protect against it.   Family members caring for patients with a very aggressive form of brain cancer had blood and saliva tested.  A matched group of controls, similar in age and background but free of major life stresses, were also tested.   Psychological tests showed the caregivers were more stressed than the average population and had more depression.  Excess inflammatory response left them vulnerable to heart disease and other illnesses that are triggered by chronic inflammation.  Nicolas Rohleder and  his team from the University of British Columbia published their work in an early online edition of the Journal of Clinical Oncology on May 11, 2009.

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