Scientists are studying the cells in the colon linings of volunteers to try to understand the effect of diet on the development of colorectal cancer. In a study reported in the February 1, 2005 edition of Cancer Research volunteers were fed one of three carefully controlled diets: high in red meat, high in fiber and red meat, or vegetarian.
Stool specimens were collected and tested for NOC (N-nitrosocompounds), a substance associated with red meat consumption and an increased risk of colorectal cancer. Cells in stool shed from the colon lining were tested for changes in DNA.
High red meat diets showed the greatest amount of NOC, as well as the most cell changes compared to vegetarian diets. High fiber-high meat diets showed intermediate changes, leading to the conclusion that fiber may modify the effect of red meat.
The scientists theorized that if DNA changes caused by consumption of red meat are not repaired, they may lead to the first changes in the process of developing colorectal cancer.
An article from Reuters explains the research.
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