Researchers in Australia have linked a protein — insulin-like growth factor binding protein 3 (IGFBP-3) – with better survival in physically active colorectal cancer patients. Increased levels of the protein resulted in a 48% reduction in colorectal cancer deaths during a median follow-up time of nearly 6 years.
For those who were not physically active, IGFBP-3 made no difference in survival.
Insulin-growth factor 1 (IFG-1) levels made no difference for either physically active or inactive patients.
The team headed by Dr. Andrew Hayden in Melbourne concluded:
This study supports the hypothesis that the beneficial effects of physical activity in reducing colorectal cancer mortality may occur through interactions with the insulin-like growth factor axis and in particular IGFBP-3.
Their results were published in the May 2006 issue of Gut
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