Comments on: Oral glutamine reduces oxaliplatin neuropathy in pilot study http://fightcolorectalcancer.org/research_news/2007/04/oral_glutamine_reduces_oxaliplatin_neuropathy_in_pilot_study We envision victory over colorectal cancer Thu, 09 Feb 2012 15:03:01 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: DE http://fightcolorectalcancer.org/research_news/2007/04/oral_glutamine_reduces_oxaliplatin_neuropathy_in_pilot_study/comment-page-1#comment-315 DE Wed, 03 Oct 2007 17:24:43 +0000 http://fightcolorectalcancer.org/uncategorized/2007/04/oral_glutamine_reduces_oxaliplatin_neuropathy_in_pilot_study#comment-315 I am a colorectal cancer patient. Originally staged 3 T2, underwent 28 days chemo-radiation with 5FU continous infusion, ending June 1. Had surgery end of July, temp. ileo. and just began Folfox. Downstaged to T2N2. After much research, I am using Glutamine (powder) 10g 3x/day mixed in juice or Gatorade, taking a time release high potency B complex, and using acupuncture. I am also taking Avemar, a wheat germ extract that has been show effective as an adjunct to traditional therapy for colorectal cancer. (Avemar.com) I will keep this board updated as treatments progress. I had chemo #1 on Monday, 10/1, experienced fatigue (not terrible), minor cold sensitivity (swallowing), and a litte tingling fingers and toes....all better by 2 days later. All anti nausea meds are working. So far, all manageable. I am a colorectal cancer patient. Originally staged 3 T2, underwent 28 days chemo-radiation with 5FU continous infusion, ending June 1. Had surgery end of July, temp. ileo. and just began Folfox. Downstaged to T2N2. After much research, I am using Glutamine (powder) 10g 3x/day mixed in juice or Gatorade, taking a time release high potency B complex, and using acupuncture. I am also taking Avemar, a wheat germ extract that has been show effective as an adjunct to traditional therapy for colorectal cancer. (Avemar.com)

I will keep this board updated as treatments progress. I had chemo #1 on Monday, 10/1, experienced fatigue (not terrible), minor cold sensitivity (swallowing), and a litte tingling fingers and toes….all better by 2 days later. All anti nausea meds are working. So far, all manageable.

]]> By: Dennis L. http://fightcolorectalcancer.org/research_news/2007/04/oral_glutamine_reduces_oxaliplatin_neuropathy_in_pilot_study/comment-page-1#comment-314 Dennis L. Sat, 14 Apr 2007 14:54:31 +0000 http://fightcolorectalcancer.org/uncategorized/2007/04/oral_glutamine_reduces_oxaliplatin_neuropathy_in_pilot_study#comment-314 This study is potentially very good news. I am a gastroenterologist who initally presented with asymptomatic Stage IV disease and underwent combined colon and liver resection with six months of Folfox 7 (includes oxaloplatin). While experiencing cold intolerance and jaw claudication (transient pain with chewing) it was not until the chemo was completed that I experienced the symptoms of a peripheral sensory neuropathy: numbness, tingling, pain, decreased fine motor skills. While the hand coordination has improved the neuropathic symptoms overall have not despite having completed chemo two years ago; although, in the majority of patients the neuropathy tends to resolve. Any prophylactic measure that could be taken concurrently with the chemo that would allow maintenance of the therapeutic dose is clinically valuable. I am curently taking 100 mg. of Vitamin B6 which has improved the pain (not numbness) somewhat. Overall,I have adopted the philosophy that if neuropathy is the only legacy that I am left with following a diagnosis of Stage IV disease I can readily accept that side effect. This study is potentially very good news. I am a gastroenterologist who initally presented with asymptomatic Stage IV disease and underwent combined colon and liver resection with six months of Folfox 7 (includes oxaloplatin). While experiencing cold intolerance and jaw claudication (transient pain with chewing) it was not until the chemo was completed that I experienced the symptoms of a peripheral sensory neuropathy: numbness, tingling, pain, decreased fine motor skills. While the hand coordination has improved the neuropathic symptoms overall have not despite having completed chemo two years ago; although, in the majority of patients the neuropathy tends to resolve. Any prophylactic measure that could be taken concurrently with the chemo that would allow maintenance of the therapeutic dose is clinically valuable. I am curently taking 100 mg. of Vitamin B6 which has improved the pain (not numbness) somewhat. Overall,I have adopted the philosophy that if neuropathy is the only legacy that I am left with following a diagnosis of Stage IV disease I can readily accept that side effect.

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