Weighing complications and survival in treating pelvic recurrences of rectal cancer

Posted by Kate Murphy on July 9th, 2007

Even after successful surgery to remove rectal cancer, pelvic recurrences can happen.  Surgery to remove the cancer offers a possibility of cure, but also has risks.

Surgical oncologists at Fox Chase Cancer Center in Philadelphia retrospectively reviewed surgeries to remove pelvic recurrences after rectal cancer surgery from 1988 through 2003 where the goal was curing the cancer. 

Studying outcomes for 90 patients, they found

  • 4 (4.4%) died during surgery
  • 53 percent had surgical complications
  • 5-year survival rate was 40%
  • 51 of 86 patients had another recurrence: 15 locally, 16 to distant organs, and 20 both locally and distant

Carcinoembryonic antigen level (CEA) before surgery and clear surgical margins helped predict successful treatment.

Writing in the Annals of Surgical Oncology, Leonard B. Henry, MD, concluded,

The resection of pelvic recurrences after colorectal surgery for cancer can be performed with low mortality and good long-term outcome; however, morbidity from such procedures is high. Low preoperative carcinoembryonic antigen and negative margin of resection predict improved survival.

SOURCE: Henry et. al. Annals of Surgical Oncology, Volume 14, Issue 7, July 2007.

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