Poorly Controlled Type 2 Diabetes Leads to Worse Outcomes for Colorectal Cancer
Posted by Kate Murphy on May 13th, 2008
Tags: colorectal cancer prognosis
Patients who have poorly controlled type-2 diabetes and colorectal cancer have worse outcomes than patients whose diabetes is controlled or patients without diabetes.
Poorly controlled type 2 diabetes led to more right-sided tumors, more advanced cancer at diagnosis, diagnosis at a younger age, and poorer five year survival.
Researchers at the Dallas Veterans Medical Center reviewed records of patients with colorectal cancer whose also had type 2 diabetes and matched them to a control group of colorectal cancer patients without diabetes. Poorly controlled type 2 diabetes was defined as a HbA1c level of 7.5 percent or more.
Patients who diabetes was well controlled were not much different than colorectal cancer patients without diabetes. However, patients whose type 2 diabetes was poorly controlled — as evidenced by a HbA1c level of 7.5 percent or more — had a clinically more aggressive form of colorectal cancer.
SOURCE: Ali A. Siddiqui et al.,Journal of Digestive Diseases and Sciences, published online April 12,2008.
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