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Cold Weather's Coming. . . and Oxaliplatin Difficulties

There was frost on the grass this morning when I let the little dog out.  A hard freeze is predicted for the next few nights, a sign that winter and its ice and snow isn’t far off. Cold is a special problem for people who are getting Eloxatin® (oxaliplatin) for colon and rectal cancer.  Almost all patients on FOLFOX will experience acute neuropathy within a few hours of each oxaliplatin infusion.  This is acute, short-term, and ends within few days. About a third will go on to a chronic peripheral neuropathy that begins as oxaliplatin doses accumulate.  Most patients will experience some tingling and numbness in their hands and feet.