The American Society for Clinical Oncology (ASCO) has published a provisional clinical opinion (PCO) advising doctors to test patients with colorectal cancer for KRAS mutations before treating them with medicines that include Erbitux® (cetuximab) or Vectibix™ (panitumumab).

The consensus of experts who reviewed recent research was that patients with metastatic colorectal cancer whose tumors have mutations in the KRAS gene do not benefit from treatment that targets the epidermal growth factor receptor (anti-EGFR therapy).  Patients should be tested for KRAS mutations and, if those mutations are found, not receive anti-EGFR antibodies as part of their treatment..

A PCO, based on expert consensus, is designed to help decision-making for oncologists faced with major research results that can potentially change the way they treat patients. Read the rest of this entry »

An panel of experts at the American Society of Clinical Oncology recommends that all patients who are being considered for anti-EGFR therapy have their tumors tested for the KRAS gene. If mutations are found, the panel says they should not be treated with Erbitux® (cetuximab) or Vectibix™ (panitumumab). Read the rest of this entry »

More News from ASCO 2008

Although men and women with metastatic colon or rectal cancer have similar overall survival after their diagnosis, age has an impact.  Women in premenopausal years, 18 to 44, live longer than younger men.  However, after the age of 75, women have significant worse survival than men.

Across all age groups, Hispanics survive the longest, followed by whites, Asians, African Americans, and, finally, Native Americans according to a study from the University of Southern California Norris Comprehensive Cancer Center and reported at ASCO. Read the rest of this entry »

Update from 2008 ASCO Meeting in Chicago

Provigil® (modafinil) reduced fatigue in cancer patients receiving chemotherapy according to a study reported by Gary Morrow PhD at the 2008 ASCO meeting.

Patients who were severely fatigued after their first chemotherapy treatment had less fatigue after they received Provigil than those who got a placebo. They were also less sleepy during the day.

Severe fatigue was considered more than 6 on a 10 point scale. Patients with mild or moderate fatigue did not have a similar improvement.

Despite improvement in severe fatigue, there was no effect on depression. Read the rest of this entry »

Update from 2008 ASCO Meeting in Chicago

Patricia Ganz, MD received the American Cancer Society Award at ASCO this year.  Professor of Medicine at the University of California at Los Angeles and Director of Cancer Prevention and Research at Jonsson Comprehensive Cancer Center, Dr. Ganz has a long history of concern for cancer patients and their quality of life.

In the lecture that accompanied the ACS Award, Dr. Ganz discussed the importance of research that looks at quality of life and the effects of cancer treatment, both during treatment and after it.  In particular she encouraged the development of survivorship care plans that improve communication among patients, their oncology care providers, and other health professionals who care for them after their cancer treatment ends. Read the rest of this entry »