Tag Archives: C-08

C-08 Avastin Trial Didn't Meet Primary Goal

When Avastin® (bevacizumab) was added to standard chemotherapy after surgery, it didn’t reduce the risk that early stage colon cancer would return, according to a press release this morning from Genentech. NSABP C-08 randomly assigned patients with stage II or III colon cancer to FOLFOX chemotherapy with or without additional Avastin.  During the Phase III clinical trial, all patients received FOLFOX (oxaliplatin, leucovorin, and infused 5-FU) every two weeks for six months.  Half also got Avastin with each treatment plus an additional six months of Avastin only. The study’s primary objective was disease-free survival, defined as lack of recurrence, another new cancer, or death for any reason.  According to Genentech, adding Avastin to

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