Tag Archives: clinical trials

Colorectal Cancer Briefs: PSA Contest,Medicare Co-Pays, NCI Bethesda Clinical Trials

Briefly The Colorectal Cancer Association of Canada is sponsoring a contest for print and video ads that raise awareness of colorectal cancer. Clinical trials at the NIH Clinical Center in Bethesda, MD are an option for cutting-edge treatment at no cost. When co-pays are raised for Medicare, the elderly make fewer outpatient visits but are hospitalized more often and stay in the hospital longer.

Stage III Cetuximab Trial Closed

It doesn’t help patients to add Erbitux to FOLFOX chemotherapy after surgery for stage III colon cancer a data monitoring committee for a clinical trial testing the new treatment has decided. Because the analysis showed that patients were not benefiting from adding Erbitux to FOLFOX chemotherapy, the trial has been closed according to a news release from the National Cancer Institute.

Trial of New Drug to Blocks Cell Changes Available at NIH Clinical Center

An oral drug that blocks activity of enzymes that change proteins in cells that leads to cancer is being tested at the National Institutes of Health. R935788 or Fostamatinib, a protein kinase inhibitor, is in a Phase II clinical trial for patients with several types of advanced cancer, including colorectal cancer.  Patients whose cancer has gotten worse on previous treatment are eligible to participate.  The trial is being conducted at the NIH Clinical Center in Bethesda, Maryland.

Test of Vaccine Against Colon Cancer Underway

Scientists at the University of Pittsburgh are testing a vaccine to recognize a protein in colon polyps and trigger the immune system to destroy them. MUC1 is a protein found in precancerous colorectal polyps and in colon cancer. The experimental vaccine causes the body’s immune system to develop antibodies against MUC1, killing tissue that contains it and potentially preventing polyps from returning.

Phase III Sutent Trial for Colorectal Cancer Discontinued

Pfizer announced yesterday, June 30, 2009, that they are discontinuing a phase III trial comparing FOLFIRI chemotherapy alone to FOLFIRI with added Sutent® (sunitinib). Based on results so far, the independent Data Monitoring Committee (DMC) determined that a significant reduction in progression-free survival was not statistically possible.  No new safety concerns were identified.

Almost There: Colon Cancer Clinical Trial Needs Six More Patients

NSABP C-10 needs only six more patients to complete enrollment and prepare to answer the question: Is it safe and effective to leave a primary tumor without symptoms in the colon or rectum and proceed directly to chemotherapy in patients with colon cancer that has spread to distant organs where it cannot be surgically removed, The trial has already enrolled 84 of the 90 patients with metastatic colon cancer needed. All patients in the study will be treated with FOLFOX (oxaliplatin, leucovorin, and continuous infusion 5-FU) and Avastin® (bevacizumab) every two weeks for as long as their cancer doesn’t get worse and they are able to tolerate side effects.  

Clinical Trial Open: Tomotherapy for Limited Cancer Mets

Cancer patients with only a few tumors that have spread to other parts of their bodies (metastases) will be part of a clinical trial to test precisely focused, high-dose radiation treatment called helical tomotherapy. Researchers at the National Institutes of Health Clinical Center want to know if helical tomography, focused on metastatic tumors, can destroy them and keep them from returning in patients whose tumors cannot be removed surgically or who are not willing to have surgery. The trial is being conducted by the National Cancer Institute on the NIH Clinical Center campus in Bethesda, MD.

How to Treat Rectal Cancer after Surgery? A Clinical Trial

Focus on Clinical Trials Can adding Avastin® (bevacizumab) to FOLFOX therapy after surgery and presurgical chemoradiotherapy reduce recurrence and improve survival for patients with rectal cancer? A clinical trial to answer this question is underway and is looking for participants.  Led by a team of researchers from several clinical trials cooperative groups, the E5204 study randomly assigns patients who have already completed a course of chemoradiotherapy and had their rectal cancer removed surgically to either FOLFOX or FOLFOX plus Avastin.

Clinical Trial: Vaccine Therapy after Surgery

Can the body develop an immune response that will destroy cancer cells in the body and prevent cancer from returning after surgery to remove metastatic tumors?  If it can, what’s the best way to do that? Researchers are studying vaccines and immune response in patients whose colorectal cancer has spread beyond their original cancer to their liver or lungs.  They’re looking for patients who have completed surgery for a  clinical trial of PANVAC-VF.

Clinical Trial Testing Ultrasound System for Painful Bone Mets

Cancer that has spread to the bone can be excruciatingly painful.  Currently radiation treatment or opiate drugs are used to manage pain, but these are not always successful. A system that combines magnetic resonance imaging (MRI) with ultrasound treatment to destroy bone tumors and treat pain is being evaluated in a randomized Phase III clinical trial at a number of centers in the United States, Canada, and Israel. BM004: A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain in Patients Who are not Candidates for Radiation Therapy is sponsored by InSightec Ltd.

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