Trial of New Drug to Blocks Cell Changes Available at NIH Clinical Center

An oral drug that blocks activity of enzymes that change proteins in cells that leads to cancer is being tested at the National Institutes of Health. R935788 or Fostamatinib, a protein kinase inhibitor, is in a Phase II clinical trial for patients with several types of advanced cancer, including colorectal cancer.  Patients whose cancer has gotten…  Read More

Test of Vaccine Against Colon Cancer Underway

Scientists at the University of Pittsburgh are testing a vaccine to recognize a protein in colon polyps and trigger the immune system to destroy them. MUC1 is a protein found in precancerous colorectal polyps and in colon cancer. The experimental vaccine causes the body’s immune system to develop antibodies against MUC1, killing tissue that contains it…  Read More

Phase III Sutent Trial for Colorectal Cancer Discontinued

Pfizer announced yesterday, June 30, 2009, that they are discontinuing a phase III trial comparing FOLFIRI chemotherapy alone to FOLFIRI with added Sutent® (sunitinib). Based on results so far, the independent Data Monitoring Committee (DMC) determined that a significant reduction in progression-free survival was not statistically possible.  No new safety concerns were identified.

Almost There: Colon Cancer Clinical Trial Needs Six More Patients

NSABP C-10 needs only six more patients to complete enrollment and prepare to answer the question: Is it safe and effective to leave a primary tumor without symptoms in the colon or rectum and proceed directly to chemotherapy in patients with colon cancer that has spread to distant organs where it cannot be surgically removed, The trial…  Read More

Clinical Trial Open: Tomotherapy for Limited Cancer Mets

Cancer patients with only a few tumors that have spread to other parts of their bodies (metastases) will be part of a clinical trial to test precisely focused, high-dose radiation treatment called helical tomotherapy. Researchers at the National Institutes of Health Clinical Center want to know if helical tomography, focused on metastatic tumors, can destroy them…  Read More

How to Treat Rectal Cancer after Surgery? A Clinical Trial

Focus on Clinical Trials Can adding Avastin® (bevacizumab) to FOLFOX therapy after surgery and presurgical chemoradiotherapy reduce recurrence and improve survival for patients with rectal cancer? A clinical trial to answer this question is underway and is looking for participants.  Led by a team of researchers from several clinical trials cooperative groups, the E5204 study randomly…  Read More