Phase III Sutent Trial for Colorectal Cancer Discontinued

Pfizer announced yesterday, June 30, 2009, that they are discontinuing a phase III trial comparing FOLFIRI chemotherapy alone to FOLFIRI with added Sutent® (sunitinib). Based on results so far, the independent Data Monitoring Committee (DMC) determined that a significant reduction in progression-free survival was not statistically possible.  No new safety concerns were identified.

Almost There: Colon Cancer Clinical Trial Needs Six More Patients

NSABP C-10 needs only six more patients to complete enrollment and prepare to answer the question: Is it safe and effective to leave a primary tumor without symptoms in the colon or rectum and proceed directly to chemotherapy in patients with colon cancer that has spread to distant organs where it cannot be surgically removed, The trial…  Read More

Clinical Trial Open: Tomotherapy for Limited Cancer Mets

Cancer patients with only a few tumors that have spread to other parts of their bodies (metastases) will be part of a clinical trial to test precisely focused, high-dose radiation treatment called helical tomotherapy. Researchers at the National Institutes of Health Clinical Center want to know if helical tomography, focused on metastatic tumors, can destroy them…  Read More

How to Treat Rectal Cancer after Surgery? A Clinical Trial

Focus on Clinical Trials Can adding Avastin® (bevacizumab) to FOLFOX therapy after surgery and presurgical chemoradiotherapy reduce recurrence and improve survival for patients with rectal cancer? A clinical trial to answer this question is underway and is looking for participants.  Led by a team of researchers from several clinical trials cooperative groups, the E5204 study randomly…  Read More

Clinical Trial: Vaccine Therapy after Surgery

Can the body develop an immune response that will destroy cancer cells in the body and prevent cancer from returning after surgery to remove metastatic tumors?  If it can, what’s the best way to do that? Researchers are studying vaccines and immune response in patients whose colorectal cancer has spread beyond their original cancer to their…  Read More

Clinical Trial Testing Ultrasound System for Painful Bone Mets

Cancer that has spread to the bone can be excruciatingly painful.  Currently radiation treatment or opiate drugs are used to manage pain, but these are not always successful. A system that combines magnetic resonance imaging (MRI) with ultrasound treatment to destroy bone tumors and treat pain is being evaluated in a randomized Phase III clinical trial…  Read More