Although overall colorectal cancer rates are lower Native Americans than in whites, there are significant regional differences that show a marked increase in colorectal cancer in Alaskan Natives and Native Americans who live in the Northwest Plains.
Alaskan Natives and Alaskan Indians were twice as likely to have colorectal cancer as non-Hispanic whites, and five times as likely as Native Americans living in the Southwest. Native Americans in the Northern Plains were diagnosed with colon or rectal cancer about 40 percent more often than whites.
Alaska natives also were diagnosed with advanced colorectal cancer almost twice as often as white Americans.

