ASCO Advises Oncologists: Test for KRAS Mutations

The American Society for Clinical Oncology (ASCO) has published a provisional clinical opinion (PCO) advising doctors to test patients with colorectal cancer for KRAS mutations before treating them with medicines that include Erbitux® (cetuximab) or Vectibix™ (panitumumab). The consensus of experts who reviewed recent research was that patients with metastatic colorectal cancer whose tumors have mutations in…  Read More

Another Gene Found Linked to Lack of Erbitux/Vectibix Response

Another mutated gene has been discovered that appears to cause resistance to treatment with the EGFR inhibitors Erbitux® (cetuximab) and  Vectibix™ (panitumumab). Only a fraction of patients who receive Erbitux or Vectibix respond to it.  There is now convincing evidence that the 30 to 40 percent of colorectal cancer patients whose tumors have mutated KRAS genes…  Read More