Tag Archives: Exact Sciences

FDA approves first non-invasive DNA test for colorectal cancer

Big news in the colorectal cancer prevention and screening community yesterday! In a never-before-seen move, the Food & Drug Administration (FDA) and Centers for Medicare & Medicaid Services (CMS) jointly proposed Cologuard as a new option for colorectal cancer screening. What is Cologuard? Cologuard, produced by Exact Sciences, is a non-invasive (not requiring insertion of instruments into the body), stool-based (you test your poo) DNA test designed to analyze the presence of blood and certain DNA mutations in a patient’s stool sample that can indicate cancer and/or precancerous polyps. Cells of DNA are released into the stool continuously as part of the digestive process. There are already at-home screening options

Improved Stool Screening Test Finds DNA Changes

Too many people avoid colonoscopy.  Too invasive, they say.  Too scary, too risky. There may be an answer for them in an improved stool test that looks for DNA that is changed in both colorectal cancer and some precancerous polyps. Of course, if the stool test identifies possible polyps or cancer, a colonoscopy is critical to evaluate the findings and remove polyps. The test that looks for methylated DNA in human feces, found 85 percent of cancers and 64 percent of large adenomas.  There were few false positives.  Only one in ten follow-up colonoscopies didn’t confirm cancer or adenomas.

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