Tag Archives: KRAS

Erbitux Approved as First-Line Treatment

The FDA has approved Erbitux™ (cetuximab) in combination with FOLFIRI for first-line treatment of patients with metastatic colorectal cancer whose tumors have a wild-type (WT) KRAS gene.  Erbitux was first approved in 2004 for patients whose cancer was not responding to available treatments. FDA’s action was prompted by results from a look back at patient outcomes and KRAS status from three trials: CRYSTAL:  phase 3, 1217 patients newly diagnosed with metastatic CRC, comparing FOLFIRI vs FOLFIRI + Erbitux OPUS: phase 2, 337 patients newly diagnosed with metastatic CRC, comparing FOLFOX vs FOLFOX + Erbitux CA225025: phase 3, 572 patients with metastatic CRC that stopped responding to available treatments, comparing Best Supportive

Highlights from ASCO 2011

While there weren’t new blockbuster announcements for colorectal cancer this year at the American Society for Clinical Oncology’s (ASCO) Annual Meeting, there was plenty of focus on making what we already have work better and on choosing the patients who will benefit the most from treatments, as well as those who might not be helped at all. (Note, many of these issues will be discussed in detail on our upcoming patient webinar.) Highlights: While adding oxaliplatin to 5-FU improves five year survival slightly for stage II colon cancer, it increases side effects, particularly tingling and numbness in the feet.  An analysis of several NSABP trials found that two or three

Personalizing Personalized Medicine

On Monday, April 25th, Fight Colorectal Cancer held a free patient webinar that tackled the somewhat complex but fascinating topic of personalized medicine. Personalized medicine is what the cancer community calls treatments that are tailored to each patient’s genetic makeup. It is the future of cancer care and in some cases, it is already making a big difference in the ways patients are treated. You can learn about these cutting edge treatments and about emerging findings in an archive of the webinar below. Our thanks to Carolyn Grande, CRNP, AOCNP for leading the discussion. She a phenomenal educator on this topic and a member of our Medical Advisory Board. She graciously

Value of KRAS and BRAF Mutations in Forecasting Survival

For stage II and III colon cancer, a tumor mutation in the KRAS gene does not impact either relapse-free survival or overall survival. BRAF mutations, which are less common, don’t help with prognosis for relapse-free survival, but do provide information about overall survival in some tumors.   Patients with BRAF mutations and microsatellite-low or stable tumors had poorer overall survival than those without mutations.

KRAS Made No Difference in Stage III Outcome

Patients with stage III colon cancer didn’t do better or worse if their tumor had mutated KRAS. Studying KRAS in the tumors of about half the patients in a large clinical trial of chemotherapy for stage III colon cancer, researchers found no differences in disease-free, recurrence-free, or overall survival.  This remained true no matter which chemotherapy the patients received.

FDA Approves Labeling Changes for Erbitux and Vectibix to Reflect KRAS Status

The Food and Drug Administration (FDA) has approved labeling changes for Vectibix and Erbitux to reflect studies that found the two drugs are not effective in patients whose tumors have mutated KRAS. The FDA has updated the indication and usage for Vectibix™  (panitumumab) and Erbitux® (cetuximab) to include a statement that: retrospective subset analyses of metastatic or advanced colorectal cancer trials have not shown a treatment benefit for ERBITUX in patients whose tumors had K-ras mutations in codon 12 or 13 and that the use of ERBITUX is not recommended for the treatment of colorectal cancer with these mutations. Retrospective subset analyses of metastatic or advanced colorectal cancer trials have not

ASCO Advises Oncologists: Test for KRAS Mutations

The American Society for Clinical Oncology (ASCO) has published a provisional clinical opinion (PCO) advising doctors to test patients with colorectal cancer for KRAS mutations before treating them with medicines that include Erbitux® (cetuximab) or Vectibix™ (panitumumab). The consensus of experts who reviewed recent research was that patients with metastatic colorectal cancer whose tumors have mutations in the KRAS gene do not benefit from treatment that targets the epidermal growth factor receptor (anti-EGFR therapy).  Patients should be tested for KRAS mutations and, if those mutations are found, not receive anti-EGFR antibodies as part of their treatment.. A PCO, based on expert consensus, is designed to help decision-making for oncologists faced with

Colorectal Cancer News in Brief: April 10

This week we review research on the impacts of colonoscopy screening in Germany, folic acid flour supplementation in Chile, and untreated anxiety and pain during the last months of life on surviving spouses of cancer patients. In the news are reports of colon cancer surgery using a tiny incision in the belly button, requirements for KRAS testing before insurance will pay for Erbitux or Vectibix treatment, and information about how stem cells in the intestinal tract become cancer stem cells, driving the development and progression of colorectal cancer.

Top