Erbitux Approved as First-Line Treatment

The FDA has approved Erbitux™ (cetuximab) in combination with FOLFIRI for first-line treatment of patients with metastatic colorectal cancer whose tumors have a wild-type (WT) KRAS gene.  Erbitux was first approved in 2004 for patients whose cancer was not responding to available treatments. FDA’s action was…

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Highlights from ASCO 2011

While there weren’t new blockbuster announcements for colorectal cancer this year at the American Society for Clinical Oncology’s (ASCO) Annual Meeting, there was plenty of focus on making what we already have work better and on choosing the patients who will benefit the most from…

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Personalizing Personalized Medicine

On Monday, April 25th, Fight Colorectal Cancer held a free patient webinar that tackled the somewhat complex but fascinating topic of personalized medicine. Personalized medicine is what the cancer community calls treatments that are tailored to each patient’s genetic makeup. It is the future of…

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Value of KRAS and BRAF Mutations in Forecasting Survival

For stage II and III colon cancer, a tumor mutation in the KRAS gene does not impact either relapse-free survival or overall survival. BRAF mutations, which are less common, don’t help with prognosis for relapse-free survival, but do provide information about overall survival in some…

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KRAS Made No Difference in Stage III Outcome

Patients with stage III colon cancer didn’t do better or worse if their tumor had mutated KRAS. Studying KRAS in the tumors of about half the patients in a large clinical trial of chemotherapy for stage III colon cancer, researchers found no differences in disease-free,…

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CancerCare Workshop on KRAS on November 5

Join a CancerCare Telephone Education Workshop on November 5th to learn more about KRAS and colon cancer. Medical Update on Colon Cancer: Understanding K-RAS November 5, 2009 1:30 pm to 2:30 pm Registration required

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Biomarkers Predict Colorectal Cancer Survival

Two gene changes that occur in some colorectal cancers can forecast chances for good or poor survival. Patients whose cancers had high microsatellite instability (MSI) had significantly better outcomes at every stage, but mutations in the KRAS gene predicted poorer survival.

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ASCO Advises Oncologists: Test for KRAS Mutations

The American Society for Clinical Oncology (ASCO) has published a provisional clinical opinion (PCO) advising doctors to test patients with colorectal cancer for KRAS mutations before treating them with medicines that include Erbitux® (cetuximab) or Vectibix™ (panitumumab). The consensus of experts who reviewed recent research was…

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