Tag Archives: leucovorin shortage

Colorectal Cancer News in Brief: May 8

This week a panda gets a colonoscopy, details are reported on swine flu cases, and information about acrylamide in food and cancer risk is reviewed.  The FDA says that the leucovorin shortage has been resolved and supplies are available. We also found a study that used stereotactic body radiosurgery (SBRS) for tumors from cancer that had spread to the spine.  In other research, the number of lymph nodes recovered during colon and rectal surgery depends on the patient’s age, where the cancer was located, and how long the removed specimen was.

Leucovorin Shortage Update

The Food and Drug Administration has updated information on the shortage of leucovorin as of January 21, 2009. Teva Parenteral Medicines reports a shortage of Leucovorin Calcium Lyophilized Powder for Injection due to “Increase in Demand”. Bedford Laboratories reports a shortage of Leucovorin Calcium Solution for Injection and Leucovorin Calcium Lyophilized Powder for Injection due to “Manufacturing Delays.”

Boehringer Ingelheim Addresses Leucovorin Shortage

Boehringer Ingelheim, parent company of Bedford Laboratories, reports that Bedford is shipping some leucovorin, but that improvements in its manufacturing facilities will cause some short-term interruptions. In a statement, Boehringer Ingleheim says that five lots of intravenous leucovorin were released between late November and mid-December, providing about 175,000 vials.  Another two lots are expect to be shipped before the end of 2008 containing another 167,000 vials. According to the statement, Bedford Laboratories will continue to work with the FDA drug shortage staff to provide updates on leucovorin.

Leucovorin Shortage Threatens Colorectal Cancer Treatment

The Food and Drug Administration is reporting shortages of leucovorin calcium, used to enhance the effectiveness of 5-FU (fluorouracil) in treating colorectal cancer.  The reason the FDA gives for the shortage is “Manufacturing Delays.” Leucovorin is supplied by Teva Pharmaceuticals and Bedford Laboratories, and the FDA directs consumers to contact them for more information. According to a bulletin from the American Society of Health System Pharmacists (ASHP), “Leucovorin calcium lyophilized powder is on back order and the company cannot estimate a release date.” In addition, ASHP has been told, “The manufacturers will not provide a reason for the shortage.” ASHP updated their information with personal communications with the manufacturers on