Tag Archives: Lynch syndrome

March 22: Lynch Syndrome Hereditary Cancer Public Awareness Day

Fight those Cougars! Colon, ovarian, uterine, gastric, renal, and skin cancer. All Lynch syndrome related cancers, and all significantly increased in families with Lynch syndrome mutations. Brain and small bowel cancer risks are also higher. In addition, new evidence finds that pancreatic and breast cancer are also part of Lynch syndrome. Today, people living with Lynch syndrome come together with researchers, genetic counselors, and healthcare professionals to spread the word that Lynch syndrome can be managed. But first it needs to be recognized. Awareness saves lives. Careful family histories and routine testing after surgery can identify people who have one of the genes that cause Lynch syndrome. When you find

ID-ing Lynch Syndrome in Women with Endometrial Cancer Saves Lives and is Cost-Effective

45,000 women were diagnosed with endometrial cancer in the United States in 2010 — and for nearly 900, cancer was due to Lynch syndrome. Women who have Lynch syndrome have an increased risk of getting endometrial cancer during their lifetime that is as high as 60 percent. Often endometrial cancer (cancer of the lining of the uterus) is the first Lynch-related cancer diagnosed, earlier than colon or rectal cancer. Identifying a mutation in these women can prevent future colorectal cancers and discover ovarian, gastric, and other Lynch cancers early when they can be treated successfully. And not only does this help the woman with endometrial cancer, it helps her family

Screening Tumors for Lynch Syndrome is Cost-Effective

Screening all new colon and rectal cancer tumors for markers that might indicate Lynch syndrome not only saves future lives, it is cost effective according to a new study. In order for tumor screening to be cost-effective, not only should new tumors be tested, but family members need to follow through with genetic testing after a new Lynch mutation is found.  Finally people with Lynch syndrome mutations need to follow surveillance guidelines to prevent cancer or find it early, Testing both tumors and at least three to four family members could cost as little of $36,000 per life year saved — well within the value of preventive health strategies.

Pre-Surgical MSI Testing for Young Patients

Digestive Disease Week 2011 Update Finding colorectal cancer patients with Lynch syndrome helps both patients and their families to prevent cancer. Lynch patients are at high risk for a second or third colon cancer, so identifying them before their colorectal surgery may change the operation planned.  Surgeons may want to remove the entire colon to prevent another colon cancer, and women may choose to have a hysterectomy during the same surgery to prevent endometrial cancer. Because young patients are more likely to have Lynch syndrome, pathologists at the Mayo Clinic tested tumors from patients 50 years old or younger for microsatellite instability (MSI) after their surgery if they had not

Does Colorectal Cancer Run in Your Family?

Miss last week’s webinar?  It’s right here. Listen to Dr. Henry Lynch talk about his early experience with families with unusually high numbers of colorectal and other cancers.  Hear what he has to say about finding families at risk and preventing cancer deaths. Lynch syndrome survivor, Kate Murphy, shares her own story and that of her family.

Widespread Early Screening for Lynch Syndrome is Cost-Effective . . . and Saves Lives

If doctors ask  healthy people simple questions about cancers in their families, they can find people who are at increased risk for Lynch syndrome, an inherited condition that greatly increases risk for colorectal and uterine cancer. Doctors can use a simple set of screening questions available online to pinpoint an individual’s risk before that person ever gets cancer.   The online tool takes less than two minutes to complete. If family history shows an individual to be at higher risk, genetic testing not only saves lives but is cost-effective. Once Lynch syndrome is diagnosed, active steps can be taken to prevent Lynch-associated cancers or diagnose them early when they can be

Is Breast Cancer Linked to Lynch Syndrome?

Although breast cancer has not traditionally been considered one of the cancers associated with Lynch syndrome, evidence is building that there might be a link. Breast cancer may actually be with in the spectrum of Lynch cancers. An Australian team reviewing the pathology of breast cancers in women who carried a mutation for Lynch syndrome ( hereditary non-polyposis colon cancer) found that half of the breast tumors were mismatch repair deficient — a hallmark of Lynch cancers.

Annual Colonoscopy for Lynch Syndrome

Annual colonoscopies for people with Lynch syndrome (HNPCC or hereditary nonpolyposis colon cancer) successfully find cancers at an early stage. A recent study by the German HNPCC Consortium confirmed the effectiveness of annual colonoscopies to find colorectal cancers at a curable stage.  Regular colonoscopies found early cancers more often than did patient symptoms. Current recommendations are for surveillance colonoscopies to begin by age 25, be repeated every 1 to 2 years until age 40, and then annually.

Choosing the Best Colon Surgery for Lynch Syndrome

Removing the entire colon (subtotal colectomy) is sometimes recommended for patients with Lynch syndrome when colon cancer is diagnosed.  In addition, some people who have an inherited Lynch mutation have their colons removed to prevent colon cancer. While subtotal colectomy didn’t reduce deaths from Lynch-related colon cancer, it did cut down on additional colorectal cancer diagnoses and the need for other abdominal surgery.

Risk for Lynch Syndrome Related Cancers in MSH6 Mutations

People with a mutation in the MSH6 gene, part of the Lynch syndrome, have a greatly increased risk of colorectal, endometrial, and other related cancers.  The cancers can occur in old age, with an increasing risk from age 70 to 80. About 4 in every 1000 colorectal cancers are due to an inherited mutation in the MSH6 gene.  It accounts for about 10 to 20 percent of Lynch syndrome mutations. By the time they are 80 years old, men have eight times the risk of getting colorectal cancer and women have 26 times the risk of endometrial cancer — cancer that begins in the lining of the uterus.