Tag Archives: Lynch syndrome

Screening Tumors for Lynch Syndrome is Cost-Effective

Screening all new colon and rectal cancer tumors for markers that might indicate Lynch syndrome not only saves future lives, it is cost effective according to a new study. In order for tumor screening to be cost-effective, not only should new tumors be tested, but family members need to follow through with genetic testing after a new Lynch mutation is found.  Finally people with Lynch syndrome mutations need to follow surveillance guidelines to prevent cancer or find it early, Testing both tumors and at least three to four family members could cost as little of $36,000 per life year saved — well within the value of preventive health strategies.

Pre-Surgical MSI Testing for Young Patients

Digestive Disease Week 2011 Update Finding colorectal cancer patients with Lynch syndrome helps both patients and their families to prevent cancer. Lynch patients are at high risk for a second or third colon cancer, so identifying them before their colorectal surgery may change the operation planned.  Surgeons may want to remove the entire colon to prevent another colon cancer, and women may choose to have a hysterectomy during the same surgery to prevent endometrial cancer. Because young patients are more likely to have Lynch syndrome, pathologists at the Mayo Clinic tested tumors from patients 50 years old or younger for microsatellite instability (MSI) after their surgery if they had not

Does Colorectal Cancer Run in Your Family?

Miss last week’s webinar?  It’s right here. Listen to Dr. Henry Lynch talk about his early experience with families with unusually high numbers of colorectal and other cancers.  Hear what he has to say about finding families at risk and preventing cancer deaths. Lynch syndrome survivor, Kate Murphy, shares her own story and that of her family.

Widespread Early Screening for Lynch Syndrome is Cost-Effective . . . and Saves Lives

If doctors ask  healthy people simple questions about cancers in their families, they can find people who are at increased risk for Lynch syndrome, an inherited condition that greatly increases risk for colorectal and uterine cancer. Doctors can use a simple set of screening questions available online to pinpoint an individual’s risk before that person ever gets cancer.   The online tool takes less than two minutes to complete. If family history shows an individual to be at higher risk, genetic testing not only saves lives but is cost-effective. Once Lynch syndrome is diagnosed, active steps can be taken to prevent Lynch-associated cancers or diagnose them early when they can be

Is Breast Cancer Linked to Lynch Syndrome?

Although breast cancer has not traditionally been considered one of the cancers associated with Lynch syndrome, evidence is building that there might be a link. Breast cancer may actually be with in the spectrum of Lynch cancers. An Australian team reviewing the pathology of breast cancers in women who carried a mutation for Lynch syndrome ( hereditary non-polyposis colon cancer) found that half of the breast tumors were mismatch repair deficient — a hallmark of Lynch cancers.

Annual Colonoscopy for Lynch Syndrome

Annual colonoscopies for people with Lynch syndrome (HNPCC or hereditary nonpolyposis colon cancer) successfully find cancers at an early stage. A recent study by the German HNPCC Consortium confirmed the effectiveness of annual colonoscopies to find colorectal cancers at a curable stage.  Regular colonoscopies found early cancers more often than did patient symptoms. Current recommendations are for surveillance colonoscopies to begin by age 25, be repeated every 1 to 2 years until age 40, and then annually.

Choosing the Best Colon Surgery for Lynch Syndrome

Removing the entire colon (subtotal colectomy) is sometimes recommended for patients with Lynch syndrome when colon cancer is diagnosed.  In addition, some people who have an inherited Lynch mutation have their colons removed to prevent colon cancer. While subtotal colectomy didn’t reduce deaths from Lynch-related colon cancer, it did cut down on additional colorectal cancer diagnoses and the need for other abdominal surgery.

Risk for Lynch Syndrome Related Cancers in MSH6 Mutations

People with a mutation in the MSH6 gene, part of the Lynch syndrome, have a greatly increased risk of colorectal, endometrial, and other related cancers.  The cancers can occur in old age, with an increasing risk from age 70 to 80. About 4 in every 1000 colorectal cancers are due to an inherited mutation in the MSH6 gene.  It accounts for about 10 to 20 percent of Lynch syndrome mutations. By the time they are 80 years old, men have eight times the risk of getting colorectal cancer and women have 26 times the risk of endometrial cancer — cancer that begins in the lining of the uterus.

Colorectal Cancer News in Brief: November 1

Briefly: Pancreatic cancer occurs in about on in five Lynch syndrome families, increasing risk for the cancer substantially. Colorectal cancer patients whose tumors don’t have EGFR on immunohistochemical testing can still benefit from Erbitux treatment. Patients learn more and like medical consultations better when doctors sit side-by-side with them to view tests. Gastroenterologists deployed in Iraq are using their skills to help military working dogs.

Aspirin Prevents Lynch Syndrome Cancers

ECCO/ESMO UPDATE — BERLIN 2009 Although initial reports found no reduction in polyps or cancer in people with Lynch syndrome who took aspirin and/or resistant starch supplements, longer follow-up tells a difference story. About five years after trial participants began taking aspirin or a placebo, differences began to emerge. Even though patients in the trial only took aspirin for four years, later followup found significantly fewer colon colon cancers among those who had used  aspirin, as well as fewer Lynch-related cancers overall.   There were almost three times as many colon cancers in Lynch carriers who took a placebo compared to those who used aspirin.

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