Tag Archives: Lynch syndrome

Aspirin Prevents Lynch Syndrome Cancers

ECCO/ESMO UPDATE — BERLIN 2009 Although initial reports found no reduction in polyps or cancer in people with Lynch syndrome who took aspirin and/or resistant starch supplements, longer follow-up tells a difference story. About five years after trial participants began taking aspirin or a placebo, differences began to emerge. Even though patients in the trial only took aspirin for four years, later followup found significantly fewer colon colon cancers among those who had used  aspirin, as well as fewer Lynch-related cancers overall.   There were almost three times as many colon cancers in Lynch carriers who took a placebo compared to those who used aspirin.

September is GYN Cancers Month

September is set aside to raise awareness of gynecological cancers.  GYN cancers affect women’s reproductive organs including the cervix, endometrium, uterus, fallopian tubes, vagina, vulva, and ovaries. In 2009 there will be an estimated 80,720 new cases of GYN cancers and 28,120 deaths. Women with Lynch syndrome (also known as hereditary non-polyposis colon cancer or HNPCC)  have a high lifetime risk of endometrial cancer, reaching 71 percent by the age of 70.  This is much higher than the general population whose risk is less than 2 percent.

Old Chemo Drug May Fight Lynch Syndrome

Methotrexate, a chemotherapy drug used as long ago as the 1940′s, may be effective against colorectal cancers caused by mutations in a gene that is part of Lynch syndrome. The drug targeted and destroyed cells that contained mutated MSH2 genes. Inherited mutations in MSH2 prevent mistakes in correct copying of DNA during cell division allowing cancer to develop and grow, particularly inherited colorectal and endometrial cancers.  In addition, MSH2 mutations can occur in some colorectal cancers that are not inherited. Based on the work done in cancer cells, a Phase II clinical trial has begun recruiting patients with advanced colorectal cancer at the Royal Marsden Cancer Hospital in the United

Lynch syndrome: Lifetime Risk of Colorectal and Endometrial Cancers

A new study estimates the lifetime risks for colorectal and endometrial cancer in people with a genetic mutation for Lynch syndrome. The analysis was controlled to avoid bias and overestimating risk. Even after adjusting for possible bias, lifetime risks for both cancers was high and the need for special surveillance was critical.

Colorectal Cancer News in Brief: August 7

Research has found aspirin or resistant starch doesn’t help people with Lynch syndrome avoid new polyps.  While almost all people had seen a cancer-related ad, very few actually got a prescription for the advertised drug. People who followed a low-fat, high-fiber diet most carefully had fewer new polyps. A Johns Hopkins team has developed SUDS — a device for cleaning ER equipment that wipes out dangerous bacteria and keeps it from returning for several days.  The Caring Connection will help you find advance directive forms and instructions for your state.

Colorectal Cancer News in Brief: July 31

Get help managing the financial costs of your cancer care from an ASCO booklet or figure out how to deal with the Medicare prescription doughnut hole using an AARP online calculator. In research, Lynch syndrome women have excellent survival after ovarian cancer, older patients have similar effectiveness and side effects from Avastin, and parents with advanced cancer often underestimate how upset their children are.  Long-term cancer survivors have no more depression than people without cancer.

Running to Raise Lynch Syndrome Awareness

Selena Martinez ran the Santa Cruz Half Marathon on April 19th to raise awareness of Lynch syndrome, or hereditary non-polyposis colon cancer (HNPCC), a genetic condition that greatly increases risk for colorectal and other cancers. The Santa Cruz was the third of eight half marathons, Martinez plans to run to honor of eight members of her family diagnosed with Lynch syndrome cancers.  Sunday’s race was for her sister Noemi Garza who survived colon and endometrial cancer. Martinez’ website Detect the Mutation provides information about recognizing and testing for Lynch syndrome. She is also raising funds for the University of California at San Francisco’s Gastrointestinal Cancer Prevention Program, which offers screenings to those in

Aspirin and Undigestible Starch Don't Protect Against Lynch Syndrome

Neither daily aspirin or undigestible starch supplements reduced the risk for polyps and cancer for people with Lynch syndrome (also known as hereditary nonpolyposis colon cancer or HNPCC.) Nearly 850 patients with identified Lynch syndrome were randomly assigned to receive aspirin, resistant starch, or placebos for up to four years.  After an average of two years, 141 developed either precancerous polyps or cancer (neoplasia). There was no difference in either overall neoplasia or advanced neoplasia whether patients took aspirin or resistant starch or received a placebo.

Screening Colorectal Tumors for Lynch Syndrome: Who Gets Missed?

Identifying colorectal cancer patients with Lynch syndrome (also known as hereditary non-polyposis colon cancer or HNPCC) makes an important difference  in preventing further cancers for them and also for their family members.  However, family or personal medical histories don’t always find everyone at risk. One of every 35 patients with colorectal cancer has Lynch syndrome, and each one has at least three family members who carry a Lynch gene and will need more intensive polyp and cancer surveillance beginning when they are young adults. Researchers at Ohio State University compared methods of testing colon tumors to screen for Lynch syndrome and predict those patients who need further genetic testing.  They

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