Tag Archives: methotrexate

Old Chemo Drug May Fight Lynch Syndrome

Methotrexate, a chemotherapy drug used as long ago as the 1940′s, may be effective against colorectal cancers caused by mutations in a gene that is part of Lynch syndrome. The drug targeted and destroyed cells that contained mutated MSH2 genes. Inherited mutations in MSH2 prevent mistakes in correct copying of DNA during cell division allowing cancer to develop and grow, particularly inherited colorectal and endometrial cancers.  In addition, MSH2 mutations can occur in some colorectal cancers that are not inherited. Based on the work done in cancer cells, a Phase II clinical trial has begun recruiting patients with advanced colorectal cancer at the Royal Marsden Cancer Hospital in the United