People with a mutation in the MSH6 gene, part of the Lynch syndrome, have a greatly increased risk of colorectal, endometrial, and other related cancers. The cancers can occur in old age, with an increasing risk from age 70 to 80.
About 4 in every 1000 colorectal cancers are due to an inherited mutation in the MSH6 gene. It accounts for about 10 to 20 percent of Lynch syndrome mutations.
By the time they are 80 years old, men have eight times the risk of getting colorectal cancer and women have 26 times the risk of endometrial cancer — cancer that begins in the lining of the uterus.