Some Colorectal Cancers Not Connected to Obesity

Although being obese increases risk for most colon and rectal cancers, the connection isn’t true in all types of colorectal cancer. Cancers that are linked to microsatellite instability (MSI) don’t appear to be influenced by obesity, strengthening the belief that…  Read More

FOLFOX Effectiveness Not Related to DNA Mismatch Repair or MSI

Colon cancers that are caused by defects in genes that repair damaged DNA don’t respond well to 5-FU treatment after surgery. However, a new analysis of patients treated with FOLFOX (oxaliplatin, leucovorin, and 5-FU) found no differences between patients with…  Read More

Biomarkers Predict Colorectal Cancer Survival

Two gene changes that occur in some colorectal cancers can forecast chances for good or poor survival. Patients whose cancers had high microsatellite instability (MSI) had significantly better outcomes at every stage, but mutations in the KRAS gene predicted poorer…  Read More