Tag Archives: side effects

Xelox as Effective as FOLFOX after Colorectal Cancer Progresses

XELOX, as second-line therapy, was found to be as effective as the more commonly used FOLFOX treatment for patients whose cancer had already gotten worse on treatment with Camptosar® (irinotecan). XELOX combines an oral drug Xeloda® (capecitabine) with Eloxatin® (oxaliplatin).  FOLFOX uses an infusional schedule of 5FU and leucovorin. Researchers randomly compared XELOX to FOLFOX4 to treat 627 patients with metastatic colorectal cancer.  Patients had already received initial therapy with Camptosar and either had their cancer progress or were unable to tolerate the treatments.  Although outcomes were similar for the two regimens, side effects differed.

Geography Affects Serious 5FU and Xeloda Side Effects

US patients treated with 5FU or Xeloda® (capecitabine) were more likely to experience serious side effects than patients outside the United States.  They also required more dose reductions and had to stop treatment more often than their non-US counterparts. Researchers reviewed the safety results of three randomized phase III clinical trials comparing bolus regimens of 5FU to Xeloda (capecitabine) to treat metastatic cancer, separating enrolled patients into those treated in the United States and those treated in other parts of the world.  They also analyzed an adjuvant trial that included US patients, patients in East Asia, and patients in the rest of the world.  Infusional 5FU was not part of