Allergic Reactions to X-Ray Contrast Can Be Treated without Long Term Problems

Occasionally people having CT scans or other imaging exams will have an allergic-type reaction to the iodine contrast, but research has found that they can be treated safely without long term effects. In fact, almost all reactions are mild and more han 99 percent patients with them will get better within a day. Radiologists at the…  Read More

Switching from 5FU to Xeloda Can Cause Significant Side Effects

An immediate switch from 5-FU treatment to Xeloda® (capecitabine) for stage III colon cancer caused so much toxicity that a trial designed to test patient preferences for treatment had to be stopped. Patients in the Patient Preference in Adjuvant Therapy (PACT) trial who switched after 6 weeks from weekly 5-FU with leucovorin to oral capecitabine experienced…  Read More

Soft Ice Cream Alternative to Nutritional Drinks

Cancer treatment can make it hard to eat.  Both chemotherapy and radiation treatment can cause mouth sores, dry mouth, or poor appetite. Some patients develop thrush, a fungus infection in their mouths and throats, that makes swallowing very painful. Traditionally canned or powdered nutritional supplement drinks like Ensure® or Boost® have been used to provide support…  Read More

Preventive Measures Reduce Rash from Vectibix

Nearly all patients who are treated with Vectibix™ (panitumumab) will develop an itchy skin rash that looks something like acne.  However, treating the rash preemptively  before it appears reduces its severity and lengthens the time before more serious rash appears. During the STEPP (Skin Toxicity Evaluation Protocol with Panitumumab) trial, researchers randomized patients who were being…  Read More

Xelox as Effective as FOLFOX after Colorectal Cancer Progresses

XELOX, as second-line therapy, was found to be as effective as the more commonly used FOLFOX treatment for patients whose cancer had already gotten worse on treatment with Camptosar® (irinotecan). XELOX combines an oral drug Xeloda® (capecitabine) with Eloxatin® (oxaliplatin).  FOLFOX uses an infusional schedule of 5FU and leucovorin. Researchers randomly compared XELOX to FOLFOX4 to…  Read More

Geography Affects Serious 5FU and Xeloda Side Effects

US patients treated with 5FU or Xeloda® (capecitabine) were more likely to experience serious side effects than patients outside the United States.  They also required more dose reductions and had to stop treatment more often than their non-US counterparts. Researchers reviewed the safety results of three randomized phase III clinical trials comparing bolus regimens of 5FU…  Read More