Value of KRAS and BRAF Mutations in Forecasting Survival

For stage II and III colon cancer, a tumor mutation in the KRAS gene does not impact either relapse-free survival or overall survival. BRAF mutations, which are less common, don’t help with prognosis for relapse-free survival, but do provide information about overall survival in some tumors.   Patients with BRAF mutations and microsatellite-low or stable tumors had…  Read More

NSAIDS Reduce Deaths from Colorectal Cancer

Using non-steroidal anti-inflammatory medicines (NSAIDS) before being diagnosed with colorectal cancer reduced women’s deaths both from any cause and from colorectal cancer five years later. Women followed as part of the California Teachers Study who used NSAIDS regularly had more than 40 percent reduction in colorectal cancer deaths and a 30 percent  reduced chance of dying…  Read More

Biomarkers Predict Colorectal Cancer Survival

Two gene changes that occur in some colorectal cancers can forecast chances for good or poor survival. Patients whose cancers had high microsatellite instability (MSI) had significantly better outcomes at every stage, but mutations in the KRAS gene predicted poorer survival.

Early Stage Patients Benefit from Regular Follow-Up

Patients with very early stage colon cancer benefit as much from regular followup testing after surgery as later stage patients do. While overall patients with stage I or IIA colon cancer (early stage) have a lower risk of cancer returning than patients with stage IIB or III (later stage), careful surveillance after surgery is as effective in…  Read More

Colorectal Cancer News in Brief: September 12

In research, cancer patients who are separated but not yet divorced have the poorest chances of surviving 5 and 10 years after their diagnoses, and researchers at the VA Medical Center in Houston have identified a strong predictor of colon and rectal cancer survival by studying if cancer has spread into nerves near tumors. The National…  Read More

Colorectal Cancer News in Brief: August 31

Clinical features of colon tumors can predict survival, acupressure bands reduce nausea during radiation therapy, and there was no connection between the amount of fish a person ate and risk for colorectal cancer.  Although blacks have an increased risk for colon and breast cancer, hospitals matter.  All patients — white or black — did worse in…  Read More