New Cancer Drug Zaltrap Discounted by 50%

By Curt Pesman and Mary Miller In an unusual move, sanofi pharmaceutical company has instituted a 50 percent discount, effective immediately, on its latest cancer drug Zaltrap.  The reason for the sharp price drop, company officials said, was “market resistance” to the initial price. Zaltrap was…

Read Full Post

Memorial Sloan-Kettering Will Not Offer Zaltrap

Memorial Sloan-Kettering Cancer Center made a very public announcement—and explanation—today in a New York Times op-ed about why they will not offer the new drug Zaltrap® (ziv-aflibercept) to its metastatic colorectal cancer patients. The authors, all world-renowned cancer specialists at the world’s oldest cancer center, in…

Read Full Post

Participants Needed for Rectal Cancer Surgery Trial

Approximately 80 more participants are needed for a multisite, Phase 3 clinical trial comparing laparoscopic-assisted versus conventional surgery in patients with stage IIA, Stage IIIA or stage IIIB rectal cancer.  Eligible participants must have completed their pre-surgery chemotherapy (Xelox™ or fluorouracil-based) and/or pre-surgery radiation therapy…

Read Full Post

FDA Approves Regorafenib for Metastatic CRC

  The FDA today approved the use of the drug regorafenib (brand name Stivarga) for patients whose metastatic colorectal cancer has progressed despite all currently approved treatment regimens. This is the second new drug approved by the FDA recently after a drought of 5 years in…

Read Full Post

Why Do the New Drugs Fail in Adjuvant Chemotherapy?

Some of the most surprising data presented at the GI Symposium in January 2011 in San Francisco was the negative result of the European trial called AVANT. In that clinical trial patients who underwent a curative resection for colon cancer received either FOLFOX or FOLFOX…

Read Full Post

Mutations are Not All the Same

We are making significant progress in understanding what genetic alterations in tumors really mean. Over the last two years, we have learned or the first time that there is an alteration in a gene called KRAS in colon cancer, and tumors which have this mutation…

Read Full Post

Cancer Stem Cell Drug PRI724 IND filed September 17

I have shared with you in the past the efforts of Dr. Michael Kahn and myself to develop novel drugs which are completely different than the existing ones. Even the smart drugs we have such as Avastin or Erbitux, which are monoclonal antibodies that attack…

Read Full Post