About Biomarkers

Knowing your biomarkers can help your doctors identify your best treatment options and help you in making well-informed decisions about how your cancer will be treated. Knowing your biomarkers will allow you to be your own best advocate.

Biomarkers (short for biological markers) are molecules found in body tissues and fluid, including tumor tissue and blood. In terms of cancer, biomarkers include vital information about your tumor. You may hear them described as “an expression of your tumor” or “your tumor type.” Typically, they are either a protein or antibody (molecule) released by a tumor, or they are a body’s response to the presence of cancer, which could show up like a gene mutation.

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Common CRC Biomarkers

KRAS

NRAS

KRAS

Wild-Type

NRAS

Wild-Type

BRAF

PIK3CA

MSI-HIGH

CEA

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Things to consider when choosing treatment

It’s vitally important to talk to your doctors about knowing your tumor type, and to get biomarker testing, as soon as possible after your diagnosis and before treatment begins. Knowing your biomarker can help you make the best treatment decisions. It’s also important to consider the following factors before beginning treatment.

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Frequently Asked Questions

  • What is the process of biomarker testing?

    Biomarker tests are done by analyzing biopsies to identify gene mutations. After the biopsy is collected it will be analyzed by a pathologist who will look for abnormalities and report back to your doctor. The pathologist will report on prognostic biomarkers, used to describe the course of a patient’s disease, and predictive biomarkers which may determine if a patient will respond well to a particular treatment. For patients who are monitoring cancer after active treatment, it is likely they will only report on recurrence.

    For more information on biomarker testing, request a packet.

  • How do I know if my tumor has been tested?

    Talk to your doctor to find out if your tumor has been tested for biomarkers.

  • What if my tumor wasn't tested and I'm already receiving treatment?

    Biomarker testing should happen as close to your diagnosis as possible, before selecting a treatment plan. If you begin receiving a treatment before knowing your tumor type, this may exclude you from future treatment options, including some clinical trials. Take the time to talk to your doctor about tumor testing before making treatment decisions.

    Even if it’s been years after diagnosis or you’re currently on treatment, it’s important to know if you’ve had your biomarkers tested!

  • What is the difference between a tumor biopsy and a liquid biopsy?

    Tumor biopsy is the removal of cells or tissues from the tumor to be examined by a pathologist. There are incisional biopsies where only a sample of tissue is removed, and excisional biopsies, where the entire tumor is removed.

    Liquid biopsy is a sample of blood that pathologists use to look for DNA from tumor cells or tumor cells circulating in the blood. They are looking for circulating tumor DNA (ctDNA) and/or circulating tumor cells (CTCs). Liquid biopsies can be used to help plan treatment or learn if a treatment is working, or if the cancer has returned.

  • I've had genetic testing. Does this mean I've had biomarker testing?

    Genetic testing is a type of biomarker testing, but does not ensure that you have received all the biomarker tests necessary to make an informed treatment decision.

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All medically-reviewed content was written, edited and produced by Fight Colorectal Cancer.

blue-star-colon-cancer-awareness

This educational resource was made possible thanks to the support of Lilly Oncology.

Inspiration.

Biomarked is dedicated to the memory of Clint Cummings, owner of Sparrows Tattoo Company and stage IV colorectal cancer fighter. Clint was passionate about raising awareness with his story. Biomarked uses tattoos to create awareness about a lifesaving topic for colorectal cancer patients and works to break the still-present taboo surrounding colorectal cancer to get people’s attention.

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The information and services provided by Fight Colorectal Cancer are for general informational purposes only and are not intended to be substitutes for professional medical advice, diagnoses or treatment. If you are ill, or suspect that you are ill, see a doctor immediately. In an emergency, call 911 or go to the nearest emergency room. Fight Colorectal Cancer never recommends or endorses any specific physicians, products or treatments for any condition. This site does not serve as an advertisement or endorsement for any products or sponsors mentioned.

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References

Gustaw Lech, Robert Stotwinski, Maciej Stodokowski, Ireneusz Krasnoddebski. Colorectal cancer tumour markers and biomarkers: Recent therapeudic advances. World Journal of Gastroenterology. February 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724606/

Takuji Tanaka, Mayu Tanaka, Takahiro Tanaka, Rikako Ishigamori. Biomarkers for Colorectal Cancer. International Journal of Molecular Science. 2010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956090/