There are differing opinions on whether breast cancers and prostate cancers are part of Lynch-associated cancers. However, studies show that Lynch patients may carry an elevated risk for these cancers.

While half of breast cancer cases in women with Lynch appear to be caused by Lynch syndrome (they have abnormal IHC or are MSI-high), there is insufficient data supporting an increased risk for breast cancer among women with Lynch syndrome.

Men with Lynch carry an elevated risk for prostate cancer (as high as 24% for Lynch patients, particularly those with mutations in the MSH2 gene, compared to 13% for average-risk men).