Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study

Program Status

Recruiting

Phase

Phase 3

Prior Immunotherapy Allowed

No

CRC-directed Trial

Yes

Drugs

Atezolizumab, fluorouracil, Leucovorin, oxaliplatin

Tags

MSI-H/ MMRd
Location Location Status
United States
Kingman Regional Medical Center
Kingman, Arizona 86401
Recruiting
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas 72401
Active, not recruiting
Kaiser Permanente-Anaheim
Anaheim, California 92806
Recruiting
Kaiser Permanente-Baldwin Park
Baldwin Park, California 91706
Recruiting
Kaiser Permanente-Bellflower
Bellflower, California 90706
Recruiting
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
Recruiting
John Muir Medical Center-Concord
Concord, California 94520
Active, not recruiting
Kaiser Permanente-Fontana
Fontana, California 92335
Recruiting
Kaiser Permanente South Bay
Harbor City, California 90710
Recruiting
Kaiser Permanente-Irvine
Irvine, California 92618
Recruiting
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California 90027
Recruiting
Kaiser Permanente West Los Angeles
Los Angeles, California 90034
Recruiting
Fremont - Rideout Cancer Center
Marysville, California 95901
Recruiting
Memorial Medical Center
Modesto, California 95355
Recruiting
Kaiser Permanente-Ontario
Ontario, California 91761
Recruiting
Saint Joseph Hospital - Orange
Orange, California 92868
Suspended
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
Active, not recruiting
Kaiser Permanente - Panorama City
Panorama City, California 91402
Recruiting
Kaiser Permanente-Riverside
Riverside, California 92505
Recruiting
Sutter Medical Center Sacramento
Sacramento, California 95816
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
Active, not recruiting
Salinas Valley Memorial
Salinas, California 93901
Active, not recruiting
Kaiser Permanente-San Diego Mission
San Diego, California 92108
Recruiting
Kaiser Permanente-San Diego Zion
San Diego, California 92120
Recruiting
Kaiser Permanente-San Marcos
San Marcos, California 92078
Recruiting
John Muir Medical Center-Walnut Creek
Walnut Creek, California 94598
Active, not recruiting
Presbyterian Intercommunity Hospital
Whittier, California 90602
Active, not recruiting
Kaiser Permanente-Woodland Hills
Woodland Hills, California 91367
Recruiting
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
Recruiting
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
Recruiting
Boulder Community Hospital
Boulder, Colorado 80301
Suspended
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
Recruiting
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Recruiting
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
Recruiting
Memorial Hospital North
Colorado Springs, Colorado 80920
Recruiting
Denver Health Medical Center
Denver, Colorado 80204
Suspended
National Jewish Health-Main Campus
Denver, Colorado 80206
Active, not recruiting
AdventHealth Porter
Denver, Colorado 80210
Suspended
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
Recruiting
Saint Joseph Hospital - Cancer Centers of Colorado
Denver, Colorado 80218
Active, not recruiting
Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
Recruiting
Mountain Blue Cancer Care Center - Swedish
Englewood, Colorado 80113
Suspended
Swedish Medical Center
Englewood, Colorado 80113
Suspended
Poudre Valley Hospital
Fort Collins, Colorado 80524
Recruiting
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
Recruiting
National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
Active, not recruiting
Banner North Colorado Medical Center
Greeley, Colorado 80631
Suspended
UCHealth Greeley Hospital
Greeley, Colorado 80631
Recruiting
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
Recruiting
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
Recruiting
Medical Center of the Rockies
Loveland, Colorado 80538
Recruiting
Banner McKee Medical Center
Loveland, Colorado 80539
Suspended
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado 80260
Active, not recruiting
Intermountain Health Lutheran Hospital
Wheat Ridge, Colorado 80401
Active, not recruiting
Danbury Hospital
Danbury, Connecticut 06810
Active, not recruiting
Hartford Hospital
Hartford, Connecticut 06102
Active, not recruiting
Midstate Medical Center
Meriden, Connecticut 06451
Active, not recruiting
The Hospital of Central Connecticut
New Britain, Connecticut 06050
Active, not recruiting
William Backus Hospital
Norwich, Connecticut 06360
Active, not recruiting
Beebe South Coastal Health Campus
Millville, Delaware 19967
Active, not recruiting
Helen F Graham Cancer Center
Newark, Delaware 19713
Active, not recruiting
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Active, not recruiting
Beebe Health Campus
Rehoboth Beach, Delaware 19971
Active, not recruiting
Kaiser Permanente-Capitol Hill Medical Center
Washington, District of Columbia 20002
Recruiting
Broward Health Medical Center
Fort Lauderdale, Florida 33316
Active, not recruiting
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida 33905
Active, not recruiting
University of Florida Health Science Center - Gainesville
Gainesville, Florida 32610
Active, not recruiting
Baptist MD Anderson Cancer Center
Jacksonville, Florida 32207
Active, not recruiting
AdventHealth Orlando
Orlando, Florida 32803
Active, not recruiting
Phoebe Putney Memorial Hospital
Albany, Georgia 31701
Recruiting
University Cancer and Blood Center LLC
Athens, Georgia 30607
Recruiting
Augusta Oncology Associates PC-D'Antignac
Augusta, Georgia 30901
Recruiting
Augusta Oncology Associates PC-Wheeler
Augusta, Georgia 30909
Recruiting
Augusta University Medical Center
Augusta, Georgia 30912
Recruiting
CTCA at Southeastern Regional Medical Center
Newnan, Georgia 30265
Active, not recruiting
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Recruiting
Saint Luke's Cancer Institute - Boise
Boise, Idaho 83712
Recruiting
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
Recruiting
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho 83814
Recruiting
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619
Recruiting
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho 83642
Recruiting
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
Recruiting
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83687
Recruiting
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho 83854
Recruiting
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho 83864
Recruiting
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301
Recruiting
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Active, not recruiting
Illinois CancerCare-Canton
Canton, Illinois 61520
Active, not recruiting
Illinois CancerCare-Carthage
Carthage, Illinois 62321
Active, not recruiting
Centralia Oncology Clinic
Centralia, Illinois 62801
Recruiting
Rush University Medical Center
Chicago, Illinois 60612
Recruiting
University of Illinois
Chicago, Illinois 60612
Recruiting
Carle at The Riverfront
Danville, Illinois 61832
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Recruiting
Illinois CancerCare-Dixon
Dixon, Illinois 61021
Active, not recruiting
Carle Physician Group-Effingham
Effingham, Illinois 62401
Recruiting
Crossroads Cancer Center
Effingham, Illinois 62401
Recruiting
Illinois CancerCare-Eureka
Eureka, Illinois 61530
Active, not recruiting
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
Recruiting
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Active, not recruiting
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
Recruiting
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
Recruiting
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Active, not recruiting
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Active, not recruiting
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Recruiting
Loyola University Medical Center
Maywood, Illinois 60153
Suspended
SSM Health Good Samaritan
Mount Vernon, Illinois 62864
Recruiting
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
Recruiting
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Active, not recruiting
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Active, not recruiting
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Active, not recruiting
Illinois CancerCare-Peru
Peru, Illinois 61354
Active, not recruiting
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Active, not recruiting
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Recruiting
Springfield Clinic
Springfield, Illinois 62702
Recruiting
Carle Cancer Center
Urbana, Illinois 61801
Recruiting
Illinois CancerCare - Washington
Washington, Illinois 61571
Active, not recruiting
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Active, not recruiting
Community Cancer Center East
Indianapolis, Indiana 46219
Active, not recruiting
Community Cancer Center South
Indianapolis, Indiana 46227
Active, not recruiting
Franciscan Health Indianapolis
Indianapolis, Indiana 46237
Recruiting
Community Cancer Center North
Indianapolis, Indiana 46256
Active, not recruiting
Community Howard Regional Health
Kokomo, Indiana 46904
Active, not recruiting
Franciscan Saint Elizabeth Health - Lafayette East
Lafayette, Indiana 47905
Recruiting
Woodland Cancer Care Center
Michigan City, Indiana 46360
Recruiting
Franciscan Health Mooresville
Mooresville, Indiana 46158
Suspended
Union Hospital
Terre Haute, Indiana 47804
Recruiting
Mary Greeley Medical Center
Ames, Iowa 50010
Suspended
McFarland Clinic - Ames
Ames, Iowa 50010
Recruiting
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa 52722
Active, not recruiting
McFarland Clinic - Boone
Boone, Iowa 50036
Suspended
Mercy Hospital
Cedar Rapids, Iowa 52403
Recruiting
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Recruiting
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Recruiting
Mission Cancer and Blood - West Des Moines
Clive, Iowa 50325
Suspended
Mission Cancer and Blood - Des Moines
Des Moines, Iowa 50309
Active, not recruiting
Broadlawns Medical Center
Des Moines, Iowa 50314
Active, not recruiting
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Recruiting
Mission Cancer and Blood - Laurel
Des Moines, Iowa 50314
Suspended
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa 50501
Suspended
Trinity Regional Medical Center
Fort Dodge, Iowa 50501
Active, not recruiting
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Active, not recruiting
McFarland Clinic - Jefferson
Jefferson, Iowa 50129
Suspended
McFarland Clinic - Marshalltown
Marshalltown, Iowa 50158
Suspended
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
Recruiting
HaysMed
Hays, Kansas 67601
Active, not recruiting
Lawrence Memorial Hospital
Lawrence, Kansas 66044
Recruiting
The University of Kansas Cancer Center - Olathe
Olathe, Kansas 66061
Recruiting
Salina Regional Health Center
Salina, Kansas 67401
Recruiting
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
Active, not recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
Active, not recruiting
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
Recruiting
Cancer Center of Kansas - Wichita
Wichita, Kansas 67214
Recruiting
Flaget Memorial Hospital
Bardstown, Kentucky 40004
Recruiting
Baptist Health Lexington
Lexington, Kentucky 40503
Recruiting
Saint Joseph Hospital East
Lexington, Kentucky 40509
Recruiting
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
Active, not recruiting
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky 40202
Active, not recruiting
Norton Audubon Hospital and Medical Campus
Louisville, Kentucky 40217
Active, not recruiting
Norton Brownsboro Hospital and Medical Campus
Louisville, Kentucky 40241
Active, not recruiting
Ochsner Medical Center Kenner
Kenner, Louisiana 70065
Active, not recruiting
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
Active, not recruiting
Harold Alfond Center for Cancer Care
Augusta, Maine 04330
Active, not recruiting
Eastern Maine Medical Center
Bangor, Maine 04401
Recruiting
Waldo County General Hospital
Belfast, Maine 04915
Active, not recruiting
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine 04005
Active, not recruiting
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Recruiting
Penobscot Bay Medical Center
Rockport, Maine 04856
Active, not recruiting
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine 04073
Active, not recruiting
Maine Medical Partners - South Portland
South Portland, Maine 04106
Active, not recruiting
Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland 21244
Recruiting
University of Maryland Shore Medical Center at Easton
Easton, Maryland 21601
Recruiting
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland 20879
Recruiting
Kaiser Permanente - Largo Medical Center
Largo, Maryland 20774
Recruiting
Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville, Maryland 21093
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
Active, not recruiting
Lowell General Hospital
Lowell, Massachusetts 01854
Active, not recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
Recruiting
McLaren Cancer Institute-Bay City
Bay City, Michigan 48706
Recruiting
McLaren Cancer Institute-Bloomfield
Bloomfield, Michigan 48302
Suspended
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114
Recruiting
Trinity Health Medical Center - Brighton
Brighton, Michigan 48114
Recruiting
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188
Recruiting
Trinity Health Medical Center - Canton
Canton, Michigan 48188
Recruiting
Chelsea Hospital
Chelsea, Michigan 48118
Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118
Recruiting
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
Recruiting
McLaren Cancer Institute-Clarkston
Clarkston, Michigan 48346
Recruiting
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
Recruiting
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Active, not recruiting
Henry Ford Medical Center-Fairlane
Dearborn, Michigan 48126
Active, not recruiting
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
Recruiting
Henry Ford Hospital
Detroit, Michigan 48202
Recruiting
Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
Recruiting
McLaren Cancer Institute-Flint
Flint, Michigan 48532
Recruiting
Singh and Arora Hematology Oncology PC
Flint, Michigan 48532
Suspended
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan 49503
Recruiting
Allegiance Health
Jackson, Michigan 49201
Active, not recruiting
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Recruiting
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing, Michigan 48910
Recruiting
University of Michigan Health - Sparrow Lansing
Lansing, Michigan 48912
Recruiting
McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan 48446
Recruiting
Hope Cancer Clinic
Livonia, Michigan 48154
Suspended
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
Recruiting
McLaren Cancer Institute-Macomb
Mount Clemens, Michigan 48043
Suspended
McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan 48858
Recruiting
Henry Ford Medical Center-Columbus
Novi, Michigan 48377
Active, not recruiting
McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan 49770
Recruiting
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
Recruiting
McLaren-Port Huron
Port Huron, Michigan 48060
Recruiting
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
Recruiting
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
Recruiting
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
Recruiting
Munson Medical Center
Traverse City, Michigan 49684
Recruiting
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
Active, not recruiting
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
Recruiting
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Recruiting
Minnesota Oncology - Burnsville
Burnsville, Minnesota 55337
Recruiting
Essentia Health - Deer River Clinic
Deer River, Minnesota 56636
Recruiting
Essentia Health Cancer Center
Duluth, Minnesota 55805
Recruiting
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
Recruiting
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
Recruiting
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Recruiting
Hennepin County Medical Center
Minneapolis, Minnesota 55415
Recruiting
Health Partners Inc
Minneapolis, Minnesota 55454
Active, not recruiting
Regions Hospital
Saint Paul, Minnesota 55101
Recruiting
United Hospital
Saint Paul, Minnesota 55102
Recruiting
Essentia Health Sandstone
Sandstone, Minnesota 55072
Recruiting
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
Recruiting
Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
Active, not recruiting
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Active, not recruiting
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri 63011
Recruiting
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Recruiting
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri 65212
Active, not recruiting
Freeman Health System
Joplin, Missouri 64804
Suspended
Mercy Hospital Joplin
Joplin, Missouri 64804
Recruiting
University Health Truman Medical Center
Kansas City, Missouri 64108
Recruiting
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
Recruiting
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
Recruiting
Community Hospital of Anaconda
Anaconda, Montana 59711
Recruiting
Billings Clinic Cancer Center
Billings, Montana 59101
Recruiting
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
Recruiting
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
Recruiting
Great Falls Clinic
Great Falls, Montana 59405
Suspended
Saint Peter's Community Hospital
Helena, Montana 59601
Suspended
Logan Health Medical Center
Kalispell, Montana 59901
Recruiting
Community Medical Center
Missoula, Montana 59804
Recruiting
Nebraska Methodist Hospital
Omaha, Nebraska 68114
Recruiting
OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
Recruiting
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
Recruiting
OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
Recruiting
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
Recruiting
Renown Regional Medical Center
Reno, Nevada 89502
Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756
Recruiting
Dartmouth Cancer Center - Manchester
Manchester, New Hampshire 03102
Recruiting
Dartmouth Cancer Center - Nashua
Nashua, New Hampshire 03063
Recruiting
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey 08690
Recruiting
Morristown Medical Center
Morristown, New Jersey 07960
Active, not recruiting
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903
Recruiting
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey 07652
Recruiting
Valley Health System Ridgewood Campus
Ridgewood, New Jersey 07450
Recruiting
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey 08876
Active, not recruiting
Overlook Hospital
Summit, New Jersey 07902
Active, not recruiting
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
Recruiting
Presbyterian Kaseman Hospital
Albuquerque, New Mexico 87110
Active, not recruiting
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico 88011
Recruiting
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico 87124
Active, not recruiting
Roswell Park Cancer Institute
Buffalo, New York 14263
Recruiting
Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York 14905
Active, not recruiting
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
Active, not recruiting
University of Rochester
Rochester, New York 14642
Recruiting
Dickstein Cancer Treatment Center
White Plains, New York 10601
Active, not recruiting
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Recruiting
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
Recruiting
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
Recruiting
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Recruiting
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
Recruiting
ECU Health Oncology Kenansville
Kenansville, North Carolina 28349
Recruiting
ECU Health Oncology Kinston
Kinston, North Carolina 28501
Recruiting
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina 28374
Recruiting
ECU Health Oncology Richlands
Richlands, North Carolina 28574
Suspended
Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
Recruiting
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Recruiting
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Recruiting
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Recruiting
Altru Cancer Center
Grand Forks, North Dakota 58201
Active, not recruiting
Cleveland Clinic Akron General
Akron, Ohio 44307
Recruiting
Strecker Cancer Center-Belpre
Belpre, Ohio 45714
Recruiting
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
Recruiting
Miami Valley Hospital South
Centerville, Ohio 45459
Active, not recruiting
Adena Regional Medical Center
Chillicothe, Ohio 45601
Recruiting
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
Active, not recruiting
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
Active, not recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Withdrawn
Mount Carmel East Hospital
Columbus, Ohio 43213
Recruiting
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
Suspended
Riverside Methodist Hospital
Columbus, Ohio 43214
Suspended
Grant Medical Center
Columbus, Ohio 43215
Suspended
The Mark H Zangmeister Center
Columbus, Ohio 43219
Recruiting
Mount Carmel Health Center West
Columbus, Ohio 43222
Recruiting
Doctors Hospital
Columbus, Ohio 43228
Suspended
Miami Valley Hospital
Dayton, Ohio 45409
Active, not recruiting
Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
Suspended
Grady Memorial Hospital
Delaware, Ohio 43015
Suspended
Greater Dayton Cancer Center
Kettering, Ohio 45409
Recruiting
Fairfield Medical Center
Lancaster, Ohio 43130
Recruiting
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
Suspended
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
Active, not recruiting
Marietta Memorial Hospital
Marietta, Ohio 45750
Recruiting
OhioHealth Marion General Hospital
Marion, Ohio 43302
Suspended
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
Active, not recruiting
Knox Community Hospital
Mount Vernon, Ohio 43050
Recruiting
Licking Memorial Hospital
Newark, Ohio 43055
Recruiting
Southern Ohio Medical Center
Portsmouth, Ohio 45662
Recruiting
North Coast Cancer Care
Sandusky, Ohio 44870
Active, not recruiting
ProMedica Flower Hospital
Sylvania, Ohio 43560
Recruiting
South Pointe Hospital
Warrensville Heights, Ohio 44122
Active, not recruiting
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
Active, not recruiting
Saint Ann's Hospital
Westerville, Ohio 43081
Recruiting
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
Recruiting
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
Recruiting
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Recruiting
Cancer Treatment Centers of America
Tulsa, Oklahoma 74133
Active, not recruiting
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
Recruiting
Saint Charles Health System
Bend, Oregon 97701
Recruiting
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Recruiting
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
Recruiting
Providence Newberg Medical Center
Newberg, Oregon 97132
Recruiting
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
Recruiting
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
Recruiting
Providence Portland Medical Center
Portland, Oregon 97213
Recruiting
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Recruiting
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
Recruiting
Saint Luke's Cancer Center - Allentown
Allentown, Pennsylvania 18104
Active, not recruiting
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania 18015
Active, not recruiting
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
Recruiting
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania 18045
Active, not recruiting
Saint Vincent Hospital
Erie, Pennsylvania 16544
Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
Recruiting
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
Recruiting
Forbes Hospital
Monroeville, Pennsylvania 15146
Recruiting
Allegheny Valley Hospital
Natrona Heights, Pennsylvania 15065
Recruiting
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Recruiting
West Penn Hospital
Pittsburgh, Pennsylvania 15224
Recruiting
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Recruiting
Saint Luke's Hospital-Quakertown Campus
Quakertown, Pennsylvania 18951
Active, not recruiting
Reading Hospital
West Reading, Pennsylvania 19611
Recruiting
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Recruiting
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Active, not recruiting
AnMed Health Cancer Center
Anderson, South Carolina 29621
Recruiting
Beaufort Memorial Hospital
Beaufort, South Carolina 29902
Active, not recruiting
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
Active, not recruiting
Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
Active, not recruiting
Saint Francis Hospital
Greenville, South Carolina 29601
Active, not recruiting
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
Active, not recruiting
Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
Active, not recruiting
Saint Francis Cancer Center
Greenville, South Carolina 29607
Active, not recruiting
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
Active, not recruiting
Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
Active, not recruiting
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
Active, not recruiting
Spartanburg Medical Center
Spartanburg, South Carolina 29303
Active, not recruiting
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota 57401
Active, not recruiting
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Recruiting
Avera Cancer Institute
Sioux Falls, South Dakota 57105
Active, not recruiting
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Recruiting
Bristol Regional Medical Center
Bristol, Tennessee 37620
Recruiting
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
Active, not recruiting
Cookeville Regional Medical Center
Cookeville, Tennessee 38501
Active, not recruiting
Wellmont Medical Associates Oncology and Hematology-Johnson City
Johnson City, Tennessee 37604
Suspended
Ballad Health Cancer Care - Kingsport
Kingsport, Tennessee 37660
Recruiting
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee 37660
Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Active, not recruiting
The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
Recruiting
Baptist Hospitals of Southeast Texas Cancer Center
Beaumont, Texas 77701
Active, not recruiting
MD Anderson in The Woodlands
Conroe, Texas 77384
Recruiting
Parkland Memorial Hospital
Dallas, Texas 75235
Recruiting
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Recruiting
STCC at DHR Health Institute for Research and Development
Edinburg, Texas 78539
Active, not recruiting
Lyndon Baines Johnson General Hospital
Houston, Texas 77026-1967
Recruiting
Houston Methodist Hospital
Houston, Texas 77030
Suspended
M D Anderson Cancer Center
Houston, Texas 77030
Recruiting
MD Anderson West Houston
Houston, Texas 77079
Recruiting
MD Anderson League City
League City, Texas 77573
Recruiting
Baptist Regional Cancer Network-Cancer Center of Southeast Texas
Port Arthur, Texas 77642
Active, not recruiting
MD Anderson in Sugar Land
Sugar Land, Texas 77478
Recruiting
Scott and White Memorial Hospital
Temple, Texas 76508
Active, not recruiting
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
Recruiting
Dartmouth Cancer Center - North
Saint Johnsbury, Vermont 05819
Recruiting
Ballad Health Cancer Care - Bristol
Bristol, Virginia 24201
Recruiting
Kaiser Permanente-Burke Medical Center
Burke, Virginia 22015
Recruiting
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia 22939
Recruiting
Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia 24501
Suspended
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia 22102
Recruiting
Ballad Health Cancer Care - Norton
Norton, Virginia 24273
Recruiting
Virginia Cancer Institute
Richmond, Virginia 23229
Recruiting
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
Recruiting
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Recruiting
VCU Community Memorial Health Center
South Hill, Virginia 23970
Recruiting
Kaiser Permanente-Caton Hill Medical Center
Woodbridge, Virginia 22192
Recruiting
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
Recruiting
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Recruiting
Jefferson Healthcare
Port Townsend, Washington 98368
Recruiting
Swedish Medical Center-First Hill
Seattle, Washington 98122
Recruiting
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Spokane, Washington 99204
Recruiting
MultiCare Deaconess Cancer and Blood Specialty Center - North
Spokane, Washington 99218
Recruiting
West Virginia University Charleston Division
Charleston, West Virginia 25304
Recruiting
West Virginia University Healthcare
Morgantown, West Virginia 26506
Active, not recruiting
Camden Clark Medical Center
Parkersburg, West Virginia 26101
Active, not recruiting
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Recruiting
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Recruiting
Ascension Saint Elizabeth Hospital
Appleton, Wisconsin 54915
Recruiting
Duluth Clinic Ashland
Ashland, Wisconsin 54806
Recruiting
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin 53045
Recruiting
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
Recruiting
Ascension Saint Francis - Reiman Cancer Center
Franklin, Wisconsin 53132
Recruiting
Bellin Memorial Hospital
Green Bay, Wisconsin 54301
Recruiting
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin 53548
Recruiting
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin 53038
Recruiting
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin 53718
Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin 53792
Recruiting
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
Recruiting
Aspirus Medford Hospital
Medford, Wisconsin 54451
Recruiting
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin 54548
Recruiting
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Recruiting
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
Recruiting
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Recruiting
Ascension Mercy Hospital
Oshkosh, Wisconsin 54904
Recruiting
Ascension All Saints Hospital
Racine, Wisconsin 53405
Recruiting
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin 54501
Recruiting
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
Recruiting
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
Recruiting
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
Recruiting
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Recruiting
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Recruiting
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa, Wisconsin 53226
Recruiting
Marshfield Medical Center - Weston
Weston, Wisconsin 54476
Recruiting
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
Recruiting
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming 82001
Suspended
Billings Clinic-Cody
Cody, Wyoming 82414
Suspended

Inclusion Criteria

Inclusion Criteria:

* The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
* Age >= 18 years
* Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
* Diagnosis of metastatic adenocarcinoma of colon or rectum without previous chemotherapy or any other systemic therapy for metastatic colorectal cancer except for one cycle of FOLFOX or capecitabine and oxaliplatin (CAPOX), either with or without bevacizumab prior to enrollment. Upon enrollment, the preceding single cycle of FOLFOX or FOLFOX + bevacizumab, if the patient received one, will not count towards patients' assessments per protocol. Cycle 1 day 1 (C1D1) of atezolizumab or C1D1 of mFOLFOX6/bevacizumab + atezolizumab will correspond to the first day the patient received therapy on trial
* Tumor determined to be mismatch-repair deficient (dMMR) by Clinical Laboratory Improvement Act (CLIA)-certified immunohistochemical (IHC) assay with a panel of all four IHC markers, including MLH1, MSH2, PMS2, and MSH6; alternatively, MSI-H diagnosed by polymerase chain reaction (PCR)-based assessment of microsatellite alterations (either Bethesda markers or Pentaplex panel) or by next-generation sequencing (NGS) are eligible
* Documentation by PET/CT scan, CT scan, or MRI that the patient has measurable metastatic disease per RECIST 1.1
* No immediate need for surgical intervention for the primary tumor or palliative diversion/bypass
* Absolute neutrophil count (ANC) must be >= 1500/mm^3 (obtained within 28 days prior randomization)
* Platelet count must be >= 100,000/mm^3 (obtained within 28 days prior randomization)
* Hemoglobin must be >= 8 g/dL (obtained within 28 days prior randomization)
* Total bilirubin must be =< 4 x ULN (upper limit of normal) (obtained within 28 days prior randomization); and
* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be =< 3 x ULN for the lab with the following exception: for patients with documented liver metastases, AST and ALT must be =< 5 x ULN (obtained within 28 days prior randomization) * Calculated creatinine clearance >= 30 mL/min (obtained within 28 days prior randomization)
* A urine sample tested for proteinuria by either the dipstick method, urinalysis (UA), or a urine protein creatinine (UPC) ratio:

* The dipstick method must indicate 0-1+ protein; if dipstick reading is >= 2+, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* A urine protein creatinine (UPC) ratio must be < 1.0; if the UPC ratio is >= 1.0 a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours
* Urinalysis must indicate < 30 mg/dl. If urinalysis >= 30 mg/dl, a 24-hour urine must be done and it must demonstrate < 1.0 g of protein per 24 hours or a UPC ratio < 1.0
* International normalized ratio of prothrombin time (INR) and prothrombin time (PT) must be =< 1.5 x ULN for the lab within 28 days before randomization; patients who are therapeutically treated with an agent such as warfarin may participate if they are on a stable dose and no underlying abnormality in coagulation parameters exists per medical history, regardless of PT/INR results
* Pregnancy test done within 28 days prior randomization must be negative (for women of childbearing potential only); pregnancy testing should be performed according to institutional standards; administration of atezolizumab or mFOLFOX6/bevacizumab/atezolizumab may have an adverse effect on pregnancy and poses a risk to the human fetus, including embryo-lethality; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
* Women of child-bearing potential and men must agree to use adequate contraception methods that result in a failure rate of < 1% per year during the treatment period (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of atezolizumab, 6 months after the last dose of bevacizumab, and 6 months after the last dose of mFOLFOX6; a woman is considered to be of childbearing potential if she is not postmenopausal, has not reached a postmenopausal state (>= 12 continuous months of amenorrhea with no identified cause other than menopause), and has not undergone surgical sterilization (removal of ovaries and/or uterus); examples of contraceptive methods with a failure rate of < 1% per year include: bilateral tubal ligation; male partner sterilization; intrauterine devices; the reliability of sexual abstinence should be evaluated in relation to the duration of the clinical study and the preferred and usual lifestyle of the patient; periodic abstinence (e.g., calendar, ovulation, symptothermal, or postovulation methods) and withdrawal are not acceptable methods of contraception; men must refrain from donating sperm during this same period

Exclusion Criteria

Exclusion Criteria:

* Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies, fluoropyrimidines, folic acid derivatives or oxaliplatin
* Uncontrolled high blood pressure defined as systolic blood pressure (BP) > 150 mmHg or diastolic BP > 100 mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria
* Documented New York Heart Association (NYHA) class III or IV congestive heart failure
* Serious or non-healing wound, skin ulcer, or bone fracture
* History of inherited bleeding diathesis, gastrointestinal (GI) perforation, significant vascular disease (e.g., aortic aneurysm requiring surgical repair or recent arterial thrombosis or symptomatic peripheral ischemia, transient ischemic attack [TIA], cerebrovascular accident [CVA] or arterial thrombotic event), abdominal fistula, intra-abdominal abscess, or active GI bleeding (with cause not addressed) within 6 months prior to randomization, or other medical condition in the opinion of the treating oncologist that makes the risk of cardiovascular or bleeding complications with bevacizumab use unacceptably high
* Other malignancies are excluded unless the patient has completed therapy for the malignancy >= 12 months prior to randomization and is considered disease-free; patients with the following cancers are eligible if diagnosed and treated within the past 12 months: in situ carcinomas or basal cell and squamous cell carcinoma of the skin
* Known DPD (dihydro pyrimidine dehydrogenase) deficiency
* Symptomatic peripheral sensory neuropathy >= grade 2 (Common Terminology Criteria for Adverse Events [CTCAE] version [v] 5.0)
* Prior treatment with oxaliplatin chemotherapy within 6 months prior to randomization
* History of grade 2 hemoptysis (defined as 2.5 mL of bright red blood per episode) within 1 month prior to screening
* Prior treatment with anti-PD-1, or anti-PD-L1 therapeutic antibody or pathway-targeting agents; patients who have received prior treatment with anti-CTLA-4 may be enrolled provided the following requirements are met:

* Minimum of 12 weeks from the first dose of anti-CTLA-4 and > 6 weeks from the last dose to randomization
* No history of severe immune-related adverse effects (CTCAE grade 3 and 4) from anti-CTLA-4
* Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 14 days prior to randomization; however,

* Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea; or chronic daily treatment with corticosteroids with a dose of =< 10 mg/day methylprednisolone equivalent) may be enrolled
* The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed
* Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease; however,

* Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HbsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible if polymerase chain reaction (PCR) for hepatits B virus (HBV) ribonucleic acid (RNA) is negative per local guidelines
* Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV RNA per local guidelines
* History or risk of autoimmune disease, including, but not limited to, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis; however,

* Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone may be eligible
* Patients with controlled type 1 diabetes mellitus on a stable insulin regimen may be eligible
* Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:

* Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations
* Rash must cover less than 10% of body surface area (BSA)
* Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)
* No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)
* History of idiopathic pulmonary fibrosis, organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or active or recently active (within 90 days of randomization) pneumonitis (including drug induced) that required systemic immunosuppressive therapy (i.e. corticosteroids, etc.). History of radiation pneumonitis in the radiation field (fibrosis) is permitted
* History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
* Patients with known active tuberculosis (TB) are excluded
* Severe infections within 28 days prior to randomization, including but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia
* Signs or symptoms of infection within 14 days prior to randomization
* Received oral or intravenous (IV) antibiotics within 14 days prior to randomization; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to randomization or anticipation of need for a major surgical procedure during the course of the study
* The administration of a live, attenuated vaccine within 28 days prior to randomization
* Pregnant women are excluded from this study because atezolizumab is an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with atezolizumab, breastfeeding should be discontinued if the mother is treated with atezolizumab; these potential risks may also apply to other agents used in this study; (Note: pregnancy testing should be performed within 28 days prior to randomization according to institutional standards for women of childbearing potential)
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
* Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation

NCT ID

NCT02997228

Date Trial Added

2016-12-20

Updated Date

2025-02-07