A study looking at using a vaccine and chemotherapy to treat advanced cancer

Program Status

Active, not recruiting

Phase

Phase 1

Prior Immunotherapy Allowed

Yes

CRC-directed Trial

No

Drugs

Celecoxib, Cyclophosphamide, imiquimod, vaccine

Tags

MSS/ MMRp

Comments

anti-Human telomerase reverse transcriptase (hTERT) vaccine. A tumor associated antigen which has been studied for many years

Inclusion Criteria

'- Have been diagnosed with a solid tumour
- Are unable to have any other standard cancer treatment
- Have not had any cancer treatment in the last 4 weeks and are not due to have any other anti cancer drugs during the time of the study
- Are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- Are willing to use reliable contraception for 4 weeks before starting treatment, during treatment and for 3 months afterwards if there is any chance that you or your partner could become pregnant
- Are aged 16 or older

Exclusion Criteria

'- You have either a primary or secondary cancer of your brain or spinal cord (central nervous system)
- You have an autoimmune condition
- You are taking any medication to dampen down your immune system (immunosuppressive therapy)
- You have problems with your heart and circulation such as coronary artery disease or left ventricular failure (LVEF)
- You have high blood pressure that is not well controlled by medication
- You have any other serious medical condition or mental health problem that the study team think could - affect you taking part
- You are pregnant or breast feeding

NCT ID

VAPER

Date Trial Added

2015-11-17

Updated Date

2017-03-16