{"id":213165,"date":"2026-05-28T20:44:52","date_gmt":"2026-05-29T00:44:52","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/alteraciones-duraderas-en-la-microbiota-intestinal-y-el-metaboloma-fecal-tras-la-extirpacion-de-un-adenoma-colorrectal-y-su-relacion-con-el-cancer-colorrectal\/"},"modified":"2026-06-17T19:08:50","modified_gmt":"2026-06-17T23:08:50","slug":"alteraciones-duraderas-en-la-microbiota-intestinal-y-el-metaboloma-fecal-tras-la-extirpacion-de-un-adenoma-colorrectal-y-su-relacion-con-el-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/alteraciones-duraderas-en-la-microbiota-intestinal-y-el-metaboloma-fecal-tras-la-extirpacion-de-un-adenoma-colorrectal-y-su-relacion-con-el-cancer-colorrectal\/","title":{"rendered":"Alteraciones duraderas en la microbiota intestinal y el metaboloma fecal tras la extirpaci\u00f3n de un adenoma colorrectal y su relaci\u00f3n con el c\u00e1ncer colorrectal"},"content":{"rendered":"
\n

Cell Host Microbe. 27 de mayo de 2026: S1931-3128(26)00177-0. doi: 10.1016\/j.chom.2026.05.001. Publicado en l\u00ednea antes de su impresi\u00f3n. <\/p>\n

RESUMEN<\/b><\/p>\n

Aunque se sabe que la microbiota intestinal est\u00e1 relacionada con el c\u00e1ncer colorrectal (CCR), a\u00fan no est\u00e1n claras las alteraciones en la microbiota y el metaboloma a lo largo de la secuencia adenoma-carcinoma. En este estudio, analizamos los metagenomas de las heces de 354 mujeres 12,1 \u00b1 4,8 a\u00f1os despu\u00e9s de la resecci\u00f3n de un adenoma y de sus controles emparejados 1:1, as\u00ed como los metabolomas de las heces de 184 pares. Los perfiles metagen\u00f3micos se comparan con los de 14 estudios independientes de casos y controles de CCR. La composici\u00f3n microbiana difiere entre los casos de adenoma y los controles, y concuerda con las alteraciones asociadas al CCR (rho de Pearson = 0,26; p < 0,0001). Treinta y un microbios, entre ellos Faecalibacterium prausnitzii y Flavonifractor plautii, presentan alteraciones en ambas condiciones y se correlacionan con factores relacionados con el estilo de vida. Treinta metabolitos y siete subv\u00edas metab\u00f3licas, sobre todo los esfingol\u00edpidos, est\u00e1n asociados a los adenomas. Los adenomas tambi\u00e9n muestran asociaciones entre microbios y metabolitos espec\u00edficas de la enfermedad, como las que hay entre Bilophila wadsworthia y los dip\u00e9ptidos que contienen alanina. Estos hallazgos revelan alteraciones en la microbiota intestinal y el metaboloma que se pueden detectar a\u00f1os despu\u00e9s de la resecci\u00f3n del adenoma, lo que respalda la presencia de un microbioma alterado a lo largo del continuo adenoma-CCR. <\/p>\n

PMID:42202778<\/a> | DOI:10.1016\/j.chom.2026.05.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Cell Host Microbe. 27 de mayo de 2026: S1931-3128(26)00177-0. doi: 10.1016\/j.chom.2026.05.001. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN Aunque se sabe que la microbiota intestinal est\u00e1 relacionada con el c\u00e1ncer colorrectal (CCR), a\u00fan no est\u00e1n claras las alteraciones en la microbiota y el metaboloma a lo largo de la secuencia adenoma-carcinoma. En este estudio, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[633],"tags":[],"class_list":["post-213165","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"\nAlteraciones duraderas en la microbiota intestinal y el metaboloma fecal tras la extirpaci\u00f3n de un adenoma colorrectal y su relaci\u00f3n con el c\u00e1ncer colorrectal - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/alteraciones-duraderas-en-la-microbiota-intestinal-y-el-metaboloma-fecal-tras-la-extirpacion-de-un-adenoma-colorrectal-y-su-relacion-con-el-cancer-colorrectal\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alteraciones duraderas en la microbiota intestinal y el metaboloma fecal tras la extirpaci\u00f3n de un adenoma colorrectal y su relaci\u00f3n con el c\u00e1ncer colorrectal - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"Cell Host Microbe. 27 de mayo de 2026: S1931-3128(26)00177-0. doi: 10.1016\/j.chom.2026.05.001. 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