{"id":213202,"date":"2026-04-28T20:04:45","date_gmt":"2026-04-29T00:04:45","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/ensayo-de-fase-ii-con-rapamicina-encapsulada-para-reducir-la-carga-de-polipos-asociada-a-la-poliposis-adenomatosa-familiar\/"},"modified":"2026-06-17T19:09:26","modified_gmt":"2026-06-17T23:09:26","slug":"ensayo-de-fase-ii-con-rapamicina-encapsulada-para-reducir-la-carga-de-polipos-asociada-a-la-poliposis-adenomatosa-familiar","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/ensayo-de-fase-ii-con-rapamicina-encapsulada-para-reducir-la-carga-de-polipos-asociada-a-la-poliposis-adenomatosa-familiar\/","title":{"rendered":"Ensayo de fase II con rapamicina encapsulada para reducir la carga de p\u00f3lipos asociada a la poliposis adenomatosa familiar"},"content":{"rendered":"
\n

Clin Cancer Res. 28 de abril de 2026. doi: 10.1158\/1078-0432.CCR-25-4126. Publicado en l\u00ednea antes de su impresi\u00f3n. <\/p>\n

RESUMEN<\/b><\/p>\n

OBJETIVO: La poliposis adenomatosa familiar (PAF) conlleva un riesgo significativo de c\u00e1ncer colorrectal o duodenal. La rapamicina encapsulada (eRapa) se ha mostrado prometedora como quimioprevenci\u00f3n de la PAF en los primeros estudios cl\u00ednicos. <\/p>\n

M\u00c9TODOS: Se incluyeron 30 pacientes con FAP en tres reg\u00edmenes de dosificaci\u00f3n de eRapa (0,5 mg): cohorte 1 \u2014cada dos d\u00edas\u2014, cohorte 2 \u2014diariamente cada dos semanas\u2014 o cohorte 3 \u2014diariamente\u2014. Los criterios de valoraci\u00f3n principales fueron la seguridad y la tolerabilidad, la farmacocin\u00e9tica y el cambio porcentual respecto al valor basal (PCFB) en la carga de p\u00f3lipos colorrectales (CPB) a los 6 meses. Los criterios de valoraci\u00f3n secundarios incluyeron el PCFB de la carga total de p\u00f3lipos (TPB) y de los p\u00f3lipos duodenales (DPB), as\u00ed como el cambio en el estadio InSiGHT y la puntuaci\u00f3n de Spigelman a los 6 y 12 meses. <\/p>\n

RESULTADOS: 29 de 30 pacientes (97 %) completaron el estudio de 12 meses con una biodisponibilidad previsible. Los efectos adversos de grado leve fueron frecuentes, pero m\u00e1s pronunciados con la dosificaci\u00f3n diaria. Dos pacientes interrumpieron el tratamiento por toxicidad. La cohorte 1 present\u00f3 la mayor disminuci\u00f3n en la mediana de PCFB, CPB, DPB y TPB a los 6 meses: -39,4 % (IQR, 108,9; p = 0,28), -33,33 % (IQR, 90,0; p = 0,04) y del -38,6 % (IQR, 88,5; p = 0,26), respectivamente. A los 12 meses, la cohorte 2 present\u00f3 la mayor disminuci\u00f3n en la mediana de PCFB, CPB y TPB: -29,3 % (IQR, 67,6; p = 0,37) y -26,3 % (IQR, 49,5; p = 0,29), respectivamente. Las cohortes con dosificaci\u00f3n intermitente (1 y 2) redujeron el DPB a los 6 meses (p = 0,04) y mejoraron el TPB a los 12 meses (p = 0,05) en comparaci\u00f3n con la dosificaci\u00f3n diaria. <\/p>\n

CONCLUSI\u00d3N: eRapa result\u00f3 seguro, bien tolerado y mostr\u00f3 una eficacia preliminar para la quimioprevenci\u00f3n de la FAP. La pauta de 0,5 mg al d\u00eda cada dos semanas se evaluar\u00e1 en un pr\u00f3ximo ensayo de fase III. <\/p>\n

PMID:42048421<\/a> | DOI:10.1158\/1078-0432.CCR-25-4126<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Clin Cancer Res. 28 de abril de 2026. doi: 10.1158\/1078-0432.CCR-25-4126. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN OBJETIVO: La poliposis adenomatosa familiar (PAF) conlleva un riesgo significativo de c\u00e1ncer colorrectal o duodenal. La rapamicina encapsulada (eRapa) se ha mostrado prometedora como quimioprevenci\u00f3n de la PAF en los primeros estudios cl\u00ednicos. M\u00c9TODOS: Se incluyeron 30 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[633],"tags":[],"class_list":["post-213202","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"\nEnsayo de fase II con rapamicina encapsulada para reducir la carga de p\u00f3lipos asociada a la poliposis adenomatosa familiar - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/ensayo-de-fase-ii-con-rapamicina-encapsulada-para-reducir-la-carga-de-polipos-asociada-a-la-poliposis-adenomatosa-familiar\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ensayo de fase II con rapamicina encapsulada para reducir la carga de p\u00f3lipos asociada a la poliposis adenomatosa familiar - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"Clin Cancer Res. 28 de abril de 2026. doi: 10.1158\/1078-0432.CCR-25-4126. 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