{"id":213259,"date":"2026-03-26T19:38:03","date_gmt":"2026-03-26T23:38:03","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/fenotipo-de-los-vasos-tumorales-en-el-microambiente-del-cancer-colorrectal-segun-la-edad-en-el-momento-del-diagnostico\/"},"modified":"2026-06-17T19:14:20","modified_gmt":"2026-06-17T23:14:20","slug":"fenotipo-de-los-vasos-tumorales-en-el-microambiente-del-cancer-colorrectal-segun-la-edad-en-el-momento-del-diagnostico","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/fenotipo-de-los-vasos-tumorales-en-el-microambiente-del-cancer-colorrectal-segun-la-edad-en-el-momento-del-diagnostico\/","title":{"rendered":"Fenotipo de los vasos tumorales en el microambiente del c\u00e1ncer colorrectal seg\u00fan la edad en el momento del diagn\u00f3stico"},"content":{"rendered":"
\n

Br J Cancer. 25 de marzo de 2026. doi: 10.1038\/s41416-026-03373-6. Publicado en l\u00ednea antes de su impresi\u00f3n. <\/p>\n

RESUMEN<\/b><\/p>\n

ANTECEDENTES: Dada la preocupaci\u00f3n mundial por el aumento de la incidencia del c\u00e1ncer colorrectal (CCR) de aparici\u00f3n precoz, hemos comprobado la hip\u00f3tesis de que los fenotipos de la vasculatura tumoral podr\u00edan variar seg\u00fan la edad en el momento del diagn\u00f3stico del CCR.<\/p>\n

M\u00c9TODO: Usamos inmunofluorescencia multiespectral in situ, combinada con an\u00e1lisis digital de im\u00e1genes y aprendizaje autom\u00e1tico, para medir la expresi\u00f3n de marcadores de c\u00e9lulas endoteliales [ACKR1 (DARC), CD34, CD36, KDR (VEGFR2), LAMB1 (laminina \u03b21), MADCAM1] y KRT (queratina) en 843 tumores procedentes de 4476 casos de CCR en cohortes prospectivas de todo EE. UU., siguiendo el m\u00e9todo del biobanco de tumores incidentes de cohortes prospectivas.<\/p>\n

RESULTADOS: Las densidades generales de vasos CD34 +<\/sup> y vasos CD34 +<\/sup> LAMB1 +<\/sup> se correlacionaron inversamente con una edad m\u00e1s joven al diagn\u00f3stico de CRC (ambas P tendencia<\/sub> < 0,0001). En los an\u00e1lisis de regresi\u00f3n log\u00edstica multivariable ajustada ponderada por probabilidad inversa, en comparaci\u00f3n con la edad \u226570, las razones de probabilidades (con intervalo de confianza del 95%) para una densidad general de vasos alta (frente a baja) fueron 0,85 (0,74-0,99) para la edad de 55-69 y 0,63 (0,48-0,81) para la edad <55, y las de una densidad de vasos CD34 +<\/sup> LAMB1 +<\/sup> alta (frente a baja\/negativa) fueron 0,56 (0,47-0,65) para la edad de 55-69 y 0,28 (0,20-0,40) para la edad <55. <\/p>\n

CONCLUSIONES: La hipovascularizaci\u00f3n de los vasos sangu\u00edneos, tanto generales como CD34 +<\/sup> LAMB1 +,<\/sup> podr\u00eda constituir una caracter\u00edstica microambiental del c\u00e1ncer colorrectal de aparici\u00f3n temprana, si se confirma mediante estudios independientes. Nuestros hallazgos resaltan las diferencias patobiol\u00f3gicas tumorales relacionadas con la edad. La identificaci\u00f3n de biomarcadores espec\u00edficos del c\u00e1ncer colorrectal de aparici\u00f3n temprana puede aportar pistas patog\u00e9nicas y etiol\u00f3gicas. <\/p>\n

PMID:41882312<\/a> | DOI:10.1038\/s41416-026-03373-6<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Br J Cancer. 25 de marzo de 2026. doi: 10.1038\/s41416-026-03373-6. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN ANTECEDENTES: Dada la preocupaci\u00f3n mundial por el aumento de la incidencia del c\u00e1ncer colorrectal (CCR) de aparici\u00f3n precoz, hemos comprobado la hip\u00f3tesis de que los fenotipos de la vasculatura tumoral podr\u00edan variar seg\u00fan la edad en el […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[633],"tags":[],"class_list":["post-213259","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"\nFenotipo de los vasos tumorales en el microambiente del c\u00e1ncer colorrectal seg\u00fan la edad en el momento del diagn\u00f3stico - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/fenotipo-de-los-vasos-tumorales-en-el-microambiente-del-cancer-colorrectal-segun-la-edad-en-el-momento-del-diagnostico\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fenotipo de los vasos tumorales en el microambiente del c\u00e1ncer colorrectal seg\u00fan la edad en el momento del diagn\u00f3stico - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"Br J Cancer. 25 de marzo de 2026. doi: 10.1038\/s41416-026-03373-6. Publicado en l\u00ednea antes de su impresi\u00f3n. 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