{"id":213267,"date":"2026-03-12T19:26:37","date_gmt":"2026-03-12T23:26:37","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/"},"modified":"2026-06-17T19:14:25","modified_gmt":"2026-06-17T23:14:25","slug":"asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/","title":{"rendered":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal"},"content":{"rendered":"<div>\n<p>Sci Rep. 13 de febrero de 2026. doi: 10.1038\/s41598-026-39644-8. Publicado en l\u00ednea antes de su impresi\u00f3n.  <\/p>\n<p><b>RESUMEN<\/b><\/p>\n<p>Las mutaciones som\u00e1ticas en el gen KRAS son un factor desencadenante habitual del c\u00e1ncer colorrectal (CCR) y se dan con frecuencias diferentes seg\u00fan la raza, el sexo, la localizaci\u00f3n del tumor, el origen \u00e9tnico y la similitud gen\u00e9tica. Las variantes germinales hereditarias pueden influir en la frecuencia de las mutaciones som\u00e1ticas del tumor al alterar los procesos de mutaci\u00f3n o de reparaci\u00f3n del ADN, o al modificar las respuestas celulares, inmunol\u00f3gicas y\/o del microambiente tras una mutaci\u00f3n. Nuestra hip\u00f3tesis era que el fondo gen\u00e9tico germinal modifica la frecuencia de las mutaciones som\u00e1ticas del gen KRAS en el CCR. Para comprobarlo, hicimos un estudio de asociaci\u00f3n del genoma completo (GWAS) en 7071 personas con CRC, usando el estado de mutaci\u00f3n del gen KRAS como fenotipo. Se seleccionaron variantes de un solo nucle\u00f3tido (SNV) para los an\u00e1lisis de validaci\u00f3n bas\u00e1ndonos en los valores de p del GWAS de descubrimiento, los efectos funcionales predichos in silico y la proximidad a genes con posible relevancia oncol\u00f3gica. Se llev\u00f3 a cabo un an\u00e1lisis de validaci\u00f3n de 101 SNV de inter\u00e9s en 2482 personas. Ninguna de las SNV se asoci\u00f3 de forma significativa con el CCR con mutaci\u00f3n en KRAS (valor P < 0,0005). Una variante, la rs73067863-T, mostr\u00f3 una asociaci\u00f3n exploratoria no significativa con un menor n\u00famero de tumores con mutaci\u00f3n en KRAS en la muestra combinada (valor de p = 9,7 \u00d7 <sup> 10\u207b\u2077<\/sup>, OR = 0,75). Se necesitan estudios de seguimiento para determinar si estas u otras variantes germinales influyen en las diferencias poblacionales en las mutaciones de KRAS en el CCR. <\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41688657\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260312192346&#038;v=2.19.0.post6+133c1fe\">41688657<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1038\/s41598-026-39644-8\">10.1038\/s41598-026-39644-8<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Sci Rep. 13 de febrero de 2026. doi: 10.1038\/s41598-026-39644-8. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN Las mutaciones som\u00e1ticas en el gen KRAS son un factor desencadenante habitual del c\u00e1ncer colorrectal (CCR) y se dan con frecuencias diferentes seg\u00fan la raza, el sexo, la localizaci\u00f3n del tumor, el origen \u00e9tnico y la similitud gen\u00e9tica. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[633],"tags":[],"class_list":["post-213267","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"Sci Rep. 13 de febrero de 2026. doi: 10.1038\/s41598-026-39644-8. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN Las mutaciones som\u00e1ticas en el gen KRAS son un factor desencadenante habitual del c\u00e1ncer colorrectal (CCR) y se dan con frecuencias diferentes seg\u00fan la raza, el sexo, la localizaci\u00f3n del tumor, el origen \u00e9tnico y la similitud gen\u00e9tica. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/\" \/>\n<meta property=\"og:site_name\" content=\"Fight Colorectal Cancer\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FightCRC\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-12T23:26:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-17T23:14:25+00:00\" \/>\n<meta name=\"author\" content=\"IntegrityAdmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:site\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"IntegrityAdmin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/\"},\"author\":{\"name\":\"IntegrityAdmin\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#\\\/schema\\\/person\\\/ce7e56170881dc28f01f529b585e16b8\"},\"headline\":\"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal\",\"datePublished\":\"2026-03-12T23:26:37+00:00\",\"dateModified\":\"2026-06-17T23:14:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/\"},\"wordCount\":322,\"publisher\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#organization\"},\"articleSection\":[\"Investiga\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/\",\"name\":\"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#website\"},\"datePublished\":\"2026-03-12T23:26:37+00:00\",\"dateModified\":\"2026-06-17T23:14:25+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"P\u00e1gina de inicio\",\"item\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/pagina-de-inicio\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/\",\"name\":\"Fight Colorectal Cancer\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#organization\",\"name\":\"Fight Colorectal Cancer\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png\",\"contentUrl\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png\",\"width\":1265,\"height\":450,\"caption\":\"Fight Colorectal Cancer\"},\"image\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/FightCRC\\\/\",\"https:\\\/\\\/x.com\\\/fightcrc\",\"https:\\\/\\\/www.instagram.com\\\/fightcrc\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@FightCRC\",\"https:\\\/\\\/www.tiktok.com\\\/@fightcrc\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/fight-colorectal-cancer\\\/\",\"https:\\\/\\\/bsky.app\\\/profile\\\/fightcrc.bsky.social\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#\\\/schema\\\/person\\\/ce7e56170881dc28f01f529b585e16b8\",\"name\":\"IntegrityAdmin\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/author\\\/integrityadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/","og_locale":"es_ES","og_type":"article","og_title":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer","og_description":"Sci Rep. 13 de febrero de 2026. doi: 10.1038\/s41598-026-39644-8. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN Las mutaciones som\u00e1ticas en el gen KRAS son un factor desencadenante habitual del c\u00e1ncer colorrectal (CCR) y se dan con frecuencias diferentes seg\u00fan la raza, el sexo, la localizaci\u00f3n del tumor, el origen \u00e9tnico y la similitud gen\u00e9tica. [&hellip;]","og_url":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/","og_site_name":"Fight Colorectal Cancer","article_publisher":"https:\/\/www.facebook.com\/FightCRC\/","article_published_time":"2026-03-12T23:26:37+00:00","article_modified_time":"2026-06-17T23:14:25+00:00","author":"IntegrityAdmin","twitter_card":"summary_large_image","twitter_creator":"@fightcrc","twitter_site":"@fightcrc","twitter_misc":{"Escrito por":"IntegrityAdmin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/#article","isPartOf":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/"},"author":{"name":"IntegrityAdmin","@id":"https:\/\/fightcolorectalcancer.org\/es\/#\/schema\/person\/ce7e56170881dc28f01f529b585e16b8"},"headline":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal","datePublished":"2026-03-12T23:26:37+00:00","dateModified":"2026-06-17T23:14:25+00:00","mainEntityOfPage":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/"},"wordCount":322,"publisher":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/#organization"},"articleSection":["Investiga"],"inLanguage":"es"},{"@type":"WebPage","@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/","url":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/","name":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal - Fight Colorectal Cancer","isPartOf":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/#website"},"datePublished":"2026-03-12T23:26:37+00:00","dateModified":"2026-06-17T23:14:25+00:00","breadcrumb":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fightcolorectalcancer.org\/es\/asociacion-entre-las-variantes-germinales-y-el-estado-de-mutacion-del-gen-kras-en-el-cancer-colorrectal\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"P\u00e1gina de inicio","item":"https:\/\/fightcolorectalcancer.org\/es\/pagina-de-inicio\/"},{"@type":"ListItem","position":2,"name":"Asociaci\u00f3n entre las variantes germinales y el estado de mutaci\u00f3n del gen KRAS en el c\u00e1ncer colorrectal"}]},{"@type":"WebSite","@id":"https:\/\/fightcolorectalcancer.org\/es\/#website","url":"https:\/\/fightcolorectalcancer.org\/es\/","name":"Fight Colorectal Cancer","description":"","publisher":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fightcolorectalcancer.org\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/fightcolorectalcancer.org\/es\/#organization","name":"Fight Colorectal Cancer","url":"https:\/\/fightcolorectalcancer.org\/es\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/fightcolorectalcancer.org\/es\/#\/schema\/logo\/image\/","url":"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2025\/10\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png","contentUrl":"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2025\/10\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png","width":1265,"height":450,"caption":"Fight Colorectal Cancer"},"image":{"@id":"https:\/\/fightcolorectalcancer.org\/es\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/FightCRC\/","https:\/\/x.com\/fightcrc","https:\/\/www.instagram.com\/fightcrc\/","https:\/\/www.youtube.com\/@FightCRC","https:\/\/www.tiktok.com\/@fightcrc","https:\/\/www.linkedin.com\/company\/fight-colorectal-cancer\/","https:\/\/bsky.app\/profile\/fightcrc.bsky.social"]},{"@type":"Person","@id":"https:\/\/fightcolorectalcancer.org\/es\/#\/schema\/person\/ce7e56170881dc28f01f529b585e16b8","name":"IntegrityAdmin","url":"https:\/\/fightcolorectalcancer.org\/es\/author\/integrityadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/posts\/213267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/comments?post=213267"}],"version-history":[{"count":0,"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/posts\/213267\/revisions"}],"wp:attachment":[{"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/media?parent=213267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/categories?post=213267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/es\/wp-json\/wp\/v2\/tags?post=213267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}