{"id":226578,"date":"2026-10-20T22:49:23","date_gmt":"2026-10-21T02:49:23","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\/"},"modified":"2026-10-22T11:30:53","modified_gmt":"2026-10-22T15:30:53","slug":"riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\/","title":{"rendered":"Riesgos de c\u00e1ncer actualizados en el s\u00edndrome de Lynch"},"content":{"rendered":"<div>\n<p>Fam Cancer. 20 de octubre de 2026; 25(4):97. doi: 10.1007\/s10689-026-00598-5.  <\/p>\n<p><b>RESUMEN<\/b><\/p>\n<p>El s\u00edndrome de Lynch, uno de los s\u00edndromes hereditarios de predisposici\u00f3n al c\u00e1ncer m\u00e1s comunes, est\u00e1 causado por variantes pat\u00f3genas en los genes de reparaci\u00f3n de desajustes (MLH1, MSH2, MSH6, PMS2) y en el gen EPCAM. Las personas que heredan variantes pat\u00f3genas en los genes asociados al s\u00edndrome de Lynch tienen un mayor riesgo a lo largo de su vida de padecer c\u00e1ncer colorrectal, de endometrio y otros tipos de c\u00e1ncer. Los riesgos de padecer c\u00e1nceres asociados al s\u00edndrome de Lynch var\u00edan seg\u00fan el gen afectado y dentro de cada gen, sobre todo en el caso de los genes de menor penetrancia. Esto supone un reto para los m\u00e9dicos a la hora de ofrecer a los pacientes y sus familias estimaciones precisas del riesgo de c\u00e1ncer y establecer protocolos de seguimiento personalizados. A este reto se suma el hecho de que los dise\u00f1os de los estudios y los posibles sesgos podr\u00edan dar lugar a estimaciones de riesgo diferentes. En esta revisi\u00f3n, presentamos estimaciones actualizadas del riesgo de c\u00e1ncer en el s\u00edndrome de Lynch y analizamos c\u00f3mo el dise\u00f1o de los estudios podr\u00eda influir en estas estimaciones.     <\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42900270\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20261020224922&#038;v=2.20.1\">42900270<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10689-026-00598-5\">10.1007\/s10689-026-00598-5<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Fam Cancer. 20 de octubre de 2026; 25(4):97. doi: 10.1007\/s10689-026-00598-5. RESUMEN El s\u00edndrome de Lynch, uno de los s\u00edndromes hereditarios de predisposici\u00f3n al c\u00e1ncer m\u00e1s comunes, est\u00e1 causado por variantes pat\u00f3genas en los genes de reparaci\u00f3n de desajustes (MLH1, MSH2, MSH6, PMS2) y en el gen EPCAM. Las personas que heredan variantes pat\u00f3genas en los [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[633],"tags":[],"class_list":["post-226578","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Riesgos de c\u00e1ncer actualizados en el s\u00edndrome de Lynch - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Riesgos de c\u00e1ncer actualizados en el s\u00edndrome de Lynch - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"Fam Cancer. 20 de octubre de 2026; 25(4):97. doi: 10.1007\/s10689-026-00598-5. RESUMEN El s\u00edndrome de Lynch, uno de los s\u00edndromes hereditarios de predisposici\u00f3n al c\u00e1ncer m\u00e1s comunes, est\u00e1 causado por variantes pat\u00f3genas en los genes de reparaci\u00f3n de desajustes (MLH1, MSH2, MSH6, PMS2) y en el gen EPCAM. Las personas que heredan variantes pat\u00f3genas en los [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fightcolorectalcancer.org\/es\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\/\" \/>\n<meta property=\"og:site_name\" content=\"Fight Colorectal Cancer\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FightCRC\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-21T02:49:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-22T15:30:53+00:00\" \/>\n<meta name=\"author\" content=\"IntegrityAdmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:site\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"IntegrityAdmin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\\\/\"},\"author\":{\"name\":\"IntegrityAdmin\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#\\\/schema\\\/person\\\/ef65659a2d39541f11f2bb0c77365317\"},\"headline\":\"Riesgos de c\u00e1ncer actualizados en el s\u00edndrome de Lynch\",\"datePublished\":\"2026-10-21T02:49:23+00:00\",\"dateModified\":\"2026-10-22T15:30:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\\\/\"},\"wordCount\":239,\"publisher\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/#organization\"},\"articleSection\":[\"Investiga\"],\"inLanguage\":\"es\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\\\/\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/es\\\/riesgos-de-cancer-actualizados-en-el-sindrome-de-lynch\\\/\",\"name\":\"Riesgos de c\u00e1ncer actualizados en el s\u00edndrome de Lynch - 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