{"id":226582,"date":"2026-10-19T22:49:05","date_gmt":"2026-10-20T02:49:05","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/identificacion-de-biomarcadores-proteomicos-prediagnosticos-para-el-cancer-de-colon-y-recto-en-tres-cohortes-prospectivas\/"},"modified":"2026-10-22T11:32:42","modified_gmt":"2026-10-22T15:32:42","slug":"identificacion-de-biomarcadores-proteomicos-prediagnosticos-para-el-cancer-de-colon-y-recto-en-tres-cohortes-prospectivas","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/es\/identificacion-de-biomarcadores-proteomicos-prediagnosticos-para-el-cancer-de-colon-y-recto-en-tres-cohortes-prospectivas\/","title":{"rendered":"Identificaci\u00f3n de biomarcadores prote\u00f3micos prediagn\u00f3sticos para el c\u00e1ncer de colon y recto en tres cohortes prospectivas"},"content":{"rendered":"<div>\n<p>J Natl Cancer Inst. 19 de octubre de 2026: djag217. doi: 10.1093\/jnci\/djag217. Publicado en l\u00ednea antes de su impresi\u00f3n.   <\/p>\n<p><b>RESUMEN<\/b><\/p>\n<p>ANTECEDENTES: La prote\u00f3mica a gran escala podr\u00eda revelar biomarcadores circulantes del c\u00e1ncer colorrectal (CCR) a\u00f1os antes del diagn\u00f3stico, aunque la reproducibilidad entre cohortes y la especificidad anat\u00f3mica siguen sin estar claras.<\/p>\n<p>M\u00c9TODOS: Realizamos estudios de casos y controles anidados en tres cohortes prospectivas con muestras de sangre almacenadas y seguimiento del c\u00e1ncer (mediana de 7 a\u00f1os), con un total de 851 casos nuevos de CCR emparejados 1:1 con controles, y 1.801 muestras de prote\u00ednas plasm\u00e1ticas previas al diagn\u00f3stico procedentes de los paneles de Olink.<\/p>\n<p>RESULTADOS: Doce prote\u00ednas mostraron diferencias significativas entre los casos de CCR y los controles (FDR <0,1), con tama\u00f1os del efecto modestos. Entre ellas se encontraban biomarcadores del CCR ya identificados anteriormente (por ejemplo, niveles m\u00e1s altos de GDF15 y TFF2), as\u00ed como asociaciones menos consolidadas (por ejemplo, niveles m\u00e1s bajos de LEPR y BCAN). Las diferencias emparejadas en las prote\u00ednas son significativamente distintas entre los pares de c\u00e1ncer de colon y de recto (P = 0,005), impulsadas por genes enriquecidos en la activaci\u00f3n leucocitaria, la activaci\u00f3n celular y los componentes extracelulares. En el an\u00e1lisis estratificado, para el c\u00e1ncer de colon, 11 de las 12 prote\u00ednas presentaban niveles m\u00e1s bajos en los casos (FDR < 0,1), incluido el BCAN con una (0,74-0,94) de odds ratio (OR, con IC del 95 %) por cada aumento de 1 unidad en el nivel de NPX normalizado por cuantiles, con consistencia entre cohortes (I\u00b2 < 0,01). En el caso del c\u00e1ncer de recto, 25 de las 28 prote\u00ednas presentaban niveles m\u00e1s altos en los casos, incluida la HDGF (OR 1,75 [1,15-2,66], I\u00b2 < 0,01). La HDGF podr\u00eda mediar parcialmente en la relaci\u00f3n entre el IMC y el riesgo de c\u00e1ncer rectal (25,0 %, FDR = 0,044). En general, descubrimos que la prote\u00f3mica plasm\u00e1tica prediagn\u00f3stica identific\u00f3 prote\u00ednas y v\u00edas con tama\u00f1os de efecto modestos y diferencias claras entre el riesgo futuro de c\u00e1ncer de colon y de recto.      <\/p>\n<p>CONCLUSI\u00d3N: Estos resultados aportan informaci\u00f3n \u00fatil para la futura validaci\u00f3n mec\u00e1nica de las prote\u00ednas plasm\u00e1ticas prediagn\u00f3sticas como biomarcadores del c\u00e1ncer colorrectal y animan a buscar biomarcadores espec\u00edficos de cada localizaci\u00f3n que permitan distinguir el c\u00e1ncer de colon del de recto.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42895287\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20261019224904&#038;v=2.20.1\">42895287<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jnci\/djag217\">10.1093\/jnci\/djag217<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Natl Cancer Inst. 19 de octubre de 2026: djag217. doi: 10.1093\/jnci\/djag217. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN ANTECEDENTES: La prote\u00f3mica a gran escala podr\u00eda revelar biomarcadores circulantes del c\u00e1ncer colorrectal (CCR) a\u00f1os antes del diagn\u00f3stico, aunque la reproducibilidad entre cohortes y la especificidad anat\u00f3mica siguen sin estar claras. M\u00c9TODOS: Realizamos estudios de [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[633],"tags":[],"class_list":["post-226582","post","type-post","status-publish","format-standard","hentry","category-investiga"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identificaci\u00f3n de biomarcadores prote\u00f3micos prediagn\u00f3sticos para el c\u00e1ncer de colon y recto en tres cohortes prospectivas - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/es\/identificacion-de-biomarcadores-proteomicos-prediagnosticos-para-el-cancer-de-colon-y-recto-en-tres-cohortes-prospectivas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificaci\u00f3n de biomarcadores prote\u00f3micos prediagn\u00f3sticos para el c\u00e1ncer de colon y recto en tres cohortes prospectivas - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"J Natl Cancer Inst. 19 de octubre de 2026: djag217. doi: 10.1093\/jnci\/djag217. Publicado en l\u00ednea antes de su impresi\u00f3n. RESUMEN ANTECEDENTES: La prote\u00f3mica a gran escala podr\u00eda revelar biomarcadores circulantes del c\u00e1ncer colorrectal (CCR) a\u00f1os antes del diagn\u00f3stico, aunque la reproducibilidad entre cohortes y la especificidad anat\u00f3mica siguen sin estar claras. 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