{"id":213170,"date":"2026-05-08T20:12:48","date_gmt":"2026-05-09T00:12:48","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/"},"modified":"2026-06-17T19:08:50","modified_gmt":"2026-06-17T23:08:50","slug":"braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/","title":{"rendered":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b"},"content":{"rendered":"<div>\n<p>\u300a\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u300b. 2026\u5e745\u67088\u65e5. doi: 10.1158\/1078-0432.CCR-25-4370. \u5728\u7ebf\u53d1\u8868\u4e8e\u5370\u5237\u7248\u4e4b\u524d.  <\/p>\n<p><b>\u6458\u8981<\/b><\/p>\n<p>\u76ee\u7684\uff1a\u589e\u5f3a\u5b50\u52a8\u6001\u5f02\u5e38\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u53d1\u751f\u548c\u53d1\u5c55\u4e2d\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5728BRAFV600E\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u4e9a\u578b\u4e2d\uff0c\u8be5\u4e9a\u578b\u5177\u6709\u72ec\u7279\u7684\u663e\u8457\u8868\u89c2\u9057\u4f20\u8868\u578b\u3002 \u57fa\u4e8e\u8fd9\u79cd\u8868\u89c2\u9057\u4f20\u8106\u5f31\u6027\uff0c\u7814\u7a76\u53d1\u73b0\u6eb4\u7ed3\u6784\u57df2\uff08\u4f5c\u4e3aH3K27ac\u6807\u8bb0\u589e\u5f3a\u5b50\u7684\u201c\u8bfb\u53d6\u5668\u201d\uff09\u4e0eBRAF\u548cEGFR\u7684\u8054\u5408\u6291\u5236\u5b58\u5728\u5408\u6210\u81f4\u6b7b\u6548\u5e94\u3002 <\/p>\n<p>\u5b9e\u9a8c\u8bbe\u8ba1\uff1a\u6211\u4eec\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u60a3\u8005\u6765\u6e90\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u8bc4\u4f30\u4e86\u9488\u5bf9\u5f02\u5e38\u589e\u5f3a\u5b50\u4f7f\u7528\u6eb4\u7ed3\u6784\u57df\u548c\u7aef\u5916\uff08BET\uff09+ MAPK\u901a\u8def\u6291\u5236\u5242\u7684\u7597\u6548\uff0c\u968f\u540e\u8fdb\u884c\u4e86\u5168\u9762\u7684\u8f6c\u5f55\u7ec4\u548c\u67d3\u8272\u8d28\u5206\u6790\u3002<\/p>\n<p>\u7ed3\u679c\uff1aBET\u8054\u5408\u6807\u51c6MAPK\u6291\u5236\u5242\u5728\u4f53\u5185\u7684\u6cbb\u7597\u6548\u679c\u9488\u5bf9BRAFV600E\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u6709\u6240\u63d0\u5347\uff0c\u5e76\u5bf9RAS\u7a81\u53d8\u578bCRC\u4e5f\u8868\u73b0\u51fa\u9009\u62e9\u6027\u6539\u5584\u3002\u4e0e\u5355\u72ec\u4f7f\u7528MAPK\u6291\u5236\u5242\u76f8\u6bd4\uff0c\u8be5\u8054\u5408\u6cbb\u7597\u8bf1\u5bfc\u4e86MAPK\u4fe1\u53f7\u901a\u8def\u7684\u66f4\u663e\u8457\u4e0b\u8c03\u3002 H3K27ac\u6807\u8bb0\u7684\u589e\u5f3a\u5b50\u4e0a\u6fc0\u6d3b\u4fe1\u53f7\u7684\u7f3a\u5931\u5bfc\u81f4\u6838\u5fc3\u8c03\u63a7\u7f51\u7edc\u5931\u8c03\uff0c\u5c24\u5176\u662fMAPK\u4e0b\u6e38\u7684E26\u8f6c\u5316\u7279\u5f02\u6027\u8f6c\u5f55\u56e0\u5b50\u5bb6\u65cf\u548cMYC\u3002\u5355\u6838RNA+ATAC\u6d4b\u5e8f\u5728\u7ec6\u80de\u7c7b\u578b\u5c42\u9762\u533a\u5206\u4e86\u8f6c\u5f55\u7ec4\u548c\u67d3\u8272\u8d28\u52a8\u6001\u7684\u5dee\u5f02\u3002 \u9ad8\u5ea6\u5206\u5316\u7ec6\u80de\u7c7b\u578b\u7684\u663e\u8457\u4e0b\u8c03\u8bc1\u5b9e\u4e86MAPK\u4fe1\u53f7\u4f20\u5bfc\u53ca\u5176\u4e0b\u6e38\u8f6c\u5f55\u56e0\u5b50\u7684\u6df1\u5ea6\u6291\u5236\u3002\u76f8\u53cd\uff0c\u5728MAPK\u6216\u8054\u5408\u6291\u5236\u540e\uff0c\u5927\u91cf\u53bb\u5206\u5316\u7ec6\u80de\u7fa4\u51fa\u73b0\uff0c\u8fd9\u8868\u660e\u6cbb\u7597\u8bf1\u5bfc\u4e86\u7ec6\u80de\u72b6\u6001\u7684\u8f6c\u6362\u548c\u9002\u5e94\u3002     <\/p>\n<p>\u7ed3\u8bba\uff1a\u6211\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0cBET\u6291\u5236\u901a\u8fc7\u5bf9\u6838\u5fc3\u8f6c\u5f55\u56e0\u5b50\u7f51\u7edc\u8fdb\u884c\u6df1\u8fdc\u7684\u8868\u89c2\u9057\u4f20\u91cd\u7f16\u7a0b\uff0c\u53ef\u589e\u5f3aMAPK\u4fe1\u53f7\u901a\u8def\u7684\u963b\u65ad\u4f5c\u7528\u3002 \u8fd9\u4e9b\u53d1\u73b0\u4e3a\u5728\u96be\u6cbb\u6027BRAFV600E\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u8bc4\u4f30BET+BRAF+EGFR\u8054\u5408\u6291\u5236\u7597\u6cd5\uff08NCT06102902\uff09\u63d0\u4f9b\u4e86\u4e34\u5e8a\u524d\u4f9d\u636e\u3002<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42101296\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260508201247&#038;v=2.20.0\">42101296<\/a>| DOI:<a href=\"https:\/\/doi.org\/10.1158\/1078-0432.CCR-25-4370\">10.1158\/1078-0432.CCR-25-4370<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u300a\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u300b. 2026\u5e745\u67088\u65e5. doi: 10.1158\/1078-0432.CCR-25-4370 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[640],"tags":[],"class_list":["post-213170","post","type-post","status-publish","format-standard","hentry","category-640"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer\" \/>\n<meta property=\"og:description\" content=\"\u300a\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u300b. 2026\u5e745\u67088\u65e5. doi: 10.1158\/1078-0432.CCR-25-4370 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/\" \/>\n<meta property=\"og:site_name\" content=\"Fight Colorectal Cancer\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FightCRC\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-09T00:12:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-17T23:08:50+00:00\" \/>\n<meta name=\"author\" content=\"IntegrityAdmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:site\" content=\"@fightcrc\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"IntegrityAdmin\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/\"},\"author\":{\"name\":\"IntegrityAdmin\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#\\\/schema\\\/person\\\/d4206898012851bc696d764062effa8c\"},\"headline\":\"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b\",\"datePublished\":\"2026-05-09T00:12:48+00:00\",\"dateModified\":\"2026-06-17T23:08:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/\"},\"wordCount\":51,\"publisher\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#organization\"},\"articleSection\":[\"\u7814\u7a76\"],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/\",\"name\":\"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#website\"},\"datePublished\":\"2026-05-09T00:12:48+00:00\",\"dateModified\":\"2026-06-17T23:08:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/#breadcrumb\"},\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u4e3b\u9875\",\"item\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#website\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/\",\"name\":\"Fight Colorectal Cancer\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"zh-Hans\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#organization\",\"name\":\"Fight Colorectal Cancer\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"zh-Hans\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png\",\"contentUrl\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/wp-content\\\/uploads\\\/2025\\\/10\\\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png\",\"width\":1265,\"height\":450,\"caption\":\"Fight Colorectal Cancer\"},\"image\":{\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/FightCRC\\\/\",\"https:\\\/\\\/x.com\\\/fightcrc\",\"https:\\\/\\\/www.instagram.com\\\/fightcrc\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@FightCRC\",\"https:\\\/\\\/www.tiktok.com\\\/@fightcrc\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/fight-colorectal-cancer\\\/\",\"https:\\\/\\\/bsky.app\\\/profile\\\/fightcrc.bsky.social\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/#\\\/schema\\\/person\\\/d4206898012851bc696d764062effa8c\",\"name\":\"IntegrityAdmin\",\"url\":\"https:\\\/\\\/fightcolorectalcancer.org\\\/zh-hans\\\/author\\\/integrityadmin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/","og_locale":"zh_CN","og_type":"article","og_title":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer","og_description":"\u300a\u4e34\u5e8a\u764c\u75c7\u7814\u7a76\u300b. 2026\u5e745\u67088\u65e5. doi: 10.1158\/1078-0432.CCR-25-4370 [&hellip;]","og_url":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/","og_site_name":"Fight Colorectal Cancer","article_publisher":"https:\/\/www.facebook.com\/FightCRC\/","article_published_time":"2026-05-09T00:12:48+00:00","article_modified_time":"2026-06-17T23:08:50+00:00","author":"IntegrityAdmin","twitter_card":"summary_large_image","twitter_creator":"@fightcrc","twitter_site":"@fightcrc","twitter_misc":{"\u4f5c\u8005":"IntegrityAdmin"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/#article","isPartOf":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/"},"author":{"name":"IntegrityAdmin","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#\/schema\/person\/d4206898012851bc696d764062effa8c"},"headline":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b","datePublished":"2026-05-09T00:12:48+00:00","dateModified":"2026-06-17T23:08:50+00:00","mainEntityOfPage":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/"},"wordCount":51,"publisher":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#organization"},"articleSection":["\u7814\u7a76"],"inLanguage":"zh-Hans"},{"@type":"WebPage","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/","url":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/","name":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b - Fight Colorectal Cancer","isPartOf":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#website"},"datePublished":"2026-05-09T00:12:48+00:00","dateModified":"2026-06-17T23:08:50+00:00","breadcrumb":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/#breadcrumb"},"inLanguage":"zh-Hans","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/braf%e7%aa%81%e5%8f%98%e5%9e%8b%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e5%9c%a8%e5%ba%94%e5%af%b9mapk%e6%8a%91%e5%88%b6%e8%bf%87%e7%a8%8b%e4%b8%ad%ef%bc%8c%e9%80%9a%e8%bf%87ets%e5%92%8cmyc%e6%a0%b8\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u4e3b\u9875","item":"https:\/\/fightcolorectalcancer.org\/zh-hans\/"},{"@type":"ListItem","position":2,"name":"BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5728\u5e94\u5bf9MAPK\u6291\u5236\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7ETS\u548cMYC\u6838\u5fc3\u8c03\u63a7\u56de\u8def\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u7f16\u7a0b"}]},{"@type":"WebSite","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#website","url":"https:\/\/fightcolorectalcancer.org\/zh-hans\/","name":"Fight Colorectal Cancer","description":"","publisher":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fightcolorectalcancer.org\/zh-hans\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"zh-Hans"},{"@type":"Organization","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#organization","name":"Fight Colorectal Cancer","url":"https:\/\/fightcolorectalcancer.org\/zh-hans\/","logo":{"@type":"ImageObject","inLanguage":"zh-Hans","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#\/schema\/logo\/image\/","url":"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2025\/10\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png","contentUrl":"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2025\/10\/e64f86851297bb53f096acdf76c859a294e23b96-1-1.png","width":1265,"height":450,"caption":"Fight Colorectal Cancer"},"image":{"@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/FightCRC\/","https:\/\/x.com\/fightcrc","https:\/\/www.instagram.com\/fightcrc\/","https:\/\/www.youtube.com\/@FightCRC","https:\/\/www.tiktok.com\/@fightcrc","https:\/\/www.linkedin.com\/company\/fight-colorectal-cancer\/","https:\/\/bsky.app\/profile\/fightcrc.bsky.social"]},{"@type":"Person","@id":"https:\/\/fightcolorectalcancer.org\/zh-hans\/#\/schema\/person\/d4206898012851bc696d764062effa8c","name":"IntegrityAdmin","url":"https:\/\/fightcolorectalcancer.org\/zh-hans\/author\/integrityadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/posts\/213170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/comments?post=213170"}],"version-history":[{"count":0,"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/posts\/213170\/revisions"}],"wp:attachment":[{"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/media?parent=213170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/categories?post=213170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fightcolorectalcancer.org\/zh-hans\/wp-json\/wp\/v2\/tags?post=213170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}