{"id":213177,"date":"2026-04-21T19:58:02","date_gmt":"2026-04-21T23:58:02","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e9%98%bf%e7%b1%b3%e4%b8%87%e5%a1%94%e9%a9%ac%e5%b8%83%e5%8d%95%e8%8d%af%e6%b2%bb%e7%96%97%e5%8c%96%e7%96%97%e9%9a%be%e6%b2%bb%e6%80%a7ras-braf%e9%87%8e%e7%94%9f%e5%9e%8b%e8%bd%ac%e7%a7%bb%e6%80%a7\/"},"modified":"2026-06-17T19:08:55","modified_gmt":"2026-06-17T23:08:55","slug":"%e9%98%bf%e7%b1%b3%e4%b8%87%e5%a1%94%e9%a9%ac%e5%b8%83%e5%8d%95%e8%8d%af%e6%b2%bb%e7%96%97%e5%8c%96%e7%96%97%e9%9a%be%e6%b2%bb%e6%80%a7ras-braf%e9%87%8e%e7%94%9f%e5%9e%8b%e8%bd%ac%e7%a7%bb%e6%80%a7","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e9%98%bf%e7%b1%b3%e4%b8%87%e5%a1%94%e9%a9%ac%e5%b8%83%e5%8d%95%e8%8d%af%e6%b2%bb%e7%96%97%e5%8c%96%e7%96%97%e9%9a%be%e6%b2%bb%e6%80%a7ras-braf%e9%87%8e%e7%94%9f%e5%9e%8b%e8%bd%ac%e7%a7%bb%e6%80%a7\/","title":{"rendered":"\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6cbb\u7597\u5316\u7597\u96be\u6cbb\u6027RAS\/BRAF\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1aOrigAMI-1\u7814\u7a76\u7ed3\u679c\uff08\u4e00\u9879\u5f00\u653e\u6807\u7b7eIb\/II\u671f\u7814\u7a76\uff09"},"content":{"rendered":"<div>\n<p>\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\uff08J Clin Oncol\uff09\u30022026\u5e744\u670821\u65e5\uff1aJCO2502187\u3002doi: 10.1200\/JCO-25-02187\u3002\u5728\u7ebf\u53d1\u8868\u4e8e\u5370\u5237\u7248\u4e4b\u524d\u3002<\/p>\n<p><b>\u6458\u8981<\/b><\/p>\n<p>\u76ee\u7684\uff1a\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\uff08Amivantamab\uff09\u662f\u4e00\u79cd\u5177\u6709\u514d\u75ab\u7ec6\u80de\u5bfc\u5411\u6d3b\u6027\u7684EGFR-MET\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u5df2\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3002\u5bf9\u4e8e\u5316\u7597\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\uff0c\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u5341\u5206\u6709\u9650\u3002 <\/p>\n<p>\u65b9\u6cd5\uff1aOrigAMI-1\uff08ClinicalTrials.gov \u6ce8\u518c\u53f7\uff1aNCT05379595\uff09\u662f\u4e00\u9879 Ib\/II \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u963f\u7c73\u4f10\u4ed6\u5355\u6297\u6cbb\u7597\u5316\u7597\u96be\u6cbb\u6027\uff08\u65e2\u5f80\u63a5\u53d7\u8fc7 2-3 \u7ebf\u6cbb\u7597\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c (mCRC) \u7684\u7597\u6548\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5747\u7ecf\u4e2d\u5fc3\u5b9e\u9a8c\u5ba4\u786e\u8ba4<i>RAS<\/i> \/ <i>BRAF<\/i> \/ <i>EGFR<\/i>\u80de\u5916\u57df\u91ce\u751f\u578b\uff0c\u4e14\u65e0<i>ERBB2<\/i> \/ <i>HER2<\/i>\u6269\u589e\u3002\u5de6\u4fa7 mCRC \u60a3\u8005\uff08\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6297 EGFR \u6297\u4f53\u6cbb\u7597\u8005\u4e3a A \u7ec4\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc7\u6297 EGFR \u6297\u4f53\u6cbb\u7597\u8005\u4e3a B \u7ec4\uff09\u6216\u53f3\u4fa7 mCRC \u60a3\u8005\uff08\u65e2\u5f80\u662f\u5426\u63a5\u53d7\u8fc7\u6297 EGFR \u6297\u4f53\u6cbb\u7597\u8005\u4e3a C \u7ec4\uff09\uff0c\u5747\u63a5\u53d7\u9759\u8109\u6ce8\u5c04\u963f\u7c73\u4f10\u4ed6\u5355\u6297 1050 mg\uff08\u4f53\u91cd \u226580 kg \u8005\u4e3a 1400 mg\uff09\uff0c\u6bcf 2 \u5468\u4e00\u6b21\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u6839\u636e RECIST v1.1 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\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u5206\u522b\u4e3a9.0\u4e2a\u6708\u548c6.1\u4e2a\u6708\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5206\u522b\u4e3a5.7\u4e2a\u6708\u548c4.6\u4e2a\u6708\u3002 \u5728\u53f3\u4fa7\u4e9a\u7ec4\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a22%\uff0823\u4f8b\u4e2d10\u4f8b\uff1b\u5176\u4e2d43%\u66fe\u63a5\u53d7\u8fc7\u6297EGFR\u6cbb\u7597\uff09\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DoR\uff09\u4e3a9.8\u4e2a\u6708\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a3.7\u4e2a\u6708\u3002 \u6700\u5e38\u89c1\u7684\u6cbb\u7597\u76f8\u5173\u22653\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u4e3a\u76ae\u75b9\uff087%\uff09\u3001\u75e4\u75ae\u6837\u76ae\u708e\uff084%\uff09\u548c\u4f4e\u767d\u86cb\u767d\u8840\u75c7\uff084%\uff09\u3002\u6709\u4e00\u540d\u53d7\u8bd5\u8005\u56e0\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u800c\u505c\u7528\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u3002     <\/p>\n<p>\u7ed3\u8bba\uff1a\u65e0\u8bba\u60a3\u8005\u662f\u5426\u66fe\u63a5\u53d7\u8fc7\u6297EGFR\u6cbb\u7597\uff0c\u4e5f\u65e0\u8bba\u539f\u53d1\u80bf\u7624\u4f4d\u4e8e\u4f55\u5904\uff0c\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6cbb\u7597\u5728\u5316\u7597\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e2d\u5747\u8868\u73b0\u51fa\u4ee4\u4eba\u9f13\u821e\u4e14\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002 \u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e2d\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u4e2d\u7684\u7ecf\u9a8c\u4e00\u81f4\u3002\u76ee\u524d\uff0c\u6709\u4e24\u9879III\u671f\u7814\u7a76\u6b63\u5728\u63a2\u7d22\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408\u5316\u7597\u65b9\u6848\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e00\u7ebf\u548c\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002  <\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42013403\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260421195801&#038;v=2.19.0.post6+133c1fe\">42013403<\/a>| DOI:<a href=\"https:\/\/doi.org\/10.1200\/JCO-25-02187\">10.1200\/JCO-25-02187<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\uff08J Clin Oncol\uff09\u30022026\u5e744\u670821\u65e5\uff1aJCO2502187\u3002doi: 10.1 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[640],"tags":[],"class_list":["post-213177","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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