{"id":213178,"date":"2026-06-05T21:12:47","date_gmt":"2026-06-06T01:12:47","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/2026%e5%b9%b4asco%e5%b9%b4%e4%bc%9a%ef%bc%9a%e6%9c%80%e6%96%b0%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%a0%94%e7%a9%b6%e5%af%b9%e6%82%a8%e6%84%8f%e5%91%b3%e7%9d%80%e4%bb%80%e4%b9%88\/"},"modified":"2026-06-17T19:09:11","modified_gmt":"2026-06-17T23:09:11","slug":"2026%e5%b9%b4asco%e5%b9%b4%e4%bc%9a%ef%bc%9a%e6%9c%80%e6%96%b0%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%a0%94%e7%a9%b6%e5%af%b9%e6%82%a8%e6%84%8f%e5%91%b3%e7%9d%80%e4%bb%80%e4%b9%88","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/2026%e5%b9%b4asco%e5%b9%b4%e4%bc%9a%ef%bc%9a%e6%9c%80%e6%96%b0%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%a0%94%e7%a9%b6%e5%af%b9%e6%82%a8%e6%84%8f%e5%91%b3%e7%9d%80%e4%bb%80%e4%b9%88\/","title":{"rendered":"2026\u5e74ASCO\u5e74\u4f1a\uff1a\u6700\u65b0\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48"},"content":{"rendered":"\n<p>2026\u5e74ASCO\u5e74\u4f1a\u4e3a\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u5e26\u6765\u4e86\u91cd\u8981\u8fdb\u5c55\uff1a\u9776\u5411\u6cbb\u7597\u5728\u751f\u5b58\u7387\u65b9\u9762\u53d6\u5f97\u4e86\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\u7684\u7a81\u7834\uff0c\u514d\u75ab\u6cbb\u7597\u8054\u5408\u65b9\u6848\u5f15\u53d1\u4e86\u65b0\u7684\u601d\u8003\uff0c\u672f\u540e\u8840\u6db2\u68c0\u6d4b\u53d6\u5f97\u4e86\u8fdb\u5c55\uff0c\u540c\u65f6\u8fd8\u516c\u5e03\u4e86\u5173\u4e8e\u751f\u6d3b\u65b9\u5f0f\u548c\u751f\u5b58\u671f\u7684\u65b0\u6570\u636e\u3002 \u672c\u603b\u7ed3\u6309\u4e3b\u9898\u5bf9\u6700\u91cd\u8981\u7684\u6700\u65b0\u8fdb\u5c55\u8fdb\u884c\u4e86\u68b3\u7406\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u627e\u5230\u5bf9\u60a8\u53ca\u60a8\u7684\u6cbb\u7597\u6700\u4e3a\u91cd\u8981\u7684\u7814\u7a76\u6210\u679c\u3002   <\/p>\n\n<p><strong>\u9605\u8bfb\u524d\u987b\u77e5\uff1a\u4e86\u89e3\u60a8\u7684\u80bf\u7624\u751f\u7269\u5b66\u7279\u5f81<\/strong>\uff1a\u4e0b\u6587\u63d0\u5230\u7684\u8bb8\u591a\u6cbb\u7597\u65b9\u6cd5\u4ec5\u5bf9\u7279\u5b9a\u7c7b\u578b\u7684\u80bf\u7624\u6709\u6548\u3002\u60a8\u7684MSI\/MMR\u72b6\u6001\u3001BRAF\u7a81\u53d8\u68c0\u6d4b\u7ed3\u679c\u3001RAS\u72b6\u6001\u53ca\u5176\u4ed6\u751f\u7269\u6807\u5fd7\u7269\u5c06\u51b3\u5b9a\u54ea\u4e9b\u5185\u5bb9\u9002\u7528\u4e8e\u60a8\u3002\u5982\u679c\u60a8\u5c1a\u672a\u8fdb\u884c\u5168\u9762\u7684\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u3002    <\/p>\n\n<h2 class=\"wp-block-heading\"><strong>1. BRAF V600E\uff1a\u4e00\u79cd\u5177\u6709\u91cc\u7a0b\u7891\u5f0f\u751f\u5b58\u83b7\u76ca\u7684\u9776\u5411\u8054\u5408\u6cbb\u7597\u65b9\u6848<\/strong> <\/h2>\n\n<p><em>\u9002\u7528\u4eba\u7fa4\uff1aBRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08\u7ea6\u5360\u6240\u6709\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u76848%\u81f310%\uff09\u3002<\/em> <\/p>\n\n<p>\u7ea68%\u81f310%\u7684\u7ed3\u76f4\u80a0\u764c\u643a\u5e26BRAF V600E\u7a81\u53d8\u3002\u8be5\u7a81\u53d8\u901a\u5e38\u4e0e\u66f4\u5177\u4fb5\u88ad\u6027\u7684\u75be\u75c5\u76f8\u5173\uff0c\u4f46\u540c\u65f6\u4e5f\u4e3a\u6cbb\u7597\u63d0\u4f9b\u4e86\u7279\u5b9a\u7684\u9776\u70b9\u3002   <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>BREAKWATER \u8bd5\u9a8c<\/strong><em> \uff1aElez \u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2025 \u5e74\uff1bKopetz \u7b49\uff0c\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b2025 \u5e74\uff1bASCO 2026 \u4f1a\u8bae\u6458\u8981 LBA3503<\/em>NCT04607421  <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u7814\u7a76\u7ed3\u679c\uff1a <\/strong>\u5728\u6807\u51c6\u5316\u7597\u65b9\u6848\u4e2d<strong>\u8054\u5408\u4f7f\u7528 <\/strong>\u6069\u79d1\u62c9\u975e\u5c3c\uff08BRAF\u6291\u5236\u5242\uff09\u548c\u897f\u59a5\u6614\u5355\u6297\uff08EGFR\u6291\u5236\u5242\uff09\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5927\u81f4\u7ffb\u4e86\u4e00\u756a\uff1a30.3\u4e2a\u6708 vs. 15.1\u4e2a\u6708\uff08HR 0.49\uff1bp&lt;0.001\uff09\u3002 \u5ba2\u89c2\u7f13\u89e3\u7387\u5206\u522b\u4e3a61%\u548c40%\u3002\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u8be5\u8054\u5408\u65b9\u6848\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\uff1bmFOLFOX6\u7814\u7a76\u7684\u6570\u636e\u63a8\u52a8\u4e86\u8fd9\u4e00\u5173\u952e\u7684\u751f\u5b58\u671f\u7ed3\u679c\u3002 \u57282026\u5e74ASCO\u5e74\u4f1a\u4e0a\uff0c\u7814\u7a76\u8005\u516c\u5e03\u4e86\u66f4\u591a\u6570\u636e\uff0c\u652f\u6301\u91c7\u7528FOLFIRI\u5316\u7597\u4e3a\u57fa\u7840\u65b9\u6848\u8054\u5408\u6069\u79d1\u62c9\u975e\u5c3c\u548c\u897f\u59a5\u6614\u5355\u6297\uff0c\u8fd9\u8fdb\u4e00\u6b65\u6269\u5c55\u4e86\u8be5\u6cbb\u7597\u65b9\u6848\u5728\u5e38\u7528\u4e00\u7ebf\u65b9\u6848\u4e2d\u7684\u8bc1\u636e\u57fa\u7840\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a <\/strong>\u82e5\u60a8\u7684\u80bf\u7624\u5b58\u5728BRAF V600E\u7a81\u53d8\u4e14\u5c1a\u672a\u63a5\u53d7\u8fc7\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u8be5\u8054\u5408\u65b9\u6848\u73b0\u5df2\u6210\u4e3a\u6807\u51c6\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u7597\u56e2\u961f\uff0c\u4e86\u89e3FOLFOX\u6216FOLFIRI\u54ea\u4e00\u79cd\u66f4\u9002\u5408\u60a8\u4f5c\u4e3a\u5316\u7597\u57fa\u7840\u65b9\u6848\u30022026\u5e74ASCO\u5927\u4f1a\u7684\u65b0\u6570\u636e\u5747\u652f\u6301\u8fd9\u4e24\u79cd\u65b9\u6848\u3002       <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff1a<\/strong> <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u6211\u7684\u80bf\u7624\u662f\u5426\u643a\u5e26BRAF V600E\u7a81\u53d8\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\uff0c\u6211\u662f\u5426\u7b26\u5408\u4f7f\u7528BREAKWATER\u8054\u5408\u7597\u6cd5\u7684\u6761\u4ef6\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u50cfFOLFOX\u6216FOLFIRI\u8fd9\u6837\u7684\u5316\u7597\u57fa\u7840\u65b9\u6848\u4e2d\uff0c\u54ea\u4e00\u79cd\u66f4\u9002\u5408\u6211\u7684\u5065\u5eb7\u53f2\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>2. MSI-H \u548c dMMR\uff1a\u514d\u75ab\u6cbb\u7597\u4e0e\u5316\u7597\u8054\u5408\u5e94\u7528\u7684\u65b0\u8bc1\u636e<\/strong> <\/h2>\n\n<p><em>\u9002\u7528\u4eba\u7fa4\uff1aMSI-H\uff08\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff09\u6216dMMR\uff08\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08\u7ea6\u5360\u8f6c\u79fb\u6027\u75c5\u4f8b\u76844-5%\uff09\u3002<\/em> <\/p>\n\n<p>\u6d3e\u59c6\u5355\u6297\u5355\u836f\u6cbb\u7597\uff08KEYNOTE-177\uff0cAndr\u00e9 \u7b49\uff0cNEJM 2020\uff09\u662f\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u76ee\u524d\u6279\u51c6\u7528\u4e8eMSI-H\/dMMR\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002 \u8be5\u65b9\u6848\u57fa\u4e8e\u65e9\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u8868\u660e\u9519\u914d\u4fee\u590d\u7f3a\u9677\u80bf\u7624\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u5177\u6709\u72ec\u7279\u7684\u654f\u611f\u6027\uff08Le \u7b49\uff0cNEJM 2015\uff09\u3002 2026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\u63a2\u8ba8\u4e86\u5728\u514d\u75ab\u6cbb\u7597\u4e2d\u8054\u5408\u5316\u7597\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u662f\u5426\u80fd\u8fdb\u4e00\u6b65\u6539\u5584\u9884\u540e\uff0c\u4ee5\u53ca\u8fd9\u79cd\u83b7\u76ca\u662f\u5426\u503c\u5f97\u627f\u53d7\u989d\u5916\u7684\u526f\u4f5c\u7528\u3002    <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>COMMIT \u8bd5\u9a8c<\/strong><em> \uff0cRocha Lima\u3001Overman \u7b49\uff0cASCO 2026 \u6458\u8981 14\uff0c<\/em>NCT02997228\uff0cNRG-GI004\/SWOG-S1610  <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u7ed3\u679c\uff1a\u5728 <\/strong>82\u540d\u60a3\u8005<strong>\u4e2d <\/strong>\uff0cmFOLFOX6\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u548c\u963f\u7279\u73e0\u5355\u6297\u7684\u6cbb\u7597\u65b9\u6848\u5c06\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5ef6\u957f\u81f330.0\u4e2a\u6708\uff0c\u800c\u4ec5\u4f7f\u7528\u963f\u7279\u73e0\u5355\u6297\u7684\u60a3\u8005\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a4.3\u4e2a\u6708\uff08HR 0.439\uff1bp=0.0103\uff09\u3002 \u5ba2\u89c2\u7f13\u89e3\u7387\u5206\u522b\u4e3a80.6%\u548c46%\u3002\u7136\u800c\uff0c\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u663e\u8457\u66f4\u9ad8\uff083\u7ea7\u53ca\u4ee5\u4e0a\u4e0d\u826f\u4e8b\u4ef6\u5206\u522b\u4e3a34\u4f8b\u548c18\u4f8b\uff09\uff0c\u5176\u4e2d\u5305\u62ec5\u4f8b\u4e0e\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\uff0c\u800c\u5355\u836f\u7ec4\u4e3a1\u4f8b\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a\u8fd9 <\/strong>\u5e76\u975e\u9002\u7528\u4e8e\u6240\u6709\u60a3\u8005\u7684\u65b0\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002 COMMIT\u8bd5\u9a8c\u4f7f\u7528\u7684\u662f\u963f\u7279\u73e0\u5355\u6297\uff0c\u8fd9\u662f\u4e00\u79cd\u4e0eFDA\u6279\u51c6\u7684\u6d3e\u59c6\u5355\u6297\u4e0d\u540c\u7684\u514d\u75ab\u6cbb\u7597\u836f\u7269\u3002\u8be5\u8bd5\u9a8c\u89c4\u6a21\u8f83\u5c0f\uff08102\u540d\u60a3\u8005\uff09\uff0c\u4e14\u63d0\u524d\u7ec8\u6b62\u3002 \u8fd9\u4e9b\u6570\u636e\u5f88\u91cd\u8981\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u75be\u75c5\u8d1f\u62c5\u8f83\u91cd\u6216\u751f\u7269\u5b66\u7279\u5f81\u4fb5\u88ad\u6027\u8f83\u9ad8\u7684\u60a3\u8005\uff0c\u4f46\u76ee\u524d\u89c2\u5bdf\u5230\u7684\u6bd2\u6027\u4fe1\u53f7\u4ee5\u53ca\u603b\u4f53\u751f\u5b58\u83b7\u76ca\u7684\u7f3a\u5931\u610f\u5473\u7740\uff0c\u60a8\u5e94\u4e0e\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u4ed4\u7ec6\u8ba8\u8bba\u6b64\u4e8b\u3002       <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff1a<\/strong> <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u6211\u7684\u80bf\u7624\u662f\u5426\u5df2\u88ab\u786e\u8bca\u4e3aMSI-H\u6216dMMR\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u6839\u636e\u6211\u7684\u75be\u75c5\u8d1f\u62c5\uff0c\u5bf9\u6211\u6765\u8bf4\uff0c\u91c7\u7528\u66f4\u5f3a\u5316\u7684\u8054\u5408\u6cbb\u7597\u65b9\u6848\u662f\u5426\u53ef\u884c\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u5982\u4f55\u6743\u8861COMMIT\u7814\u7a76\u4e2d\u663e\u793a\u7684\u7597\u6548\u8fdb\u5c55\u4e0e\u5b89\u5168\u6027\u6570\u636e\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>3. MSS\u7ed3\u76f4\u80a0\u764c\uff1a\u60e0\u53ca\u5927\u591a\u6570\u60a3\u8005\u7684\u8fdb\u5c55<\/strong> <\/h2>\n\n<p><em>\u9002\u7528\u4eba\u7fa4\uff1a\u7ea685%\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5176\u80bf\u7624\u5448\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS \u6216 pMMR\uff09\uff0c\u4e14\u901a\u5e38\u5bf9\u6807\u51c6\u514d\u75ab\u6cbb\u7597\u65e0\u53cd\u5e94\u3002<\/em> <\/p>\n\n<p>\u5bf9\u4e8e\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\uff0c\u4ec5\u91c7\u7528\u6807\u51c6\u514d\u75ab\u6cbb\u7597\u901a\u5e38\u6548\u679c\u4e0d\u4f73\u3002\u9488\u5bf9\u8be5\u4e9a\u578b\u7684\u7814\u7a76\u4fa7\u91cd\u4e8e\u8054\u5408\u6cbb\u7597\uff0c\u901a\u8fc7\u8054\u5408\u9776\u5411\u6cbb\u7597\u3001\u653e\u7597\u6216\u5316\u7597\uff0c\u521b\u9020\u66f4\u6709\u5229\u4e8e\u514d\u75ab\u5e94\u7b54\u53d1\u751f\u7684\u6761\u4ef6\u3002\u57282026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0c\u6709\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u52a8\u4e86\u8fd9\u4e00\u6cbb\u7597\u7b56\u7565\u7684\u53d1\u5c55\u3002    <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>SWOG S2107<\/strong><em> \u6458\u8981 3504\uff0c\u8303\u00b7K\u00b7\u83ab\u91cc\u65af\u4e8c\u4e16<\/em> <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u53d1\u73b0\uff1a\u4e00\u9879 <\/strong>\u968f\u673a\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u9a8c\u8bc1\u5728\u6069\u79d1\u62c9\u975e\u5c3c+\u897f\u59a5\u6614\u5355\u6297\uff08BRAF\u9776\u5411\u6cbb\u7597\uff09\u65b9\u6848\u4e2d\u8054\u5408\u5c3c\u6c83\u5362\u5355\u6297\uff08\u514d\u75ab\u6cbb\u7597\uff09\u662f\u5426\u80fd\u6539\u5584\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684MSS\u578bBRAF V600E\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u9884\u540e\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a\u5927\u591a\u6570 <\/strong>BRAF V600E\u80bf\u7624\u5c5e\u4e8eMSS\u578b\u3002SWOG S2107\u7814\u7a76\u65e8\u5728\u9a8c\u8bc1\u4ee5\u4e0b\u5047\u8bbe\uff1aBRAF\u9776\u5411\u6cbb\u7597\u53ef\u589e\u5f3a\u80bf\u7624\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u6027\u2014\u2014\u8fd9\u662f\u6b64\u524d\u5728MSS\u578b\u7ed3\u76f4\u80a0\u764c\u4e2d\u5c1a\u672a\u80fd\u53ef\u9760\u5b9e\u73b0\u7684\u3002 2026\u5e74ASCO\u4f1a\u8bae\u7684\u521d\u6b65\u7ed3\u679c\u5e76\u672a\u663e\u793a\u6dfb\u52a0\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u80fd\u5e26\u6765\u660e\u663e\u7684\u4e34\u5e8a\u83b7\u76ca\u3002\u5c3d\u7ba1\u8be5\u7814\u7a76\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u751f\u7269\u5b66\u89c1\u89e3\uff0c\u4f46\u76ee\u524d\u5c1a\u4e0d\u652f\u6301\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\u5e38\u89c4\u5c06\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u6069\u79d1\u62c9\u975e\u5c3c\u548c\u897f\u59a5\u6614\u5355\u6297\u8fdb\u884c\u6cbb\u7597\u3002     <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>mRCAT-III<\/strong><em> \u6458\u8981 LBA3515<\/em> <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u7814\u7a76\u7ed3\u679c\uff1a <\/strong>\u9488\u5bf9MSS\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c<strong>\uff0c\u6bd4\u8f83 <\/strong>\u6539\u826f\u77ed\u7a0b\u653e\u7597\u8054\u5408CAPOX\u5316\u7597\u53caPD-1\u6291\u5236\u5242\u8482\u65af\u5229\u73e0\u5355\u6297\u4e0e\u6807\u51c6\u77ed\u7a0b\u653e\u7597\u8054\u5408CAPOX<strong>\u7684\u7597\u6548 <\/strong>\u3002\u4e3b\u8981\u7ec8\u70b9\uff1a\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08\u624b\u672f\u65f6\u65e0\u6b8b\u7559\u764c\u7076\uff09\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a\u8be5 <\/strong>\u8bd5\u9a8c\u65e8\u5728\u9a8c\u8bc1\u9776\u5411\u653e\u7597\u80fd\u5426\u5728MSS\u76f4\u80a0\u80bf\u7624\u4e2d\u8bf1\u5bfc\u514d\u75ab\u5e94\u7b54\uff0c\u4ece\u800c\u4e3a\u4ec5\u9760\u514d\u75ab\u6cbb\u7597\u65e0\u6cd5\u83b7\u76ca\u7684\u60a3\u8005\u7fa4\u4f53\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u3002   <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff1a<\/strong> <\/p>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u6211\u7684\u80bf\u7624\u662f\u5426\u5df2\u7ecf\u8fdb\u884c\u4e86\u5168\u9762\u68c0\u6d4b\uff0c\u5305\u62ecBRAF\u3001RAS\u3001KRAS G12C\u3001HER2\u548cNTRK\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u76ee\u524d\u662f\u5426\u6709\u9488\u5bf9MSS\u578b\u7ed3\u76f4\u80a0\u764c\u3001\u4e14\u7b26\u5408\u6211\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u53f2\u7684\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>4. ctDNA\u68c0\u6d4b\uff1a\u4e00\u9879\u53ef\u4e3a\u672f\u540e\u51b3\u7b56\u63d0\u4f9b\u6307\u5bfc\u7684\u8840\u6db2\u68c0\u6d4b<\/strong> <\/h2>\n\n<p><em>\u9002\u7528\u4eba\u7fa4\uff1a\u4e3b\u8981\u9488\u5bf9\u5df2\u63a5\u53d7\u624b\u672f\u6cbb\u7597\u3001\u76ee\u524d\u6b63\u5728\u8003\u8651\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u7684II\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u3002<\/em> <\/p>\n\n<p>\u672f\u540e\uff0c\u4e00\u4e2a\u5173\u952e\u95ee\u9898\u662f\u4f53\u5185\u662f\u5426\u8fd8\u6b8b\u7559\u6709\u764c\u7ec6\u80de\u3002\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u68c0\u6d4b\u65e8\u5728\u68c0\u6d4b\u8840\u6db2\u4e2d\u7684\u764c\u7ec6\u80deDNA\u7247\u6bb5\u3002\u672f\u540e\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u8868\u660e\u590d\u53d1\u98ce\u9669\u8f83\u9ad8\uff1b\u7ed3\u679c\u5448\u9634\u6027\u5219\u8868\u660e\u98ce\u9669\u8f83\u4f4e\uff0c\u4f46\u8fd9\u5e76\u4e0d\u80fd\u4fdd\u8bc1\u764c\u75c7\u4e0d\u4f1a\u590d\u53d1\u3002     <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>CIRCULATE \u8bd5\u9a8c<\/strong><em> Folprecht\uff0cASCO 2026 \u6458\u8981 LBA3500<\/em>NCT04089631  <\/td><\/tr><tr><td><strong>\u5173\u952e\u53d1\u73b0\uff1a\u4e00\u9879 <\/strong>\u6b27\u6d32III\u671f\u968f\u673a\u8bd5\u9a8c\uff0c\u6839\u636ectDNA\u68c0\u6d4b\u7ed3\u679c\uff0c\u5c06\u672f\u540eII\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3\u5316\u7597\u7ec4\u6216\u89c2\u5bdf\u7ec4\u3002\u8fd9\u6b63\u662f\u5c06ctDNA\u4ece\u6709\u524d\u666f\u7684\u6307\u6807\u8f6c\u53d8\u4e3a\u4e34\u5e8a\u6807\u51c6\u6240\u5fc5\u9700\u7684\u524d\u77bb\u6027\u8bc1\u636e\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a\u5982\u679c <\/strong>\u8bc1\u5b9e\u57fa\u4e8ectDNA\u7684\u51b3\u7b56\u80fd\u6539\u5584\u6cbb\u7597\u7ed3\u679c\uff0c\u8fd9\u4e00\u53d1\u73b0\u53ef\u80fd\u4f1a\u6539\u53d8II\u671f\u7ed3\u80a0\u764c\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u8fd9\u6709\u52a9\u4e8e\u63a8\u52a8\u8be5\u9886\u57df\u5229\u7528ctDNA\u6765\u8bc6\u522b\u54ea\u4e9b\u60a3\u8005\u5728\u672f\u540e\u6700\u6709\u53ef\u80fd\u9700\u8981\u5316\u7597\uff0c\u54ea\u4e9b\u60a3\u8005\u53ef\u4ee5\u5b89\u5168\u5730\u8fdb\u884c\u89c2\u5bdf\u3002    <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u652f\u6301\u6027\u8bc1\u636e\uff1a <\/strong>DYNAMIC<strong>\u8bd5\u9a8c <\/strong>\uff08Tie\u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2022\u5e74\uff09\u663e\u793a\uff0c\u5728II\u671f\u60a3\u8005\u4e2d\uff0c\u91c7\u7528ctDNA\u6307\u5bfc\u53ef\u5c06\u5316\u7597\u4f7f\u7528\u7387\u4ece28%\u964d\u81f315%\uff0c\u4e14\u4e0d\u5f71\u54cd\u65e0\u590d\u53d1\u751f\u5b58\u671f\u3002 GALAXY\u7814\u7a76\uff08Nakamura\u7b49\uff0c\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b2024\uff09\u53d1\u73b0\uff0c\u672f\u540ectDNA\u9633\u6027\u4e0e\u65e0\u75c5\u751f\u5b58\u671f\uff08HR 11.99\uff09\u548c\u603b\u751f\u5b58\u671f\uff08HR 9.68\uff09\u7684\u663e\u8457\u6076\u5316\u76f8\u5173\u3002   <\/p>\n\n<h4 class=\"wp-block-heading\"><strong>\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff1a<\/strong> <\/h4>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u8003\u8651\u5230\u6211\u7684\u75c5\u671f\u548c\u624b\u672f\u7ed3\u679c\uff0c\u6211\u9002\u5408\u8fdb\u884cctDNA\u68c0\u6d4b\u5417\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201cctDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u6216\u9634\u6027\uff0c\u5bf9\u6211\u7684\u6cbb\u7597\u65b9\u6848\u610f\u5473\u7740\u4ec0\u4e48\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>5. GLP-1\u7c7b\u836f\u7269\uff1a\u7ed3\u76f4\u80a0\u764c\u9886\u57df\u7684\u4e00\u4e2a\u65b0\u4fe1\u53f7<\/strong> <\/h2>\n\n<p><em>\u9002\u7528\u4eba\u7fa4\uff1a\u5df2\u4f7f\u7528\u6216\u53ef\u80fd\u7b26\u5408\u4f7f\u7528GLP-1\u7c7b\u836f\u7269\u6cbb\u7597\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u75c7\u6216\u5fc3\u8840\u7ba1\u98ce\u9669\u6761\u4ef6\u7684\u60a3\u8005\u3002\u672c\u4ea7\u54c1\u5e76\u975e\u764c\u75c7\u6cbb\u7597\u836f\u7269\u3002 <\/em> <\/p>\n\n<p>GLP-1\u7c7b\u836f\u7269\u6700\u521d\u5e76\u975e\u4f5c\u4e3a\u6297\u764c\u836f\u7269\u7814\u53d1\u7684\uff0c\u4f46\u4eca\u5e74\u5728\u764c\u75c7\u7814\u7a76\u9886\u57df\u5f15\u8d77\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002 \u5728ASCO GI\u4f1a\u8bae\u548cASCO 2026\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u65b0\u7814\u7a76\u6210\u679c\uff0c\u5f15\u53d1\u4e86\u5173\u4e8e\u8fd9\u4e9b\u836f\u7269\u662f\u5426\u4f1a\u5f71\u54cd\u7ed3\u76f4\u80a0\u764c\u98ce\u9669\u3001\u75be\u75c5\u8fdb\u5c55\u6216\u751f\u5b58\u9884\u540e\u7b49\u5173\u952e\u95ee\u9898\u7684\u63a2\u8ba8\u3002\u5c3d\u7ba1\u76f8\u5173\u8bc1\u636e\u5c1a\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u548c\u4e34\u5e8a\u533b\u751f\u5bf9\u6b64\u8868\u73b0\u51fa\u7684\u6d53\u539a\u5174\u8da3\uff0c\u4f7f\u5f97\u8fd9\u4e00\u9886\u57df\u503c\u5f97\u6301\u7eed\u5173\u6ce8\u3002    <\/p>\n\n<p>\u4e09\u4e2a\u72ec\u7acb\u7684\u7814\u7a76\u56e2\u961f\u63a2\u8ba8\u4e86\u585e\u739b\u683c\u9c81\u80bd\u3001\u5229\u62c9\u9c81\u80bd\u6216\u5ea6\u62c9\u9c81\u80bd\u7b49GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u662f\u5426\u53ef\u80fd\u5f71\u54cd\u7ed3\u76f4\u80a0\u764c\u7684\u98ce\u9669\u6216\u9884\u540e\u3002\u8fd9\u4e9b\u7814\u7a76\u5747\u672a\u8bc1\u660e\u8fd9\u4e9b\u836f\u7269\u5bf9\u764c\u75c7\u6cbb\u7597\u6709\u6548\u3002\u4f46\u7efc\u5408\u6765\u770b\uff0c\u8fd9\u4e9b\u53d1\u73b0\u8db3\u591f\u5f15\u4eba\u5173\u6ce8\uff0c\u503c\u5f97\u8fdb\u4e00\u6b65\u7814\u7a76\uff0c\u4e0d\u8fc7\u4ec5\u51ed\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5c1a\u4e0d\u8db3\u4ee5\u6539\u53d8\u764c\u75c7\u7684\u8bca\u7597\u65b9\u6848\u3002    <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u743c\u65af\u7b49\u4eba<\/strong><em>  ASCO GI 2026 \u6458\u8981 18<\/em> <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u53d1\u73b0\uff1a <\/strong>\u4e0e\u963f\u53f8\u5339\u6797\u4f7f\u7528\u8005\u76f8\u6bd4<strong>\uff0cGLP-1\u4f7f\u7528\u8005\u7684 <\/strong>\u7ed3\u76f4\u80a0\u764c\u53d1\u75c5\u7387\u7ea6\u4f4e\u4e09\u5206\u4e4b\u4e00\uff0c\u4e14\u4e25\u91cd\u51fa\u8840\u526f\u4f5c\u7528\u8f83\u5c11\u3002\u8fd9\u4e00\u76ca\u5904\u5728\u4e0d\u540c\u5e74\u9f84\u3001\u4f53\u91cd\u53ca\u57fa\u7840\u75be\u75c5\u4eba\u7fa4\u4e2d\u5747\u8868\u73b0\u4e00\u81f4\u3002<strong>\u8fd9\u5bf9\u60a8\u610f\u5473\u7740\u4ec0\u4e48\uff1a\u5982\u679c\u60a8 <\/strong>\u5c5e\u4e8e\u7ed3\u76f4\u80a0\u764c\u9ad8\u5371\u4eba\u7fa4\uff0c\u4e14\u5b58\u5728\u7b26\u5408\u6761\u4ef6\u7684\u533b\u5b66\u6307\u5f81\uff0c\u8bf7\u4e0e\u60a8\u7684\u533b\u7597\u56e2\u961f\u5546\u8ba8GLP-1\u6cbb\u7597\u65b9\u6848\u3002   <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>Arya\u7b49\u4eba<\/strong><em>  ASCO GI 2026 \u6458\u8981 83<\/em> <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u53d1\u73b0\uff1a\u5728 <\/strong>\u5df2\u786e\u8bca\u7ed3\u80a0\u764c\u4e14\u4f34\u6709\u80a5\u80d6\u7684\u60a3\u8005<strong>\u4e2d <\/strong>\uff0c\u4f7f\u7528GLP-1\u4e0e\u6b7b\u4ea1\u7387\u964d\u4f4e\u53ca\u4e25\u91cd\u533b\u7597\u4e8b\u4ef6\u51cf\u5c11\u76f8\u5173\u3002<strong>\u8fd9\u5bf9\u60a8\u7684\u610f\u4e49\uff1a <\/strong>\u5982\u679c\u60a8\u60a3\u6709\u6d3b\u52a8\u6027\u7ed3\u76f4\u80a0\u764c\u4e14\u4f34\u6709\u80a5\u80d6\uff0c<strong>\u8fd9\u4e00\u53d1\u73b0\u5bf9\u60a8\u5177\u6709\u53c2\u8003\u4ef7\u503c\u3002 <\/strong>\u5efa\u8bae\u60a8\u5728\u5236\u5b9a\u6574\u4f53\u5065\u5eb7\u8ba1\u5212\u65f6\uff0c\u5c31\u6b64\u4e0e\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u8fdb\u884c\u6c9f\u901a\u3002   <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u5965\u5170\u5fb7\u7b49\u4eba<\/strong><em>  ASCO 2026 \u6458\u8981 3143\uff0c\u514b\u5229\u592b\u5170\u8bca\u6240<\/em> <\/td><\/tr><tr><td><strong>\u4e3b\u8981\u53d1\u73b0\uff1a <\/strong>\u5728I-III\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0c<strong>\u4f7f\u7528GLP-1\u53ef <\/strong>\u663e\u8457\u964d\u4f4e\u8fdb\u5c55\u81f3IV\u671f\u7684\u53d1\u751f\u7387\uff1a13.4% \u5bf9\u6bd4 22.2%\uff08HR 0.69\uff1b95% CI 0.54-0.88\uff1bp=0.003\uff09\u3002GLP-1\u53d7\u4f53\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\u7684\u80bf\u7624\uff0c\u5176\u603b\u751f\u5b58\u671f\u4e5f\u66f4\u957f\u3002<strong>\u8fd9\u5bf9\u60a8\u7684\u610f\u4e49\uff1a <\/strong>\u60a3\u6709\u4ee3\u8c22\u6027\u75be\u75c5\u7684<strong>\u65e9\u671f <\/strong>\u60a3\u8005\u4e0d\u59a8\u5c31\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u4e0e\u533b\u751f\u8fdb\u884c\u8ba8\u8bba\u3002\u6839\u636e\u73b0\u6709\u8bc1\u636e\uff0c\u4e0d\u5e94\u4ec5\u56e0\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u8003\u8651\u800c\u5f00\u59cb\u4f7f\u7528GLP-1\u7c7b\u836f\u7269\u3002\u4ecd\u9700\u5f00\u5c55\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002     <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u91cd\u8981\u63d0\u793a\uff1a\u8fd9\u4e9b\u662f <\/strong>\u663e\u793a\u5173\u8054\u6027\u7684\u89c2\u5bdf\u6027\u7814\u7a76\uff0c\u5e76\u975e\u5bf9\u7597\u6548\u7684\u8bc1\u660e\u30022025\u5e74\u7684\u4e00\u9879\u835f\u8403\u5206\u6790\uff08Zhong\u7b49\uff0cBMC Gastroenterology 2025\uff09\u53d1\u73b0\uff0c\u6839\u636e\u5bf9\u7167\u7ec4\u7684\u4e0d\u540c\uff0c\u7814\u7a76\u7ed3\u679c\u5b58\u5728\u5dee\u5f02\u3002\u8bf7\u52ff\u4ec5\u56e0\u62c5\u5fc3\u764c\u75c7\u800c\u5f00\u59cb\u670d\u7528\u8fd9\u4e9b\u836f\u7269\u3002    <\/p>\n\n<h4 class=\"wp-block-heading\"><strong>\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff1a<\/strong> <\/h4>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u6211\u662f\u5426\u6709\u533b\u5b66\u4e0a\u7684\u7406\u7531\uff08\u4f8b\u5982\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u6216\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669\uff09\u9700\u8981\u8003\u8651\u4f7f\u7528GLP-1\u7c7b\u836f\u7269\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<ul class=\"wp-block-list\">\n<li><em>\u201c\u5982\u679c\u6211\u5df2\u7ecf\u5728\u670d\u7528\u67d0\u79cd\u836f\u7269\uff0c\u5b83\u4f1a\u4e0e\u6211\u7684\u764c\u75c7\u6cbb\u7597\u4ea7\u751f\u4ec0\u4e48\u76f8\u4e92\u4f5c\u7528\uff1f\u201d<\/em> <\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\"><strong>\u503c\u5f97\u4e86\u89e3\u7684\u5176\u4ed6\u7814\u7a76<\/strong> <\/h2>\n\n<p>\u8fd9\u4e9b\u7814\u7a76\u5bf9\u7279\u5b9a\u60a3\u8005\u7fa4\u4f53\u53ef\u80fd\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5176\u4e2d\u4e00\u4e9b\u7814\u7a76\u7ed3\u679c\u5df2\u8f83\u4e3a\u6210\u719f\uff0c\u800c\u53e6\u4e00\u4e9b\u5219\u5c1a\u5904\u4e8e\u521d\u671f\u9636\u6bb5\u6216\u4ecd\u5728\u8fdb\u884c\u4e2d\uff0c\u56e0\u6b64\u6b63\u786e\u7684\u505a\u6cd5\u662f\u601d\u8003\u8fd9\u4e9b\u95ee\u9898\u662f\u5426\u4e0e\u60a8\u7684\u8bca\u65ad\u3001\u751f\u7269\u6807\u5fd7\u7269\u53ca\u6cbb\u7597\u53f2\u76f8\u5173\u3002   <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u5b66\u4e60<\/strong> <\/td><td><strong>\u6458\u8981<\/strong> <\/td><td><strong>\u6d4b\u8bd5\u5185\u5bb9<\/strong> <\/td><\/tr><tr><td><strong>CodeBreaK 300<\/strong> <\/td><td><em>\u6458\u8981 3511<\/em> <\/td><td>KRAS G12C \u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\uff1actDNA \u6e05\u9664\u80fd\u5426\u9884\u6d4b\u65e9\u671f\u6cbb\u7597\u53cd\u5e94\uff1f  <\/td><\/tr><tr><td><strong>\u7b2c\u4e09\u96c6<\/strong> <\/td><td><em>\u6458\u8981 LBA3508<\/em> <\/td><td>III\u671f\u7ed3\u80a0\u764c\uff1a\u672f\u540e\u670d\u7528\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u80fd\u5426\u9884\u9632\u590d\u53d1\uff1f  <\/td><\/tr><tr><td><strong>PUMP\u8bd5\u9a8c<\/strong> <\/td><td><em>\u6458\u8981 LBA3506<\/em> <\/td><td>\u5df2\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\uff1a\u809d\u624b\u672f\u540e\u5728\u6807\u51c6\u6cbb\u7597\u57fa\u7840\u4e0a\u8054\u5408\u5e94\u7528\u809d\u52a8\u8109\u704c\u6ce8\u6cf5\uff08HAIP\uff09\u6cbb\u7597  <\/td><\/tr><tr><td><strong>CR-SEQUENCE<\/strong> <\/td><td><em>\u6458\u8981 3512<\/em> <\/td><td>\u5de6\u4fa7RAS\u91ce\u751f\u578b\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\uff1a\u4ee5\u6297EGFR\u6cbb\u7597\u4e3a\u9996\u9009\u4e0e\u4ee5\u6297VEGF\u6cbb\u7597\u4e3a\u9996\u9009\uff0c\u662f\u5426\u4f1a\u5f71\u54cd\u603b\u4f53\u6cbb\u7597\u83b7\u76ca\uff1f  <\/td><\/tr><tr><td><strong>CRDF-004<\/strong> <\/td><td><em>\u6458\u8981 3510<\/em> <\/td><td>KRAS\/NRAS\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1a\u4e00\u7ebf\u6cbb\u7597\u4e2donvansertib\u8054\u5408\u5316\u7597\u4e0e\u5355\u7528\u5316\u7597\u7684\u6bd4\u8f83  <\/td><\/tr><tr><td><strong>\u56fe\u62c9\u7f8e\u66ff\u5c3c + \u7ef4\u83ab\u62c9\u975e\u5c3c<\/strong> <\/td><td><em>\u6458\u8981 LBA3509<\/em> <\/td><td>\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\uff1a\u4e0d\u540c\u9776\u5411\u8054\u5408\u7597\u6cd5\u4e0e\u5316\u7597\u7684\u6bd4\u8f83  <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\"><strong>\u7ed3\u8bba<\/strong> <\/h2>\n\n<p>2026\u5e74ASCO\u5e74\u4f1a\u5e76\u975e\u4ec5\u7531\u67d0\u4e00\u6761\u5934\u6761\u65b0\u95fb\u6240\u5b9a\u4e49\uff0c\u800c\u662f\u51f8\u663e\u4e86\u5728\u7ed3\u76f4\u80a0\u764c\u8bca\u7597\u5168\u8fc7\u7a0b\u4e2d\u53d6\u5f97\u7684\u5b9e\u8d28\u6027\u8fdb\u5c55\u3002   <\/p>\n\n<p>\u7814\u7a76\u4eba\u5458\u62a5\u544a\u4e86\u9488\u5bf9BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u65b0\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c \u5173\u4e8e\u5982\u4f55\u9488\u5bf9\u7279\u5b9aMSI-H\/dMMR\u80bf\u7624\u4f18\u5316\u5f3a\u5316\u6cbb\u7597\u65b9\u6848\u7684\u65b0\u95ee\u9898\uff1b\u6301\u7eed\u52aa\u529b\u62d3\u5c55\u9488\u5bf9MSS\u75be\u75c5\u7684\u514d\u75ab\u6cbb\u7597\u7b56\u7565\uff1b\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u652f\u6301\u672f\u540e\u57fa\u4e8ectDNA\u7684\u6cbb\u7597\u51b3\u7b56\uff1b\u4ee5\u53ca\u65b0\u5174\u7814\u7a76\u6b63\u5728\u63a2\u7d22\u4ee3\u8c22\u5065\u5eb7\u3001\u751f\u5b58\u671f\u4e0e\u7ed3\u76f4\u80a0\u764c\u9884\u540e\u4e4b\u95f4\u7684\u5173\u8054\u3002  <\/p>\n\n<p>\u8fd9\u4e9b\u7ed3\u679c\u4e0d\u80fd\u66ff\u4ee3\u60a8\u4e0e\u80bf\u7624\u79d1\u533b\u751f\u4e4b\u95f4\u7684\u6c9f\u901a\u3002\u4f46\u5b83\u4eec\u53ef\u4ee5\u5e2e\u52a9\u60a8\u63d0\u51fa\u66f4\u6709\u9488\u5bf9\u6027\u7684\u95ee\u9898\u3002   <\/p>\n\n<p>\u4e86\u89e3\u60a8\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u54a8\u8be2\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76f8\u5173\u4fe1\u606f\u3002\u5173\u6ce8\u751f\u6d3b\u8d28\u91cf\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u80bf\u7624\u53cd\u5e94\u3002\u8bf7\u8bb0\u4f4f\uff1a\u60a8\u4e0d\u5fc5\u72ec\u81ea\u9762\u5bf9\u8fd9\u4e00\u5207\u3002\u201cFight CRC\u201d\u7ec4\u7ec7\u968f\u65f6\u51c6\u5907\u4e3a\u60a8\u63d0\u4f9b\u5e2e\u52a9\uff0c\u52a9\u60a8\u4e86\u89e3\u53ef\u9009\u65b9\u6848\u3001\u63d0\u51fa\u6709\u9488\u5bf9\u6027\u7684\u95ee\u9898\uff0c\u5e76\u4e89\u53d6\u60a8\u5e94\u5f97\u7684\u6cbb\u7597\u3002      <\/p>\n\n<p><a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e6%82%a3%e8%80%85%e5%92%8c%e6%8a%a4%e7%90%86%e4%ba%ba%e5%91%98\/%e6%95%99%e8%82%b2%e4%b8%8e%e8%b5%84%e6%ba%90\/%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u8ba2\u9605\u300a\u4e34\u5e8a\u8bd5\u9a8c\u901a\u8baf\u300b<\/a><\/p>\n\n<p><strong>Fight CRC Resources<\/strong> <\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u8d44\u6e90<\/strong> <\/td><td><strong>\u4e3a\u4f55\u80fd\u4ea7\u751f\u5171\u9e23<\/strong> <\/td><\/tr><tr><td><a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e6%82%a3%e8%80%85%e5%92%8c%e6%8a%a4%e7%90%86%e4%ba%ba%e5%91%98\/%e6%95%99%e8%82%b2%e4%b8%8e%e8%b5%84%e6%ba%90\/%e8%af%8a%e6%96%ad%e6%b5%8b%e8%af%95%e4%b8%8e%e6%89%ab%e6%8f%8f\/%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b<\/strong><\/a><strong><\/strong> <\/td><td>BREAKWATER\u3001COMMIT\u3001MSS\u3001ctDNA\uff1a\u4ece\u8fd9\u91cc\u5f00\u59cb\u4e86\u89e3\u60a8\u7684\u80bf\u7624\u6807\u5fd7\u7269  <\/td><\/tr><tr><td><a href=\"https:\/\/chatbot.fightcolorectalcancer.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u804a\u5929\u5ba4<\/a>  <\/td><td>SWOG S2107\u3001CIRCULATE\u3001CRDF-004\u3001CodeBreaK 300 \u548c mRCAT-III \u53ef\u80fd\u6b63\u5728\u62db\u52df\u53d7\u8bd5\u8005  <\/td><\/tr><tr><td><a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e6%82%a3%e8%80%85%e5%92%8c%e6%8a%a4%e7%90%86%e4%ba%ba%e5%91%98\/%e6%95%99%e8%82%b2%e4%b8%8e%e8%b5%84%e6%ba%90\/%e5%b9%b8%e5%ad%98%e8%80%85\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u5e78\u5b58\u8005\u8d44\u6e90<\/strong><\/a> <\/td><td>\u5173\u4e8e\u6b65\u884c\u3001\u75b2\u52b3\u3001GLP-1\u4ee3\u8c22\u5065\u5eb7\u53ca\u751f\u6d3b\u8d28\u91cf\u7684\u8d44\u6e90  <\/td><\/tr><tr><td><a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e5%85%b3%e4%ba%8e%e5%a4%a7%e8%82%a0%e7%99%8c\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u5173\u4e8e\u5927\u80a0\u764c<\/strong><\/a> <\/td><td>\u521a\u63a5\u89e6MSI-H\u3001dMMR\u3001MSS\u3001BRAF\u6216ctDNA\uff1f\u8bf7\u4ece\u8fd9\u91cc\u5f00\u59cb   <\/td><\/tr><tr><td><a href=\"https:\/\/www.asco.org\/annual-meeting\/search?filters=%7B%22mediaTypes%22:%5B%22Abstracts%22%5D%7D&amp;userInput=&amp;sortBy=AbstractBrowse&amp;contentKey=ANNUAL_MEETING&amp;contentKeyYear=2026\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2026\u5e74ASCO\u5e74\u4f1a<\/strong><\/a> <\/td><td>\u672c\u7efc\u8ff0\u4e2d\u6240\u6709\u8bd5\u9a8c\u7684\u5b8c\u6574\u6458\u8981\u76ee\u5f55  <\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong> <\/p>\n\n<p><strong>1a.  <\/strong>Elez \u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2025\u5e74\u3002  https:\/\/doi.org\/10.1056\/NEJMoa2501912\n <\/p>\n\n<p><strong>1b.  <\/strong>Kopetz \u7b49\uff0c\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b2025\u5e74\u3002  https:\/\/doi.org\/10.1038\/s41591-024-03443-3\n <\/p>\n\n<p><strong>1c. Kopetz <\/strong>\u7b49\u3002ASCO 2026\uff0c\u6458\u8981 LBA3503\u3002NCT04607421\u3002  <\/p>\n\n<p><strong>2a. Rocha <\/strong>Lima\u3001Overman \u7b49\u3002ASCO 2026\uff0c\u6458\u8981 14\u3002NCT02997228\u3002  <\/p>\n\n<p><strong>2b.  <\/strong>Andr\u00e9 \u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2020\u5e74\u3002  https:\/\/doi.org\/10.1056\/NEJMoa2017699\n <\/p>\n\n<p><strong>2c.  <\/strong>Le \u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff0c2015\u5e74\u3002  https:\/\/doi.org\/10.1056\/NEJMoa1500596\n <\/p>\n\n<p><strong>3a.  <\/strong>Morris VK II \u7b49\u3002ASCO 2026\uff0c\u6458\u8981 3504\u3002SWOG S2107\u3002    <\/p>\n\n<p><strong>3b.  <\/strong>Bai\u7b49\u4eba\uff0cASCO 2026\uff0c\u6458\u8981 LBA3515\u3002mRCAT-III\u3002    <\/p>\n\n<p><strong>4a. Folprecht <\/strong>\uff0cASCO 2026\uff0c\u6458\u8981 LBA3500\u3002NCT04089631\u3002  <\/p>\n\n<p><strong>4b.  <\/strong>Tie \u7b49\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b2022\u5e74\u3002  https:\/\/doi.org\/10.1056\/NEJMoa2200075\n <\/p>\n\n<p><strong>4c.  <\/strong>\u4e2d\u6751\u7b49\u4eba\uff0c\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b2024\u5e74\u3002  https:\/\/doi.org\/10.1038\/s41591-024-03254-6\n <\/p>\n\n<p><strong>5a.  <\/strong>\u743c\u65af\u7b49\u4eba\uff0cASCO GI 2026\uff0c\u6458\u8981 18\u3002   <\/p>\n\n<p><strong>5b.  <\/strong>Arya \u7b49\u3002ASCO GI 2026\uff0c\u6458\u8981 83\u3002   <\/p>\n\n<p><strong>5c.  <\/strong>Orland \u7b49\uff0cASCO 2026\uff0c\u6458\u8981 3143\u3002 <strong> <\/strong> <\/p>\n\n<p><strong>6a<\/strong>. Pietrantonio \u7b49\uff0cASCO 2026\uff0c\u6458\u8981 3511\u3002CodeBreaK 300\u3002     <\/p>\n\n<p><strong>6b.<\/strong>  \u7b2c\u4e09\u96c6\u30022026\u5e74ASCO\u5e74\u4f1a\uff0c\u6458\u8981LBA3508\u3002   <\/p>\n\n<p><strong>6c.<\/strong>  PUMP \u8bd5\u9a8c\u3002ASCO 2026\uff0c\u6458\u8981 LBA3506\u3002   <\/p>\n\n<p><strong>6d.<\/strong>  \u8428\u62c9\u8428\u5c14\u7b49\u4eba\uff0cASCO 2026\uff0c\u6458\u8981 3512\u3002CR-SEQUENCE\u3002    <\/p>\n\n<p><strong>6e.<\/strong>  Lenz \u7b49\uff0cASCO 2026\uff0c\u6458\u8981 3510\u3002CRDF-004\u3002    <\/p>\n\n<p><strong>6f.<\/strong>  \u5f90\u7b49\u4eba\uff0cASCO 2026\uff0c\u6458\u8981 LBA3509\u3002   <\/p>\n\n<p><strong>\u533b\u7597\u514d\u8d23\u58f0\u660e\uff1a\u672c <\/strong>\u535a\u5ba2\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u533b\u7597\u5efa\u8bae\u3002\u7814\u7a76\u7ed3\u679c\u53ef\u80fd\u5e76\u4e0d\u9002\u7528\u4e8e\u6bcf\u4f4d\u60a3\u8005\u3002\u5728\u505a\u51fa\u4efb\u4f55\u6cbb\u7597\u51b3\u5b9a\u4e4b\u524d\uff0c\u8bf7\u52a1\u5fc5\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u3002\u201cFight CRC\u201d\u662f\u4e00\u5bb6\u60a3\u8005\u6743\u76ca\u5021\u5bfc\u7ec4\u7ec7\uff0c\u5e76\u975e\u533b\u7597\u670d\u52a1\u63d0\u4f9b\u65b9\u3002     <\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026\u5e74ASCO\u5e74\u4f1a\u4e3a\u7ed3\u76f4\u80a0\u764c\u7814\u7a76\u5e26\u6765\u4e86\u91cd\u8981\u8fdb\u5c55\uff1a\u9776\u5411\u6cbb\u7597\u5728\u751f\u5b58\u7387\u65b9\u9762\u53d6\u5f97\u4e86\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\u7684\u7a81\u7834\uff0c\u514d\u75ab\u6cbb\u7597\u8054\u5408 [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[650,640],"tags":[],"class_list":["post-213178","post","type-post","status-publish","format-standard","hentry","category-650","category-640"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - 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