{"id":213192,"date":"2026-09-17T14:09:32","date_gmt":"2026-09-17T18:09:32","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2026%e5%b9%b46%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0\/"},"modified":"2026-09-21T11:28:14","modified_gmt":"2026-09-21T15:28:14","slug":"%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2026%e5%b9%b46%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2026%e5%b9%b46%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0\/","title":{"rendered":"\u5173\u6ce8\u7126\u70b9\uff1a2026\u5e749\u6708\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0<\/h2>\n\n<p class=\"wp-block-paragraph\">\u672c\u6708\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u4ecb\u7ecd\u4e94\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6db5\u76d6\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7814\u7a76\u7684\u4e09\u4e2a\u6d3b\u8dc3\u9886\u57df\uff1aMSS\u578b\u75be\u75c5\u7684\u514d\u75ab\u6cbb\u7597\u3001\u672f\u540e\u57fa\u4e8ectDNA\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u4ee5\u53ca\u9488\u5bf9\u809d\u8f6c\u79fb\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6cd5\u3002\u8fd9\u4e9b\u6458\u8981\u4e13\u4e3a\u60a3\u8005\u3001\u7167\u62a4\u8005\u53ca\u7814\u7a76\u5021\u5bfc\u8005\u64b0\u5199\uff0c\u65e8\u5728\u5e2e\u52a9\u60a8\u4e0e\u533b\u7597\u56e2\u961f\u5c55\u5f00\u77e5\u60c5\u5bf9\u8bdd\u3002   <\/p>\n\n<p class=\"wp-block-paragraph\"><em>\u9700\u8981\u5e2e\u52a9\u7406\u89e3<\/em> <a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e6%82%a3%e8%80%85%e5%92%8c%e6%8a%a4%e7%90%86%e4%ba%ba%e5%91%98\/%e6%95%99%e8%82%b2%e4%b8%8e%e8%b5%84%e6%ba%90\/%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c\/\" target=\"_blank\" rel=\"noopener\"><em>\u4e34\u5e8a\u8bd5\u9a8c<\/em><\/a> <em>\u6216<\/em> <a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e6%82%a3%e8%80%85%e5%92%8c%e6%8a%a4%e7%90%86%e4%ba%ba%e5%91%98\/%e6%95%99%e8%82%b2%e4%b8%8e%e8%b5%84%e6%ba%90\/%e8%af%8a%e6%96%ad%e6%b5%8b%e8%af%95%e4%b8%8e%e6%89%ab%e6%8f%8f\/%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e7%94%9f%e7%89%a9%e6%a0%87%e5%bf%97%e7%89%a9\/\" target=\"_blank\" rel=\"noopener\"><em>\u751f\u7269\u6807\u5fd7\u7269<\/em><\/a> <em>\u68c0\u6d4b\uff1f\u8bf7\u67e5\u9605\u6211\u4eec\u7684\u8d44\u6e90\u2014\u2014\u6216\u8005\u54a8\u8be2<a href=\"https:\/\/chatbot.fightcolorectalcancer.org\/\">\u201cChatCRC\u201d<\/a>\uff08Fight CRC\u7684AI\u5de5\u5177\uff09\uff0c\u5b83\u80fd\u5e2e\u52a9\u60a8\u89e3\u8bfb\u751f\u7269\u6807\u5fd7\u7269\u62a5\u544a\uff0c\u6216\u4e3a\u60a8\u5bfb\u627e\u4e0e\u60a8\u7684\u8bca\u65ad\u76f8\u5339\u914d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/em><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">2026\u5e749\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. \u5355\u7528\u6216\u8054\u5408\u5e94\u7528 Denikitug\uff08GS-1811\uff09\uff1a\u9488\u5bf9\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u79cd\u65b0\u578b TIGIT \u9776\u5411\u6cbb\u7597\u65b9\u6cd5<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5fae\u536b\u661f\u7a33\u5b9a\uff08MSS\uff09\/\u9ad8\u6548\u9519\u914d\u4fee\u590d\uff08pMMR\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e8c\u9636\u6bb5 \/ 14\u4e2a\u7814\u7a76\u5730\u70b9\uff0c\u5305\u62ec\u8036\u9c81\u5927\u5b66\u3001\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240\u3001\u8d1d\u65af\u4ee5\u8272\u5217\u5973\u6267\u4e8b\u533b\u9662\u3001\u534e\u76db\u987f\u5927\u5b66\u3001\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\u3001\u963f\u7ef4\u62c9\u764c\u75c7\u7814\u7a76\u6240\uff08\u7f8e\u56fd\uff09\u4ee5\u53ca\u6fb3\u5927\u5229\u4e9a  <br\/><strong>\u75c5\u671f\uff1a<\/strong>\u665a\u671f\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b\u6b64\u524d\u6700\u591a\u63a5\u53d7\u8fc72\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c<strong>\u65e8\u5728\u8bc4\u4f30<\/strong>\u767b\u57fa\u56fe\u683c\uff08GS-1811\uff09\uff0c\u8fd9\u662f\u4e00\u79cd\u7531\u5409\u5229\u5fb7\u8d5e\u52a9\u7684\u3001\u9488\u5bf9TIGIT\u7684\u8bd5\u9a8c\u6027\u6297\u4f53\u3002TIGIT\u662f\u4e00\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\uff0c\u6709\u52a9\u4e8e\u80bf\u7624\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb\u3002 \u8be5\u7814\u7a76\u9488\u5bf9\u65e2\u5f80\u63a5\u53d7\u8fc7\u4e0d\u8d85\u8fc7\u4e24\u7ebf\u6cbb\u7597\u7684MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\uff0c\u6d4b\u8bd5\u4e86\u767b\u57fa\u56fe\u683c\u5355\u836f\u6cbb\u7597\u3001\u4e0e\u5c3c\u6c83\u5362\u5355\u6297\uff08\u6297PD-1\uff09\u8054\u5408\u6cbb\u7597\uff0c\u4ee5\u53ca\u4e0e\u4e09\u6c1f\u5c3f\u5627\u5576-\u66ff\u5339\u62c9\u897f\u5c14\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u7684\u6548\u679c\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>MSS\u578b\u7ed3\u76f4\u80a0\u764c\u7ea6\u5360\u6240\u6709\u8f6c\u79fb\u6027\u75c5\u4f8b\u768485%\u81f390%\uff0c\u4f46\u5728MSI-H\/dMMR\u75be\u75c5\u4e2d\u89c2\u5bdf\u5230\u7684\u514d\u75ab\u6cbb\u7597\u8fdb\u5c55\u4e2d\uff0c\u8be5\u7c7b\u578b\u60a3\u8005\u5927\u591a\u88ab\u6392\u9664\u5728\u5916\u3002 TIGIT\u662f\u4e00\u79cd\u4e0ePD-1\u548cCTLA-4\u4e0d\u540c\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u9776\u70b9\uff0c\u963b\u65ad\u8be5\u9776\u70b9\u53ef\u80fd\u6709\u52a9\u4e8e\u6fc0\u6d3b\u76ee\u524d\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u7684\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u5e94\u7b54\u3002 \u8fd9\u662f\u9996\u4e2a\u4e13\u95e8\u9488\u5bf9MSS\u7ed3\u76f4\u80a0\u764c\u3001\u8bbe\u6709\u591a\u4e2a\u8054\u5408\u6cbb\u7597\u7ec4\u7684TIGIT\u9776\u5411II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e3a\u5f53\u524d\u7f3a\u4e4f\u514d\u75ab\u6cbb\u7597\u9009\u62e9\u7684\u6700\u5927\u60a3\u8005\u7fa4\u4f53\u5f00\u8f9f\u4e86\u4e00\u6761\u771f\u6b63\u5d2d\u65b0\u7684\u7814\u7a76\u65b9\u5411\u3002    <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSS\u6216pMMR\u7c7b\u578b\uff0c\u4e14\u6b64\u524d\u5df2\u63a5\u53d7\u8fc7\u4e00\u81f3\u4e24\u4e2a\u5316\u7597\u65b9\u6848\uff0c\u8bf7\u5411\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u54a8\u8be2\uff1a\u201c\u662f\u5426\u6709\u9488\u5bf9TIGIT\u6216\u5176\u4ed6\u65b0\u578b\u514d\u75ab\u68c0\u67e5\u70b9\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6211\u53ef\u80fd\u7b26\u5408\u53c2\u4e0e\u6761\u4ef6\uff1f\u201d MSS\u5e76\u4e0d\u610f\u5473\u7740\u514d\u75ab\u6cbb\u7597\u5b8c\u5168\u884c\u4e0d\u901a\uff1b\u8fd9\u53ea\u662f\u610f\u5473\u7740\u6cbb\u7597\u65b9\u6848\u9700\u8981\u6709\u6240\u8c03\u6574\uff0c\u800c\u50cf\u672c\u6b21\u8fd9\u6837\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4e3a\u6b64\u94fa\u5e73\u9053\u8def\u3002   <br\/><strong>\u533b\u62a4\u4eba\u5458\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u6b64\u524d\u5df2\u63a5\u53d7\u8fc7\u4e00\u81f3\u4e24\u4e2a\u5316\u7597\u65b9\u6848\uff0c\u4e14\u80bf\u7624\u4e3aMSS\u578b\uff0c\u60a8\u53ef\u80fd\u7b26\u5408\u53c2\u4e0e\u672c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6761\u4ef6\u2014\u2014\u4f46\u65f6\u673a\u81f3\u5173\u91cd\u8981\u3002 \u8bf7\u786e\u4fdd\u60a8\u7684\u533b\u7597\u56e2\u961f\u4e86\u89e3\u60a8\u7684\u5b8c\u6574\u6cbb\u7597\u53f2\uff0c\u5305\u62ec\u662f\u5426\u66fe\u63a5\u53d7\u8fc7\u4e09\u6c1f\u5c3f\u5627\u5576-\u66ff\u5339\u62c9\u897f\u3001\u96f7\u6208\u62c9\u975e\u5c3c\u6216\u5f17\u9c81\u594e\u66ff\u5c3c\u6cbb\u7597\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u4fe1\u606f\u4f1a\u5f71\u54cd\u60a8\u7b26\u5408\u54ea\u4e00\u7814\u7a76\u7ec4\u7684\u5165\u7ec4\u6761\u4ef6\u3002 \u5982\u679c\u4ea4\u901a\u4fbf\u5229\uff0c\u4e0d\u59a8\u54a8\u8be2\u5305\u62ec\u8fbe\u7eb3-\u6cd5\u4f2f\u764c\u75c7\u4e2d\u5fc3\u548c\u534e\u76db\u987f\u5927\u5b66\u5728\u5185\u7684\u4e3b\u8981\u764c\u75c7\u4e2d\u5fc3\u7684\u8bd5\u9a8c\u70b9\u3002    <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07527858\" target=\"_blank\" rel=\"noopener\">NCT07527858<\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. \u5df4\u65af\u66ff\u5229\u5355\u6297 + \u535a\u817e\u897f\u5229\u5355\u6297 + 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<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u7531\u7814\u7a76\u4eba\u5458\u53d1\u8d77\u7684\u3001\u5728\u65af\u514b\u91cc\u666e\u65af\u5065\u5eb7\u4e2d\u5fc3\uff08Scripps Health\uff09\u5f00\u5c55\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u6d4b\u8bd5\u4e00\u79cd\u4e09\u836f\u8054\u5408\u65b9\u6848\uff1a\u5df4\u5c14\u65af\u5229\u9a6c\u5e03\uff08\u6297PD-1\uff09\u3001 \u535a\u6ed5\u897f\u5229\u5355\u6297\uff08Fc\u589e\u5f3a\u578b\u6297CTLA-4\uff09\u4ee5\u53caagenT-797\uff08\u4e00\u79cd\u5f02\u4f53\u4e0d\u53d8\u81ea\u7136\u6740\u4f24T\u7ec6\u80de\uff08iNKT\uff09\u7597\u6cd5\uff09\u3002 \u8be5\u7814\u7a76\u4e13\u95e8\u62db\u52dfMSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e14\u5df2\u8f6c\u79fb\u81f3\u809d\u810f\u7684\u60a3\u8005\uff0c\u7531\u4e8e\u809d\u810f\u5fae\u73af\u5883\u4f1a\u79ef\u6781\u6291\u5236\u514d\u75ab\u6d3b\u6027\uff0c\u8be5\u4eba\u7fa4\u5386\u6765\u5bf9\u514d\u75ab\u6cbb\u7597\u7684\u54cd\u5e94\u7387\u8f83\u4f4e\u3002\u60a3\u8005\u5fc5\u987b\u81f3\u5c11\u6709\u4e00\u4e2a\u53ef\u6d4b\u91cf\u7684\u809d\u810f\u75c5\u7076\uff0c\u4e14\u6b64\u524d\u672a\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3002    <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>ESMO GI 2026\u4f1a\u8bae\u4e0a\u516c\u5e03\u7684BOT\/BAL\u7597\u6cd5\u4e09\u5e74\u751f\u5b58\u6570\u636e\u5f15\u53d1\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u4f46\u8be5\u6570\u636e\u96c6\u57fa\u672c\u6392\u9664\u4e86\u6d3b\u52a8\u6027\u809d\u8f6c\u79fb\u60a3\u8005\u2014\u2014\u800c\u8fd9\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u662f\u4e00\u79cd\u5e38\u89c1\u4e14\u5177\u6709\u91cd\u8981\u4e34\u5e8a\u610f\u4e49\u7684\u60c5\u51b5\u3002 \u672c\u8bd5\u9a8c\u5728BOT\/BAL\u57fa\u7840\u6cbb\u7597\u65b9\u6848\u4e2d\u6dfb\u52a0\u4e86\u73b0\u6210iNKT\u7ec6\u80de\u7597\u6cd5agenT-797\uff0c\u65e8\u5728\u63a2\u7a76\u7ec6\u80de\u7597\u6cd5\u80fd\u5426\u5e2e\u52a9\u7a81\u7834\u809d\u810f\u7684\u514d\u75ab\u62b5\u6297\u3002\u8fd9\u662f\u9996\u4e2a\u4e13\u95e8\u9488\u5bf9\u4f34\u6709\u809d\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\uff0c\u5c06iNKT\u7ec6\u80de\u7597\u6cd5\u4e0e\u53cc\u91cd\u68c0\u67e5\u70b9\u963b\u65ad\u76f8\u7ed3\u5408\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002    <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u764c\u75c7\u5df2\u8f6c\u79fb\u81f3\u809d\u810f\uff0c\u4e14\u80bf\u7624\u5c5e\u4e8eMSS\u578b\uff0c\u90a3\u4e48\u5173\u4e8e\u514d\u75ab\u6cbb\u7597\u7684\u8ba8\u8bba\u53ef\u80fd\u4f1a\u8ba9\u60a8\u611f\u5230\u6cae\u4e27\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u63a2\u7a76\uff1a\u5728\u53cc\u91cd\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u7684\u57fa\u7840\u4e0a\u8054\u5408\u7ec6\u80de\u7597\u6cd5\uff0c\u662f\u5426\u80fd\u6539\u53d8\u8fd9\u4e00\u5c40\u9762\u3002 \u867d\u7136\u8be5\u8bd5\u9a8c\u4ec5\u5728\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u8bbe\u6709\u4e00\u4e2a\u7814\u7a76\u4e2d\u5fc3\uff0c\u53ef\u80fd\u5e76\u975e\u6240\u6709\u4eba\u90fd\u80fd\u524d\u5f80\uff0c\u4f46\u5982\u679c\u60a8\u5411\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u54a8\u8be2\u9488\u5bf9MSS\u578b\u809d\u8f6c\u79fb\u6027\u75be\u75c5\u3001\u5c06\u7ec6\u80de\u7597\u6cd5\u4e0e\u514d\u75ab\u7597\u6cd5\u76f8\u7ed3\u5408\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6216\u8bb8\u80fd\u4e3a\u60a8\u5f00\u542f\u5176\u4ed6\u7c7b\u4f3c\u6cbb\u7597\u65b9\u6848\u7684\u5927\u95e8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07550088\" target=\"_blank\" rel=\"noopener\">NCT07550088<\/a><br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. TAS-102 \u7528\u4e8e ctDNA \u9633\u6027\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff1a\u9a8c\u8bc1\u6cbb\u7597\u80fd\u5426\u5728\u624b\u672f\u540e\u6d88\u9664\u201c\u9690\u533f\u6027\u201d\u764c\u75c7<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u6839\u6cbb\u6027\u624b\u672f\u548c\u8f85\u52a9\u5316\u7597\u540ectDNA\u9633\u6027\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\uff08MRD\uff09  <br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e8c\u9636\u6bb5 \/ \u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\uff0c\u5fb7\u514b\u8428\u65af\u5dde\u4f11\u65af\u987f  <br\/><strong>\u5206\u671f\uff1a<\/strong>II\u671f\u3001III\u671f\u6216IV\u671f\uff1b\u5df2\u884cR0\u5207\u9664\u672f\uff0c\u5df2\u5b8c\u6210\u4ee5\u6cbb\u6108\u4e3a\u76ee\u7684\u7684\u6cbb\u7597\uff0cctDNA\u9633\u6027\uff0c\u4e14\u5f71\u50cf\u5b66\u4e0a\u65e0\u75c5\u7076  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u7531MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u5f00\u5c55\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u9a8c\u8bc1\uff1a\u53e3\u670d\u5316\u7597\u836f\u7269\u4e09\u6c1f\u5c3f\u5627\u5576-\u66ff\u5339\u62c9\u897f\uff08TAS-102\uff09\u80fd\u5426\u6e05\u9664\u5df2\u5b8c\u6210\u6839\u6cbb\u6027\u624b\u672f\u5e76\u63a5\u53d7\u81f3\u5c11\u4e09\u4e2a\u6708\u4ee5\u5965\u6c99\u5229\u94c2\u4e3a\u57fa\u7840\u7684\u8f85\u52a9\u5316\u7597\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u8840\u6db2\u4e2d\u7684\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u3002 \u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005\u5fc5\u987bctDNA\u68c0\u6d4b\u5448\u9633\u6027\uff0c\u4e14\u5f71\u50cf\u5b66\u68c0\u67e5\u672a\u89c1\u53ef\u89c1\u80bf\u7624\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u8fd9\u79cd\u72b6\u6001\u79f0\u4e3a\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u3002\u8be5\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u6807\u662f\u8bc4\u4f30\u57286\u4e2a\u6708\u65f6\u6709\u591a\u5c11\u60a3\u8005\u5b9e\u73b0\u4e86ctDNA\u6e05\u9664\u3002    <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u672f\u540ectDNA<strong>\u68c0\u6d4b<\/strong>\u5448\u9633\u6027\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u590d\u53d1\u98ce\u9669\u7684\u6700\u5f3a\u4fe1\u53f7\u4e4b\u4e00\uff0c\u901a\u5e38\u5728\u5f71\u50cf\u5b66\u68c0\u67e5\u663e\u793a\u5f02\u5e38\u6570\u6708\u524d\u5373\u53ef\u68c0\u6d4b\u5230\u3002\u4f46\u8fd9\u4e00\u53d1\u73b0\u63d0\u51fa\u4e86\u4e00\u4e2a\u8be5\u9886\u57df\u5c1a\u672a\u89e3\u7b54\u7684\u7d27\u8feb\u95ee\u9898\uff1a\u5982\u679c\u68c0\u6d4b\u5230\u4e86\uff0c\u6211\u4eec\u80fd\u5426\u8fdb\u884c\u6cbb\u7597\uff1f \u8fd9\u662f\u9996\u6279\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e2dctDNA\u9633\u6027\u5fae\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff09\u8fdb\u884c\u79ef\u6781\u6cbb\u7597\u5e72\u9884\uff08\u800c\u975e\u4ec5\u8fdb\u884c\u76d1\u6d4b\uff09\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002\u82e5\u8bd5\u9a8c\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u5c06\u91cd\u5851\u76ee\u524d\u5c1a\u65e0\u660e\u786e\u6cbb\u7597\u6807\u51c6\u7684\u9ad8\u5371\u4eba\u7fa4\u7684\u672f\u540e\u62a4\u7406\u65b9\u6848\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5df2\u5b8c\u6210\u624b\u672f\u548c\u5316\u7597\uff0c\u5f71\u50cf\u68c0\u67e5\u7ed3\u679c\u6b63\u5e38\uff0c\u4f46\u542c\u8bf4\u8fc7ctDNA\u68c0\u6d4b\uff0c\u90a3\u4e48\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u662f\u9488\u5bf9\u60a8\u7684\u60c5\u51b5\u3002 \u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201c\u6211\u7684ctDNA\u662f\u5426\u5df2\u8fdb\u884c\u68c0\u6d4b\uff1f\u5982\u679c\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u662f\u5426\u6709\u9488\u5bf9\u6b8b\u7559\u75c5\u7076\u8bbe\u8ba1\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1f\u201d\u5e76\u975e\u6240\u6709\u533b\u7597\u673a\u6784\u90fd\u4f1a\u5728\u672f\u540e\u5e38\u89c4\u8fdb\u884cctDNA\u68c0\u6d4b\uff0c\u56e0\u6b64\u4e3b\u52a8\u8be2\u95ee\u662f\u81f3\u5173\u91cd\u8981\u7684\u4e00\u6b65\u3002    <br\/><strong>\u533b\u62a4\u4eba\u5458\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5728\u624b\u672f\u548c\u5316\u7597\u540e\u5f71\u50cf\u68c0\u67e5\u7ed3\u679c\u6b63\u5e38\uff0c\u4f46ctDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\uff0c\u90a3\u4e48\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u80fd\u662f\u503c\u5f97\u63a2\u8ba8\u7684\u9009\u62e9\u3002 \u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u786e\u8ba4\u60a8\u7684ctDNA\u68c0\u6d4b\u7ed3\u679c\u662f\u5426\u7ecf\u7531CLIA\u8ba4\u8bc1\u5b9e\u9a8c\u5ba4\u786e\u8ba4\u2014\u2014Signatera\u662f\u672c\u8bd5\u9a8c\u5165\u7ec4\u7684\u9996\u9009\u68c0\u6d4b\u65b9\u6cd5\u3002\u8be5\u8bd5\u9a8c\u5728\u4f11\u65af\u987f\u7684MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u8fdb\u884c\uff0c\u56e0\u6b64\u9700\u8981\u524d\u5f80\u5f53\u5730\u5c31\u8bca\uff0c\u4f46\u5bf9\u4e8e\u5e0c\u671b\u9488\u5bf9\u9633\u6027ctDNA\u7ed3\u679c\u91c7\u53d6\u884c\u52a8\u800c\u975e\u7b49\u5f85\u7684\u60a3\u8005\u800c\u8a00\uff0c\u8fd9\u503c\u5f97\u6df1\u5165\u63a2\u8ba8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05343013\" target=\"_blank\" rel=\"noopener\">NCT05343013<\/a><br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. \u6258\u91cc\u5e15\u5229\u5355\u6297\u8f85\u52a9\u6cbb\u7597\uff1a\u9ad8\u5371dMMR\/MSI-H\u7ed3\u80a0\u764c\u672f\u540e\u514d\u75ab\u6cbb\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\/ MSI-H\uff1bIIB\u671f\u3001IIC\u671f\u6216III\u671f\u7ed3\u80a0\u764c  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e8c\u9636\u6bb5 \/ \u57c3\u9ed8\u91cc\u5927\u5b66\u7f51\u7edc\u76845\u4e2a\u7814\u7a76\u5730\u70b9\uff0c\u4f50\u6cbb\u4e9a\u5dde\u4e9a\u7279\u5170\u5927\uff08\u7531\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\u8d44\u52a9\uff09  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u5c40\u9650\u6027\uff1bIIB\u671f\u3001IIC\u671f\u6216III\u671f\u7ed3\u80a0\u764c\uff0cR0\u5207\u9664  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u7531\u57c3\u9ed8\u91cc\u5927\u5b66\u4e0e\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u5408\u4f5c\u5f00\u5c55\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c<strong>\u65e8\u5728<\/strong>\u8bc4\u4f30\u6297PD-1\u514d\u75ab\u7597\u6cd5\u6258\u91cc\u5e15\u5229\u5355\u6297\uff08toripalimab\uff09\u4f5c\u4e3a\u9ad8\u5371dMMR\/MSI-H\u7ed3\u80a0\u764c\u60a3\u8005\u5b8c\u5168\u5207\u9664\u672f\u540e\u5355\u836f\u8f85\u52a9\u6cbb\u7597\u7684<strong>\u7597\u6548<\/strong>\u3002 \u53d7\u8bd5\u8005\u5c06\u5728\u516d\u4e2a\u6708\u5185\u63a5\u53d7\u516b\u6b21\u7ed9\u836f\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3a\u4e09\u5e74\u65e0\u75c5\u751f\u5b58\u7387\u3002 \u4e0eATOMIC\u8bd5\u9a8c\uff08\u8be6\u89c1\u300aFight CRC\u300b2026\u5e741\u6708\u7efc\u8ff0\uff09\u5728\u8f85\u52a9\u5316\u7597\u4e2d\u6dfb\u52a0\u514d\u75ab\u7597\u6cd5\u4e0d\u540c\uff0c\u672c\u7814\u7a76\u4ec5\u6d4b\u8bd5\u514d\u75ab\u7597\u6cd5\u5355\u836f\u6cbb\u7597\uff0c\u65e8\u5728\u63a2\u7a76\u6b64\u7c7b\u80bf\u7624\u7684dMMR\u751f\u7269\u5b66\u7279\u5f81\u662f\u5426\u80fd\u4f7f\u65e0\u5316\u7597\u65b9\u6848\u65e2\u6709\u6548\u53c8\u66f4\u6613\u8010\u53d7\u3002    <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u5bf9\u4e8edMMR\u60a3\u8005\u800c\u8a00\uff0c\u514d\u75ab\u7597\u6cd5\u80fd\u5426\u53d6\u4ee3\u2014\u2014\u800c\u4e0d\u4ec5\u4ec5\u662f\u8865\u5145\u2014\u2014\u672f\u540e\u5316\u7597\uff0c\u8fd9\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u9886\u57df\u4e2d\u4e0e\u60a3\u8005\u606f\u606f\u76f8\u5173\u7684\u91cd\u8981\u672a\u89e3\u95ee\u9898\u4e4b\u4e00\u3002 \u8bb8\u591a\u5904\u4e8e\u8fd9\u79cd\u60c5\u51b5\u7684\u60a3\u8005\u90fd\u5e0c\u671b\uff0c\u5982\u679c\u751f\u7269\u5b66\u8bc1\u636e\u652f\u6301\u7684\u8bdd\uff0c\u80fd\u591f\u907f\u514d\u5316\u7597\u7684\u526f\u4f5c\u7528\u3002\u8be5\u8bd5\u9a8c\u9664\u4e86\u6536\u96c6\u7597\u6548\u6570\u636e\u5916\uff0c\u8fd8\u540c\u6b65\u8bb0\u5f55\u4e86\u60a3\u8005\u62a5\u544a\u7684\u7ed3\u679c\uff0c\u8fd9\u610f\u5473\u7740\u7814\u7a76\u7ed3\u679c\u4e0d\u4ec5\u5c06\u53cd\u6620\u751f\u5b58\u60c5\u51b5\uff0c\u8fd8\u5c06\u4f53\u73b0\u751f\u6d3b\u8d28\u91cf\u2014\u2014\u8fd9\u5bf9\u6b63\u5728\u6743\u8861\u4e0b\u4e00\u6b65\u6cbb\u7597\u65b9\u6848\u7684\u672f\u540e\u60a3\u8005\u800c\u8a00\u81f3\u5173\u91cd\u8981\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u521a\u521a\u63a5\u53d7\u4e86IIB\u671f\u3001IIC\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u7684\u624b\u672f\u6cbb\u7597\uff0c\u4e14\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSI-H\u6216dMMR\u7c7b\u578b\uff0c\u60a8\u53ef\u80fd\u5904\u4e8e\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5165\u7ec4\u7a97\u53e3\u671f\u5185\u3002\u8be5\u7a97\u53e3\u671f\u8f83\u77ed\uff1a\u624b\u672f\u540e4\u81f312\u5468\u2014\u2014\u56e0\u6b64\u9700\u8981\u5c3d\u5feb\u4e0e\u533b\u62a4\u56e2\u961f\u6c9f\u901a\u3002 \u5728\u5f00\u59cb\u8f85\u52a9\u5316\u7597\u4e4b\u524d\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201c\u6211\u662f\u5426\u7b26\u5408\u672f\u540e\u4ec5\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5165\u9009\u6761\u4ef6\uff1f\u201d  <br\/><strong>\u533b\u751f\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u521a\u521a\u63a5\u53d7\u4e86dMMR\u6216MSI-H\u7ed3\u80a0\u764c\u7684\u624b\u672f\u6cbb\u7597\uff0c\u53c2\u4e0e\u672c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7a97\u53e3\u671f\u4e3a\u672f\u540e4\u81f312\u5468\uff0c\u56e0\u6b64\u8bf7\u5728\u672f\u540e\u9996\u6b21\u590d\u8bca\u65f6\u5411\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u63d0\u51fa\u6b64\u4e8b\uff0c\u4e14\u5728\u4efb\u4f55\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u786e\u5b9a\u4e4b\u524d\u3002 \u8bf7\u786e\u4fdd\u60a8\u7684\u75c5\u7406\u62a5\u544a\u786e\u8ba4\u4e86dMMR\u6216MSI-H\u72b6\u6001\uff0c\u5e76\u544a\u77e5\u60a8\u7684\u533b\u7597\u56e2\u961f\u60a8\u5728\u624b\u672f\u524d\u662f\u5426\u63a5\u53d7\u8fc7\u4efb\u4f55\u6cbb\u7597\uff0c\u56e0\u4e3a\u8fd9\u53ef\u80fd\u4f1a\u5f71\u54cd\u60a8\u7684\u5165\u7ec4\u8d44\u683c\u3002 <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07140679\" target=\"_blank\" rel=\"noopener\">NCT07140679<\/a><br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>5. PUMP \u8bd5\u9a8c\uff1a\u9488\u5bf9\u4e0d\u53ef\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u7684\u809d\u52a8\u8109\u8f93\u6ce8\u6cf5\u5316\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u91cd\u70b9\uff1a<\/strong>\u65e0\u7279\u5b9a\u751f\u7269\u6807\u5fd7\u7269\u8981\u6c42\uff1b\u5c40\u9650\u4e8e\u809d\u810f\u4e14\u65e0\u6cd5\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u8f6c\u79fb\u7076\uff08\u4e0d\u5305\u62ecMSI-H\uff09  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u673a\u6784\uff1a<\/strong>III\u671f \/ \u904d\u5e03\u7ea620\u4e2a\u5dde\u768462\u5bb6\u7f8e\u56fd\u7814\u7a76\u673a\u6784\uff0c\u5305\u62ecMSK\u3001\u6885\u5965\u8bca\u6240\u3001\u897f\u5317\u5927\u5b66\u3001\u675c\u514b\u5927\u5b66\u3001\u57c3\u9ed8\u91cc\u5927\u5b66\u3001\u5fb7\u514b\u8428\u65af\u5927\u5b66\u897f\u5357\u533b\u5b66\u4e2d\u5fc3\u3001\u4fc4\u4ea5\u4fc4\u5dde\u7acb\u5927\u5b66\u3001\u798f\u514b\u65af\u8521\u65af\u764c\u75c7\u4e2d\u5fc3\u3001\u8303\u5fb7\u6bd4\u5c14\u7279\u5927\u5b66\u7b49\uff08ECOG-ACRIN \/ \u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u8d44\u52a9\uff09  <br\/><strong>\u5206\u671f\uff1a<\/strong>IV\u671f\uff1b\u4e0d\u53ef\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\uff0c\u75c5\u7076\u5c40\u9650\u4e8e\u809d\u810f\uff0c\u7ecf3\u81f36\u4e2a\u6708\u7684\u4e00\u7ebf\u5316\u7597\u540e\u75c5\u60c5\u7a33\u5b9a\u6216\u6709\u53cd\u5e94  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>PUMP\u8bd5\u9a8c\u662f\u4e00\u9879\u968f\u673a\u2162\u671f\u7814\u7a76\uff0c<strong>\u65e8\u5728<\/strong>\u6bd4\u8f83\u5355\u72ec\u91c7\u7528\u6807\u51c6\u5168\u8eab\u5316\u7597\u4e0e\u5168\u8eab\u5316\u7597\u8054\u5408\u809d\u52a8\u8109\u704c\u6ce8\uff08HAI\uff09<strong>\u7684\u7597\u6548<\/strong>\u3002HAI\u662f\u4e00\u79cd\u901a\u8fc7\u624b\u672f\u690d\u5165\u7684\u6cf5\uff0c\u53ef\u5c06\u6c1f\u5c3f\u5627\u5576\u5316\u7597\u836f\u7269\u76f4\u63a5\u8f93\u9001\u5230\u809d\u810f\u7684\u8840\u6db2\u4f9b\u5e94\u7cfb\u7edf\u4e2d\u3002 \u8be5\u8bd5\u9a8c\u7531ECOG-ACRIN\u548c\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u5171\u540c\u8d5e\u52a9\uff0c\u62db\u52df\u7684\u60a3\u8005\u4e3a\u7ed3\u76f4\u80a0\u764c\u4ec5\u8f6c\u79fb\u81f3\u809d\u810f\u4e14\u65e0\u6cd5\u901a\u8fc7\u624b\u672f\u5207\u9664\u7684\u60a3\u8005\uff0c\u4e14\u5728\u5b8c\u62103\u81f36\u4e2a\u6708\u7684\u4e00\u7ebf\u5316\u7597\u540e\uff0c\u75c5\u60c5\u7a33\u5b9a\u6216\u5bf9\u6cbb\u7597\u6709\u53cd\u5e94\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\u671f\u3002    <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>HAI\u6cf5\u5316\u7597\u5df2\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff0c\u5e76\u5728\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7b49\u9ad8\u75c5\u4f8b\u91cf\u533b\u7597\u673a\u6784\u4e2d\u5c55\u73b0\u51fa\u663e\u8457\u7597\u6548\uff0c\u4f46\u5728\u5168\u7f8e\u8303\u56f4\u5185\u4ecd\u672a\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\uff0c\u8fd9\u4e3b\u8981\u662f\u56e0\u4e3a\u5927\u591a\u6570\u60a3\u8005\u4ece\u672a\u542c\u8bf4\u8fc7\u8fd9\u79cd\u7597\u6cd5\u3002 \u901a\u8fc7\u5c06\u5316\u7597\u836f\u7269\u76f4\u63a5\u8f93\u9001\u5230\u809d\u52a8\u8109\u4f9b\u8840\u7cfb\u7edf\uff0cHAI\u5728\u80bf\u7624\u90e8\u4f4d\u8fbe\u5230\u7684\u836f\u7269\u6d53\u5ea6\u8fdc\u9ad8\u4e8e\u4ec5\u9760\u5168\u8eab\u5316\u7597\u6240\u80fd\u8fbe\u5230\u7684\u6c34\u5e73\u3002 PUMP\u8bd5\u9a8c\u662f\u8fc4\u4eca\u4e3a\u6b62\u89c4\u6a21\u6700\u5927\u7684\u968f\u673a\u8bd5\u9a8c\uff0c\u65e8\u5728\u786e\u5b9a\u5c06HAI\u7597\u6cd5\u4e0e\u73b0\u4ee3\u5168\u8eab\u5316\u7597\u76f8\u7ed3\u5408\u80fd\u5426\u5ef6\u957f\u751f\u5b58\u671f\uff1b\u8be5\u8bd5\u9a8c\u5728\u7f8e\u56fd\u8bbe\u670962\u4e2a\u7814\u7a76\u7ad9\u70b9\uff0c\u4f7f\u5176\u6210\u4e3a\u672c\u671f\u300a\u7efc\u8ff0\u300b\u4e2d\u5730\u7406\u8986\u76d6\u8303\u56f4\u6700\u5e7f\u7684\u8bd5\u9a8c\u4e4b\u4e00\u3002    <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u7ed3\u76f4\u80a0\u764c\u5df2\u8f6c\u79fb\u81f3\u809d\u810f\uff0c\u4e14\u533b\u751f\u8868\u793a\u76ee\u524d\u65e0\u6cd5\u8fdb\u884c\u624b\u672f\uff0c\u8bf7\u5177\u4f53\u8be2\u95ee\uff1a\u201c\u6211\u662f\u5426\u9002\u5408\u63a5\u53d7\u809d\u52a8\u8109\u704c\u6ce8\u6cf5\u6cbb\u7597\uff1f\u6211\u6240\u5728\u5730\u533a\u662f\u5426\u6709\u53c2\u4e0ePUMP\u8bd5\u9a8c\u7684\u673a\u6784\uff1f\u201d\u7531\u4e8e\u809d\u52a8\u8109\u704c\u6ce8\u6cf5\uff08HAI\uff09\u6cbb\u7597\u5728\u975e\u4e13\u79d1\u4e2d\u5fc3\u5c1a\u672a\u5e7f\u6cdb\u5f00\u5c55\uff0c\u8bb8\u591a\u672c\u53ef\u4ece\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u5f80\u5f80\u4e0d\u77e5\u9053\u8be5\u5982\u4f55\u8be2\u95ee\u3002 \u8be5\u8bd5\u9a8c\u5728\u5168\u56fd\u5404\u5927\u764c\u75c7\u4e2d\u5fc3\u5747\u8bbe\u6709\u8bd5\u9a8c\u70b9\uff0c\u5176\u8986\u76d6\u8303\u56f4\u6bd4\u5927\u591a\u6570\u8bd5\u9a8c\u90fd\u8981\u5e7f\u6cdb\u3002  <br\/><strong>\u7814\u7a76\u673a\u6784\u63d0\u793a\uff1a<\/strong>\u4e3b\u8981\u5165\u9009\u6807\u51c6\uff1a\u7ecf\u591a\u5b66\u79d1\u8bc4\u5ba1\u786e\u8bca\u7684\u5c40\u9650\u4e8e\u809d\u810f\u4e14\u4e0d\u53ef\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\uff1b\u7ecf3-6\u4e2a\u6708\u4e00\u7ebf\u5316\u7597\u540e\u75c5\u60c5\u7a33\u5b9a\u6216\u6709\u5e94\u7b54\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7HAI\u6216FUDR\u6cbb\u7597\uff1b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u809d\u810f\u9776\u5411\u6cbb\u7597\uff08TACE\u3001TARE\uff09\uff1b \u65e0MSI-H\u75c5\u53d8\uff0cECOG\u8bc4\u52060\u20131\uff0c\u809d\u80bf\u7624\u8d1f\u8377\u226470%\u3002\u968f\u673a\u5206\u7ec4\u524d4\u5468\u5185\u9700\u8fdb\u884cCT\u8840\u7ba1\u9020\u5f71\uff0c\u4ee5\u786e\u8ba4\u809d\u52a8\u8109\u89e3\u5256\u7ed3\u6784\u7b26\u5408\u8981\u6c42\u3002 PUMP\u8bd5\u9a8c\u5728\u7f8e\u56fd\u62e5\u670962\u4e2a\u6d3b\u8dc3\u7814\u7a76\u7ad9\u70b9\uff0c\u662f\u672c\u6708\u201c\u7efc\u8ff0\u201d\u4e2d\u5730\u7406\u8986\u76d6\u8303\u56f4\u6700\u5e7f\u7684\u8bd5\u9a8c\uff0c\u503c\u5f97\u9488\u5bf9\u5c40\u9650\u6027\u809d\u8f6c\u79fb\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e3b\u52a8\u8fdb\u884c\u8f6c\u8bca\u6c9f\u901a\u3002    <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05863195\" target=\"_blank\" rel=\"noopener\">NCT05863195<\/a><br\/><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<p class=\"wp-block-paragraph\"><em>\u514d\u8d23\u58f0\u660e\uff1a\u672c\u6c47\u603b\u4e2d\u5217\u51fa\u7684\u5185\u5bb9\u5e76\u4e0d\u610f\u5473\u7740\u5bf9\u5176\u7684\u8ba4\u53ef\u6216\u4fdd\u8bc1\u5176\u6709\u6548\u6027\u3002\u8bf7\u52a1\u5fc5\u54a8\u8be2\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\uff0c\u4ee5\u786e\u5b9a\u67d0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002\u62db\u52df\u72b6\u6001\u4ee5\u53d1\u5e03\u65f6\u4e3a\u51c6\uff0c\u53ef\u80fd\u4f1a\u6709\u53d8\u52a8\u3002\u5728\u505a\u51fa\u4efb\u4f55\u6cbb\u7597\u51b3\u7b56\u4e4b\u524d\uff0c\u8bf7\u5728ClinicalTrials.gov\u4e0a\u6838\u5b9e\u6700\u65b0\u72b6\u6001\u3002   <\/em> <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"280\" src=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/08\/Updated_Clinical-Trials-Newsletter_Footer-2.png\" alt=\"\" class=\"wp-image-225460\" style=\"width:602px;height:auto\" srcset=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/08\/Updated_Clinical-Trials-Newsletter_Footer-2.png 600w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/08\/Updated_Clinical-Trials-Newsletter_Footer-2-300x140.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n<\/div>\n<h2 class=\"wp-block-heading\">2026\u5e748\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. Symbiotic-GI-03 \u2014 \u4e00\u9879\u9488\u5bf9\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u6f5c\u5728\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9<\/strong>\uff1aIII\u671f \/ \u5168\u7403\u7ea6210\u4e2a\u7814\u7a76\u7ad9\u70b9<br\/><strong>\u5206\u671f<\/strong>\uff1aIV\u671f\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u817a\u764c<br\/><strong>\u62db\u8058\u72b6\u6001<\/strong>\uff1a\u6b63\u5728\u62db\u8058<br\/><strong>\u7814\u7a76\u5185\u5bb9<\/strong>\uff1a\u8f89\u745e\u516c\u53f8<strong>\u6b63\u5728\u5f00\u5c55\u4e00\u9879<\/strong>III\u671f\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u4e00\u79cd\u6f5c\u5728\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u9002\u7528\u4e8e\u6b64\u524d\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u6297\u764c\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002 \u7814\u7a76\u836f\u7269PF-08634404\u662f\u4e00\u79cd\u6b63\u5728\u7814\u7a76\u4e2d\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff0c\u53ef\u540c\u65f6\u9776\u5411PD-1\uff08\u4e00\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\uff09\u548cVEGF\uff08\u4e00\u79cd\u4fc3\u8fdb\u80bf\u7624\u8840\u7ba1\u751f\u957f\u7684\u86cb\u767d\u8d28\uff09\u3002 \u7814\u7a76\u8ba4\u4e3a\uff0c\u901a\u8fc7\u4e0e\u8fd9\u4e9b\u86cb\u767d\u8d28\u7ed3\u5408\uff0c\u8be5\u7814\u7a76\u836f\u7269\u53ef\u80fd\u6709\u52a9\u4e8e\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\u5e76\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u540c\u65f6\u53ef\u80fd\u5ef6\u7f13\u80bf\u7624\u751f\u957f\u3002\u53d7\u8bd5\u8005\u5c06\u63a5\u53d7\u7814\u7a76\u836f\u7269\u8054\u5408\u5316\u7597\uff0c\u6216\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u6cbb\u7597\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981<\/strong>\uff1a\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4ecd\u662f\u7ed3\u76f4\u80a0\u764c\u5e38\u89c1\u7684\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u7597\u6548\u4ecd\u6709\u9650\u3002 \u5927\u591a\u6570\u7ed3\u76f4\u80a0\u764c\uff0c\u5c24\u5176\u662f\u975eMSI-H\/dMMR\u7684\u75c5\u4f8b\uff0c\u5bf9\u5355\u7528\u514d\u75ab\u6cbb\u7597\u65e0\u53cd\u5e94\u3002\u672c\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\uff0c\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u65b9\u6848\u76f8\u6bd4\uff0c\u8be5\u7814\u7a76\u836f\u7269\u7ec4\u5408\u80fd\u5426\u6539\u5584\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u88ab\u8bca\u65ad\u4e3a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e14\u5c1a\u672a\u5f00\u59cb\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u751f\uff0c\u4e86\u89e3\u50cfSymbiotic-GI-03\u8fd9\u6837\u7684\u4e00\u7ebf\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002 \u5efa\u8bae\u5bf9\u60a8\u7684\u80bf\u7624\u8fdb\u884c\u5173\u952e\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\uff0c\u5305\u62ecRAS\u3001BRAF V600E\u548cMSI\/dMMR\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u68c0\u6d4b\u7ed3\u679c\u6709\u52a9\u4e8e\u786e\u5b9a\u60a8\u662f\u5426\u7b26\u5408\u53c2\u4e0e\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6761\u4ef6\u3002   <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07222800\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NCT07222800<\/strong><\/a> | <a href=\"http:\/\/www.pfizerstudyforcrc.com\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>www.PfizerStudyforCRC.com<\/strong><\/a> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. INCA033890-303 \u2014 \u4e00\u7ebfMSS\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63a5\u53d7\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u5e76\u8054\u5408\u6216\u4e0d\u8054\u5408INCA33890\u7684\u6cbb\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a\u5fae\u536b\u661f <\/strong>\u7a33\u5b9a\u578b\uff08MSS\uff09\/\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\u578b\uff08pMMR\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b\u4e0d\u5305\u62ecMSI-H\/dMMR\u548cBRAF V600E  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1aIII\u671f <\/strong>\/\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7814\u7a76\u7ad9\u70b9\uff08\u7531Incyte\u8d5e\u52a9\uff09  <br\/><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u817a\u764c\uff0c\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aINCA033890-303 <\/strong>\u662f\u4e00\u9879 III \u671f\u968f\u673a\u3001\u53cc\u76f2\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u6807\u51c6\u4e00\u7ebf\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u4e0e\u8054\u5408\u6216\u4e0d\u8054\u5408 INCA033890\uff08\u4e00\u79cd\u9488\u5bf9 PD-1 \u548c TGF\u03b2R2 \uff08\u8f6c\u5316\u751f\u957f\u56e0\u5b50\u03b2\u53d7\u4f532\uff09\u3002\u8be5\u8bd5\u9a8c\u62db\u52df\u672a\u66fe\u63a5\u53d7\u8fc7\u8f6c\u79fb\u6027\u75be\u75c5\u5168\u8eab\u6027\u6cbb\u7597\u7684MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1aMSS\u578b\u7ed3\u76f4\u80a0 <\/strong>\u764c\u5360\u8f6c\u79fb\u6027\u75c5\u4f8b\u7684\u7edd\u5927\u591a\u6570\uff0c\u4e14\u5386\u6765\u5bf9\u514d\u75ab\u6cbb\u7597\u8010\u836f\u3002\u4e00\u4e2a\u5173\u952e\u539f\u56e0\u662f\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684TGF-\u03b2\u4fe1\u53f7\u4f20\u5bfc\u4f1a\u4e3b\u52a8\u6291\u5236\u514d\u75ab\u5e94\u7b54\u3002 INCA33890\u65e8\u5728\u901a\u8fc7\u7279\u5f02\u6027\u963b\u65ad\u540c\u65f6\u8868\u8fbePD-1\u7684\u514d\u75ab\u7ec6\u80de\u4e0a\u7684TGF-\u03b2R2\u53d7\u4f53\u6765\u89e3\u51b3\u8fd9\u4e00\u95ee\u9898\uff0c\u8fd9\u79cd\u9776\u5411\u6027\u66f4\u5f3a\u7684\u7b56\u7565\u4f18\u4e8e\u6b64\u524d\u4f1a\u5f15\u8d77\u663e\u8457\u6bd2\u6027\u7684TGF-\u03b2\u6291\u5236\u5242\u3002 \u4e0e Symbiotic-GI-03 \u548c HARMONi-GI3 \u4e00\u8d77\uff0c\u5b83\u662f\u76ee\u524d\u4ec5\u6709\u7684\u4e09\u9879\u65e8\u5728\u6539\u53d8 MSS \u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u7684 III \u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002     <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1aMSS\u662f <\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u6700\u5e38\u89c1\u7684\u751f\u7269\u6807\u5fd7\u7269\u8c31\uff0c\u5386\u53f2\u4e0a\u8fd9\u610f\u5473\u7740\u53ef\u9009\u7684\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u8f83\u5c11\u3002\u5982\u679c\u60a8\u7684\u8bca\u65ad\u7ed3\u679c\u4e0e\u6b64\u76f8\u4f3c\uff0c\u5728\u5f00\u59cb\u6807\u51c6\u6cbb\u7597\u4e4b\u524d\uff0c\u4e0d\u59a8\u5411\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u54a8\u8be2\u60a8\u6240\u5728\u5730\u533a\u662f\u5426\u53ef\u4ee5\u53c2\u52a0\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u5165\u7ec4\u6761\u4ef6\u4ec5\u9650\u4e8e\u4e00\u7ebf\u6cbb\u7597\u9636\u6bb5\uff0c\u56e0\u6b64\u5fc5\u987b\u5728\u5316\u7597\u5f00\u59cb\u524d\u4e0e\u533b\u751f\u8fdb\u884c\u6c9f\u901a\u3002    <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07284849\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NCT07284849<\/strong><\/a> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. ROSETTA CRC-203 \u2014 \u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0c\u666e\u7c73\u66ff\u5c3c\u8054\u5408\u5316\u7597\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u6bd4\u8f83<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a <\/strong>\u65e0dMMR\u3001MSI-H\u6216BRAF<strong>V600E\u7a81\u53d8\u7684\u4e00\u7ebf <\/strong>mCRC\uff08\u5e7f\u4e49MSS\/RAS\u4e9a\u7fa4\uff09<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1aII\/III\u671f <\/strong>\/ \u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7814\u7a76\u7ad9\u70b9\uff08\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\/BioNTech\uff09  <br\/><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aROSETTA <\/strong>CRC-203<strong>\u7814\u7a76 <\/strong>\u65e8\u5728\u8bc4\u4f30\u666e\u7c73\u5854\u7c73\u683c\uff08pumitamig\uff09\u2014\u2014\u4e00\u79cd\u540c\u65f6\u9776\u5411 PD-L1 \u548c VEGF-A \u7684\u5728\u7814\u53cc\u7279\u5f02\u6027\u6297\u4f53\u2014\u2014\u8054\u5408\u6807\u51c6\u5316\u7597\uff0c\u5e76\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u65b9\u6848\u8fdb\u884c\u5bf9\u6bd4\uff0c\u7814\u7a76\u5bf9\u8c61\u4e3a\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e14\u65e0 dMMR\u3001 MSI-H\u6216BRAF V600E\u7a81\u53d8\u7684\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\uff0c\u5c06\u666e\u7c73\u5854\u7c73\u683c\u8054\u5408\u6807\u51c6\u5316\u7597\u65b9\u6848\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u65b9\u6848\u8fdb\u884c\u5bf9\u6bd4\u30022026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u65e9\u671fII\u671f\u6570\u636e\u663e\u793a\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\uff0c\u8be5\u7814\u7a76\u76ee\u524d\u6b63\u5728\u62db\u52dfIII\u671f\u6ce8\u518c\u961f\u5217\u7684\u53d7\u8bd5\u8005\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1aPumitamig <\/strong>\u9776\u5411 PD-L1 \u800c\u975e PD-1\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u8fd9\u5728 MSS \u7ed3\u76f4\u80a0\u764c\u7684\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u53ef\u80fd\u5177\u6709\u4f18\u52bf\u3002 ASCO 2026\u4f1a\u8bae\u4e0a\u516c\u5e03\u7684\u4e2d\u671f\u6570\u636e\u5f15\u53d1\u4e86\u5e7f\u6cdb\u5173\u6ce8\uff0c\u800c\u53c2\u4e0e\u8be5\u8bd5\u9a8c\u7684III\u671f\u90e8\u5206\uff0c\u4e3a\u60a3\u8005\u63d0\u4f9b\u4e86\u5728\u8be5\u836f\u7269\u5c1a\u672a\u5b8c\u6210\u5173\u952e\u6027\u8bd5\u9a8c\u4e4b\u524d\u5c31\u83b7\u5f97\u6cbb\u7597\u7684\u65e9\u671f\u673a\u4f1a\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong>\u76ee\u524d\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e00\u7ebf\u6cbb\u7597\u7684\u7814\u7a76<strong>\u8fdb\u5c55\u8fc5\u901f <\/strong>\uff0c\u60f3\u8981\u8ddf\u4e0a\u8fd9\u4e9b\u8fdb\u5c55\u53ef\u80fd\u4f1a\u8ba9\u4eba\u611f\u5230\u4e0d\u77e5\u6240\u63aa\u3002 \u4ee5\u4e0b\u662f\u4e00\u4e2a\u503c\u5f97\u5728\u4e0b\u6b21\u5c31\u8bca\u65f6\u63d0\u51fa\u7684\u7b80\u5355\u95ee\u9898\uff1a\u201c\u662f\u5426\u6709\u4efb\u4f55\u9488\u5bf9\u4e00\u7ebf\u6cbb\u7597\u65b0\u8054\u5408\u65b9\u6848\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6211\u53ef\u80fd\u7b26\u5408\u53c2\u4e0e\u6761\u4ef6\uff1f\u201d\u5728\u6cbb\u7597\u5f00\u59cb\u524d\u5c3d\u65e9\u8be2\u95ee\uff0c\u662f\u552f\u4e00\u80fd\u786e\u5b9a\u50cfROSETTA CRC-203\u8fd9\u6837\u7684\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u7684\u65b9\u6cd5\u3002    <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07221357\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NCT07221357<\/strong><\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. MOUNTAINEER-03 \u2014 \u56fe\u5361\u66ff\u5c3c + \u66f2\u59a5\u73e0\u5355\u6297 + mFOLFOX6 \u7528\u4e8e HER2 \u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6cbb\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aHER2\u9633\u6027 <\/strong>\u3001RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u70b9\uff1aIII\u671f <\/strong>\/ \u5168\u740350\u591a\u4e2a\u8bd5\u9a8c\u70b9\uff0c\u5305\u62ec\u7f8e\u56fd  <br\/><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aMOUNTAINEER-03 \u8bd5\u9a8c\u65e8\u5728 <\/strong>\u8bc4\u4f30\u5728\u6807\u51c6\u4e00\u7ebf\u5316\u7597\u65b9\u6848\u4e2d\u8054\u5408\u4f7f\u7528\u56fe\u5361\u66ff\u5c3c\u548c\u66f2\u59a5\u73e0\u5355\u6297\uff08\u4e00\u79cd\u53cc\u91cd\u9776\u5411 HER2 \u7684\u8054\u5408\u7597\u6cd5\uff09\uff0c\u80fd\u5426\u6539\u5584\u7ea6 4% \u7684 HER2 \u6269\u589e\u3001RAS \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u9884\u540e\u3002 \u8fd9\u9879III\u671f\u8bd5\u9a8c\u5c06\u56fe\u5361\u66ff\u5c3c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u52a0mFOLFOX6\u65b9\u6848\u4e0e\u5f53\u524d\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u8fdb\u884c\u5bf9\u6bd4\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1aHER2\u9776\u5411 <\/strong>\u6cbb\u7597\u5df2\u663e\u793a\u51fa\u5bf9\u65e2\u5f80\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684HER2\u9633\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5177\u6709\u663e\u8457\u7597\u6548\u3002MOUNTAINEER-03\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\uff0c\u82e5\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u7684\u7b2c\u4e00\u7ebf\u5c31\u66f4\u65e9\u5f00\u59cbHER2\u9776\u5411\u6cbb\u7597\uff0c\u80fd\u5426\u8fdb\u4e00\u6b65\u5ef6\u957f\u8fd9\u4e9b\u7597\u6548\u3002 \u82e5\u7814\u7a76\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u8fd9\u5c06\u4e3a\u8be5\u751f\u7269\u6807\u5fd7\u7269\u4e9a\u7ec4\u786e\u7acb\u65b0\u7684\u9996\u7ebf\u6cbb\u7597\u6807\u51c6\u3002    <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong>\u521d\u6b21\u786e\u8bca\u65f6<strong>\uff0cHER2 <\/strong>\u68c0\u6d4b\u5e76\u4e0d\u603b\u662f\u4f1a\u81ea\u52a8\u5305\u542b\u5728\u5185\u3002\u5982\u679c\u60a8\u5df2\u6536\u5230\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7ed3\u679c\uff0c\u4f46\u4e0d\u786e\u5b9a\u662f\u5426\u8fdb\u884c\u4e86HER2\u68c0\u6d4b\uff0c\u8bf7\u52a1\u5fc5\u5177\u4f53\u8be2\u95ee\u3002\u8fd9\u662f\u4e00\u4e2a\u7b80\u5355\u7684\u95ee\u9898\uff0c\u4f46\u7b54\u6848\u53ef\u80fd\u81f3\u5173\u91cd\u8981\u2014\u2014\u7279\u522b\u662f\u5f53\u60a8\u5c5e\u4e8eRAS\u91ce\u751f\u578b\u65f6\u3002 \u60a8\u7684\u533b\u7597\u56e2\u961f\u53ef\u4ee5\u5b89\u6392\u8fd9\u9879\u68c0\u6d4b\uff0c\u8fd9\u5c06\u5e2e\u52a9\u60a8\u660e\u786e\u81ea\u5df1\u53ef\u80fd\u7b26\u5408\u54ea\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5165\u7ec4\u6761\u4ef6\uff0c\u4ece\u800c\u907f\u514d\u76f2\u76ee\u731c\u6d4b\u3002     <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05253651\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NCT05253651<\/strong><\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>5. FRUITFUL \u2014\u2014 \u5f17\u9c81\u6606\u66ff\u5c3c\u8054\u5408FOLFIRI\u65b9\u6848\u4f5c\u4e3a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e8c\u7ebf\u6cbb\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a <\/strong>\u65e0BRAF<strong>V <\/strong>600E<strong>\u7a81\u53d8\u7684MSS\/pMMR\u578b\u7ed3\u76f4\u80a0\u764c <\/strong>\uff1b\u65e2\u5f80\u66fe\u63a5\u53d7\u5965\u6c99\u5229\u94c2\u3001\u6c1f\u5627\u5576\u7c7b\u836f\u7269\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a <\/strong>\u7b2c\u4e8c<strong>\u9636\u6bb5 <\/strong>\/ \u5206\u5e03\u4e8e9\u4e2a\u5dde\u768414\u4e2a\u7f8e\u56fd\u7814\u7a76\u7ad9\u70b9\uff08\u7531SCRI\u8d5e\u52a9\uff09  <br\/><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4e8c\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aFRUITFUL <\/strong>\u662f\u4e00\u9879 II \u671f\u7814\u7a76\uff0c<strong>\u65e8\u5728\u8bc4\u4f30\u5df2\u83b7 <\/strong>FDA \u6279\u51c6\u7684\u53e3\u670d VEGFR \u6291\u5236\u5242\u5f17\u9c81\u6606\u66ff\u5c3c\uff08fruquintinib\uff09\u8054\u5408 FOLFIRI \u5316\u7597\u65b9\u6848\uff0c\u4f5c\u4e3a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e8c\u7ebf\u6cbb\u7597\u3002 \u53d7\u8bd5\u8005\u5fc5\u987b\u5df2\u5b8c\u6210\u4ee5\u5965\u6c99\u5229\u94c2\u3001\u6c1f\u5627\u5576\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u8be5\u7814\u7a76\u65e8\u5728\u9a8c\u8bc1\u5728\u6807\u51c6\u7684\u4e8c\u7ebfFOLFIRI\u57fa\u7840\u65b9\u6848\u4e2d\u6dfb\u52a0\u5f17\u9c81\u6606\u66ff\u5c3c\uff0c\u80fd\u5426\u6539\u5584\u4e00\u7ebf\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\u60a3\u8005\u7684\u9884\u540e\u3002    <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u5f17\u9c81\u6606\u66ff\u5c3c\uff08Fruquintinib\uff09 <\/strong>\u5df2\u83b7\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff0c\u4f5c\u4e3a\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u540e\u671f\u5355\u836f\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u8fd9\u9879\u8bd5\u9a8c\u65e8\u5728\u63a2\u7d22\uff0c\u5f53\u5c06\u5176\u4e0e\u5316\u7597\u5728\u6cbb\u7597\u6d41\u7a0b\u7684\u65e9\u671f\u9636\u6bb5\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u5176\u6297\u8840\u7ba1\u751f\u6210\u673a\u5236\u662f\u5426\u80fd\u53d1\u6325\u66f4\u4f73\u7597\u6548\u3002 \u5bf9\u4e8e\u5df2\u5b8c\u6210\u4e00\u7ebf\u6cbb\u7597\u5e76\u6b63\u5728\u89c4\u5212\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u7684\u60a3\u8005\u800c\u8a00\uff0c\u8fd9\u4e3a\u4ed6\u4eec\u5728\u5173\u952e\u7684\u6cbb\u7597\u8fc7\u6e21\u9636\u6bb5\u83b7\u5f97\u65b0\u578b\u8054\u5408\u7597\u6cd5\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u610f\u4e49\u7684\u673a\u4f1a\u3002\u8be5\u8bd5\u9a8c\u8986\u76d6\u4e5d\u4e2a\u5dde\uff0c\u4f7f\u5176\u6210\u4e3a\u76ee\u524d\u6b63\u5728\u62db\u52df\u60a3\u8005\u4e14\u5730\u7406\u8986\u76d6\u8303\u56f4\u8f83\u5e7f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002    <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u521a\u521a\u5b8c\u6210\u4e00\u7ebf\u6cbb\u7597\uff0c\u4e14\u764c\u75c7\u5df2\u51fa\u73b0\u8fdb\u5c55\uff0c\u90a3\u4e48\u5728\u4e0b\u6b21\u5c31\u8bca\u65f6\uff0c\u4e0d\u59a8\u4e3b\u52a8\u8be2\u95ee\u4e00\u4e0b\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u5165\u7ec4\u6807\u51c6\u76f8\u5f53\u7b80\u5355\uff1a\u65e2\u5f80\u63a5\u53d7\u8fc7\u4ee5\u5965\u6c99\u5229\u94c2\u4e3a\u57fa\u7840\u7684\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\uff0c\u4e14\u672a\u66fe\u63a5\u53d7\u8fc7\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u3002\u5165\u7ec4\u65e0\u9700\u7279\u5b9a\u7684\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7ed3\u679c\uff0c\u8fd9\u4f7f\u5f97\u8be5\u8bd5\u9a8c\u76ee\u524d\u6210\u4e3a\u9762\u5411\u66f4\u5e7f\u6cdb\u60a3\u8005\u7fa4\u4f53\u3001\u53c2\u4e0e\u95e8\u69db\u8f83\u4f4e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002    <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07011576\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>NCT07011576<\/strong><\/a><\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"478\" src=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png\" alt=\"\" class=\"wp-image-213123\" style=\"width:602px;height:auto\" srcset=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png 1024w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-300x140.png 300w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-768x358.png 768w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1.png 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<h2 class=\"wp-block-heading\"><strong>2026\u5e747\u6708<\/strong> <\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. OrigAMI-1 \u2014 \u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6216\u8054\u5408\u5316\u7597\u6cbb\u7597\u5316\u7597\u96be\u6cbb\u6027RAS\/BRAF\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aRAS\/BRAF <\/strong>\u91ce\u751f\u578b\u4e14HER2\u672a\u6269\u589e\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b\u8bc4\u4f30\u4e86\u80bf\u7624\u4fa7\u522b  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1aIb\/II\u671f <\/strong>\/ \u56fd\u9645\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7684\u7814\u7a76\u7ad9\u70b9  <br\/><strong>\u75c5\u671f\uff1a\u665a\u671f <\/strong>\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u6b64\u524d\u5df2\u63a5\u53d7\u8fc7\u4e24\u81f3\u4e09\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u52df\u72b6\u6001\uff1a\u6d3b\u8dc3 <\/strong>\uff0c\u6b63\u5728\u8fdb\u884c\u4e2d\uff08\u8054\u5408\u5316\u7597\u7ec4\uff09  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a <\/strong>OrigAMI-1\u662f\u4e00\u9879\u57fa\u7840\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\uff08\u4e00\u79cd\u540c\u65f6\u9776\u5411EGFR\u548cMET\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u7684\u7597\u6548\uff0c\u8be5\u836f\u7269\u53ef\u5355\u72ec\u4f7f\u7528\uff0c\u4e5f\u53ef\u4e0emFOLFOX6\u6216FOLFIRI\u5316\u7597\u65b9\u6848\u8054\u5408\u4f7f\u7528\uff0c\u9002\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u8fc7\u4e24\u81f3\u4e09\u7ebf\u6cbb\u7597\u7684RAS\/BRAF\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a <\/strong>\u57282026\u5e74ASCO GI\u5e74\u4f1a\u4e0a<strong>\u516c\u5e03\u7684\u6700\u65b0 <\/strong>\u7ed3\u679c\u663e\u793a\uff0c\u4e00\u7ebf\u8054\u5408\u5316\u7597\u4e9a\u7ec4\u4e2d\u8d85\u8fc770%\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u7597\u6548\u53cd\u5e94\uff0c\u4e14\u5927\u591a\u6570\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u8d85\u8fc716\u4e2a\u6708\uff1b\u6b63\u662f\u8fd9\u4e9b\u7ed3\u679c\u4fc3\u6210\u4e86\u4e24\u9879\u5173\u952e\u6027III\u671f\u7814\u7a76\uff08OrigAMI-2\u548cOrigAMI-3\uff0c\u8be6\u89c1\u4e0b\u6587\uff09\u7684\u542f\u52a8\uff0c\u76ee\u524d\u8fd9\u4e24\u9879\u7814\u7a76\u6b63\u5728\u62db\u52df\u53d7\u8bd5\u8005\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u60a3\u6709RAS\/BRAF\u91ce\u751f\u578b\u7ed3\u76f4\u80a0\u764c\uff0c\u4e14\u5df2\u63a5\u53d7\u8fc7\u591a\u7ebf\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u7597\u56e2\u961f\uff0c\u4e86\u89e3\u7814\u7a76\u65b0\u578bEGFR\u9776\u5411\u8054\u5408\u7597\u6cd5\u7684\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u4ecd\u5728\u62db\u52df\u60a3\u8005\u3002<br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05379595\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05379595 <\/a> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. OrigAMI-2 \u2014 \u5de6\u4fa7RAS\/BRAF\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0c\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408\u5316\u7597\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u7684\u6bd4\u8f83<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u91cd\u70b9\uff1aRAS\/BRAF <\/strong>\u91ce\u751f\u578b\uff08KRAS\u3001NRAS\u548cBRAF\u5747\u4e3a\u91ce\u751f\u578b\uff09\uff1b\u5de6\u4fa7\u539f\u53d1\u80bf\u7624  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1aIII\u671f <\/strong>\/ \u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7684\u7814\u7a76\u7ad9\u70b9  <br\/><strong>\u5206\u671f\uff1a\u4e0d\u53ef\u5207\u9664 <\/strong>\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff0c\u4e00\u7ebf\u6cbb\u7597  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aOrigAMI-2 \u7814\u7a76\u65e8\u5728 <\/strong>\u6bd4\u8f83\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408\u5316\u7597\uff08mFOLFOX6 \u6216 FOLFIRI\uff09\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u4f5c\u4e3a\u5de6\u4fa7 RAS\/BRAF \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u7684\u7597\u6548\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a <\/strong>\u5bf9\u4e8e\u8fd9\u4e00\u60a3\u8005\u7fa4\u4f53<strong>\uff0c\u6297EGFR\u7597\u6cd5 <\/strong>\u8054\u5408\u5316\u7597\u5df2\u662f\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff0c\u4f46\u5927\u591a\u6570\u60a3\u8005\u6700\u7ec8\u4f1a\u51fa\u73b0\u8010\u836f\u6027\u3002ESMO GI 2026\u4f1a\u8bae\u7684\u6570\u636e\u8868\u660e\uff0c\u6db2\u4f53\u6d3b\u68c0\u53ef\u76d1\u6d4b\u8fd9\u79cd\u8010\u836f\u6027\u7684\u53d1\u5c55\uff1bOrigAMI-2\u7814\u7a76\u6b63\u5728\u63a2\u7d22\uff0c\u4ece\u6cbb\u7597\u521d\u671f\u540c\u65f6\u9776\u5411EGFR\u548cMET\u662f\u5426\u80fd\u5ef6\u7f13\u8010\u836f\u6027\u7684\u51fa\u73b0\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c <\/strong>\u60a8\u7684\u80bf\u7624\u4e3aRAS\/BRAF\u91ce\u751f\u578b\u4e14\u4f4d\u4e8e\u5de6\u4fa7\uff0c\u5728\u5f00\u59cb\u6807\u51c6\u6cbb\u7597\u524d\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u7597\u56e2\u961f\uff0c\u4e86\u89e3\u662f\u5426\u6709\u9488\u5bf9\u65b0\u4e00\u4ee3EGFR\u9776\u5411\u7597\u6cd5\u7684\u4e00\u7ebf\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06662786\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06662786<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. OrigAMI-3 \u2014 \u963f\u7c73\u4e07\u5854\u9a6c\u5e03 + FOLFIRI \u4e0e \u897f\u59a5\u6614\u5355\u6297\u6216\u8d1d\u4f10\u5355\u6297 + FOLFIRI \u5728 RAS\/BRAF \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e8c\u7ebf\u6cbb\u7597\u4e2d\u7684\u6bd4\u8f83<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aRAS\/BRAF <\/strong>\u91ce\u751f\u578b\uff08KRAS\u3001NRAS\u548cBRAF\u5747\u4e3a\u91ce\u751f\u578b\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u673a\u6784\uff1aIII\u671f <\/strong>\/ \u5168\u7403\u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7684\u7814\u7a76\u673a\u6784\uff08\u798f\u514b\u65af\u8521\u65af\u764c\u75c7\u4e2d\u5fc3\u3001\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u7b49\uff09  <br\/><strong>\u5206\u671f\uff1a\u4e00\u7ebf\u5316\u7597\u540e\u590d\u53d1 <\/strong>\u3001\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1aOrigAMI-3 \u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30 <\/strong>\u76ae\u4e0b\u7ed9\u836f\u7684\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408 FOLFIRI \u65b9\u6848\uff0c\u4e0e\u6807\u51c6\u4e8c\u7ebf\u6cbb\u7597\uff08\u897f\u59a5\u6614\u5355\u6297\u6216\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408 FOLFIRI\uff09\u76f8\u6bd4\uff0c\u5728\u63a5\u53d7\u4e00\u7ebf\u5316\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684 RAS\/BRAF \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684<strong>\u7597\u6548 <\/strong>\u3002  <br\/><strong>\u91cd\u8981\u6027\uff1aMET\u57fa\u56e0 <\/strong>\u6269\u589e\u662f\u5df2\u77e5\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u5728\u7ecf\u5386\u4e00\u7ebf\u6cbb\u7597\u540e\u5bf9\u6297EGFR\u6cbb\u7597\u4ea7\u751f\u8010\u836f\u6027\u7684\u673a\u5236\u4e4b\u4e00<strong>\uff1b <\/strong>\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u540c\u65f6\u9776\u5411EGFR\u548cMET\uff0c\u4e14\u57282026\u5e74ASCO\u80c3\u80a0\u764c\u4f1a\u8bae\u4e0a\u516c\u5e03\u76841b\/2\u671f\u7814\u7a76\u6570\u636e\u663e\u793a\uff0c\u5373\u4f7f\u5728\u63a5\u53d7\u8fc7\u6297EGFR\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u8be5\u836f\u7269\u4e5f\u8868\u73b0\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u60a3\u6709RAS\/BRAF\u91ce\u751f\u578b\u7ed3\u76f4\u80a0\u764c\uff0c\u4e14\u5728\u4e00\u7ebf\u6cbb\u7597\u671f\u95f4\u75c5\u60c5\u8fdb\u5c55\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u7597\u56e2\u961f\uff0c\u4e86\u89e3\u9488\u5bf9EGFR\u548cMET\u7684\u53cc\u91cd\u9776\u5411\u4e8c\u7ebf\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06750094\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06750094<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. \u535a\u817e\u897f\u5229\u5355\u6297 + \u5df4\u65af\u5229\u5355\u6297 + \u6a21\u62df\u7981\u98df\u996e\u98df + \u7ef4\u751f\u7d20C\u7528\u4e8eKRAS\u7a81\u53d8\u578bMSS\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aKRAS\u7a81\u53d8 <\/strong>\u3001\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1aIb\u671f <\/strong>\/ \u5357\u52a0\u5dde\u5927\u5b66\uff08\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde\u6d1b\u6749\u77f6\uff09  <br\/><strong>\u75c5\u671f\uff1a <\/strong>\u65e2\u5f80\u63a5\u53d7\u8fc7\u6c1f\u5627\u5576\u3001\u5965\u6c99\u5229\u94c2\u548c\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u540e\u7684<strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c <\/strong> <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30 <\/strong>\u535a\u6ed5\u897f\u5229\u5355\u6297\uff08botensilimab\uff09\u548c\u5df4\u5c14\u65af\u5229\u5355\u6297\uff08balstilimab\uff09\u8054\u5408\u6a21\u62df\u7981\u98df\u996e\u98df\uff08\u4e00\u79cd\u7ed3\u6784\u5316\u7684\u3001\u4ee5\u690d\u7269\u4e3a\u57fa\u7840\u7684\u3001\u4f4e\u70ed\u91cf\u996e\u98df\u65b9\u6848\uff09\u53ca\u5927\u5242\u91cf\u9759\u8109\u6ce8\u5c04\u7ef4\u751f\u7d20C\uff0c\u5bf9KRAS\u7a81\u53d8\u578bMSS\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u7597\u6548\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1aESMO <\/strong>GI 2026\u4f1a\u8bae\u516c\u5e03\u4e86\u535a\u66ff\u897f\u5229\u5355\u6297\u8054\u5408\u5df4\u66ff\u897f\u5229\u5355\u6297\u6cbb\u7597MSS\u578b\u7ed3\u76f4\u80a0\u764c\u7684\u4e09\u5e74\u751f\u5b58\u6570\u636e<strong>\uff1b <\/strong>\u8be5\u8bd5\u9a8c\u65e8\u5728\u63a2\u8ba8\u662f\u5426\u901a\u8fc7\u6dfb\u52a0\u4ee3\u8c22\u5e72\u9884\u7b56\u7565\uff0c\u53ef\u5c06\u8fd9\u4e00\u83b7\u76ca\u6269\u5c55\u81f3KRAS\u7a81\u53d8\u60a3\u8005\u2014\u2014\u8fd9\u7c7b\u60a3\u8005\u5728MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u75c5\u4f8b\u4e2d\u5360\u5f88\u5927\u6bd4\u4f8b\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c <\/strong>\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSS\u578b\u4e14\u643a\u5e26KRAS\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u533b\u7597\u56e2\u961f\uff0c\u4e86\u89e3\u662f\u5426\u6709\u5c06\u514d\u75ab\u6cbb\u7597\u4e0e\u8425\u517b\u6216\u4ee3\u8c22\u7b56\u7565\u76f8\u7ed3\u5408\u7684\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u4f9b\u60a8\u53c2\u4e0e\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06336902\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06336902<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"> <strong>5. \u535a\u6ed5\u897f\u5229\u5355\u6297 + \u5df4\u5c14\u65af\u5229\u5355\u6297 + \u7acb\u4f53\u5b9a\u5411\u653e\u5c04\u6cbb\u7597\uff08SBRT\uff09\u7528\u4e8e\u6cbb\u7597\u4f34\u6709\u809d\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a\u975eMSI-H\u6216 <\/strong>\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\uff08pMMR\uff09\u4e14\u4f34\u6709\u809d\u8f6c\u79fb\u7684\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a\u8bd5\u70b9 <\/strong>\u7814\u7a76 \/ \u9a6c\u8428\u8bf8\u585e\u5dde\u603b\u533b\u9662\uff08\u9a6c\u8428\u8bf8\u585e\u5dde\u6ce2\u58eb\u987f\uff09  <br\/><strong>\u5206\u671f\uff1a <\/strong>\u4f34\u6709\u809d\u8f6c\u79fb\u7684<strong>\u8f6c\u79fb\u6027 <\/strong>\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong> <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a\u8be5\u7814\u7a76 <\/strong>\u8bc4\u4f30\u4e86\u535a\u817e\u897f\u5229\u5355\u6297\uff08botensilimab\uff09\u548c\u5df4\u5c14\u65af\u5229\u5355\u6297\uff08balstilimab\uff09\u8054\u5408\u7acb\u4f53\u5b9a\u5411\u4f53\u90e8\u653e\u5c04\u6cbb\u7597\uff08SBRT\uff09\u6cbb\u7597\u4e2d\u5ea6\u654f\u611f\u578b\uff08MSS\uff09\u6216\u5047\u6027MMR\u578b\uff08pMMR\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u809d\u8f6c\u79fb\u7684\u60c5\u51b5\uff0c\u65e8\u5728\u63a2\u7a76\u5728\u514d\u75ab\u6cbb\u7597\u5355\u72ec\u4f7f\u7528\u6548\u679c\u6b20\u4f73\u7684\u60c5\u51b5\u4e0b\uff0c\u7cbe\u51c6\u9776\u5411\u653e\u5c04\u6cbb\u7597\u80fd\u5426\u6fc0\u6d3b\u514d\u75ab\u5e94\u7b54\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u8fd9\u9879 <\/strong>\u4e3a\u671f\u4e09\u5e74\u7684ESMO GI 2026 BOT\/BAL\u7814\u7a76\u6570\u636e\u6765\u6e90\u4e8e\u65e0\u6d3b\u52a8\u6027\u809d\u8f6c\u79fb\u7684\u60a3\u8005\uff1b\u809d\u810f\u53d7\u7d2f\u4e0eMSS\u578b\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u514d\u75ab\u6cbb\u7597\u5e94\u7b54\u7387\u8f83\u4f4e\u76f8\u5173\uff0c\u800c\u8be5\u8bd5\u9a8c\u76f4\u63a5\u586b\u8865\u4e86\u8fd9\u4e00\u7814\u7a76\u7a7a\u767d\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c <\/strong>\u60a8\u7684\u764c\u75c7\u5df2\u8f6c\u79fb\u81f3\u809d\u810f\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff0c\u60a8\u7684\u6cbb\u7597\u4e2d\u5fc3\u662f\u5426\u63d0\u4f9b\u5c06\u653e\u7597\u4e0e\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\u76f8\u7ed3\u5408\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07128355\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07128355 <\/a> <\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"478\" src=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png\" alt=\"\" class=\"wp-image-213123\" style=\"width:664px;height:auto\" srcset=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png 1024w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-300x140.png 300w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-768x358.png 768w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1.png 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<h2 class=\"wp-block-heading\">2026\u5e746\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. HARMONi-GI3 \u2014 \u4f0a\u6c83\u5185\u897f\u5355\u6297\u8054\u5408mFOLFOX6\u65b9\u6848\u7528\u4e8e\u4e00\u7ebf\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1b\u514d\u75ab\u7597\u6cd5\u4e0eVEGF\u901a\u8def\u6cbb\u7597\u7b56\u7565<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>III\u671f\/\u591a\u4e2d\u5fc3<br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong><br\/><strong>\u5b83\u7814\u7a76\u7684\u5185\u5bb9\uff1a<\/strong><br\/>\u672c\u7814\u7a76\u6bd4\u8f83\u4e86\u4f0a\u6c83\u897f\u5355\u6297\u8054\u5408 mFOLFOX6 \u5316\u7597\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408 mFOLFOX6 \u5316\u7597\u5728\u5c1a\u672a\u63a5\u53d7\u5168\u8eab\u6cbb\u7597\u7684\u8f6c\u79fb\u6027 CRC \u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong><br\/>\u9996\u6b21\u6cbb\u7597\u51b3\u7b56\u5f80\u5f80\u4ee4\u4eba\u611f\u5230\u8feb\u5728\u7709\u776b\u4e14\u4e0d\u77e5\u6240\u63aa\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\uff0c\u5c06\u5316\u7597\u4e0e\u4e00\u79cd\u540c\u65f6\u9488\u5bf9\u514d\u75ab\u53cd\u5e94\u548c\u80bf\u7624\u8840\u7ba1\u751f\u957f\u7684\u6cbb\u7597\u65b9\u6cd5\u76f8\u7ed3\u5408\uff0c\u662f\u5426\u80fd\u63d0\u4f9b\u53e6\u4e00\u79cd\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><br\/>\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201c\u6211\u662f\u5426\u4e86\u89e3\u81ea\u5df1\u7684MSI\/MMR\u72b6\u6001\uff1f\u662f\u5426\u6709\u7b26\u5408\u6211\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u76ee\u6807\u7684\u4e00\u7ebf\u4e34\u5e8a\u8bd5\u9a8c\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07228832\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07228832<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. BAY 3771249 \u2014 \u9488\u5bf9KRAS G12D\u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u9776\u5411\u6cbb\u7597<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aKRAS <\/strong>G12D\u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a <\/strong>\u7b2c\u4e00<strong>\u9636\u6bb5 <\/strong>\/\u591a\u4e2d\u5fc3<br\/><strong>\u5206\u671f\uff1a\u665a\u671f <\/strong>\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6b63\u5728\u62db\u8058 <\/strong><br\/><strong>\u5b83\u7814\u7a76\u7684\u5185\u5bb9\uff1a<br\/><\/strong>\u672c\u7814\u7a76\u6b63\u5728\u8bc4\u4f30 BAY 3771249\uff0c\u8fd9\u662f\u4e00\u79cd\u7814\u7a76\u6027\u6cbb\u7597\u836f\u7269\uff0c\u6b63\u5728\u5355\u72ec\u6216\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u60a3\u6709 KRAS G12D \u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027 CRC \u60a3\u8005\u3002<br\/><strong>\u4e3a\u4ec0\u4e48\u8fd9\u5f88\u91cd\u8981\uff1a<br\/><\/strong> KRAS G12D \u7684\u9776\u5411\u6cbb\u7597\u9009\u62e9\u6709\u9650\u3002\u8fd9\u9879\u8bd5\u9a8c\u53cd\u6620\u4e86\u4eba\u4eec\u65e5\u76ca\u91cd\u89c6\u5f00\u53d1\u57fa\u4e8e\u7279\u5b9a KRAS \u7a81\u53d8\uff08\u9a71\u52a8\u764c\u75c7\u53d1\u751f\u7684\u5177\u4f53\u7a81\u53d8\uff09\u7684\u6cbb\u7597\u65b9\u6cd5\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<br\/><\/strong>\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201c\u6211\u662f\u5426\u643a\u5e26KRAS G12D\u7a81\u53d8\uff1f\u662f\u5426\u6709\u4e13\u95e8\u9488\u5bf9\u8fd9\u4e00\u4e9a\u578b\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07535112\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07535112<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. SGN-CEACAM5C \u2014 \u9776\u5411CEACAM5\u7684\u6297\u4f53\u836f\u7269\u5076\u8054\u7269<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>CEACAM5\u7684\u8868\u8fbe<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e00\u9636\u6bb5 \/ \u4e0e\u7f8e\u56fd\u7814\u7a76\u5730\u70b9\u5408\u4f5c\u7684\u56fd\u9645\u7814\u7a76<br\/><strong>\u9636\u6bb5\uff1a<\/strong>\u665a\u671f\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\u961f\u5217<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong><br\/>\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30SGN-CEACAM5C\uff08\u53c8\u79f0PF-08046050\uff09\u5728\u665a\u671f\u5b9e\u4f53\u7624\u6210\u4eba\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u5176\u4e2d\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u7fa4\u4f53\u3002\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u7684\u8bbe\u8ba1\u65e8\u5728\u5c06\u836f\u7269\u66f4\u76f4\u63a5\u5730\u8f93\u9001\u81f3\u5177\u6709\u7279\u5b9a\u9776\u70b9\u7684\u764c\u7ec6\u80de\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong><br\/>\u5f53\u6807\u51c6\u6cbb\u7597\u4e0d\u518d\u6709\u6548\u65f6\uff0c\u60a3\u8005\u901a\u5e38\u5e0c\u671b\u4e86\u89e3\u76ee\u524d\u6b63\u5728\u7814\u7a76\u7684\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5c31\u662f\u63a2\u7d22\u9488\u5bf9\u665a\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u66f4\u5177\u9776\u5411\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\u7684\u7814\u7a76\u4e4b\u4e00\u3002 <br\/><strong>\u60a3\u8005\u5c0f\u8d34\u58eb\uff1a<\/strong><br\/>\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u8be2\u95ee\uff1a\u201c\u662f\u5426\u5df2\u5bf9\u6211\u7684\u80bf\u7624\u8fdb\u884c\u4e86\u6807\u5fd7\u7269\u68c0\u6d4b\uff0c\u4ee5\u5e2e\u52a9\u786e\u5b9a\u6211\u662f\u5426\u9002\u5408\u53c2\u52a0\u9776\u5411\u6cbb\u7597\u6216\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u4e34\u5e8a\u8bd5\u9a8c\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06131840\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06131840<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. EMPIRE \/ NSABP FC-13 \u2014 \u9488\u5bf9ctDNA\u9633\u6027\u5fae\u5c0f\u6b8b\u7559\u75c5\u7684\u514d\u75ab\u6cbb\u7597<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u540ectDNA\u9633\u6027\u7684\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>II\u671f\/\u591a\u4e2d\u5fc3<br\/><strong>\u5206\u671f\uff1a<\/strong>\u7ecf\u6839\u6cbb\u6027\u624b\u672f\u548c\u5316\u7597\u540e\u7684\u7ed3\u76f4\u80a0\u764c\uff0c\u4e14ctDNA\u68c0\u6d4b\u5448\u9633\u6027<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058<br\/><strong>\u5b83\u7814\u7a76\u7684\u5185\u5bb9\uff1a<\/strong><br\/> EMPIRE \u7814\u7a76\u6b63\u5728\u63a2\u7d22 cemiplimab \u5355\u836f\u6cbb\u7597\u6216\u4e0e\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\u8054\u5408\u6cbb\u7597\uff0c\u7528\u4e8e\u6cbb\u7597\u624b\u672f\u548c\u5316\u7597\u540e ctDNA \u9633\u6027\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002ctDNA \u662f\u80bf\u7624 DNA\uff0c\u6709\u65f6\u53ef\u901a\u8fc7\u8840\u6db2\u68c0\u6d4b\u53d1\u73b0\u3002 <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong><br\/>\u8bb8\u591a\u60a3\u8005\u60f3\u4e86\u89e3ctDNA\u68c0\u6d4b\u7ed3\u679c\u5bf9\u590d\u53d1\u98ce\u9669\u53ca\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u610f\u5473\u7740\u4ec0\u4e48\u3002\u8fd9\u9879\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\uff0c\u5bf9\u4e8ectDNA\u9633\u6027\u4e14\u5b58\u5728\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u57fa\u4e8e\u514d\u75ab\u7597\u6cd5\u7684\u6cbb\u7597\u80fd\u5426\u5e2e\u52a9\u5ef6\u7f13\u6216\u9884\u9632\u75be\u75c5\u590d\u53d1\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><br\/>\u5982\u679c\u60a8\u5df2\u5b8c\u6210\u624b\u672f\u548c\u5316\u7597\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201cctDNA\u68c0\u6d4b\u662f\u5426\u9002\u5408\u6211\uff1f\u5982\u679c\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u662f\u5426\u4f1a\u6539\u53d8\u6211\u7684\u968f\u8bbf\u8ba1\u5212\u6216\u4e34\u5e8a\u8bd5\u9a8c\u9009\u62e9\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07058012\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07058012<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>5. KANDLELIT-012 \u2014 \u5361\u5fb7\u62c9\u897f\u5e03\uff08MK-1084\uff09+ \u897f\u59a5\u6614\u5355\u6297 + mFOLFOX6 \u7528\u4e8e\u6cbb\u7597 KRAS G12C \u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>KRAS G12C\u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>III\u671f\/\u591a\u4e2d\u5fc3<br\/><strong>\u5206\u671f\uff1a<\/strong>\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058<br\/><strong>\u5b83\u7814\u7a76\u7684\u5185\u5bb9\uff1a<\/strong><br\/>\u672c\u7814\u7a76\u8bc4\u4f30\u4e86\u5728 KRAS G12C \u7a81\u53d8\u578b CRC \u4e2d\uff0c\u4f7f\u7528 calderasib\uff08\u4e5f\u79f0\u4e3a MK-1084\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u548c mFOLFOX6 \u5316\u7597\u4e0e\u4f7f\u7528\u6216\u4e0d\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u7684 mFOLFOX6 \u5316\u7597\u7684\u7597\u6548\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong><br\/>KRAS\u7a81\u53d8\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e2d\u5f88\u5e38\u89c1\uff0c\u4f46\u5e76\u975e\u6240\u6709KRAS\u7a81\u53d8\u90fd\u76f8\u540c\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e13\u6ce8\u4e8eKRAS G12C\u7a81\u53d8\uff0c\u4f53\u73b0\u4e86\u6cbb\u7597\u65b9\u6848\u4e0e\u7279\u5b9a\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\u76f8\u5339\u914d\u7684\u53d1\u5c55\u8d8b\u52bf\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><br\/>\u5982\u679c\u60a8\u7684\u533b\u7597\u56e2\u961f\u544a\u77e5\u60a8\u7684\u80bf\u7624\u5b58\u5728KRAS\u7a81\u53d8\uff0c\u8bf7\u8be2\u95ee\uff1a\u201c\u6211\u643a\u5e26\u7684\u662f\u54ea\u79cdKRAS\u7a81\u53d8\uff1f\u8fd9\u4e00\u5177\u4f53\u68c0\u6d4b\u7ed3\u679c\u662f\u5426\u4f7f\u6211\u7b26\u5408\u53c2\u4e0e\u4efb\u4f55\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6761\u4ef6\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06997497\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06997497<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>6. \u7814\u7a76\u52a8\u6001\uff1aCRDF-004 \u2014 \u5965\u4e07\u585e\u66ff\u5e03\u8054\u5408\u5316\u7597\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597RAS\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>KRAS \u6216 NRAS \u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>II\u671f \/ \u7f8e\u56fd\u591a\u4e2d\u5fc3\u7814\u7a76<br\/><strong>\u5206\u671f\uff1a<\/strong>\u4e00\u7ebf\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058<br\/><strong>\u5b83\u7814\u7a76\u7684\u5185\u5bb9\uff1a<\/strong><br\/> CRDF-004 \u7814\u7a76 onvansertib \u8054\u5408\u6807\u51c6\u5316\u7597\u548c\u8d1d\u4f10\u5355\u6297\u6cbb\u7597\u60a3\u6709 KRAS \u6216 NRAS \u7a81\u53d8\u7684\u8f6c\u79fb\u6027 CRC \u6210\u5e74\u60a3\u8005\u7684\u7597\u6548\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong><br\/>RAS\u7a81\u53d8\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u8f83\u4e3a\u5e38\u89c1\uff0c\u7814\u7a76\u4eba\u5458\u4ecd\u5728\u6301\u7eed\u63a2\u7d22\u66f4\u4f18\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002\u5c3d\u7ba1\u8be5\u8bd5\u9a8c\u76ee\u524d\u5df2\u505c\u6b62\u62db\u52df\u60a3\u8005\uff0c\u4f46\u4ecd\u503c\u5f97\u6301\u7eed\u5173\u6ce8\uff0c\u56e0\u4e3a\u57282026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\uff0cCRDF-004\u8bd5\u9a8c\u9488\u5bf9RAS\u7a81\u53d8\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u516c\u5e03\u4e86\u4e2d\u671f\u7ed3\u679c\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><br\/>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5b58\u5728KRAS\u6216NRAS\u7a81\u53d8\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff1a\u201c\u76ee\u524d\u6216\u5373\u5c06\u5f00\u5c55\u7684\u9488\u5bf9RAS\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u662f\u5426\u6709\u9002\u5408\u6211\u6cbb\u7597\u65b9\u6848\u7684\uff1f\u201d<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06106308\">NCT06106308<\/a><\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e5%8f%82%e4%b8%8e%e5%85%b6%e4%b8%ad\/%e6%88%90%e4%b8%ba%e8%b5%9e%e5%8a%a9%e5%95%86\/\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"478\" src=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png\" alt=\"\" class=\"wp-image-213123\" style=\"aspect-ratio:2.142289799160331;width:653px;height:auto\" srcset=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-1024x478.png 1024w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-300x140.png 300w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1-768x358.png 768w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/05\/Updated_Clinical-Trials-Newsletter_Footer-1.png 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n<\/div>\n<h2 class=\"wp-block-heading\">2026\u5e745\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. NCI ComboMATCH \u2014 \u57fa\u4e8e\u80bf\u7624\u9057\u4f20\u5b66\u7684\u8054\u5408\u6cbb\u7597<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u53ef\u5e72\u9884\u7684\u57fa\u56e0\u6539\u53d8  <br\/><strong>\u4e34\u5e8a\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u652f\u6301\u591a\u9879II\u671f\u6cbb\u7597\u5b50\u7814\u7a76\u7684\u7b5b\u9009\u8bd5\u9a8c \/ \u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u7f51\u7edc  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u665a\u671f\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u7b26\u5408\u751f\u7269\u6807\u5fd7\u7269\u6807\u51c6\u7684\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>ComboMATCH<strong>\u9879\u76ee<\/strong>\u5229\u7528\u4e00\u4e2a\u5c06\u60a3\u8005\u4e0e\u7279\u5b9a\u5b50\u7814\u7a76\u8fdb\u884c\u5339\u914d\u7684\u7b5b\u9009\u5e73\u53f0\uff0c\u6839\u636e\u80bf\u7624\u7684\u57fa\u56e0\u53d8\u5316\uff08\u800c\u975e\u4ec5\u4f9d\u636e\u764c\u75c7\u7c7b\u578b\uff09\u4e3a\u60a3\u8005\u5206\u914d\u6cbb\u7597\u65b9\u6848\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u9879<strong>\u7814\u7a76<\/strong>\u5728\u7cbe\u51c6\u533b\u5b66\u7684\u57fa\u7840\u4e0a\uff0c\u901a\u8fc7\u6d4b\u8bd5\u9776\u5411\u836f\u7269\u7ec4\u5408\u80fd\u5426\u6539\u5584\u80bf\u7624\u5b58\u5728\u53ef\u5e72\u9884\u7a81\u53d8\u7684\u60a3\u8005\u7684\u9884\u540e\uff0c\u8fdb\u4e00\u6b65\u63a8\u8fdb\u4e86\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u66fe\u63a5\u53d7\u8fc7\u57fa\u56e0\u7ec4\u68c0\u6d4b\uff0c\u8bf7\u8be2\u95ee\u60a8\u7684\u68c0\u6d4b\u7ed3\u679c\u4e2d\u662f\u5426\u5305\u542b\u53ef\u80fd\u4e0e\u7cbe\u51c6\u533b\u5b66\u4e34\u5e8a\u8bd5\u9a8c\u76f8\u5339\u914d\u7684\u57fa\u56e0\u53d8\u5f02\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05564377\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05564377<\/a> <br\/> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. BASECAMP-1 \u2014 \u672a\u6765CEA\u9776\u5411\u7ec6\u80de\u7597\u6cd5\u7684\u7b5b\u9009\u7814\u7a76<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u91cd\u70b9\uff1a<\/strong>CEA\u8868\u8fbe\u3001HLA\u5206\u578b\uff08\u5305\u62ecHLA\u6742\u5408\u6027\u7f3a\u5931\uff09\u3001\u80bf\u7624\u514d\u75ab\u6807\u5fd7\u7269  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u89c2\u5bdf\u6027\u7b5b\u67e5\u7814\u7a76\/\u7f8e\u56fd\u7814\u7a76\u5730\u70b9  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>BASECAMP-1<strong>\u7814\u7a76\u65e8\u5728\u5bf9<\/strong>\u60a3\u8005\u8fdb\u884c\u751f\u7269\u6807\u5fd7\u7269\u7b5b\u67e5\uff0c\u4ee5\u786e\u5b9a\u5176\u662f\u5426\u7b26\u5408\u672a\u6765 CEA \u9776\u5411\u7ec6\u80de\u7597\u6cd5\u7814\u7a76\u7684\u5165\u7ec4\u6807\u51c6\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u5c06\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7684\u8303\u56f4\u4ece\u80bf\u7624\u7a81\u53d8\u6269\u5c55\u5230\u4e86\u514d\u75ab\u5339\u914d\u548c\u7ec6\u80de\u7597\u6cd5\u9002\u7528\u6027\u8bc4\u4f30\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5bf9\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\u611f\u5174\u8da3\uff0c\u8bf7\u54a8\u8be2HLA\u5206\u578b\u6216CEA\u68c0\u6d4b\u662f\u5426\u4e0e\u6b64\u76f8\u5173\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04981119\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04981119<\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><strong>Onvansertib\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u2014\u2014KRAS\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>KRAS\u7a81\u53d8  <br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u4e2d\u5fc3\uff1a<\/strong>II\u671f \/ \u7f8e\u56fd\u53ca\u56fd\u9645\u8bd5\u9a8c\u4e2d\u5fc3  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76<strong>\u65e8\u5728<\/strong>\u8bc4\u4f30onvansertib\u8054\u5408\u6807\u51c6\u5316\u7597\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u5728KRAS\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>KRAS\u7a81\u53d8\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e2d\u5f88\u5e38\u89c1\uff0c\u4f46\u8bb8\u591aKRAS\u7a81\u53d8\u80bf\u7624\u76ee\u524d\u4ecd\u7f3a\u4e4f\u6709\u6548\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002\u672c\u7814\u7a76\u805a\u7126\u4e8e\u4e00\u4e2a\u57fa\u4e8e\u751f\u7269\u5b66\u7279\u5f81\u754c\u5b9a\u7684\u7ed3\u76f4\u80a0\u764c\u4e9a\u7fa4\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5b58\u5728KRAS\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u5177\u4f53\u662f\u54ea\u79cdKRAS\u53d8\u5f02\uff0c\u4ee5\u53ca\u65e2\u5f80\u6cbb\u7597\u662f\u5426\u4f1a\u5f71\u54cd\u60a8\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8d44\u683c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06106308\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06106308<\/a> <br\/> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><strong>P-MUC1C-ALLO1 \u2014 \u9488\u5bf9MUC1-C\u7684\u5f02\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>MUC1-C\u7684\u8868\u8fbe  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e00\u9636\u6bb5 \/ \u5305\u62ec\u7f8e\u56fd\u7684\u7814\u7a76\u5730\u70b9  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86\u4e00\u79cd\u9488\u5bf9MUC1-C\u7684\u5f02\u4f53CAR-T\u7ec6\u80de\u7597\u6cd5\uff0cMUC1-C\u662f\u4e00\u79cd\u5728\u591a\u79cd\u4e0a\u76ae\u6027\u764c\u75c7\u4e2d\u8868\u8fbe\u7684\u80bf\u7624\u76f8\u5173\u6807\u5fd7\u7269\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u9886\u57df\u7684\u7ec6\u80de\u7597\u6cd5\u7814\u7a76\u6b63\u5728\u4e0d\u65ad\u6269\u5c55\uff0c\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u6216\u8bb8\u6709\u52a9\u4e8e\u8bc6\u522b\u80bf\u7624\u8868\u8fbeMUC1-C\u7b49\u9776\u70b9\u7684\u60a3\u8005\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u8bf7\u8be2\u95ee\u60a8\u7684\u80bf\u7624\u68c0\u6d4b\u662f\u5426\u5305\u62ec\u86cb\u767d\u8d28\u8868\u8fbe\u6807\u5fd7\u7269\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662fDNA\u7a81\u53d8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05239143\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05239143<\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>5. GCC19CART \u2014 \u9488\u5bf9\u665a\u671f\u80c3\u80a0\u9053\u764c\u75c7\u4e2dGCC\u7684CAR-T\u7597\u6cd5<\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>GCC \/ \u9e1f\u82f7\u9178\u73af\u5316\u9176C\u7684\u8868\u8fbe  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c\u4e00\u9636\u6bb5\/\u7f8e\u56fd\u7814\u7a76\u5730\u70b9  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u4e34\u5e8a\u8bd5\u9a8c<strong>\u65e8\u5728<\/strong>\u8bc4\u4f30\u9488\u5bf9GCC\u7684CAR-T\u7ec6\u80de\uff0cGCC\u662f\u4e00\u79cd\u5e38\u4e0e\u7ed3\u76f4\u80a0\u764c\u7ec6\u80de\u76f8\u5173\u7684\u6807\u5fd7\u7269\u3002  <br\/><strong>\u91cd\u8981\u6027\uff1a<\/strong>\u4ee5GCC\u4e3a\u9776\u70b9\u7684\u7ec6\u80de\u7597\u6cd5\u662f\u4e00\u79cd\u4e0e\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u7684\u751f\u7269\u6807\u5fd7\u7269\u7b56\u7565\uff0c\u4e5f\u662f\u9488\u5bf9\u665a\u671f\u60a3\u8005\u7684\u4e00\u9879\u65b0\u5174\u7814\u7a76\u65b9\u5411\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u6b63\u5728\u8003\u8651\u7ec6\u80de\u6cbb\u7597\u65b9\u6848\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u662f\u5426\u8868\u8fbeGCC\uff0c\u6216\u8005\u662f\u5426\u6709\u9488\u5bf9GCC\u7684\u4e34\u5e8a\u7814\u7a76\u53ef\u4f9b\u53c2\u4e0e\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05319314\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05319314<\/a> <br\/><\/p>\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"280\" src=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/04\/Updated_Clinical-Trials-Newsletter_Footer.png\" alt=\"\" class=\"wp-image-206900\" srcset=\"https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/04\/Updated_Clinical-Trials-Newsletter_Footer.png 600w, https:\/\/fightcolorectalcancer.org\/wp-content\/uploads\/2026\/04\/Updated_Clinical-Trials-Newsletter_Footer-300x140.png 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n<\/div>\n<h2 class=\"wp-block-heading\">2026\u5e744\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05610163\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>1. JANUS \u76f4\u80a0\u764c\u4e34\u5e8a\u8bd5\u9a8c\u2014\u2014\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u7684\u7efc\u5408\u65b0\u8f85\u52a9\u6cbb\u7597<\/strong> <\/a><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u57fa\u4e8e\u7597\u6548\u7684\u6cbb\u7597\u4e0e\u5668\u5b98\u4fdd\u62a4\u7b56\u7565  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>II\u671f \/ \u7f8e\u56fd\u534f\u4f5c\u7ec4\uff0c\u591a\u4e2d\u5fc3  <br\/><strong>\u5206\u671f\uff1a<\/strong>II-III\u671f \/ \u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a\u6d3b\u8dc3 <\/strong>\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>JANUS<strong>\u7814\u7a76\u65e8\u5728<\/strong>\u6bd4\u8f83\u957f\u7597\u7a0b\u5316\u653e\u7597\u540e\u91c7\u7528 mFOLFIRINOX \u65b9\u6848\u4e0e mFOLFOX6 \u65b9\u6848\uff0c\u4ee5\u671f\u63d0\u9ad8\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7387\u5e76\u6539\u5584\u5668\u5b98\u4fdd\u7559\u6548\u679c\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u9879\u7814\u7a76\u4e4b\u6240\u4ee5\u5177\u6709\u73b0\u5b9e\u610f\u4e49\uff0c\u662f\u56e0\u4e3a\u5b83\u805a\u7126\u4e8e\u76f4\u80a0\u764c\u6cbb\u7597\u7684\u5f3a\u5316\u53ca\u5668\u5b98\u4fdd\u7559\u76ee\u6807\u2014\u2014<strong>\u8fd9\u662f<\/strong>\u60a3\u8005\u548c\u4e34\u5e8a\u533b\u751f\u90fd\u9ad8\u5ea6\u5173\u6ce8\u7684\u9886\u57df\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u6b63\u5728\u5546\u8ba8\u76f4\u80a0\u764c\u624b\u672f\u524d\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3\u5168\u8eab\u65b0\u8f85\u52a9\u6cbb\u7597\u6216\u5668\u5b98\u4fdd\u7559\u7b56\u7565\u662f\u5426\u9002\u5408\u60a8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05610163\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05610163<\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04751370\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>2. EA2201 \u2014 \u9488\u5bf9dMMR II\/III\u671f\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597<\/strong> <\/a><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\/ MSI-H  <br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u5730\u70b9\uff1a<\/strong>II\u671f\/\u7f8e\u56fd\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c  <br\/><strong>\u5206\u671f\uff1a<\/strong>II\u2013III\u671f\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u817a\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>EA2201<strong>\u7814\u7a76\u65e8\u5728<\/strong>\u8bc4\u4f30\u5c3c\u6c83\u5362\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u4e0e\u77ed\u671f\u653e\u7597\u65b9\u6848\u5728MSI-H\/dMMR\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\uff0c\u65e8\u5728\u63d0\u9ad8\u6cbb\u7597\u53cd\u5e94\u7387\uff0c\u540c\u65f6\u53ef\u80fd\u51cf\u5c11\u5bf9\u66f4\u5f3a\u6548\u5e38\u89c4\u6cbb\u7597\u7684\u9700\u6c42\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>dMMR\u76f4\u80a0\u764c\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e2d\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u6cbb\u7597\u7684\u6700\u5178\u578b\u4f8b\u5b50\u4e4b\u4e00\u3002\u8fd9\u9879\u8bd5\u9a8c\u53cd\u6620\u4e86\u6cbb\u7597\u6b63\u671d\u7740\u57fa\u4e8e\u80bf\u7624\u751f\u7269\u5b66\u7279\u5f81\u8fdb\u884c\u4e2a\u6027\u5316\u8c03\u6574\u7684\u65b9\u5411\u8f6c\u53d8\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5c5e\u4e8edMMR\u6216MSI-H\u7c7b\u578b\uff0c\u8bf7\u5728\u624b\u672f\u524d\u54a8\u8be2\u662f\u5426\u53ef\u4ee5\u53c2\u52a0\u57fa\u4e8e\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04751370\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04751370 <\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02997228\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>3. COMMIT \u7814\u7a76\u2014\u2014\u8f6c\u79fb\u6027 dMMR\/MSI-H \u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u7b56\u7565<\/strong> <\/a><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>dMMR \/ MSI-H  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>III\u671f\/\u5168\u56fd\u591a\u4e2d\u5fc3\u8bd5\u9a8c  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>COMMIT<strong>\u8bd5\u9a8c\u6b63\u5728<\/strong>\u9488\u5bf9\u8f6c\u79fb\u6027 dMMR \u7ed3\u76f4\u80a0\u764c\uff0c\u6d4b\u8bd5\u4ee5\u963f\u7279\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5305\u62ec\u542b\u5316\u7597\/\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u6cbb\u7597\u65b9\u6848\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u5c3d\u7ba1\u514d\u75ab\u6cbb\u7597\u5728dMMR\/MSI-H\u578b\u7ed3\u76f4\u80a0\u764c\u4e2d\u5df2\u53d1\u6325\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u5e76\u975e\u6240\u6709\u60a3\u8005\u90fd\u80fd\u83b7\u5f97\u6301\u4e45\u7684\u83b7\u76ca\u3002COMMIT\u7814\u7a76\u65e8\u5728\u4e3a\u8be5\u60a3\u8005\u7fa4\u4f53\u4f18\u5316\u6700\u4f73\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u60a3\u6709\u8f6c\u79fb\u6027dMMR\/MSI-H\u7ed3\u76f4\u80a0\u764c\u4e14\u5373\u5c06\u5f00\u59cb\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u662f\u5426\u53ef\u4ee5\u53c2\u52a0\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02997228\" target=\"_blank\" rel=\"noreferrer noopener\">NCT02997228 <\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05039177\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>4. ERAS-007 \u9488\u5bf9\u665a\u671f\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624\uff08\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\uff09\u7684\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c<\/strong> <\/a><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>MAPK\u901a\u8def\uff0fBRAF\u548cRAS\u901a\u8def\u4fe1\u53f7\u4f20\u5bfc  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>Ib\/II\u671f \/ \u591a\u4e2d\u5fc3\u7814\u7a76\uff0c\u5305\u62ec\u7f8e\u56fd\u7684\u7814\u7a76\u7ad9\u70b9  <br\/><strong>\u75c5\u671f\uff1a<\/strong>\u665a\u671f\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624\uff0c\u5305\u62ec\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30ERK\u6291\u5236\u5242ERAS-007\u5728\u8054\u5408\u6cbb\u7597\u65b9\u6848\u4e2d\u7684\u7597\u6548\uff0c\u8fd9\u4e9b\u65b9\u6848\u65e8\u5728\u963b\u65ad\u80c3\u80a0\u9053\u764c\u75c7\uff08\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\uff09\u4e2d\u7684\u4e0b\u6e38MAPK\u4fe1\u53f7\u4f20\u5bfc\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8bb8\u591a\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u80bf\u7624\u662f\u7531\u4fe1\u53f7\u901a\u8def\u5f02\u5e38\u9a71\u52a8\u7684\uff0c\u800c\u8fd9\u4e9b\u5f02\u5e38\u76ee\u524d\u4ecd\u96be\u4ee5\u76f4\u63a5\u9776\u5411\u6cbb\u7597\u3002ERAS-007 \u4f53\u73b0\u4e86\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u65e8\u5728\u901a\u8fc7\u963b\u65ad\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\u6765\u6539\u5584\u6cbb\u7597\u6548\u679c\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u764c\u75c7\u5b58\u5728BRAF\u6216RAS\u901a\u8def\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3\u9488\u5bf9\u4e0b\u6e38\u901a\u8def\u7684\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05039177\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05039177 <\/a> <br\/><\/p>\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05078866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>5. \u6797\u5947\u7efc\u5408\u5f81\u4e2d\u201cNous-209\u201d\u75ab\u82d7\u9884\u9632\u7814\u7a76<\/strong> <\/a><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u6797\u5947\u7efc\u5408\u5f81\/\u9519\u914d\u4fee\u590d\u7f3a\u9677\u98ce\u9669  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>Ib\/II\u671f \/ \u7f8e\u56fd\u5f00\u5c55\u7684\u9884\u9632\u7814\u7a76  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u60a3\u6709\u6797\u5947\u7efc\u5408\u5f81\u7684\u9ad8\u5371\u4eba\u7fa4  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30Nous-209\u75ab\u82d7\u7b56\u7565\u5728\u6797\u5947\u7efc\u5408\u5f81\u643a\u5e26\u8005\u4e2d\u7684\u764c\u75c7\u9884\u9632\u6548\u679c\uff0c\u8fd9\u4e9b\u643a\u5e26\u8005\u60a3\u7ed3\u80a0\u764c\u53ca\u5176\u4ed6\u6797\u5947\u7efc\u5408\u5f81\u76f8\u5173\u764c\u75c7\u7684\u98ce\u9669\u8f83\u9ad8\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u662f\u4e00\u9879\u4ee5\u9884\u9632\u4e3a\u91cd\u70b9\u7684\u8bd5\u9a8c\uff0c\u800c\u975e\u6cbb\u7597\u8bd5\u9a8c\uff0c\u4f46\u5b83\u4e0e\u7ed3\u76f4\u80a0\u764c\u5bc6\u5207\u76f8\u5173\uff0c\u56e0\u4e3a\u5176\u65e8\u5728\u964d\u4f4e\u4e00\u4e2a\u754c\u5b9a\u660e\u786e\u7684\u9ad8\u5371\u4eba\u7fa4\u672a\u6765\u60a3\u764c\u7684\u98ce\u9669\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u6216\u60a8\u7684\u5bb6\u4eba\u60a3\u6709\u6797\u5947\u7efc\u5408\u5f81\uff0c\u8bf7\u54a8\u8be2\u662f\u5426\u9002\u5408\u53c2\u52a0\u9884\u9632\u7814\u7a76\u6216\u4ee5\u76d1\u6d4b\u4e3a\u91cd\u70b9\u7684\u7814\u7a76\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05078866\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05078866 <\/a> <\/p>\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<h2 class=\"wp-block-heading\">2026\u5e743\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1.<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07318389\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>ARPA-H ADAPT \u80bf\u7624\u5b66\u5e73\u53f0\u2014\u2014\u7ed3\u76f4\u80a0\u764c\u961f\u5217<\/strong><\/a><strong><\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u4e13\u9898\uff1a<\/strong>\u5b9e\u65f6\u751f\u7269\u6807\u5fd7\u7269\u6574\u5408\u4e0e\u9002\u5e94\u6027\u8bd5\u9a8c\u57fa\u7840\u8bbe\u65bd  <br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a<\/strong>\u65e9\u671f\u7814\u7a76\u8ba1\u5212 \/ \u7f8e\u56fd  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u7ed3\u76f4\u80a0\u764c\uff08\u53c2\u89c1\u7814\u7a76\u65b9\u6848\u4e2d\u7684\u5165\u9009\u6807\u51c6\uff09  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u5c1a\u672a\u5f00\u59cb\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u7531ARPA-H\u8d44\u52a9\u7684\u9879\u76ee\u662fADAPT\u80bf\u7624\u5b66\u5e73\u53f0\u7684\u4e00\u90e8\u5206\uff0c\u65e8\u5728\u63a8\u52a8\u764c\u75c7\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u5f0f\u7684\u73b0\u4ee3\u5316\u3002\u8be5\u5e73\u53f0\u6574\u5408\u4e86\u5148\u8fdb\u7684\u751f\u7269\u6807\u5fd7\u7269\u76d1\u6d4b\u3001\u534f\u8c03\u7684\u6570\u636e\u7cfb\u7edf\u4ee5\u53ca\u81ea\u9002\u5e94\u6cbb\u7597\u7b56\u7565\uff0c\u4ee5\u52a0\u901f\u7ed3\u76f4\u80a0\u764c\u53ca\u5176\u4ed6\u764c\u75c7\u7684\u6cbb\u7597\u65b9\u6cd5\u7814\u53d1\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u4e0e\u6d4b\u8bd5\u5355\u4e00\u836f\u7269\u4e0d\u540c\uff0c\u8fd9\u9879\u56fd\u5bb6\u5c42\u9762\u7684\u6295\u8d44\u7740\u773c\u4e8e\u53d8\u9769\u4e34\u5e8a\u8bd5\u9a8c\u4f53\u7cfb\u672c\u8eab\u2014\u2014\u8fd9\u6709\u671b\u52a0\u901f\u6709\u524d\u666f\u7684\u6cbb\u7597\u65b9\u6cd5\u4ece\u6982\u5ff5\u5230\u4e34\u5e8a\u5e94\u7528\u7684\u8fdb\u7a0b\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5373\u4f7f\u62db\u52df\u5de5\u4f5c\u5c1a\u672a\u5f00\u59cb\uff0c\u4e5f\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\u5373\u5c06\u5f00\u5c55\u7684\u3001\u7531\u8054\u90a6\u653f\u5e9c\u8d44\u52a9\u7684\u7814\u7a76\u9879\u76ee\uff0c\u8fd9\u4e9b\u9879\u76ee\u53ef\u80fd\u4f1a\u4e3a\u60a8\u5e26\u6765\u65b0\u7684\u673a\u4f1a\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07318389\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07318389<\/a><\/p>\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02465060\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u57fa\u4e8e\u80bf\u7624\u9057\u4f20\u5b66\u7684\u5206\u5b50\u6307\u5bfc\u6cbb\u7597\uff1aNCI-MATCH<\/strong><\/a><strong><\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u53ef\u5e72\u9884\u7684\u57fa\u56e0\u7a81\u53d8  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c2\u9636\u6bb5\/\u5168\u56fd\u8303\u56f4\uff08\u7531NCI\u8d44\u52a9\uff09  <br\/><strong>\u75c5\u671f\uff1a<\/strong>\u665a\u671f\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>NCI-MATCH<strong>\u9879\u76ee<\/strong>\u6839\u636e\u80bf\u7624\u4e2d\u53d1\u73b0\u7684\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u6765\u786e\u5b9a\u6cbb\u7597\u65b9\u6848\uff0c\u800c\u975e\u4f9d\u636e\u764c\u75c7\u5728\u4f53\u5185\u7684\u4f4d\u7f6e\u3002\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u82e5\u5176\u80bf\u7624\u643a\u5e26\u53ef\u5e72\u9884\u7a81\u53d8\uff0c\u5219\u53ef\u5339\u914d\u9488\u5bf9\u8fd9\u4e9b\u7a81\u53d8\u8bbe\u8ba1\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u9879\u5168\u56fd\u6027\u7684\u7cbe\u51c6\u533b\u5b66\u8bd5\u9a8c\u5e2e\u52a9\u91cd\u65b0\u5b9a\u4e49\u4e86\u6211\u4eec\u5bf9\u6cbb\u7597\u65b9\u6848\u9009\u62e9\u7684\u8ba4\u77e5\u3002\u4e0e\u201c\u4e00\u5200\u5207\u201d\u7684\u505a\u6cd5\u4e0d\u540c\uff0cMATCH \u8bd5\u9a8c\u4f53\u73b0\u4e86\u6cbb\u7597\u65b9\u5f0f\u6b63\u671d\u7740\u57fa\u4e8e\u80bf\u7624\u751f\u7269\u5b66\u7684\u65b9\u5411\u8f6c\u53d8\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5df2\u63a5\u53d7\u8fc7\u5168\u9762\u57fa\u56e0\u7ec4\u68c0\u6d4b\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u7a81\u53d8\u662f\u5426\u7b26\u5408\u53c2\u4e0eMATCH\u5b50\u7814\u7a76\u7684\u6761\u4ef6\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02465060\" target=\"_blank\" rel=\"noreferrer noopener\">NCT02465060<\/a><\/p>\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04068103\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>COBRA\u8bd5\u9a8c\uff1aIIA\u671f\u764c\u75c7\u4e2d\u57fa\u4e8ectDNA\u7684\u9884\u540e\u9884\u6d4b\u56e0\u5b50<\/strong><\/a><strong><\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>\u7b2c2\/3\u9636\u6bb5 \/ \u7f8e\u56fd\u5408\u4f5c\u7814\u7a76\u7ec4  <br\/><strong>\u5206\u671f\uff1a<\/strong>II\u671f\u7ed3\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>COBRA\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u672f\u540e\u8fdb\u884cctDNA\u68c0\u6d4b\u80fd\u5426\u8bc6\u522b\u51fa\u771f\u6b63\u9700\u8981\u5316\u7597\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u54ea\u4e9b\u60a3\u8005\u53ef\u4ee5\u5b89\u5168\u5730\u907f\u514d\u5316\u7597\u3002  <br\/><strong>\u91cd\u8981\u6027\uff1a<\/strong>\u8fd9\u9879\u7814\u7a76\u53cd\u6620\u4e86\u8840\u6db2\u751f\u7269\u6807\u5fd7\u7269\u5728\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597\u65b9\u9762\u65e5\u76ca\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5176\u76ee\u6807\u662f\u5728\u4fdd\u6301\u4f18\u5f02\u6cbb\u7597\u6548\u679c\u7684\u540c\u65f6\uff0c\u51cf\u5c11\u8fc7\u5ea6\u6cbb\u7597\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u60a3\u6709\u2161\u671f\u7ed3\u80a0\u764c\uff0c\u8bf7\u54a8\u8be2\u533b\u751fctDNA\u68c0\u6d4b\u662f\u5426\u9002\u5408\u60a8\uff0c\u4ee5\u53ca\u662f\u5426\u53ef\u4ee5\u8003\u8651\u53c2\u52a0\u751f\u7269\u6807\u5fd7\u7269\u6307\u5bfc\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04068103\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04068103<\/a><\/p>\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04963283\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>SWOG S2107\uff1aMSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597\u7b56\u7565<\/strong><\/a><strong><\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5fae\u536b\u661f\u7a33\u5b9a\uff08MSS\uff09\u4e0eBRAF V600E\u7a81\u53d8  <br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c2\u9636\u6bb5 \/ \u56fd\u5bb6\u534f\u4f5c\u7ec4\uff08SWOG\uff09  <br\/><strong>\u5206\u671f\uff1a<\/strong>\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76<strong>\u65e8\u5728<\/strong>\u9a8c\u8bc1\u5728\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u7684\u57fa\u7840\u4e0a\u52a0\u7528\u5c3c\u6c83\u5362\u5355\u6297\uff08\u514d\u75ab\u6cbb\u7597\uff09\u662f\u5426\u80fd\u6539\u5584BRAF V600E\/MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u9884\u540e\u3002  <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u7ea685%\u201390%\u7684\u7ed3\u76f4\u80a0\u764c\u5c5e\u4e8e\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u3002\u9488\u5bf9\u8fd9\u4e00\u4eba\u7fa4\u62d3\u5c55\u514d\u75ab\u6cbb\u7597\u7b56\u7565\uff0c\u4ecd\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u9886\u57df\u6700\u7d27\u8feb\u7684\u7814\u7a76\u91cd\u70b9\u4e4b\u4e00\uff0c\u5c24\u5176\u662f\u5bf9\u4e8e\u5386\u53f2\u4e0a\u65e0\u6cd5\u4ece\u5355\u836f\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e2d\u83b7\u76ca\u7684\u4eba\u7fa4\u800c\u8a00\u3002   <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u88ab\u544a\u77e5\u81ea\u5df1\u7684\u80bf\u7624\u5c5e\u4e8eMSS\u578b\uff0c\u4e14\u5355\u7528\u514d\u75ab\u7597\u6cd5\u53ef\u80fd\u6548\u679c\u4e0d\u4f73\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u6cbb\u7597\u4e2d\u5fc3\u662f\u5426\u6709\u514d\u75ab\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002  <br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04963283\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04963283<\/a> <\/p>\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p class=\"wp-block-paragraph\"><strong>5. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05174169\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>CIRCULATE-US (NRG-GI008) \u2014\u2014 II\/III\u671f\u60a3\u8005\u7684ctDNA\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597\u7b56\u7565<\/strong><\/a><strong><\/strong> <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09  <br\/><strong>\u4e34\u5e8a\u9636\u6bb5\/\u8bd5\u9a8c\u5730\u70b9\uff1a<\/strong>II\/III\u671f \/ \u5317\u7f8e\uff08NRG Oncology\uff09  <br\/><strong>\u5206\u671f\uff1a<\/strong>II\u671f\u548cIII\u671f\uff08\u5df2\u5207\u9664\uff09\u7ed3\u80a0\u764c  <br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u968f\u673a\u7814\u7a76<strong>\u65e8\u5728\u8bc4\u4f30<\/strong>\u672f\u540ectDNA\u68c0\u6d4b\u80fd\u5426\u4e3aII\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u5316\u7597\u5f3a\u5ea6\u7684\u8c03\u6574\uff08\u52a0\u5f3a\u6216\u51cf\u91cf\uff09\u63d0\u4f9b\u6307\u5bfc\u3002ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u7684\u60a3\u8005\u53ef\u80fd\u63a5\u53d7\u5f3a\u5316\u6cbb\u7597\uff0c\u800c\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\u7684\u60a3\u8005\u5219\u53ef\u80fd\u63a5\u53d7\u5f3a\u5ea6\u8f83\u4f4e\u7684\u6cbb\u7597\u3002   <br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>ctDNA\u6b63\u9010\u6e10\u6210\u4e3a\u4e00\u79cd\u7cbe\u51c6\u5de5\u5177\uff0c\u53ef\u7528\u4e8e\u68c0\u6d4b\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\u5e76\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597\u7684\u4e2a\u6027\u5316\u51b3\u7b56\u3002  <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u66fe\u56e0II\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u63a5\u53d7\u8fc7\u624b\u672f\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3ctDNA\u68c0\u6d4b\u6216\u53c2\u52a0\u4ee5ctDNA\u4e3a\u6307\u5bfc\u7684\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002  <br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05174169\" target=\"_blank\" rel=\"noreferrer noopener\">NCT05174169<\/a> <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">2026\u5e742\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\"><strong>BRAFTOVI\u00ae + \u897f\u59a5\u6614\u5355\u6297 + FOLFIRI \u2014 \u9488\u5bf9BRAF V600E\u7a81\u53d8\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u65b0\u4e09\u8054\u65b9\u6848<\/strong><\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF V600E\u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u4e2d\u5fc3\uff1a<\/strong>\u7b2c2\u9636\u6bb5 \/ \u591a\u56fd\uff08\u8f89\u745e\u8d5e\u52a9\uff09<br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027\uff08mCRC\uff09<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6d3b\u8dc3\uff0c\u6682\u4e0d\u62db\u8058<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u672c\u7814\u7a76<strong>\u65e8\u5728<\/strong>\u8bc4\u4f30<strong>\u6069\u79d1\u62c9\u975e\u5c3c+\u897f\u59a5\u6614\u5355\u6297+FOLFIRI<\/strong>\u65b9\u6848\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u3001\u643a\u5e26BRAF V600E\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>ASCO GI 2026\u4f1a\u8bae\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5386\u53f2\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u603b\u4f53\u53cd\u5e94\u7387\uff08ORR\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u5747\u663e\u8457\u63d0\u9ad8\u3002<br\/><strong>\u91cd\u8981\u6027\uff1a<\/strong>\u4e3aBRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63d0\u4f9b\u4e86\u5728\u6cbb\u7597\u65e9\u671f\u9636\u6bb5\u5373\u53ef\u91c7\u7528\u7684\u3001\u524d\u666f\u53ef\u671f\u7684\u9776\u5411\u6cbb\u7597\u65b9\u6848\u3002<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u4e3aBRAF V600E\u9633\u6027\uff0c\u4e14\u6b64\u524d\u5df2\u63a5\u53d7\u8fc7\u6cbb\u7597\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\u8be5\u8054\u5408\u7597\u6cd5\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\"> NCT04607421<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2026.44.2_suppl.TPS256\"><strong>CIRCULATE-\u5317\u7f8e\uff08NRG-GI008\uff09\u2014\u2014II\/III\u671f\u7ed3\u76f4\u80a0\u764c\u7684ctDNA\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597<\/strong><\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09<br\/><strong>\u4e34\u5e8a\u9636\u6bb5\/\u8bd5\u9a8c\u5730\u70b9\uff1a<\/strong>II\/III\u671f \/ \u5317\u7f8e\uff08NRG Oncology\uff09<br\/><strong>\u5206\u671f\uff1a<\/strong>II\u671f\u548cIII\u671f\uff08\u5df2\u5207\u9664\uff09<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8fd9\u9879\u968f\u673a\u8bd5\u9a8c<strong>\u65e8\u5728<\/strong>\u8bc4\u4f30\u672f\u540e\u8fdb\u884cctDNA\u68c0\u6d4b\u80fd\u5426\u4e3aII\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u662f\u5426\u9700\u8981\u8f85\u52a9\u5316\u7597\u63d0\u4f9b\u6307\u5bfc\u3002ctDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u7684\u60a3\u8005\u53ef\u63a5\u53d7\u5f3a\u5316\u6cbb\u7597\uff0c\u800cctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\u7684\u60a3\u8005\u5219\u53ef\u907f\u514d\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u5316\u7597\u3002 <br\/><strong>\u53d1\u8868\u4e8e\uff1a<\/strong>ASCO GI 2026<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>ctDNA\u6b63\u9010\u6e10\u6210\u4e3a\u8bc4\u4f30\u5fae\u5c0f\u6b8b\u7559\u75c5\uff08MRD\uff09\u7684\u7cbe\u51c6\u5de5\u5177\u3002\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6709\u671b\u5e2e\u52a9\u60a3\u8005\u907f\u514d\u8fc7\u5ea6\u6cbb\u7597\uff0c\u6216\u66f4\u65e9\u5730\u8bc6\u522b\u590d\u53d1\u98ce\u9669\u3002 <br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u66fe\u56e0II\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u63a5\u53d7\u8fc7\u624b\u672f\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3ctDNA\u68c0\u6d4b\u662f\u5426\u6709\u52a9\u4e8e\u5236\u5b9a\u60a8\u7684\u968f\u8bbf\u6cbb\u7597\u65b9\u6848\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2026.44.2_suppl.TPS256\">ASCO \u6458\u8981\uff1aNRG-GI008<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04003636\"><strong>KEYNOTE-975 \u4e9a\u7ec4\u5206\u6790\u2014\u2014\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597dMMR\/MSI-H\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong><\/a><strong><\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>dMMR \/ MSI-H<br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u4e2d\u5fc3\uff1a<\/strong>\u7b2c3\u9636\u6bb5\/\u5168\u7403<br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u8fdb\u884c\u4e2d<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8bc4\u4f30\u6d3e\u59c6\u5355\u6297\u4f5c\u4e3adMMR\/MSI-H\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u7684\u7597\u6548\u3002<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>\u5728\u672a\u66fe\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u6301\u4e45\u7684\u6cbb\u7597\u53cd\u5e94\uff0c\u5176\u4e2d\u5305\u62ec\u5408\u5e76\u75c7\u60a3\u8005\u548c\u9ad8\u9f84\u60a3\u8005\u3002<br\/><strong>\u610f\u4e49\u4f55\u5728\uff1a<\/strong>\u8bc1\u5b9e\u4e86\u514d\u75ab\u7597\u6cd5\u53ef\u4f5c\u4e3adMMR\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u2014\u2014\u800c\u4e0d\u4ec5\u9650\u4e8e\u7406\u60f3\u7684\u5019\u9009\u60a3\u8005\u3002<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSI-H\u6216dMMR\u7c7b\u578b\uff0c\u8bf7\u54a8\u8be2\u60a8\u662f\u5426\u7b26\u5408\u4e00\u7ebf\u514d\u75ab\u6cbb\u7597\u7684\u6761\u4ef6\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04003636\"> NCT04003636<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02928224\"><strong>BEACON-Lite A\u7ec4\u2014\u2014BRAF\u9633\u6027\u7ed3\u76f4\u80a0\u764c\u4e09\u8054\u7597\u6cd5\u7684\u771f\u5b9e\u4e16\u754c\u8bc4\u4f30<\/strong><\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF V600E\u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u70b9\uff1a<\/strong>\u7b2c2\u9636\u6bb5\/\u6269\u5927\u5165\u7ec4<br\/><strong>\u5206\u671f\uff1a<\/strong>\u8f6c\u79fb\u6027<br\/><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u4e0d\u518d\u63a5\u53d7\u65b0\u53c2\u4e0e\u8005<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u9879\u9488\u5bf9\u4e0d\u7b26\u5408\u539f\u59cbBEACON\u8bd5\u9a8c\u5165\u7ec4\u6761\u4ef6\u7684\u60a3\u8005\uff0c\u8bc4\u4f30\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u53ca\u5316\u7597\u7597\u6548\u7684\u961f\u5217<strong>\u7814\u7a76<\/strong>\u3002<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>\u521d\u6b65\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e\u8868\u660e\uff0c\u8be5\u7597\u6cd5\u5bf9\u8001\u5e74\u60a3\u8005\u548c\u5408\u5e76\u75c7\u60a3\u8005\u6709\u6548\u3002<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u652f\u6301\u91c7\u7528\u66f4\u5177\u5305\u5bb9\u6027\u7684\u6807\u51c6\uff0c\u4f7f\u60a3\u8005\u80fd\u591f\u83b7\u5f97\u6709\u524d\u666f\u7684\u4e09\u8054\u7597\u6cd5\u3002<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u6b64\u524d\u66fe\u88ab\u6392\u9664\u5728BRAF\u9776\u5411\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3\u73b0\u5b9e\u4e16\u754c\u6570\u636e\u662f\u5426\u73b0\u5df2\u652f\u6301\u8fd9\u79cd\u6cbb\u7597\u65b9\u6848\u3002<br\/><strong>ClinicalTrials.gov\uff1a <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02928224\">NCT02928224<\/a><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">2026\u5e741\u6708<\/h2>\n\n<p class=\"wp-block-paragraph\"><strong>1. <\/strong><a href=\"https:\/\/www.asco.org\/about-asco\/press-center\/news-releases\/combining-encorafenib-cetuximab-folfiri-may-be-effective-first-line-treatment-some-people-advanced-colorectal-cancer\"><strong>BREAKWATER<\/strong><\/a><strong><a href=\"https:\/\/www.asco.org\/about-asco\/press-center\/news-releases\/combining-encorafenib-cetuximab-folfiri-may-be-effective-first-line-treatment-some-people-advanced-colorectal-cancer\">\u4e34\u5e8a\u8bd5\u9a8c<\/a>\u2014\u2014\u4e09\u8054\u7597\u6cd5\u4e3aBRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u786e\u7acb\u65b0\u6807\u51c6<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1aBRAF V600E\u7a81\u53d8  <\/strong><br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a\u7b2c3\u9636\u6bb5\/\u8de8\u56fd<\/strong><br\/><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\uff08\u8f6c\u79fb\u6027\uff09<br\/><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210\uff08\u7b2c3\u9636\u6bb5\uff09<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u6069\u79d1\u62c9\u975e\u5c3c\uff0b\u897f\u59a5\u6614\u5355\u6297\uff0bFOLFIRI\u65b9\u6848\u4e0e\u5316\u7597\u5728\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e00\u7ebf\u6cbb\u7597\u4e2d\u7684<strong>\u6bd4\u8f83<\/strong><br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u51e0\u4e4e\u7ffb\u4e86\u4e00\u756a\uff0812.8\u4e2a\u6708 vs 7.1\u4e2a\u6708\uff09\uff1b\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4ece15.1\u4e2a\u6708\u5ef6\u957f\u81f330.3\u4e2a\u6708<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u4e00\u79cd\u65b0\u7684\u4e09\u8054\u7597\u6cd5\u6709\u671b\u53d6\u4ee3\u5316\u7597\uff0c\u6210\u4e3aBRAF\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u60a3\u6709BRAF V600E\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e14\u5373\u5c06\u5f00\u59cb\u4e00\u7ebf\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\u662f\u5426\u8003\u8651\u91c7\u7528\u8fd9\u79cd\u4e09\u8054\u7597\u6cd5\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong>\u4e0d\u9002\u7528<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>2. <\/strong><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02912559\"><strong>ATOMIC\u8bd5\u9a8c<\/strong><\/a> <strong>\u2014 \u2162\u671fdMMR\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63a5\u53d7\u963f\u7279\u73e0\u5355\u6297\u8054\u5408\u5316\u7597<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR \/ MSI-H\uff09<br\/><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c3\u9636\u6bb5\/\u591a\u4e2d\u5fc3<br\/><strong>\u5206\u671f\uff1a<\/strong>III\u671f\uff08\u5df2\u5207\u9664\uff09<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u672f\u540e<strong>\u63a5\u53d7<\/strong>mFOLFOX6<strong>\u65b9\u6848<\/strong>\uff0c\u5e76\u8054\u5408\u6216\u4e0d\u8054\u5408\u963f\u7279\u73e0\u5355\u6297\u6cbb\u7597<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>3\u5e74\u65e0\u75c5\u751f\u5b58\u7387\u4ece76.6%\u63d0\u9ad8\u81f386.4%<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u8fd9<\/strong>\u53ef\u80fd\u4f1a\u6539\u53d8\u65e9\u671fdMMR\u7ed3\u76f4\u80a0\u764c\u7684\u8f85\u52a9\u6cbb\u7597\u65b9\u6848<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSI-H\/dMMR\u7c7b\u578b\uff0c\u4e14\u6b63\u5728\u63a5\u53d7\u8f85\u52a9\u5316\u7597\uff0c\u8bf7\u8be2\u95ee\u60a8\u7684\u6cbb\u7597\u673a\u6784\u662f\u5426\u66fe\u8003\u8651\u8fc7\u6216\u7814\u7a76\u8fc7\u514d\u75ab\u6cbb\u7597\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02912559\">NCT02912559<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>3. <\/strong><a href=\"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_2\/CT115\/761846\"><strong>IVX037 \u8054\u5408 Sintilimab \u6cbb\u7597 MSS \u7ed3\u76f4\u80a0\u764c<\/strong><\/a><strong> \u2014 \u9488\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u8010\u836f\u80bf\u7624\u7684RNA\u75c5\u6bd2\u7597\u6cd5<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5fae\u536b\u661f\u7a33\u5b9a\uff08MSS\uff09\u3001KRAS\u7a81\u53d8<br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a<\/strong>\u7b2c1\u9636\u6bb5\/\u5355\u4e00\u5730\u70b9\uff08\u6269\u5efa\uff09<br\/><strong>\u5206\u671f\uff1a<\/strong>IV\u671f\uff08\u96be\u6cbb\u6027\uff09<br\/><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u6269\u5927\u62db\u52df\u89c4\u6a21\uff08\u7b2c\u4e00\u9636\u6bb5A\u5df2\u5b8c\u6210\uff09<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a\u5c06\u4e00\u79cd<\/strong>\u7ecf\u751f\u7269\u7b5b\u9009\u3001\u9776\u5411\u53d7\u4f53\u7684\u6eb6\u7624RNA\u75c5\u6bd2\uff08IVX037\uff09\u6ce8\u5165\u80bf\u7624\uff0c\u5e76\u8054\u5408\u6297PD-1\u5355\u6297\u8f9b\u66ff\u5229\u5355\u6297\uff08sintilimab\uff09<strong>\u8fdb\u884c\u6cbb\u7597<\/strong><br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>MSS\u578b\u548cKRAS G12D\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u75be\u75c5\u63a7\u5236\uff1b\u89c2\u5bdf\u5230\u65e9\u671f\u514d\u75ab\u6fc0\u6d3b<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u8fd9\u662f<\/strong>\u9996\u6279\u5728\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\u4e2d\u663e\u793a\u7597\u6548\u7684\u80bf\u7624\u5185\u75c5\u6bd2\u7597\u6cd5\u4e4b\u4e00\uff1a\u8be5\u4eba\u7fa4\u901a\u5e38\u5bf9\u514d\u75ab\u7597\u6cd5\u65e0\u53cd\u5e94\u3002<br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u7684\u80bf\u7624\u5c5e\u4e8eMSS\u578b\uff0c\u4e14\u5df2\u7528\u5c3d\u5316\u7597\u65b9\u6848\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\u6709\u5173\u63a2\u7d22\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u8054\u5408\u65b9\u6848\u6216\u75c5\u6bd2\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong>\u4e0d\u9002\u7528<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>4. <\/strong><a href=\"https:\/\/gicancer.org.au\/news\/dynamic-iii-trial-results\/\"><strong>DYNAMIC-III \u8bd5\u9a8c<\/strong><\/a><strong> \u2014\u2014III\u671f\u7ed3\u76f4\u80a0\u764c\u4e2d\u57fa\u4e8ectDNA\u7684\u5242\u91cf\u9012\u589e\u6cbb\u7597<\/strong><br\/><br\/><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09<br\/><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a<\/strong>\u7b2c2\u9636\u6bb5\/\u6fb3\u5927\u5229\u4e9a<br\/><strong>\u5206\u671f\uff1a<\/strong>III\u671f\uff08\u5df2\u5207\u9664\uff09<br\/><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5229\u7528\u672f\u540e\u8840\u6e05\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u6307\u5bfc\u5316\u7597\u5f3a\u5ea6<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>\u6839\u636ectDNA\u9633\u6027\u7ed3\u679c\u8fdb\u884c\u6cbb\u7597\u5347\u7ea7\u53ef\u6539\u5584\u9884\u540e\uff1bctDNA\u9634\u6027\u7684\u60a3\u8005\u5219\u907f\u514d\u4e86\u4e0d\u5fc5\u8981\u7684\u5316\u7597<br\/><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86ctDNA\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u51b3\u7b56\u5de5\u5177<strong>\u7684\u4ef7\u503c<\/strong><br\/><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u66fe\u56e0III\u671f\u7ed3\u76f4\u80a0\u764c\u63a5\u53d7\u8fc7\u624b\u672f\uff0c\u8bf7\u54a8\u8be2\u533b\u751f\uff0c\u4e86\u89e3ctDNA\u68c0\u6d4b\u662f\u5426\u6709\u52a9\u4e8e\u4e3a\u60a8\u5236\u5b9a\u4e2a\u6027\u5316\u7684\u5316\u7597\u65b9\u6848\u3002<br\/><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03803553\">NCT03803553<\/a><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>5. <\/strong><a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2025.43.16_suppl.e23304\"><strong>\u7ed3\u76f4\u80a0\u764c\u4e2d\u201c\u65e0\u7279\u5b9a\u9776\u70b9\u201dADC\u7684\u5e94\u7528\u2014\u2014\u5173\u4e8eKRAS G12C\u548cHER2+\u4e9a\u578b\u7684\u771f\u5b9e\u4e16\u754c\u6570\u636e<\/strong><br\/><\/a><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>KRAS G12C\u3001HER2\u53caADC\u54cd\u5e94\u7279\u5f81<br\/><strong>\u7814\u7a76\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u56de\u987e\u6027\u7814\u7a76\/\u591a\u4e2d\u5fc3\u7814\u7a76<br\/><strong>\u5206\u671f\uff1a<\/strong>IV\u671f\uff08\u96be\u6cbb\u6027\uff09<br\/><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5bf9\u771f\u5b9e\u4e16\u754c\u60a3\u8005\u7684\u56de\u987e\u6027\u5206\u6790\uff08\u975e\u5e72\u9884\u6027\u8bd5\u9a8c\uff09<br\/><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5728\u63a5\u53d7\u80bf\u7624\u975e\u7279\u5f02\u6027\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADCs\uff09\u6cbb\u7597\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4e2d\uff0c\u4e09\u7ebf\u53ca\u4ee5\u540e\u6cbb\u7597\u9636\u6bb5\u7684\u7597\u6548<br\/><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong>HER2+\u548cKRAS 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[&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":213198,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[650],"tags":[642,662,643,644,658,659,655,660,661,656,645,657,654,663,641],"class_list":["post-213192","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials","tag-crc","tag-dna","tag-fight-colorectal-cancer","tag-fight-crc","tag-her2","tag-kras","tag-clinical-trials","tag-660","tag-circulating-tumor-dna","tag-656","tag-645","tag-657","tag-cancer","tag-663","tag-colorectal-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u5173\u6ce8\u7126\u70b9\uff1a2026\u5e749\u6708\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0 - Fight Colorectal Cancer<\/title>\n<meta name=\"description\" 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