{"id":213260,"date":"2026-03-12T19:26:37","date_gmt":"2026-03-12T23:26:37","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e9%81%97%e4%bc%a0%e9%a3%8e%e9%99%a9%e5%9b%a0%e7%b4%a0%e4%bc%9a%e8%b0%83%e8%8a%82%e8%ba%ab%e4%bd%93%e6%b4%bb%e5%8a%a8%e4%b8%8e%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b9%8b%e9%97%b4%e7%9a%84%e5%85%b3\/"},"modified":"2026-06-17T19:14:20","modified_gmt":"2026-06-17T23:14:20","slug":"%e9%81%97%e4%bc%a0%e9%a3%8e%e9%99%a9%e5%9b%a0%e7%b4%a0%e4%bc%9a%e8%b0%83%e8%8a%82%e8%ba%ab%e4%bd%93%e6%b4%bb%e5%8a%a8%e4%b8%8e%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b9%8b%e9%97%b4%e7%9a%84%e5%85%b3","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e9%81%97%e4%bc%a0%e9%a3%8e%e9%99%a9%e5%9b%a0%e7%b4%a0%e4%bc%9a%e8%b0%83%e8%8a%82%e8%ba%ab%e4%bd%93%e6%b4%bb%e5%8a%a8%e4%b8%8e%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b9%8b%e9%97%b4%e7%9a%84%e5%85%b3\/","title":{"rendered":"\u9057\u4f20\u98ce\u9669\u56e0\u7d20\u4f1a\u8c03\u8282\u8eab\u4f53\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\u4e4b\u95f4\u7684\u5173\u8054"},"content":{"rendered":"<div>\n<p>\u300aBMC\u533b\u5b66\u300b2026\u5e742\u67085\u65e5\uff1b24(1):146\u3002doi: 10.1186\/s12916-026-04675-5\u3002 <\/p>\n<p><b>\u6458\u8981<\/b><\/p>\n<p>\u80cc\u666f\uff1a\u4f53\u80b2\u6d3b\u52a8\u5df2\u88ab\u516c\u8ba4\u4e3a\u9884\u9632\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u4fdd\u62a4\u56e0\u7d20\uff0c\u4f46\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u57fa\u56e0\u53d8\u5f02\u662f\u5426\u4f1a\u5f71\u54cd\u8fd9\u4e00\u6548\u5e94\u3002\u4e3a\u63a2\u8ba8\u8fd9\u4e00\u53ef\u80fd\u6027\uff0c\u6211\u4eec\u5f00\u5c55\u4e86\u4e00\u9879\u5168\u57fa\u56e0\u7ec4\u8303\u56f4\u7684\u57fa\u56e0\u4e0e\u4f53\u80b2\u6d3b\u52a8\u76f8\u4e92\u4f5c\u7528\u5206\u6790\u3002 <\/p>\n<p>\u65b9\u6cd5\uff1a\u91c7\u7528\u903b\u8f91\u56de\u5f52\uff081 \u4e2a\u81ea\u7531\u5ea6\uff09\u3001\u4e24\u6b65\u7b5b\u9009\u4e0e\u68c0\u9a8c\u6cd5\uff08EDGE\uff09\u4ee5\u53ca\u8054\u5408\u68c0\u9a8c\uff083 \u4e2a\u81ea\u7531\u5ea6\uff09\uff0c\u5206\u6790\u4e86\u5168\u57fa\u56e0\u7ec4\u8303\u56f4\u5185\u5e38\u89c1\u57fa\u56e0\u53d8\u5f02\u4e0e\u8eab\u4f53\u6d3b\u52a8\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u98ce\u9669\u65b9\u9762\u7684\u4ea4\u4e92\u4f5c\u7528\u3002 \u6839\u636e\u81ea\u6211\u62a5\u544a\u7684\u4f53\u80b2\u6d3b\u52a8\u6c34\u5e73\uff0c\u53d7\u8bd5\u8005\u88ab\u5206\u4e3a\u201c\u6d3b\u8dc3\u7ec4\u201d\uff08\u2265 8.75 MET-h\/\u5468\uff09\u4e0e\u201c\u4e0d\u6d3b\u8dc3\u7ec4\u201d\uff08< 8.75 MET-h\/\u5468\uff1b39,992\u540d\u53d7\u8bd5\u8005\uff09\uff0c\u5e76\u6309\u7814\u7a76\u7279\u5f02\u6027\u548c\u6027\u522b\u7279\u5f02\u6027\u6d3b\u52a8\u6c34\u5e73\u5212\u5206\u4e3a\u56db\u5206\u4f4d\u7ec4\uff0842,602\u540d\u53d7\u8bd5\u8005\uff09\u3002 <\/p>\n<p>\u7ed3\u679c\uff1a\u603b\u4f53\u800c\u8a00\uff0c\u8eab\u4f53\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u98ce\u9669\u5448\u8d1f\u76f8\u5173\uff08\u6bd4\u503c\u6bd4 [\u6d3b\u8dc3\u7ec4 vs. \u4e0d\u6d3b\u8dc3\u7ec4] = 0.85\uff1b95% \u7f6e\u4fe1\u533a\u95f4 = 0.81-0.90\uff09\u3002 \u4e24\u6b65EDGE\u65b9\u6cd5\u8bc6\u522b\u51fa\u4f4d\u4e8eGREM1\u548cSCG5\u57fa\u56e0\u9644\u8fd1\u7684\u57fa\u56e0\u95f4\u53d8\u5f02rs4779584\u4e0e\u4f53\u80b2\u6d3b\u52a8\u5728\u7ed3\u76f4\u80a0\u764c\u98ce\u9669\u65b9\u9762\u5b58\u5728\u4ea4\u4e92\u4f5c\u7528\uff08\u4ea4\u4e92\u4f5c\u7528p\u503c = 2.6 \u00d7<sup> 10\u207b\u2078<\/sup>\uff09\u3002 \u6309\u8be5\u4f4d\u70b9\u57fa\u56e0\u578b\u8fdb\u884c\u5206\u5c42\u5206\u6790\u663e\u793a\uff0c\u4e0e\u4e0d\u6d3b\u8dc3\u7684CC\u57fa\u56e0\u578b\u53c2\u4e0e\u8005\u76f8\u6bd4\uff0c\u6d3b\u8dc3\u7684CC\u57fa\u56e0\u578b\u53c2\u4e0e\u8005\u7ed3\u76f4\u80a0\u764c\u98ce\u9669\u663e\u8457\u964d\u4f4e\u4e8620%\uff08OR = 0.80\uff1b95% CI = 0.75-0.85\uff09\uff0c\u4f46\u5728CT\u6216TT\u57fa\u56e0\u578b\u643a\u5e26\u8005\u4e2d\uff0c\u8eab\u4f53\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\u4e4b\u95f4\u672a\u89c1\u663e\u8457\u5173\u8054\u3002 \u5f53\u5c06\u4f53\u80b2\u6d3b\u52a8\u6309\u56db\u5206\u4f4d\u6570\u5efa\u6a21\u65f6\uff0c1-d.f. \u68c0\u9a8c\u53d1\u73b0\uff0c\u4f4d\u4e8e KCNG1 \u57fa\u56e0\u9644\u8fd1\u7684\u57fa\u56e0\u95f4\u53d8\u5f02 rs56906466 \u4fee\u9970\u4e86\u4f53\u80b2\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\u4e4b\u95f4\u7684\u5173\u8054\uff08\u4ea4\u4e92\u4f5c\u7528 p \u503c = 3.5 \u00d7<sup> 10\u207b\u2078<\/sup>\uff09\u3002 \u5bf9\u8be5\u4f4d\u70b9\u8fdb\u884c\u5206\u5c42\u5206\u6790\u663e\u793a\uff0c\u4ec5\u5728TT\u7b49\u4f4d\u57fa\u56e0\u643a\u5e26\u8005\u4e2d\uff0c\u4f53\u80b2\u6d3b\u52a8\u91cf\u7684\u589e\u52a0\uff08\u6700\u9ad8\u56db\u5206\u4f4d\u6570\u4e0e\u6700\u4f4e\u56db\u5206\u4f4d\u6570\u76f8\u6bd4\uff09\u4e0e\u7ed3\u76f4\u80a0\u764c\u98ce\u9669\u964d\u4f4e\u76f8\u5173\uff08OR = 0.77\uff1b95% CI = 0.72-0.82\uff09\u3002 <\/p>\n<p>\u7ed3\u8bba\uff1a\u7efc\u4e0a\u6240\u8ff0\uff0c\u6211\u4eec\u9274\u5b9a\u51fa\u4e24\u4e2a\u4f1a\u4fee\u9970\u4f53\u80b2\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u98ce\u9669\u4e4b\u95f4\u5173\u8054\u7684\u57fa\u56e0\u53d8\u5f02\u3002 \u5176\u4e2d\u4e00\u79cd\u53d8\u5f02\u4e0eGREM1\u548cSCG5\u76f8\u5173\uff0c\u8868\u660e\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d\uff08BMP\uff09\u76f8\u5173\u3001\u708e\u75c7\u548c\/\u6216\u80f0\u5c9b\u7d20\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def\u53ef\u80fd\u53c2\u4e0e\u4e86\u4f53\u80b2\u6d3b\u52a8\u4e0e\u7ed3\u76f4\u80a0\u764c\u53d1\u751f\u4e4b\u95f4\u7684\u4fdd\u62a4\u6027\u5173\u8054\u3002 <\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41645200\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260312192346&#038;v=2.19.0.post6+133c1fe\">41645200<\/a>| PMC:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/PMC12973902\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260312192346&#038;v=2.19.0.post6+133c1fe\">PMC12973902<\/a>| DOI:<a href=\"https:\/\/doi.org\/10.1186\/s12916-026-04675-5\">10.1186\/s12916-026-04675-5<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u300aBMC\u533b\u5b66\u300b2026\u5e742\u67085\u65e5\uff1b24(1):146\u3002doi: 10.1186\/s12916-026-0467 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[640],"tags":[],"class_list":["post-213260","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - 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