{"id":213265,"date":"2026-03-12T19:26:37","date_gmt":"2026-03-12T23:26:37","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b8%ad%e8%83%9a%e7%b3%bb%e5%8f%98%e5%bc%82%e4%b8%8ekras%e7%aa%81%e5%8f%98%e7%8a%b6%e6%80%81%e7%9a%84%e7%9b%b8%e5%85%b3%e6%80%a7\/"},"modified":"2026-06-17T19:14:25","modified_gmt":"2026-06-17T23:14:25","slug":"%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b8%ad%e8%83%9a%e7%b3%bb%e5%8f%98%e5%bc%82%e4%b8%8ekras%e7%aa%81%e5%8f%98%e7%8a%b6%e6%80%81%e7%9a%84%e7%9b%b8%e5%85%b3%e6%80%a7","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%e4%b8%ad%e8%83%9a%e7%b3%bb%e5%8f%98%e5%bc%82%e4%b8%8ekras%e7%aa%81%e5%8f%98%e7%8a%b6%e6%80%81%e7%9a%84%e7%9b%b8%e5%85%b3%e6%80%a7\/","title":{"rendered":"\u7ed3\u76f4\u80a0\u764c\u4e2d\u80da\u7cfb\u53d8\u5f02\u4e0eKRAS\u7a81\u53d8\u72b6\u6001\u7684\u76f8\u5173\u6027"},"content":{"rendered":"<div>\n<p>\u300a\u79d1\u5b66\u62a5\u544a\u300b2026\u5e742\u670813\u65e5\u3002doi: 10.1038\/s41598-026-39644-8\u3002\u5728\u7ebf\u53d1\u8868\u4e8e\u5370\u5237\u7248\u4e4b\u524d\u3002  <\/p>\n<p><b>\u6458\u8981<\/b><\/p>\n<p>KRAS\u57fa\u56e0\u7684\u4f53\u7ec6\u80de\u7a81\u53d8\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u5e38\u89c1\u9a71\u52a8\u56e0\u7d20\uff0c\u5176\u53d1\u751f\u9891\u7387\u56e0\u79cd\u65cf\u3001\u6027\u522b\u3001\u80bf\u7624\u90e8\u4f4d\u3001\u6c11\u65cf\u53ca\u9057\u4f20\u76f8\u4f3c\u6027\u800c\u5f02\u3002 \u9057\u4f20\u6027\u80da\u7cfb\u53d8\u5f02\u53ef\u80fd\u901a\u8fc7\u6539\u53d8\u7a81\u53d8\u6216DNA\u4fee\u590d\u8fc7\u7a0b\uff0c\u6216\u6539\u53d8\u7a81\u53d8\u540e\u7684\u7ec6\u80de\u3001\u514d\u75ab\u548c\/\u6216\u5fae\u73af\u5883\u53cd\u5e94\uff0c\u4ece\u800c\u5f71\u54cd\u80bf\u7624\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u9891\u7387\u3002\u6211\u4eec\u5047\u8bbe\u80da\u7cfb\u9057\u4f20\u80cc\u666f\u4f1a\u4fee\u9970CRC\u4e2dKRAS\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u9891\u7387\u3002 \u4e3a\u9a8c\u8bc1\u8fd9\u4e00\u5047\u8bbe\uff0c\u6211\u4eec\u9488\u5bf97071\u540dCRC\u60a3\u8005\u5f00\u5c55\u4e86\u4e00\u9879\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\uff0c\u5e76\u5c06KRAS\u7a81\u53d8\u72b6\u6001\u4f5c\u4e3a\u8868\u578b\u6307\u6807\u3002\u6839\u636e\u53d1\u73b0\u6027GWAS\u7684P\u503c\u3001\u8ba1\u7b97\u673a\u6a21\u62df\u9884\u6d4b\u7684\u529f\u80fd\u6548\u5e94\u4ee5\u53ca\u4e0e\u6f5c\u5728\u764c\u75c7\u76f8\u5173\u57fa\u56e0\u7684\u90bb\u8fd1\u6027\uff0c\u9009\u53d6\u4e86\u82e5\u5e72\u5355\u6838\u82f7\u9178\u53d8\u5f02\uff08SNVs\uff09\u8fdb\u884c\u9a8c\u8bc1\u5206\u6790\u3002 \u6211\u4eec\u5bf92482\u540d\u53d7\u8bd5\u8005\u8fdb\u884c\u4e86101\u4e2a\u76ee\u6807\u5355\u6838\u82f7\u9178\u53d8\u5f02\uff08SNV\uff09\u7684\u9a8c\u8bc1\u5206\u6790\u3002\u672a\u53d1\u73b0\u4efb\u4f55SNV\u4e0eKRAS\u7a81\u53d8\u578bCRC\u5b58\u5728\u663e\u8457\u5173\u8054\uff08P\u503c < 0.0005\uff09\u3002 \u5176\u4e2d\u4e00\u4e2a\u53d8\u5f02 rs73067863-T \u5728\u5408\u5e76\u6837\u672c\u4e2d\u663e\u793a\u51fa\u4e0e KRAS \u7a81\u53d8\u80bf\u7624\u6570\u91cf\u8f83\u5c11\u5b58\u5728\u975e\u663e\u8457\u6027\u7684\u63a2\u7d22\u6027\u5173\u8054\uff08P \u503c = 9.7 \u00d7<sup> 10\u207b\u2077\uff0c<\/sup>OR = 0.75\uff09\u3002 \u9700\u8981\u5f00\u5c55\u540e\u7eed\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u8fd9\u4e9b\u6216\u5176\u5b83\u80da\u7cfb\u53d8\u5f02\u662f\u5426\u4f1a\u5f71\u54cd\u7ed3\u76f4\u80a0\u764c\u4e2dKRAS\u7a81\u53d8\u7684\u7fa4\u4f53\u5dee\u5f02\u3002 <\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41688657\/?utm_source=SimplePie&#038;utm_medium=rss&#038;utm_campaign=pubmed-2&#038;utm_content=1zCzv8cgXYLTFpYKqcnmEQSRKKzgHYU2epGXR7qqB04ouFsEtP&#038;fc=20260305170338&#038;ff=20260312192346&#038;v=2.19.0.post6+133c1fe\">41688657<\/a>| DOI:<a href=\"https:\/\/doi.org\/10.1038\/s41598-026-39644-8\">10.1038\/s41598-026-39644-8<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u300a\u79d1\u5b66\u62a5\u544a\u300b2026\u5e742\u670813\u65e5\u3002doi: 10.1038\/s41598-026-39644-8\u3002\u5728\u7ebf\u53d1\u8868\u4e8e\u5370 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[640],"tags":[],"class_list":["post-213265","post","type-post","status-publish","format-standard","hentry","category-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - 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