{"id":213470,"date":"2025-12-01T13:00:00","date_gmt":"2025-12-01T18:00:00","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2025%e5%b9%b412%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0\/"},"modified":"2026-06-17T19:16:02","modified_gmt":"2026-06-17T23:16:02","slug":"%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2025%e5%b9%b412%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e5%85%b3%e6%b3%a8%e7%84%a6%e7%82%b9%ef%bc%9a2025%e5%b9%b412%e6%9c%88%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e7%bb%bc%e8%bf%b0\/","title":{"rendered":"\u5173\u6ce8\u7126\u70b9\uff1a2025\u5e7412\u6708\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><em>\u7531Fight CRC\u533b\u7597\u987e\u95ee\u59d4\u5458\u4f1a\u53ca\u7814\u7a76\u5021\u5bfc\u57f9\u8bad\u4e0e\u652f\u6301\uff08RATS\uff09\u56e2\u961f\u7cbe\u5fc3\u7b56\u5212\u3002  <\/em><\/p>\n\n<p class=\"wp-block-paragraph\">\u672c\u6708\u7efc\u8ff0\u91cd\u70b9\u4ecb\u7ecd\u4e86MSS\u514d\u75ab\u6cbb\u7597\uff08IO\uff09\u3001KRAS G12C\u9776\u5411\u6cbb\u7597\u3001ctDNA\u751f\u7269\u6807\u5fd7\u7269\u4ee5\u53ca\u4e09\u7ebf\uff083L\uff09\u6cbb\u7597\u521b\u65b0\u65b9\u9762\u5177\u6709\u524d\u666f\u7684\u7814\u7a76\u3002\u76ee\u524d\uff0c\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u63a2\u7d22\u66f4\u6df1\u5165\u7684\u514d\u75ab\u6cbb\u7597\u8054\u5408\u65b9\u6848\u3001\u65e9\u671fKRAS\u9776\u5411\u6cbb\u7597\u4ee5\u53ca\u80bf\u7624\u5fae\u73af\u5883\u8c03\u63a7\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u9700\u8981\u4e86\u89e3\u4e34\u5e8a\u8bd5\u9a8c\u6216\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7684\u76f8\u5173\u4fe1\u606f\u5417\uff1f<a href=\"https:\/\/fightcolorectalcancer.org\/resources\/treatment-with-biomarker-testing\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u8bf7\u70b9\u51fb\u6b64\u5904\u67e5\u770b\u6211\u4eec\u7684\u751f\u7269\u6807\u5fd7\u7269\u8d44\u6e90<\/a>\u3002  <\/strong><\/p>\n\n<h2 class=\"wp-block-heading\">1. mKRAS-VAX \u8054\u5408\u5c3c\u6c83\u5362\u5355\u6297\/\u4f0a\u5339\u6728\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u2014\u2014KRAS \u75ab\u82d7\u4fc3\u8fdb\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u7597\u6cd5\u53cd\u5e94<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9636\u6bb5\uff1a<\/strong>\u65e9\u671f\uff08I\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e14\u643a\u5e26KRAS\u7a81\u53d8\uff08G12C\/D\/V\/A\/R\uff09\u7684<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u80fd\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\u7684\u80bd\u75ab\u82d7\uff08mKRAS-VAX\uff09\uff0c\u8054\u5408\u6297PD-1\u548c\u6297CTLA-4\u6297\u4f53<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u65e9\u671f\u8ff9\u8c61\u8868\u660e\uff0c\u5373\u4f7f\u662f\u901a\u5e38\u5bf9\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08IO\uff09\u8010\u836f\u7684MSS\u80bf\u7624\uff0c\u5728T\u7ec6\u80de\u7ecf\u9776\u5411\u75ab\u82d7\u63a5\u79cd\u6fc0\u6d3b\u540e\uff0c\u4e5f\u53ef\u80fd\u4ea7\u751f\u53cd\u5e94<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u88ab\u544a\u77e5\u81ea\u5df1\u7684\u80bf\u7624\u4e3aMSS\u4e14KRAS\u9633\u6027\uff0c\u8bf7\u5411\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u54a8\u8be2\u6709\u5173\u75ab\u82d7\u8054\u5408\u6cbb\u7597\u7684\u7814\u7a76\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">2. IVX037 \u8054\u5408\u8f9b\u66ff\u5229\u5355\u6297\u6cbb\u7597\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\u2014\u2014TLR9\u6fc0\u52a8\u5242\u8054\u5408\u514d\u75ab\u6cbb\u7597\uff08IO\uff09\u5728\u201c\u51b7\u80bf\u7624\u201d\u4e2d\u7684\u5e94\u7528<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9636\u6bb5\uff1a<\/strong>\u4e00<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>MSS\u578b\u7ed3\u76f4\u80a0\u764c<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u57fa\u4e8e\u80bf\u7624\u5185DNA\u7684\u514d\u75ab\u523a\u6fc0\u5242\uff08TLR9\u6fc0\u52a8\u5242\uff09\uff0c\u8054\u5408\u5168\u8eab\u6027PD-1\u6291\u5236\u5242\u4f7f\u7528<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>MSS CRC\u901a\u5e38\u5177\u6709\u514d\u75ab\u51b7\u6027\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u201c\u6fc0\u6d3b\u201d\u5c40\u90e8\u514d\u75ab\u5e94\u7b54\uff0c\u5e76\u8bf1\u5bfc\u5168\u8eab\u6027\u80bf\u7624\u6392\u65a5\u53cd\u5e94\u3002 <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u80bf\u7624\u5185 <\/strong>\u514d\u75ab\u6cbb\u7597\u836f\u7269\u53ef\u80fd\u4e3a\u514d\u75ab\u6cbb\u7597\u5f00\u8f9f\u65b0\u7684\u9014\u5f84\uff0c\u8bf7\u54a8\u8be2\u9644\u8fd1\u662f\u5426\u6709\u6b63\u5728\u5f00\u5c55\u7684\u533a\u57df\u6027\u7814\u7a76\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">3. EVEREST-2 CAR-T \u4e34\u5e8a\u8bd5\u9a8c\u2014\u2014\u9488\u5bf9 HLA-A*02 \u76f8\u5173\u7ed3\u76f4\u80a0\u764c\u7684\u903b\u8f91\u95e8\u63a7 Tmod CAR-T \u7597\u6cd5<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9636\u6bb5\uff1a<\/strong>1\/2<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>HLA-A*02\u7f3a\u5931\u4e14\u8868\u8fbe\u95f4\u76ae\u7d20<strong>\u7684\u5927\u80a0\u764c\uff08CRC\uff09 <\/strong>\u60a3\u8005<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u65b0\u578bCAR-T\u7ec6\u80de\u7597\u6cd5\uff08A2B694\uff09\uff0c\u53ef\u9009\u62e9\u6027\u5730\u5728\u5177\u6709\u7279\u5b9a\u514d\u75ab\u9003\u9038\u7279\u5f81\u7684\u80bf\u7624\u4e2d\u6fc0\u6d3b<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u79cd\u57fa\u4e8e\u903b\u8f91\u95e8\u63a7\u5236\u7684\u7597\u6cd5\u5728\u9488\u5bf9\u5b9e\u4f53\u7624\uff08\u5305\u62ec\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff09\u7684\u540c\u65f6\uff0c\u5c06\u975e\u80bf\u7624\u6bd2\u6027\u964d\u81f3\u6700\u4f4e<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u8bf7\u54a8\u8be2 <\/strong>HLA\u5206\u578b\u68c0\u6d4b\u7684\u76f8\u5173\u4fe1\u606f\uff0c\u5e76\u4e86\u89e3\u60a8\u7684\u80bf\u7624\u662f\u5426\u8868\u8fbe\u95f4\u76ae\u7d20\uff0c\u8fd9\u4e9b\u56e0\u7d20\u5728CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u7684\u914d\u5bf9\u4e2d\u6b63\u53d8\u5f97\u8d8a\u6765\u8d8a\u91cd\u8981\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">4. FOG-001\uff1a\u7528\u4e8e\u5faesatellite\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\u7684\u9996\u521b\u03b2-catenin\u6291\u5236\u5242\u2014\u2014\u9776\u5411Wnt\u4fe1\u53f7\u901a\u8def<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9636\u6bb5\uff1a<\/strong>1\/2<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>Wnt\/\u03b2-catenin\u901a\u8def\u6fc0\u6d3b\u7684MSS\u578b\u80bf\u7624<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u80fd\u5e72\u6270\u03b2-catenin\u4ecb\u5bfc\u7684\u8f6c\u5f55\u7684\u65b0\u578b\u5c0f\u5206\u5b50\uff0c\u636e\u4fe1\u53ef\u589e\u5f3a\u514d\u75ab\u7ec6\u80de\u7684\u6d78\u6da6<\/li>\n\n\n\n<li><strong>\u91cd\u8981\u6027\uff1a<\/strong> Wnt\u901a\u8def\u6fc0\u6d3b\u9a71\u52a8\u514d\u75ab\u6392\u65a5&gt;80%\u7684MSS CRC\uff0c\u8fd9\u53ef\u80fd\u4f1a\u9006\u8f6c\u8fd9\u79cd\u673a\u5236\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u8bf7\u8be2\u95ee <\/strong>\u60a8\u7684\u80bf\u7624\u662f\u5426\u5b58\u5728Wnt\u901a\u8def\u6fc0\u6d3b\u6216T\u7ec6\u80de\u6392\u65a5\u73b0\u8c61\uff1b\u90e8\u5206\u5206\u5b50\u68c0\u6d4b\u62a5\u544a\u4f1a\u63d0\u4f9b\u6b64\u7c7b\u4fe1\u606f\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">5. \u7ef4\u62c9\u65af\u6258\u5df4\u7279 + \u963f\u7279\u73e0\u5355\u6297\u2014\u2014\u8840\u6d46TMB\u53ef\u9884\u6d4b\u514d\u75ab\u6cbb\u7597\u53cd\u5e94<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u9636\u6bb5\uff1a<\/strong>\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>pTMB\u503c\u8f83\u9ad8\u4e14ctDNA\u68c0\u6d4b\u5448\u9633\u6027\u7684<strong>MSS\u578b <\/strong>\u60a3\u8005<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u9488\u5bf9III\u671f\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\u7684\u5355\u514b\u9686\u6297\u4f53+\u514d\u75ab\u6cbb\u7597\uff08IO\uff09\u8054\u5408\u7597\u6cd5<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u8fd9\u5f88\u91cd\u8981\uff1a<\/strong>\u901a\u8fc7ctDNA\u76d1\u6d4b\u7684\u8840\u6d46\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08pTMB\uff09\u5728\u9884\u6d4b\u6cbb\u7597\u53cd\u5e94\u65b9\u9762\u4f18\u4e8e\u5f71\u50cf\u5b66\u68c0\u67e5<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u5df2\u63a5\u53d7\u8fc7ctDNA\u68c0\u6d4b\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684pTMB\u7ed3\u679c\u2014\u2014\u8fd9\u53ef\u80fd\u4f1a\u4e3a\u60a8\u5e26\u6765\u65b0\u7684\u514d\u75ab\u6cbb\u7597\u9009\u62e9\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">\u8981\u70b9\uff1a<\/h2>\n\n<p class=\"wp-block-paragraph\">12\u6708\u7684\u7efc\u8ff0\u5c55\u793a\u4e86\u9488\u5bf9MSS\u7684\u514d\u75ab\u6cbb\u7597\u9886\u57df\u65e5\u8d8b\u6210\u719f\u3001KRAS\u6cbb\u7597\u7b56\u7565\u4e0d\u65ad\u6269\u5c55\uff0c\u4ee5\u53cactDNA\u4f5c\u4e3a\u52a8\u6001\u751f\u7269\u6807\u5fd7\u7269\u7684\u4f5c\u7528\u65e5\u76ca\u51f8\u663e\u3002 \u4e34\u5e8a\u8bd5\u9a8c\u65e5\u76ca\u7cbe\u7ec6\u5316\u3001\u4e2a\u6027\u5316\uff0c\u4e14\u5f80\u5f80\u9488\u5bf9\u4e09\u7ebf\u53ca\u540e\u7eed\u6cbb\u7597\u4e2d\u7684\u8010\u836f\u673a\u5236\u3002\u6b64\u5916\uff0c\u5b9e\u4f53\u7624CAR-T\u7597\u6cd5\u9996\u6b21\u5e94\u7528\u4e8e\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u5373\u4f7f\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u4e0d\u9002\u5408\u60a8\uff0c\u4e86\u89e3\u73b0\u6709\u9009\u9879\u4e5f\u80fd\u5e2e\u52a9\u60a8\u548c\u60a8\u7684\u533b\u7597\u56e2\u961f\u89c4\u5212\u4e0b\u4e00\u6b65\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u6216\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u6709\u7591\u95ee\u5417\uff1f\u8bf7\u8bbf\u95ee<a href=\"https:\/\/chatbot.fightcolorectalcancer.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cChat CRC<\/a>\u201d\uff0c\u8054\u7cfb\u201cFight CRC\u201d\u7684\u6307\u5bfc\u987e\u95ee\uff0c\u83b7\u53d6\u901a\u4fd7\u6613\u61c2\u7684\u89e3\u7b54\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u514d\u8d23\u58f0\u660e\uff1a<\/strong>\u672c\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u533b\u7597\u5efa\u8bae\u3002\u5173\u4e8e\u68c0\u67e5\u3001\u6cbb\u7597\u65b9\u6848\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u8d44\u683c\u4ee5\u53ca\u526f\u4f5c\u7528\u7ba1\u7406\u7b49\u95ee\u9898\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u6cbb\u7597\u56e2\u961f\u3002 <\/em><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">11\u6708<\/h2>\n\n<h2 class=\"wp-block-heading\">1. BESPOKE-CRC\uff08NCT04264702\uff09\u2014\u2014\u672f\u540e\u4e2a\u6027\u5316\u62a4\u7406<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5f00\u653e\u5e76\u6b63\u5728\u62db\u52df\uff08\u7f8e\u56fd\u591a\u5730\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>\u63a5\u53d7\u8fc7\u624b\u672f\u6cbb\u7597\u7684\u2160\u2013\u2163\u671f\u7ed3\u76f4\u80a0\u764c<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u7814\u7a76\u5229\u7528\u4e00\u79cd\u540d\u4e3actDNA\u7684\u8840\u6db2\u68c0\u6d4b\u65b9\u6cd5\uff0c\u5728\u624b\u672f\u540e\u68c0\u6d4b\u4f53\u5185\u662f\u5426\u5b58\u5728\u5fae\u91cf\u764c\u7ec6\u80de\u3002<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u8fd9\u5f88\u91cd\u8981\uff1a<\/strong>\u5982\u679c\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u6ca1\u6709\u764c\u75c7\u8ff9\u8c61\uff0c\u90e8\u5206\u60a3\u8005\u6216\u8bb8\u53ef\u4ee5\u514d\u4e8e\u63a5\u53d7\u989d\u5916\u6cbb\u7597\uff1b\u5982\u679c\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u6709\u764c\u75c7\u8ff9\u8c61\uff0c\u533b\u751f\u5219\u80fd\u66f4\u65e9\u91c7\u53d6\u884c\u52a8\u3002 <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\uff1a<\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u8bf7\u54a8\u8be2 <\/strong>\u60a8\u7684\u533b\u751f\uff0c\u4e86\u89e3ctDNA\u68c0\u6d4b\u662f\u5426\u6709\u52a9\u4e8e\u6307\u5bfc\u60a8\u672f\u540e\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">2. CodeBreaK-301\uff08NCT06252649\uff09\u2014\u2014\u9488\u5bf9KRAS\u57fa\u56e0\u7a81\u53d8\u7684\u65b0\u578b\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u751f\u72b6\u6001\uff1a<\/strong>\u5f00\u653e\u62db\u751f\uff08\u56fd\u9645\u9879\u76ee\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>\u643a\u5e26KRAS G12C\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8be5\u8bd5\u9a8c<strong>\u65e8\u5728\u6d4b\u8bd5<\/strong>\u4e00\u79cd\u65b0\u7684\u836f\u7269\u7ec4\u5408\uff08\u7d22\u6258\u62c9\u897f\u5e03\uff0b\u5e15\u5c3c\u5355\u6297\uff0b\u5316\u7597\uff09\uff0c\u4ee5\u8bc4\u4f30\u5176\u4f5c\u4e3a\u643a\u5e26\u8be5\u57fa\u56e0\u7a81\u53d8\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u662f\u5426\u66f4\u6709\u6548\u3002<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u8fd9\u53ef\u80fd\u5728\u6cbb\u7597\u521d\u671f\u63d0\u4f9b\u66f4\u6709\u6548\u3001\u66f4\u6709\u9488\u5bf9\u6027\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c <\/strong>\u60a8\u7684\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u5b58\u5728KRAS G12C\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u60a8\u6240\u5728\u5730\u533a\u662f\u5426\u5f00\u5c55\u6b64\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">3. KRYSTAL-10\uff08NCT04793958\uff09\u2014\u2014\u5316\u7597\u540e\u7684\u9776\u5411\u6cbb\u7597<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u4e0d\u518d\u62db\u52df\uff08\u7ed3\u679c\u5373\u5c06\u516c\u5e03\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>\u5df2\u63a5\u53d7\u8fc7\u4e00\u8f6e\u6cbb\u7597\u7684KRAS G12C<strong>\u7a81\u53d8\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a\u8be5 <\/strong>\u7814\u7a76\u5c06\u4e00\u79cd\u9776\u5411\u836f\u7269\u7ec4\u5408\uff08\u963f\u8fbe\u683c\u62c9\u897f\u5e03\uff0b\u897f\u59a5\u6614\u5355\u6297\uff09\u4e0e\u6807\u51c6\u5316\u7597\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u5982\u679c\u60a3\u8005\u7684\u764c\u75c7\u5728\u5316\u7597\u540e\u7ee7\u7eed\u53d1\u5c55\uff0c\u8fd9\u53ef\u80fd\u4f1a\u4e3a\u4ed6\u4eec\u63d0\u4f9b\u53e6\u4e00\u79cd\u6cbb\u7597\u9009\u62e9\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u643a\u5e26KRAS G12C\u7a81\u53d8\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u65b0\u7ed3\u679c\u4f55\u65f6\u516c\u5e03\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">4. CodeBreaK-101\uff08NCT04185883\uff09\u2014\u2014\u5bfb\u627e\u6700\u4f73\u836f\u7269\u7ec4\u5408<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5f00\u653e\u5e76\u6b63\u5728\u62db\u52df\uff08\u7f8e\u56fd\u591a\u4e2a\u7814\u7a76\u5730\u70b9\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>KRAS G12C\u9633\u6027\u665a\u671f\u7ed3\u76f4\u80a0\u764c<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u6d4b\u8bd5\u7d22\u6258\u62c9\u897f\u5e03\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u5408\u4f7f\u7528\u65f6\u7684\u7597\u6548\uff0c\u4ee5\u53ca\u54ea\u4e9b\u7ec4\u5408\u53ef\u80fd\u6548\u679c\u6700\u4f73\u3002<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u8fd9<\/strong>\u53ef\u80fd\u6709\u52a9\u4e8e\u533b\u751f\u4e86\u89e3\u5982\u4f55\u63d0\u9ad8\u9776\u5411\u836f\u7269\u7684\u7597\u6548\u5e76\u5ef6\u957f\u5176\u4f5c\u7528\u65f6\u95f4\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong><\/em><em>\u5982\u679c\u60a8\u7684\u764c\u75c7\u5b58\u5728KRAS G12C\u57fa\u56e0\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u662f\u5426\u6709\u53ef\u53c2\u4e0e\u7684\u8054\u5408\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">5. City of Hope BOT\/BAL \u00b1 \u96f7\u6208\u62c9\u975e\u5c3c\uff08NCT06575725\uff09\u2014\u2014\u8ba9\u514d\u75ab\u7597\u6cd5\u60e0\u53ca\u66f4\u591a\u60a3\u8005<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5f00\u653e\u5e76\u6b63\u5728\u62db\u52df\uff08\u7f8e\u56fd\u7814\u7a76\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c<strong>\u60a3\u8005 <\/strong>\uff0c\u4e14\u75c5\u60c5\u5df2\u53d1\u751f\u8f6c\u79fb\u6216\u590d\u53d1<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a\u5c06<\/strong>\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff08\u535a\u66ff\u897f\u5229\u5355\u6297\uff0b\u5df4\u5c14\u65af\u5229\u5355\u6297\uff09\u4e0e\u53e6\u4e00\u79cd\u836f\u7269\uff08\u96f7\u6208\u62c9\u975e\u5c3c\uff09\u8054\u5408\u4f7f\u7528\u6216\u5355\u72ec\u4f7f\u7528\uff0c\u4ee5\u8bc4\u4f30\u8be5\u65b9\u6848\u80fd\u5426\u5e2e\u52a9\u514d\u75ab\u7cfb\u7edf\u653b\u51fbMSS\u80bf\u7624\u3002<\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a<\/strong>\u76ee\u524d\uff0c\u514d\u75ab\u7597\u6cd5\u5bf9MSS\u60a3\u8005\u51e0\u4e4e\u65e0\u6548\u3002\u8fd9\u9879\u7814\u7a76\u6216\u8bb8\u80fd\u6539\u53d8\u8fd9\u4e00\u73b0\u72b6\u3002 <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u88ab\u544a\u77e5\u4e0d\u9002\u5408\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u50cf\u8fd9\u6837\u8054\u5408\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">6. TAPUR\uff08NCT02693535\uff09\u2014\u2014\u9776\u5411\u6cbb\u7597\u7684\u5b9e\u9645\u53ef\u53ca\u6027<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u8fdb\u884c\u4e2d\uff08\u7f8e\u56fd\u591a\u5730\uff09<\/li>\n\n\n\n<li><strong>\u9002\u7528\u4eba\u7fa4\uff1a <\/strong>\u5b58\u5728\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\u7684\u665a\u671f\u764c\u75c7\uff08\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\uff09<strong>\u60a3\u8005 <\/strong><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4ee5\u65b0\u65b9\u5f0f\u4f7f\u7528\u5df2\u83b7\u6279\u7684\u836f\u7269\u2014\u2014\u6839\u636e\u60a3\u8005\u7684\u80bf\u7624\u57fa\u56e0\u7279\u5f81\u6765\u5339\u914d\u836f\u7269\uff0c\u5373\u4f7f\u8be5\u836f\u7269\u5e76\u975e\u6b63\u5f0f\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u3002<\/li>\n\n\n\n<li><strong>\u91cd\u8981\u6027\uff1a<\/strong>\u6709\u52a9\u4e8e\u8ba9\u66f4\u591a\u60a3\u8005\u5728\u73b0\u5b9e\u4e34\u5e8a\u73af\u5883\u4e2d\u83b7\u5f97\u4e2a\u6027\u5316\u3001\u57fa\u4e8e\u57fa\u56e0\u5339\u914d\u7684\u6cbb\u7597\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c <\/strong>\u60a8\u7684\u80bf\u7624\u68c0\u6d4b\u7ed3\u679c\u663e\u793a\u5b58\u5728\u57fa\u56e0\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u9644\u8fd1\u533b\u7597\u673a\u6784\u662f\u5426\u63d0\u4f9bTAPUR\u6cbb\u7597\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">\u8981\u70b9\uff1a<\/h2>\n\n<p class=\"wp-block-paragraph\">\u6b64\u5904\u5217\u51fa\u7684\u6bcf\u9879\u4e34\u5e8a\u8bd5\u9a8c\u90fd\u5728\u63a8\u52a8\u764c\u75c7\u6cbb\u7597\u7684\u53d1\u5c55\u2014\u2014\u901a\u8fc7\u5f00\u53d1\u66f4\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u65b9\u6848\u3001\u4e3aMSS\u75be\u75c5\u5bfb\u627e\u65b0\u7684\u6cbb\u7597\u9009\u62e9\uff0c\u4ee5\u53ca\u4f7f\u7814\u7a76\u66f4\u5177\u5305\u5bb9\u6027\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5373\u4f7f\u76ee\u524d\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u4e0d\u9002\u5408\u60a8\uff0c\u4e86\u89e3\u73b0\u6709\u9009\u9879\u4e5f\u80fd\u5e2e\u52a9\u60a8\u548c\u60a8\u7684\u533b\u7597\u56e2\u961f\u89c4\u5212\u4e0b\u4e00\u6b65\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u6216\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u6709\u7591\u95ee\u5417\uff1f\u8bf7\u8bbf\u95ee<a href=\"https:\/\/chatbot.fightcolorectalcancer.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cChat CRC<\/a>\u201d\uff0c\u8054\u7cfb\u201cFight CRC\u201d\u7684\u6307\u5bfc\u987e\u95ee\uff0c\u83b7\u53d6\u901a\u4fd7\u6613\u61c2\u7684\u89e3\u7b54\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u514d\u8d23\u58f0\u660e\uff1a<\/strong>\u672c\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u533b\u7597\u5efa\u8bae\u3002\u5173\u4e8e\u68c0\u67e5\u3001\u6cbb\u7597\u65b9\u6848\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u8d44\u683c\u4ee5\u53ca\u526f\u4f5c\u7528\u7ba1\u7406\u7b49\u95ee\u9898\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u6cbb\u7597\u56e2\u961f\u3002 <\/em><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">\u5341\u6708<\/h2>\n\n<h2 class=\"wp-block-heading\">1. MOUNTAINEER\u201103\uff08NCT05253651\uff09\u2014\u2014\u56fe\u5361\u66ff\u5c3c + \u66f2\u59a5\u73e0\u5355\u6297 + FOLFOX\uff08\u4e00\u7ebf\u6cbb\u7597\uff09  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058\uff08\u5168\u740350\u591a\u4e2a\u5730\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\/\u8bd5\u9a8c\u4e2d\u5fc3\uff1a<\/strong>\u968f\u673a\u5bf9\u7167III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0850\u591a\u4e2a\u56fd\u9645\u8bd5\u9a8c\u4e2d\u5fc3\uff09  <\/li>\n\n\n\n<li><strong>\u5206\u671f\uff1a<\/strong>\u4e3b\u8981\u4e3aIV\u671f\uff08\u8f6c\u79fb\u6027\uff09\uff1b\u8fd8\u5305\u62ec\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u7684<br\/>\u7ed3\u76f4\u80a0\u764c\uff08IIIc\u671f\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8bc4\u4f30\u56fe\u5361\u66ff\u5c3c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u4e0e\u5316\u7597\uff08FOLFOX\uff09\u4f5c\u4e3aHER2\u9633\u6027\u3001RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u6216\u4e0d\u53ef\u5207\u9664\u75c5\u53d8\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002  <\/li>\n\n\n\n<li><strong>\u610f\u4e49\u4f55\u5728\uff1a\u8be5\u7814\u7a76<\/strong>\u5728MOUNTAINEER I\/II\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u4e86\u7597\u6548\u7684\u6301\u4e45\u6027\uff1b\u8fd9\u53ef\u80fd\u63a8\u52a8HER2\u9776\u5411\u6cbb\u7597\u6210\u4e3a\u6807\u51c6\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05253651\">clinicaltrials.gov\/study\/NCT05253651<\/a> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong> <a href=\"https:\/\/doi.org\/10.1016\/S1470-2045(23)00150-X\">Strickler, J. H. \u7b49\uff082023\uff09\u3002\u56fe\u5361\u66ff\u5c3c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597HER2\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3002\u300a\u67f3\u53f6\u5200\u00b7\u80bf\u7624\u5b66\u300b\u3002<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong><\/em><em>\u521a\u88ab\u786e\u8bca\u4e3aHER2\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1f\u8bf7\u54a8\u8be2\u60a8\u9644\u8fd1\u662f\u5426\u6709\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u62db\u52df\u60a3\u8005\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">2. DESTINY\u2011CRC02 (NCT04744831) \u2014 \u66f2\u59a5\u73e0\u5355\u6297\u5fb7\u9c81\u514b\u66ff\u5eb7\uff08\u5242\u91cf\u4f18\u5316\uff09<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>\u968f\u673a\u5316\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u4e9a\u6d32\u517120\u591a\u4e2a\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u5206\u671f\uff1a<\/strong>IV\u671f\uff08\u4ec5\u9650\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u6bd4\u8f83T\u2011DXd\u7684\u8f83\u4f4e\u5242\u91cf\uff085.4 mg\/kg\uff09\u4e0e\u6807\u51c6\u5242\u91cf\u5728\u51cf\u8f7b\u6076\u5fc3\u548c\u964d\u4f4e\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\u98ce\u9669\u65b9\u9762\u7684<strong>\u6548\u679c<\/strong>\uff0c\u540c\u65f6\u4fdd\u6301\u6cbb\u7597\u76ca\u5904\u3002  <\/li>\n\n\n\n<li><strong>\u91cd\u8981\u6027\uff1a<\/strong>\u65e8\u5728\u5b9e\u73b0\u66f4\u5b89\u5168\u7684\u7ed9\u836f\u65b9\u6848\uff0c\u540c\u65f6\u4fdd\u6301\u76f8\u4f3c\u7684\u7597\u6548\uff0c\u4ee5\u652f\u6301\u957f\u671f\u6cbb\u7597\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04744831\">clinicaltrials.gov\/study\/NCT04744831<\/a> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\u6587\u732e\uff1a <\/strong><a href=\"https:\/\/doi.org\/10.1016\/S1470-2045(24)00380-2\">Raghav, K. \u7b49\uff082024\uff09\u3002\u66f2\u59a5\u73e0\u5355\u6297\u5fb7\u9c81\u514b\u66ff\u5eb7\u6cbb\u7597HER2\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08DESTINY-CRC02\uff09\u3002\u300a\u67f3\u53f6\u5200\u00b7\u80bf\u7624\u5b66\u300b\u3002<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong><\/em><em>\u6b63\u5728\u670d\u7528\u6216\u8003\u8651\u670d\u7528T\u2011DXd\uff1f\u8bf7\u54a8\u8be2\u51cf\u91cf\u65b9\u6848\u53ca\u80ba\u90e8\u75c7\u72b6\u76d1\u6d4b\u7684\u76f8\u5173\u4fe1\u606f\u3002 <\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">3. HERACLES\u2011B\uff08NCT03225937\uff09\u2014\u2014\u66f2\u59a5\u73e0\u5355\u6297\u827e\u7f8e\u5766\u8f9b\uff08T\u2011DM1\uff09+ \u5e15\u59a5\u73e0\u5355\u6297<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u672a\u77e5\uff08\u6b64\u524d\u5904\u4e8e\u62db\u8058\u72b6\u6001\uff0c\u76ee\u524d\u672a\u62db\u8058\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u5355\u81c2\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u6b27\u6d32\u5b66\u672f\u4e2d\u5fc3\uff09  <\/li>\n\n\n\n<li><strong>\u5206\u671f\uff1aIV\u671f <\/strong>\uff08\u4ec5\u9650\u8f6c\u79fb\u6027\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u8bc4\u4f30\u5728HER2\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7HER2\u6cbb\u7597\u540e\uff0c\u91c7\u7528T\u2011DM1\u8054\u5408pertuzumab<strong>\u6cbb\u7597\u7684\u6548\u679c<\/strong>\u3002  <\/li>\n\n\n\n<li><strong>\u610f\u4e49\u4f55\u5728\uff1a\u663e\u793a\u51fa <\/strong>\u5728\u4f4e\u6bd2\u6027\u6761\u4ef6\u4e0b\u53ef\u63a7\u5236\u75be\u75c5\uff1b\u53ef\u80fd\u9002\u7528\u4e8e\u63a5\u53d7\u8fc7\u5176\u4ed6HER2\u6cbb\u7597\u7684\u60a3\u8005\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03225937\">clinicaltrials.gov\/study\/NCT03225937<\/a> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\u6587\u732e\uff1a <\/strong><a href=\"https:\/\/doi.org\/10.1016\/j.annonc.2020.04.478\">Sartore\u2011Bianchi, A. \u7b49\uff082020\uff09\u3002\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e2d\u7684\u53cc\u91cdHER2\u9776\u5411\u6cbb\u7597\uff1aHERACLES\u7814\u7a76\u7ecf\u9a8c\u3002\u300a\u80bf\u7624\u5b66\u5e74\u9274\u300b\u3002<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong><\/em><em>\u66fe\u5728\u6b27\u6d32\u63a5\u53d7\u8fc7\u6cbb\u7597\u4e14\u5df2\u5b8c\u6210HER2\u6cbb\u7597\uff1f\u8bf7\u54a8\u8be2\u76f8\u5173\u51c6\u5165\u9879\u76ee\u6216\u968f\u8bbf\u7814\u7a76\u3002 <\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">4. SWOG S1613 (NCT03365882) \u2014 \u66f2\u59a5\u73e0\u5355\u6297 + \u5e15\u59a5\u73e0\u5355\u6297 \u5bf9\u6bd4 \u897f\u59a5\u6614\u5355\u6297 + \u4f0a\u7acb\u66ff\u5eb7<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u8fdb\u884c\uff0c\u6682\u4e0d\u62db\u52df\uff08\u7f8e\u56fd\u591a\u4e2d\u5fc3\uff09  <\/li>\n\n\n\n<li><strong>\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\/\u8bd5\u9a8c\u4e2d\u5fc3\uff1a<\/strong>\u968f\u673a\u5316\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u7f8e\u56fd100\u591a\u4e2a\u8bd5\u9a8c\u4e2d\u5fc3\uff09  <\/li>\n\n\n\n<li><strong>\u5206\u671f\uff1a<\/strong>\u4ec5\u9650IV\u671f\uff08\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u6bd4\u8f83\u53cc\u9776\u70b9HER2\u6297\u4f53\u4e0e\u57fa\u4e8eEGFR\u7684\u6807\u51c6\u5316\u7597\u5728HER2\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e2d\u7684\u7597\u6548\u3002  <\/li>\n\n\n\n<li><strong>\u610f\u4e49\u4f55\u5728\uff1a<\/strong>\u65e8\u5728\u4ee5\u66f4\u5c11\u7684\u9ad8\u7ea7\u522b\u6bd2\u6027\u5b9e\u73b0\u7c7b\u4f3c\u7684\u80bf\u7624\u63a7\u5236\u6548\u679c\uff1bHER2\u57fa\u56e0\u62f7\u8d1d\u6570\u8f83\u9ad8\u53ef\u80fd\u9884\u793a\u6cbb\u7597\u83b7\u76ca\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03365882\">clinicaltrials.gov\/study\/NCT03365882<\/a> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\u6587\u732e\uff1a <\/strong><a href=\"https:\/\/doi.org\/10.1200\/JCO.2023.41.4_suppl.356\">Meric\u2011Bernstam, F. \u7b49\uff082023\uff09\u3002SWOG S1613 \u7814\u7a76\u7ed3\u679c\uff08\u6458\u8981\uff09\u3002\u300a\u4e34\u5e8a\u80bf\u7624\u5b66\u6742\u5fd7\u300b\u3002<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a\u5982\u679c\u60a8 <\/strong>\u6b64\u524d\u63a5\u53d7\u8fc7\u22651\u79cd\u5316\u7597\u65b9\u6848\uff0c\u8bf7\u8be2\u95ee\u60a8\u7684HER2\u68c0\u6d4b\u62a5\u544a\u4e2d\u662f\u5426\u5305\u542b\u57fa\u56e0\u62f7\u8d1d\u6570\u4fe1\u606f\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">5. MSK\uff08NCT05672524\uff09\u2014\u2014\u56fe\u5361\u66ff\u5c3c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058\uff08MSK\uff0c\u7ebd\u7ea6\/\u65b0\u6cfd\u897f\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u5355\u81c2\u3001II\u671f\uff08\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\uff0c\u4f4d\u4e8e\u7ebd\u7ea6\u5dde\u548c\u65b0\u6cfd\u897f\u5dde\u76847\u4e2a\u5730\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u5206\u671f\uff1a<\/strong>II\/III\u671f\uff08\u975e\u8f6c\u79fb\u6027\u3001\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5728HER2\u9633\u6027\/RAS\u91ce\u751f\u578b\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0c\u4e8eCAPOX\/FOLFOX\u65b9\u6848\u6cbb\u7597\u524d\u53ca\u6cbb\u7597\u671f\u95f4\u8054\u5408\u4f7f\u7528\u56fe\u5361\u66ff\u5c3c\u548c\u66f2\u59a5\u73e0\u5355\u6297\uff0c\u4ee5\u671f\u66f4\u65e9\u7f29\u5c0f\u80bf\u7624\u3002  <\/li>\n\n\n\n<li><strong>\u4e3a\u4f55\u91cd\u8981\uff1a\u8fd9<\/strong>\u53ef\u80fd\u63d0\u9ad8\u5668\u5b98\u4fdd\u5b58\u7684\u6210\u529f\u7387\uff0c\u6216\u4f7f\u624b\u672f\u8303\u56f4\u66f4\u5c0f\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05672524\">clinicaltrials.gov\/study\/NCT05672524<\/a> <\/li>\n\n\n\n<li><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05672524\">\u65af\u9686-\u51ef\u7279\u7433\u7eaa\u5ff5\u764c\u75c7\u4e2d\u5fc3\u3002\uff082025\uff09\u3002ClinicalTrials.gov \u7f51\u7ad9\u4e0a\u5173\u4e8e NCT05672524 \u7684\u8bb0\u5f55\u3002<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a <\/strong><\/em><em>\u521a\u88ab\u786e\u8bca\u4e3aHER2\u9633\u6027\/RAS\u91ce\u751f\u578b\u76f4\u80a0\u764c\uff1f\u8bf7\u54a8\u8be2MSK\u4e86\u89e3\u60a8\u662f\u5426\u7b26\u5408\u53c2\u4e0e\u6761\u4ef6\u3002 <\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">\u652f\u6301\u6027\u62a4\u7406\u805a\u7126\u2014\u2014\u76ae\u75b9\u9884\u9632<\/h2>\n\n<p class=\"wp-block-paragraph\">\u963b\u65adEGFR\u6216HER2\u7684\u9776\u5411\u6cbb\u7597\u53ef\u80fd\u4f1a\u5f15\u8d77\u76ae\u75b9\u3002\u5c3d\u65e9\u9884\u9632\u76ae\u75b9\u6709\u52a9\u4e8e\u60a8\u575a\u6301\u6cbb\u7597\uff0c\u5e76\u5728\u6cbb\u7597\u671f\u95f4\u611f\u89c9\u66f4\u8212\u9002\u3002   <\/p>\n\n<ul class=\"wp-block-list\">\n<li>\u7b2c1\u5929\u5f00\u59cb\u53e3\u670d\u591a\u897f\u73af\u7d20100\u6beb\u514b\uff0c\u6bcf\u65e5\u4e24\u6b21\uff0c\u6216\u7c73\u8bfa\u73af\u7d20100\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21\u3002  <\/li>\n\n\n\n<li>\u5728\u9762\u90e8\u548c\u4e0a\u534a\u8eab\u4f7f\u7528\u6e29\u548c\u7684\u7c7b\u56fa\u9187\u8f6f\u818f\uff081%\u6c22\u5316\u53ef\u7684\u677e\uff09\u3002  <\/li>\n\n\n\n<li>\u6bcf\u5929\u6d82\u62b9SPF 30+\u7684\u9632\u6652\u971c\uff1b\u9009\u62e9\u6e29\u548c\u7684\u6d01\u9762\u4ea7\u54c1\u548c\u4fdd\u6e7f\u971c\u3002  <\/li>\n\n\n\n<li>\u5982\u679c\u76ae\u75b9\u52a0\u91cd\uff0c\u8bf7\u5c3d\u65e9\u5bfb\u6c42\u76ae\u80a4\u79d1\u533b\u751f\u5e2e\u52a9\u3002  <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u90e8\u5206\u53c2\u8003\u6587\u732e\uff08APA\u683c\u5f0f\uff09\uff1a  <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">Melosky, B. \u7b49\uff082009\uff09\u3002 \u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624EGFR\u9776\u5411\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u671f\u95f4\u76ae\u75b9\u7684\u7ba1\u7406\uff1a\u52a0\u62ff\u5927\u6307\u5357\u3002<em>\u300a\u5f53\u4ee3\u80bf\u7624\u5b66<\/em>\u300b\uff0c16(1)\uff0c16\u201326\u3002[\u94fe\u63a5\uff1a<a href=\"https:\/\/www.mdpi.com\/1718-7729\/16\/1\/361\" target=\"_blank\" rel=\"noreferrer noopener\">\u80c3\u80a0\u9053\u6076\u6027\u80bf\u7624EGFR\u9776\u5411\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u671f\u95f4\u76ae\u75b9\u7684\u7ba1\u7406\u2026<\/a>]  <\/p>\n\n<p class=\"wp-block-paragraph\">Hofheinz, R. D. \u7b49\uff082016\uff09\u3002 \u300aEGFR\u6291\u5236\u5242\u5f15\u8d77\u7684\u76ae\u80a4\u53cd\u5e94\u9884\u9632\u6027\u7ba1\u7406\u5efa\u8bae\u300b\u3002<em>\u300a\u80bf\u7624\u5b66\u5bb6\u300b<\/em>\uff0c21(12)\uff0c1483\u20131491\u3002[\u94fe\u63a5\uff1a<a href=\"https:\/\/academic.oup.com\/oncolo\/article\/21\/12\/1483\/6401597\" target=\"_blank\" rel=\"noreferrer noopener\">\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u6291\u5236\u5242\u8bf1\u5bfc\u7684\u76ae\u80a4\u53cd\u5e94\u9884\u9632\u6027\u7ba1\u7406\u5efa\u8bae\u2026<\/a>]  <\/p>\n\n<p class=\"wp-block-paragraph\">Belum, V. R. \u7b49\uff082013\uff09\u3002\u4e0b\u6d88\u5316\u9053\u764c\u75c7\u4e2d\u7684\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\uff1a\u7ba1\u7406\u7b56\u7565\u3002<em>\u300a\u80bf\u7624\u5b66\u6700\u65b0\u6cbb\u7597\u65b9\u6848\u300b<\/em>\uff0c14\uff0c389\u2013404\u3002 [\u94fe\u63a5\uff1a<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11864-013-0254-4\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e0b\u6d88\u5316\u9053\u764c\u75c7\u9776\u5411\u6cbb\u7597\u4e2d\u7684\u76ae\u80a4\u4e0d\u826f\u53cd\u5e94\uff1a\u4e34\u5e8a\u8868\u73b0\u4e0e\u7ba1\u7406\u7b56\u7565\u2026<\/a>]  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u514d\u8d23\u58f0\u660e\uff1a<\/strong> <em>\u672c\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\uff0c\u4e0d\u6784\u6210\u533b\u7597\u5efa\u8bae\u3002\u5173\u4e8e\u68c0\u67e5\u3001\u6cbb\u7597\u65b9\u6848\u3001\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u8d44\u683c\u4ee5\u53ca\u526f\u4f5c\u7528\u7ba1\u7406\u7b49\u95ee\u9898\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u6cbb\u7597\u56e2\u961f\u3002<\/em><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">\u4e5d\u6708<\/h2>\n\n<h2 class=\"wp-block-heading\">1. ABBV-400 \u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u2014\u2014c-Met \u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08Telisotuzumab Adizutecan\uff09  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c1\u9636\u6bb5\uff08NCT05029882\uff09\uff1a<\/strong>\u5df2\u5b8c\u6210\uff0f\u4e0d\u518d\u62db\u52df\uff087\u201310\u4e2a\u5242\u91cf\u9012\u589e\u4e2d\u5fc3 + \u7ea685\u201395\u4e2a\u6269\u5c55\u4e2d\u5fc3\uff0c\u591a\u79cd\u764c\u75c7\u7c7b\u578b\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c2\u9636\u6bb5\uff08NCT06107413\uff09\uff1a<\/strong>\u6b63\u5728\u5168\u7403\u8303\u56f4\u5185\u62db\u52df\u53d7\u8bd5\u8005\uff08\u7ea665\u4e2a\u5168\u7403\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>ABBV-400 \u662f\u4e00\u79cd\u4ee5 c-Met \u4e3a\u9776\u70b9\u7684\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\uff0c\u5176\u6709\u6548\u8f7d\u8377\u4e3a TOP1 \u6291\u5236\u5242\u3002  <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c\u4e00\u9636\u6bb5\uff1a<\/strong>\u8bc1\u5b9e\u4e86\u8be5\u836f\u7269\u5728\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\u5728\u5185\u7684\u591a\u79cd\u764c\u75c7\u4e2d\u7684\u5b89\u5168\u6027\u3001\u7ed9\u836f\u5242\u91cf\u53ca\u65e9\u671f\u7597\u6548\u3002  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u7b2c2\u9636\u6bb5\uff1a<\/strong>\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\uff0c\u8bc4\u4f30ABBV-400\u8054\u5408FOLFOX\u65b9\u6848\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u7597\u6548\u3002  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05029882\">NCT05029882<\/a>|<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06107413\">NCT06107413<\/a> <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff08ASCO\uff09\uff1a<\/strong> <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>Raghav, K. \u7b49\uff082023\uff09\u3002\u5242\u91cf\u9012\u589e\u7814\u7a76\u7ed3\u679c\uff0c<em>ASCO\u5e74\u4f1a\u6458\u8981\u3002<\/em>  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65e9\u671f\u6570\u636e\uff1a\u53cd\u5e94\u7387\u4ee4\u4eba\u9f13\u821e\uff0c\u5b89\u5168\u6027\u53ef\u63a7\u3002  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/www.onclive.com\/view\/effectively-targeting-c-met-in-colorectal-cancer-is-becoming-a-reality-with-novel-approaches\" target=\"_blank\" rel=\"noreferrer noopener\">Onclive \u2013 \u62c9\u52a0\u592b\u533b\u751f<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u60a3\u6709c-Met\u9633\u6027\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\uff0c\u8bf7\u54a8\u8be2\u60a8\u662f\u5426\u7b26\u5408\u6b63\u5728\u8fdb\u884c\u7684 <\/em><em>II\u671f\u6216III\u671fABBV-400\u7814\u7a76<\/em><em> \u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">2. ABBV-400 III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u2014\u2014c-Met\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u4e0e\u6807\u51c6\u6cbb\u7597\u7684\u5bf9\u6bd4  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u52df\uff08NCT06614192\uff09  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>\u7b2c3\u9636\u6bb5\uff0851\u4e2a\u56fd\u9645\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>ABBV-400 \u4e0e\u4e09\u6c1f\u5c3f\u5627\u5576\/\u66ff\u5339\u62c9\u897f\uff08LONSURF\uff09\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09<strong>\u4e2d\u7684\u7597\u6548\u6bd4\u8f83<\/strong>\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06614192\">NCT06614192<\/a> <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff08ASCO 2025\uff09\uff1a<\/strong>Strickler, J. \u7b49\u3002Telisotuzumab adizutecan \u7528\u4e8e c-Met \u9633\u6027\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08\u6458\u8981 TPS3635\uff09\u3002   <\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/www.vjoncology.com\/video\/fb7lgc-ivpq-telisotuzumab-adizutecan-in-c-met-expressing-refractory-mcrc\/\" target=\"_blank\" rel=\"noreferrer noopener\">VJ Oncology \u2013 ASCO 25 \u4e13\u8bbf<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8\u6b64\u524d\u5df2\u63a5\u53d7\u8fc7LONSURF\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u6cbb\u7597\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\uff0c\u4e86\u89e3\u672c\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u65b9\u6848\u662f\u5426\u9002\u7528\u4e8e\u60a8\uff0c\u6216\u8005\u662f\u5426\u53ef\u4ee5\u901a\u8fc7\u5176\u4ed6\u7814\u7a76\u83b7\u5f97ABBV-400\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">3. PROCEADE-CRC \u8bd5\u9a8c\u2014\u2014\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\u7684\u6269\u5c55  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u65e9\u671f\u7814\u7a76\uff08\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\u6742\u5fd7\uff0c2024\u5e748\u6708\uff09  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u8bd5\u9a8c\u70b9\uff1a<\/strong>\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5b66\u672f\u4e2d\u5fc3\uff08\u9884\u8ba1\u7ea610\u201315\u5bb6\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u4e0b\u4e00\u4ee3\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\uff0c\u91cd\u70b9\u5728\u4e8e\u589e\u5f3aTOP1\u6291\u5236\u5242\u6709\u6548\u8f7d\u8377\u5411\u80bf\u7624\u90e8\u4f4d\u7684\u8f93\u9001\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a\u672a <\/strong>\u6ce8\u518c\u2014\u2014<em>\u8bf7\u53c2\u9605\u4e0b\u6587\u4e86\u89e3\u66f4\u591a\u4fe1\u606f<\/em> <\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/www.nature.com\/articles\/s41591-025-03843-z\" target=\"_blank\" rel=\"noreferrer noopener\">\u300a\u81ea\u7136\u300b\u2014\u2014PROCEADE-CRC<\/a>  <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u8fd9\u4e9b\u65b0\u578bADC\u4ecd\u5904\u4e8e\u7814\u53d1\u521d\u671f\u3002\u82e5\u8003\u8651\u53c2\u52a0ADC\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bf7\u5411\u60a8\u7684\u533b\u751f\u54a8\u8be2 <\/em><em>\u5165\u7ec4\u9650\u5236<\/em><em> \uff08\u4f8b\u5982\uff0c\u662f\u5426\u66fe\u63a5\u89e6\u8fc7ADC\uff09\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">4. BATTMAN \u8bd5\u9a8c\u2014\u2014BOT\/BAL \u8054\u5408\u6cbb\u7597  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>2025\u5e7411\u6708\u5f00\u653e\u62a5\u540d\uff08\u52a0\u62ff\u5927\u3001\u6cd5\u56fd\u3001\u82f1\u56fd\uff09\u2014\u2014\u7f8e\u56fd\u4e0d\u62db\u6536\u5b66\u5458  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7ad9\u70b9\uff1a<\/strong>\u7b2c3\u9636\u6bb5\uff0830\u201340\u4e2a\u56fd\u9645\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u9488\u5bf9\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u7684BOT\/BAL\u7597\u6cd5III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong>\u5f85\u6ce8\u518c  <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5c45\u4f4f\u5728\u7f8e\u56fd\u5883\u5916\uff0c\u7279\u522b\u662f <\/em><em>\u52a0\u62ff\u5927\u3001\u6cd5\u56fd\u6216\u82f1\u56fd<\/em><em>\uff0c\u8bf7\u54a8\u8be2\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u5c06\u4e8e2025\u5e74\u5e95\u5728\u60a8\u6240\u5728\u5730\u533a\u9644\u8fd1\u5f00\u5c55\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">*5. \u5f17\u9c81\u6606\u66ff\u5c3c\u8054\u5408\u7528\u836f\u8bd5\u9a8c\u2014\u2014\u8d85\u8d8a\u5355\u836f\u6cbb\u7597  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u52df\/\u8ba1\u5212\u4e2d\uff08\u7f8e\u56fd4\u5bb6\u4e2d\u5fc3\uff1bMDA MRD\u8bd5\u9a8c\u5c06\u4e8e2026\u5e742\u6708\u542f\u52a8\uff1bNCT07136077\u5c1a\u672a\u5f00\u59cb\u62db\u52df\uff09  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u5730\u70b9\uff1a<\/strong> <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u5f17\u9c81\u6606\u66ff\u5c3c + \u5316\u7597\/\u514d\u75ab\u6cbb\u7597\/\u8d1d\u4f10\u73e0\u5355\u6297\uff1aII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u591a\u4e2d\u5fc3\uff0c\u7ea610\u201320\u4e2a\u7f8e\u56fd\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>Fruquintinib \u8054\u5408\u514d\u75ab\u6cbb\u7597\uff08I\/O\uff09\u7528\u4e8e\u5fae\u5c0f\u6b8b\u7559\u75c5\uff08MRD\uff09\u7684\u6cbb\u7597\uff1aII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08MDA\uff0c\u5355\u4e2d\u5fc3\uff0c2026\u5e742\u6708\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u5f17\u9c81\u6606\u66ff\u5c3c + \u8482\u65af\u5229\u73e0\u5355\u6297\uff08NCT07136077\uff09\uff1aII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff081\u4e2a\u7814\u7a76\u4e2d\u5fc3\uff0c\u5c1a\u672a\u5f00\u59cb\u62db\u52df\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5f17\u9c81\u6606\u66ff\u5c3c\u6b63\u5728\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\u8fdb\u884c\u591a\u79cd\u8054\u5408\u7528\u836f\u65b9\u6848\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1a  <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u5f17\u9c81\u6606\u66ff\u5c3c + \u5316\u7597<\/strong> <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u5f17\u9c81\u6606\u66ff\u5c3c + \u514d\u75ab\u6cbb\u7597\uff08I\/O\uff09<\/strong>\u2014\u2014\u5305\u62ec<strong>\u8482\u65af\u5229\u73e0\u5355\u6297\u4e34\u5e8a\u8bd5\u9a8c\uff08NCT07136077\uff09<\/strong> <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>\u5f17\u9c81\u6606\u66ff\u5c3c + \u8d1d\u4f10\u73e0\u5355\u6297<\/strong> <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>Fruquintinib \u8054\u5408\u514d\u75ab\u6cbb\u7597\u7528\u4e8e\u5fae\u5c0f\u6b8b\u7559\u75c5<\/strong>\uff08<strong>MRD\uff09\u7684\u6cbb\u7597<\/strong>\uff08MDA\u4e3b\u5bfc\u7684\u8bd5\u9a8c\uff0c2026\u5e742\u6708\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/search?term=fruquintinib&amp;cond=Colorectal+Cancer\">\u641c\u7d22\u5f17\u9c81\u6606\u66ff\u5c3c\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a>|<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07136077\">NCT07136077<\/a> <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong>\u5f17\u9c81\u6606\u66ff\u5c3c\u5df2\u83b7FDA\u6279\u51c6\u4f5c\u4e3a\u5355\u836f\u6cbb\u7597\uff1b\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u63a2\u8ba8\u8054\u5408\u7528\u836f\u80fd\u5426\u6269\u5927\u6cbb\u7597\u83b7\u76ca\uff0c\u7279\u522b\u662f\u5728\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\u60a3\u8005\u4e2d\u3002  <\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a<\/strong> <a href=\"https:\/\/www.youtube.com\/watch?v=jUqikOxP4rM\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e0e\u51ef\u831c\u00b7\u6069\u683c\u535a\u58eb\u4e00\u8d77\u53c2\u4e0e\u201cFight CRC\u201d\u9879\u76ee<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8\u60a3\u6709MSS\u578b\u7ed3\u76f4\u80a0\u764c\uff0c\u8bf7\u54a8\u8be2\u60a8\u662f\u5426\u7b26\u5408 <\/em><em>\u8054\u5408\u6cbb\u7597\u7814\u7a76<\/em><em> \u2014\u2014\u5c24\u5176\u662f\u5f17\u9c81\u6606\u66ff\u5c3c\u8054\u5408\u514d\u75ab\u7597\u6cd5\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">6. TP53\u70ed\u70b9\u7a81\u53d8\u8bd5\u9a8c\u2014\u2014\u591a\u79cd\u65b9\u6cd5  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058\/\u8ba1\u5212\u4e2d  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>\u7b2c1\/2\u9636\u6bb5\uff08\u591a\u56fd\uff1a\u7f8e\u56fd\u3001\u6b27\u76df\u3001\u4e9a\u592a\u5730\u533a\uff1b\u7ea615\u201325\u4e2a\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a  <\/strong> <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u9a6c\u4e07\u00b7\u6cd5\u57fa\u8d6b\u535a\u58eb\uff08\u5e0c\u671b\u4e4b\u57ce\uff09\uff1a\u9488\u5bf9TP53\u7684\u4e34\u5e8a\u8bd5\u9a8c  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>David Hong \u535a\u58eb\uff08MDA\uff09\uff1aPynacle \u8bd5\u9a8c  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u5c3c\u53e4\u62c9\u65af\u00b7\u514b\u83b1\u95e8\u535a\u58eb\uff08\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff09\uff1a\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a\u6709\u591a\u4e2a <\/strong>\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\u2014\u2014\u641c\u7d22<strong>\u201cTP53 \u7ed3\u76f4\u80a0\u764c\u201d<\/strong>\u6216\u67e5\u770b\u5177\u4f53\u8bd5\u9a8c  <\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a <\/strong>\u76f4\u63a5<strong>\u8054\u7cfb <\/strong>\u8c03\u67e5\u4eba\u5458  <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u9a6c\u4e07\u00b7\u6cd5\u57fa\u8d6b\u535a\u58eb\uff08\u5e0c\u671b\u4e4b\u57ce\uff09\uff1aTP53\u9776\u5411\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8054\u7cfb\u65b9\u5f0f\uff1a<a href=\"mailto:mfakih@coh.org\">mfakih@coh.org<\/a>\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>David Hong \u535a\u58eb\uff08MDA\uff09\uff1aPynacle \u8bd5\u9a8c\uff08\u591a\u4e2d\u5fc3\uff09  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li>\u5c3c\u53e4\u62c9\u65af\u00b7\u514b\u83b1\u95e8\u535a\u58eb\uff08\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff09\uff1a\u7ec6\u80de\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8054\u7cfb\u65b9\u5f0f\uff1a<a href=\"mailto:nicholas.klemen@nih.org\">nicholas.klemen@nih.org<\/a>\uff09  <\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u662f\u5426\u5b58\u5728 <\/em><em>TP53\u70ed\u70b9\u7a81\u53d8<\/em><em>\uff1b\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u5c1a\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u4f46\u53ef\u80fd\u4e3a\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u6709\u9650\u7684\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">*7. DYNAMIC \u8bd5\u9a8c\u2014\u2014II\u671f\u7ed3\u80a0\u764c\u7684ctDNA\u6307\u5bfc\u5316\u7597  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u5df2\u5b8c\u6210\uff08\u6fb3\u5927\u5229\u4e9a\u548c\u65b0\u897f\u5170\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\u4e2d\u5fc3\uff1aACTRN12615000381583\uff09  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7814\u7a76\u7ad9\u70b9\uff1a<\/strong>\u7b2c2\u9636\u6bb5\u968f\u673a\u5206\u7ec4\uff08\u6fb3\u5927\u5229\u4e9a22\u4e2a\u7814\u7a76\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u6bd4\u8f83\u4e86II\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u4e2d\u57fa\u4e8ectDNA\u6307\u5bfc\u7684\u5316\u7597\u4e0e\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684<strong>\u7597\u6548<\/strong>\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong>NCT03437501  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong>Tie, J. \u7b49\uff082022\uff09\u3002<em>\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM<\/em>\uff09\u3002\u57fa\u4e8ectDNA\u7684\u6cbb\u7597\u6307\u5bfc\u4f7f\u5316\u7597\u4f7f\u7528\u7387\u964d\u4f4e\u4e8628%\uff0c\u4e14\u672a\u5f71\u54cd\u65e0\u590d\u53d1\u751f\u5b58\u671f\u3002   <\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a\u9605\u8bfb\u5168\u6587 <\/strong>\uff1a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08<a href=\"https:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2200075?utm\" target=\"_blank\" rel=\"noreferrer noopener\">NEJM\uff09\u2014\u2014DYNAMIC\u7814\u7a76<\/a> <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong>\u5982\u679c\u60a8\u5904\u4e8eII\u671f\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\uff0c\u4e86\u89e3\u60a8\u662f\u5426\u66fe\u63a5\u53d7\u8fc7 <\/em><em>ctDNA\u68c0\u6d4b<\/em><em>\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u907f\u514d\u4e0d\u5fc5\u8981\u7684\u5316\u7597\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">*8. CIRCULATE-\u65e5\u672c\uff08GALAXY\u3001VEGA\u3001ALTAIR\uff09  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u8058\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u8058  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7ad9\u70b9\uff1a<\/strong>GALAXY\uff1a\u89c2\u6d4b\u9636\u6bb5\uff1bVEGA + ALTAIR\uff1a\u7b2c3\u9636\u6bb5\uff08\u65e5\u672c\u5883\u5185\u7ea6150\u4e2a\u7ad9\u70b9\uff0c\u65e5\u672c\u5883\u59161\u4e2a\u7ad9\u70b9\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong> <\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>GALAXY\uff1a<\/strong>\u901a\u8fc7ctDNA\u8ffd\u8e2a\u590d\u53d1\u98ce\u9669\u7684\u89c2\u5bdf\u6027\u767b\u8bb0\u7814\u7a76  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>VEGA\uff1a<\/strong>\u51cf\u91cf\u6cbb\u7597\u8bd5\u9a8c\u2014\u2014\u82e5ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u5219\u4e0d\u8fdb\u884c\u5316\u7597  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\n<ul class=\"wp-block-list\">\n<li><strong>ALTAIR\uff1a<\/strong>\u5f3a\u5316\u6cbb\u7597\u8bd5\u9a8c\u2014\u2014\u82e5ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u5219\u52a0\u7528\u6cbb\u7597  <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u4e86\u89e3\u66f4\u591a\uff1a <\/strong><a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/31\/2\/328\/751096\">GALAXY\u7814\u7a76\u2014\u2014AACR\u3002<\/a> <em>\u6587\u732e\uff1a<\/em>Nakamura, Y. \u7b49\uff082025\uff09\u3002\u300a<em>\u4e34\u5e8a\u764c\u75c7\u7814\u7a76<\/em>\u300b\uff0c31(2)\uff0c328\u2013337\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8 <\/em><em>\u672f\u540ectDNA\u68c0\u6d4b\u5448\u9633\u6027<\/em><em>\uff0c\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u5851\u9020\u4e0b\u4e00\u4ee3\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u3002<\/em> <\/p>\n\n<h2 class=\"wp-block-heading\">*9. CIRCULATE\u2013\u5317\u7f8e (NRG-GI008)  <\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong>\u6b63\u5728\u62db\u52df\uff08NCT05174169\uff09  <\/li>\n\n\n\n<li><strong>\u9636\u6bb5\/\u7814\u7a76\u5730\u70b9\uff1a<\/strong>\u7b2c2\/3\u9636\u6bb5\uff08\u8ba1\u5212\u62db\u52df\u7ea61,600\u540d\u60a3\u8005\uff0c\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u5f00\u5c55\u7684\u591a\u4e2d\u5fc3\u7814\u7a76\uff09  <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5229\u7528\u672f\u540ectDNA\u6307\u5bfcIII\u671f\u6216\u9ad8\u5371II\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u5316\u7597\u3002  <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05174169\">NCT05174169<\/a> <\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong>\u4f5c\u4e3a\u5168\u7403<strong>CIRCULATE\u5e73\u53f0\u7684<\/strong>\u7f8e\u56fd\u5206\u652f\uff0c\u672c\u7814\u7a76\u65e8\u5728\u8bc4\u4f30ctDNA\u80fd\u5426\u4e3a\u6cbb\u7597\u5f3a\u5ea6\u8c03\u6574\uff08\u5347\u7ea7\/\u964d\u7ea7\uff09\u51b3\u7b56\u63d0\u4f9b\u6307\u5bfc\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u8bf7\u5411\u60a8\u7684\u533b\u7597\u56e2\u961f\u54a8\u8be2\uff0c\u4e86\u89e3\u60a8\u662f\u5426\u7b26\u5408 <\/em><em>CIRCULATE-US<\/em><em>\uff0c\u56e0\u4e3a\u8fd9\u662f\u5317\u7f8e\u89c4\u6a21\u6700\u5927\u7684ctDNA\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002<\/em> <\/p>\n\n<p class=\"wp-block-paragraph\"><em>*9\u6708\u201c\u70ed\u70b9\u4e34\u5e8a\u8bd5\u9a8c\u201d\u680f\u76ee\u91cd\u70b9\u63a8\u4ecb\u7684\u201c\u5fc5\u987b\u4e86\u89e3\u7684\u5173\u952ectDNA\u8bd5\u9a8c\u201d\u3002<\/em><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\">8\u6708<\/h2>\n\n<h2 class=\"wp-block-heading\">1. BREAKWATER \u8bd5\u9a8c\u2014\u2014\u6069\u79d1\u62c9\u975e\u5c3c + \u897f\u59a5\u6614\u5355\u6297 \u00b1 mFOLFOX6<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6682\u4e0d\u62db\u52df<\/em>\uff08NCT04607421\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u9488\u5bf9BRAF V600E\u7a81\u53d8\u7684\u65b0\u8bca\u65ad\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u9776\u5411\u6cbb\u7597\u4e0e\u5316\u7597\u8054\u5408\u65b9\u6848<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04607421<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff08ASCO\uff09\uff1a<\/strong> <em>Kopetz, S. \u7b49\uff08<\/em>2025\uff09\u3002\u6069\u79d1\u62c9\u975e\u5c3c\u3001\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u6cbb\u7597BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\uff1a\u4e00\u9879\u968f\u673a\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b\u3002  <br\/><strong><a href=\"https:\/\/www.nature.com\/articles\/s41591-024-03443-3\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><em> \u5982\u679c\u60a8\u643a\u5e26BRAF V600E\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\uff0c\u4e86\u89e3\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u7ed3\u679c\u662f\u5426\u9002\u7528\u4e8e\u60a8\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/em><\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6682\u4e0d\u62db\u52df<\/em>\uff08NCT04607421\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u9488\u5bf9BRAF V600E\u7a81\u53d8\u7684\u65b0\u8bca\u65ad\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u9776\u5411\u6cbb\u7597\u4e0e\u5316\u7597\u8054\u5408\u65b9\u6848<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\" target=\"_blank\" rel=\"noreferrer noopener\">NCT04607421<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff08ASCO\uff09\uff1a<\/strong> <em>Kopetz, S. \u7b49\uff08<\/em>2025\uff09\u3002\u6069\u79d1\u62c9\u975e\u5c3c\u3001\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u5316\u7597\u6cbb\u7597BRAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\uff1a\u4e00\u9879\u968f\u673a\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u300a\u81ea\u7136\u00b7\u533b\u5b66\u300b\u3002  <br\/><strong><a href=\"https:\/\/www.nature.com\/articles\/s41591-024-03443-3\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/strong><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><em> \u5982\u679c\u60a8\u643a\u5e26BRAF V600E\u7a81\u53d8\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\uff0c\u4e86\u89e3\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u7ed3\u679c\u662f\u5426\u9002\u7528\u4e8e\u60a8\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">2. \u535a\u6ed5\u897f\u5229\u5355\u6297 + \u5df4\u5c14\u65af\u5229\u5355\u6297\uff08\u00b1 \u96f7\u6208\u62c9\u975e\u5c3c\uff09<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u90e8\u5206\u7814\u7a76\u4ecd\u5728\u62db\u52df\u53d7\u8bd5\u8005<\/em>\uff08<a href=\"https:\/\/clinicaltrials.gov\/search?term=botensilimab%20balstilimab%20colorectal&amp;viewType=Table\" target=\"_blank\" rel=\"noreferrer noopener\">\u53ef\u5728ClinicalTrials.gov\u7f51\u7ad9\u6309\u836f\u7269\u540d\u79f0\u641c\u7d22<\/a>\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong>\u9488\u5bf9\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\uff0c\u91c7\u7528\u4e24\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7684\u65b0\u578b\u8054\u5408\u65b9\u6848\uff0c\u6709\u65f6\u4f1a\u8054\u5408\u5316\u7597\u3002\u8fd9\u5305\u62ec<strong>\u675c\u514b\u5927\u5b66\u5f00\u5c55<\/strong>\u7684\u4e00\u7ebf<strong>BBOPCO\u8bd5\u9a8c<\/strong>\uff0c\u4ee5\u53ca\u5c06Botensilimab + Balstilimab\u4e0e\u5176\u4ed6\u6cbb\u7597\u65b9\u6848\u8054\u5408\u4f7f\u7528\u7684\u89c4\u6a21\u8f83\u5c0f\u7684\u7814\u7a76\u3002 <\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong>\u641c\u7d22<a href=\"https:\/\/clinicaltrials.gov\/search?term=Botensilimab\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cBotensilimab<\/a>\u201d\u6216<a href=\"https:\/\/clinicaltrials.gov\/search?term=Balstilimab\" target=\"_blank\" rel=\"noreferrer noopener\">\u201cBalstilimab\u201d<\/a><\/li>\n\n\n\n<li><strong>\u503c\u5f97\u5173\u6ce8\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1a<\/strong>BBOPCO\u8bd5\u9a8c\uff08\u4e00\u7ebf\u6cbb\u7597\uff0c\u5fae\u5206\u5316\u7ed3\u76f4\u80a0\u764c\uff0c\u675c\u514b\u5927\u5b66\uff09\u3002\u8be5\u8bd5\u9a8c\u65e0\u96c6\u4e2d\u94fe\u63a5\u2014\u2014\u5fc5\u987b\u901a\u8fc7\u836f\u7269\u540d\u79f0\u6216\u8bd5\u9a8c\u540d\u79f0\u8fdb\u884c\u68c0\u7d22\u3002 <\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><em><\/em><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong><em> \u5982\u679c\u60a8\u5df2\u88ab\u786e\u8bca\u4e3aMSS\u578b\u7ed3\u76f4\u80a0\u764c\uff0c\u4e14\u514d\u75ab\u6cbb\u7597\u5c1a\u672a\u7eb3\u5165\u60a8\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u65b9\u6848\u6216\u8bb8\u80fd\u4e3a\u60a8\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002\u8bf7\u54a8\u8be2\u60a8\u662f\u5426\u7b26\u5408\u67d0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5165\u7ec4\u6761\u4ef6\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">3. RMC\u20116236<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u91cd\u70b9\uff1a<\/strong>KRAS \u6216 BRAF \u7a81\u53d8\uff08\u4e0d\u5305\u62ec G12C \u7a81\u53d8\uff09<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6b63\u5728\u62db\u52df<\/em>\uff08NCT06445062\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u591a\u9776\u70b9\u836f\u7269\uff0c\u53ef\u963b\u65ad\u591a\u79cd\u9a71\u52a8\u764c\u75c7\u7684\u86cb\u767d\u8d28\uff0c\u5305\u62ecKRAS\u548cBRAF<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06445062\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06445062<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong> <em>Jiang, J. \u7b49\uff08<\/em>2024\uff09\u3002RMC-6236 \u6291\u5236 RAS-GTP \u5728 RAS \u9a71\u52a8\u578b\u764c\u75c7\u4e2d\u7684\u8f6c\u5316\u4e0e\u6cbb\u7597\u8bc4\u4f30<em>\u3002<\/em>\u300a\u764c\u75c7\u53d1\u73b0\u300b\uff0c14(6)\uff0c994\u20131010\u3002  <br\/><a href=\"https:\/\/watermark02.silverchair.com\/994.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAA0cwggNDBgkqhkiG9w0BBwagggM0MIIDMAIBADCCAykGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMY2TKrpfjhW03KbsJAgEQgIIC-mTPGEYRcD-vUS3cGQj8cFAWfh_A_0bDf5_IP92KIv2jbyn9DlmGUlKdAQ-UnIBnvOJ_fFxwpEc_dDD12r8Cy0lxbKXPp5hu44BmFfFKKcnwpQEf_kRvw2qALYv_dBVZvAxyB1mNXBhOqOZOQTUO9xG7LATSJ-A188kuMuXyJ9gUAeaJISL7hoDxay2VwHI3NbLCh6ThIbSvLgISGIgobmQvcOiym6auTT0tYmCr6dRor3ZFNCinQZXz_G_dX2sX3h4afrWKH1QKFip6-4mYFDWJxKQkauwf0E7YKTahZkwUy8Ikma-lzvWGf6uX6_DAxoi-gykbHjOCXhGa1mdfR0qb6QqUejseoMpKc0PoXMTrCfYTC1mhfdMmKDDsPkzeFL4AxJpdRm-vzEMFSUUCYW4gEAAk5EgKR4wIKkSuvnUfpqiWjwKUCjqSfk4aq87kAj8HDcNgaZ8PjjSXl_SSMe4G9OKr6WujfDqolK0AtNs1mIFOk-BPQx0c9OMab3zjbqbUxiA0TGFIDqXucKdMRwDyN04cAYA-M8dOlbSCk15ZkjaAwhRmymadU_lf4QZS1ADpkZHHDohn5zmXLJuM3m5_scSUoSV440gVYcHDhJedGlzRR-MZP-yZQh3hB4xqLWWZwVU8szQ1TYbfd82MwfCB0OrvIvquZorIQLbfjadl_eK08E4qkIk30s90U1Kba8WkCoaInVgWNB7j0YNtf_rc0edVt9krtjtGj7HGSvI1h3Bb--e6AAvSFxYNK2mD5o9y-oHfBOKirkptYsjMLEgIH-lnpOHhSNEkAMF2FHrVVnsHmztb81b7H_0fdUBPhEQu3rvzLRYW3wRD6O7SjvwO0n06G8wZJKL9pFB2t06UemzxOK3dXULwdByYiDYCvqY-i_7XrQA55g2Y6jE5d5DT8NNPdGz4FxdNEeNqHYrp9vH7IvjfXLAu08ZaqpXR3kSfAuCaa3q1j4oLvMN2M-urXYiyue6BHfDjX0sSPicybVO2cpYatgfewQ\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8\u7684\u764c\u75c7\u5b58\u5728KRAS\u6216BRAF\u57fa\u56e0\u7a81\u53d8\uff0c\u4e14\u60a8\u5df2\u7ecf\u63a5\u53d7\u8fc7\u6807\u51c6\u6cbb\u7597\uff0c\u8fd9\u53ef\u80fd\u662f\u4e00\u4e2a\u503c\u5f97\u8003\u8651\u7684\u9009\u62e9\u2014\u2014\u7279\u522b\u662f\u5982\u679c\u60a8\u613f\u610f\u53c2\u4e0e\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8bdd\u3002<\/em><\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u5021\u5bfc\u8005\u6ce8\uff1a<\/strong>KRAS G12D\u7a81\u53d8\u76ee\u524d\u5df2\u6210\u4e3a\u4e3b\u8981\u7684\u7814\u7a76\u91cd\u70b9\uff0c\u622a\u81f32025\u5e747\u670831\u65e5\uff0c\u7f8e\u56fd\u5df2\u6709\u8d85\u8fc716\u9879\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002 \u7ea640%\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u75c5\u4f8b\u4e2d\u5b58\u5728KRAS\u7a81\u53d8\uff0c\u5176\u4e2dKRAS G12D\u7a81\u53d8\u7ea6\u5360\u6240\u6709mCRC\u75c5\u4f8b\u768415%\u3002   <a href=\"https:\/\/clinicaltrials.gov\/search?term=NCT07023731%20OR%20NCT07020221%20OR%20NCT06917079%20OR%20NCT06179160%20OR%20NCT06586515%20OR%20NCT06835569%20OR%20NCT06797336%20OR%20NCT06607185%20OR%20NCT06599502%20OR%20NCT06040541%20OR%20NCT06364696%20OR%20NCT06385925%20OR%20NCT07023731%20OR%20NCT06619587%20OR%20NCT06227377%20OR%20NCT06447662%20OR%20NCT07094204&amp;viewType=Table\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u67e5\u770b\u8bd5\u9a8c\u3002<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">4. IK\u2011595<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF II\/III\u7c7b\u53ca\u5176\u4ed6RAF\/RAS\u7a81\u53d8<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6b63\u5728\u62db\u52df<\/em>\uff08NCT06270082\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u4e00\u79cd\u9776\u5411\u7597\u6cd5\uff0c\u5176\u4f5c\u7528\u5982\u540c\u201c\u5206\u5b50\u80f6\u201d\uff0c\u53ef\u963b\u65ad\u643a\u5e26\u975eV600E\u578bBRAF\u6216RAS\u7a81\u53d8\u7684\u80bf\u7624\u4e2d\u7684\u5f02\u5e38\u4fe1\u53f7\u4f20\u5bfc<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06270082\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06270082<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong> <em>Li, J. \u7b49<\/em>\uff082024\uff09\u3002\u6fc0\u9176\u6291\u5236\u5242\u4e0e\u4ee5\u6fc0\u9176\u4e3a\u9776\u70b9\u7684\u764c\u75c7\u6cbb\u7597\uff1a\u6700\u65b0\u8fdb\u5c55\u4e0e\u672a\u6765\u5c55\u671b\u3002   <em>\u300a\u56fd\u9645\u5206\u5b50\u79d1\u5b66\u6742\u5fd7\u300b\uff0c25(10)\uff0c5489\u3002<\/em> <a href=\"https:\/\/www.mdpi.com\/1422-0067\/25\/10\/5489\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8\u88ab\u544a\u77e5\u60a8\u7684\u7a81\u53d8\u4e3a\u201c\u975eV600E\u201d\u578bBRAF\u6216RAS\u57fa\u56e0\u7a81\u53d8\uff0c\u8fd9\u53ef\u80fd\u662f\u4e3a\u6570\u4e0d\u591a\u7684\u4e13\u95e8\u9488\u5bf9\u60a8\u8fd9\u79cd\u80bf\u7624\u7c7b\u578b\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u4e00\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">5. ZEN003694 + \u6069\u79d1\u62c9\u975e\u5c3c + \u897f\u59a5\u6614\u5355\u6297<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>BRAF V600E\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6b63\u5728\u62db\u52df<\/em>\uff08NCT06102902\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5c06\u4e00\u79cd\u65b0\u578b\u8868\u89c2\u9057\u4f20\u836f\u7269\u4e0e\u5df2\u77e5\u7684\u9776\u5411\u6cbb\u7597\u7ec4\u5408\u642d\u914d\u4f7f\u7528\uff0c\u4ee5\u63a2\u7a76\u80fd\u5426\u8fdb\u4e00\u6b65\u63d0\u9ad8\u80bf\u7624\u7684\u6cbb\u7597\u53cd\u5e94\u7387<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06102902\" target=\"_blank\" rel=\"noreferrer noopener\">NCT06102902<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong> <em>Gu, R. \u7b49<\/em>\uff082024\uff09\u3002BRAFV600E\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u5206\u5b50\u7279\u5f81\u53ca\u6cbb\u7597\u9776\u70b9\u7684\u7efc\u5408\u6982\u8ff0\u3002   <em>\u300a\u4e34\u5e8a\u4e0e\u8f6c\u5316\u533b\u5b66\u300b<\/em><br\/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ctm2.1764\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u5982\u679c\u60a8\u5df2\u7ecf\u5c1d\u8bd5\u8fc7BRAF\u9776\u5411\u6cbb\u7597\uff0c\u5e76\u6b63\u5728\u8003\u8651\u4e0b\u4e00\u6b65\u65b9\u6848\uff0c\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6216\u8bb8\u80fd\u4e3a\u60a8\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u3002\u7531\u4e8e\u8be5\u8bd5\u9a8c\u5c1a\u5904\u4e8e\u65e9\u671f\u9636\u6bb5\uff0c\u8bf7\u52a1\u5fc5\u54a8\u8be2\u76f8\u5173\u7684\u5b89\u5168\u6027\u548c\u5165\u7ec4\u6807\u51c6\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\">6. METIMMOX \u8bd5\u9a8c<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u751f\u7269\u6807\u5fd7\u7269\u805a\u7126\uff1a<\/strong>\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\uff0c\u53ef\u80fd\u5b58\u5728BRAF\u7a81\u53d8<\/li>\n\n\n\n<li><strong>\u62db\u52df\u72b6\u6001\uff1a<\/strong> <em>\u6682\u4e0d\u62db\u52df<\/em>\uff08NCT03388190\uff09<\/li>\n\n\n\n<li><strong>\u7814\u7a76\u5185\u5bb9\uff1a<\/strong>\u5c06\u77ed\u671f\u5316\u7597\u65b9\u6848\u4e0e\u514d\u75ab\u7597\u6cd5\u76f8\u7ed3\u5408\uff0c\u4ee5\u8bc4\u4f30\u5176\u80fd\u5426\u6539\u5584MSS\u60a3\u8005\u7684\u514d\u75ab\u5e94\u7b54<\/li>\n\n\n\n<li><strong>ClinicalTrials.gov\uff1a<\/strong> <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03388190\" target=\"_blank\" rel=\"noreferrer noopener\">NCT03388190<\/a><\/li>\n\n\n\n<li><strong>\u7814\u7a76\u6982\u8ff0\uff1a<\/strong> <em>Ree, A.H. \u7b49<\/em>\uff082024\uff09\u3002\u9488\u5bf9\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u5965\u6c99\u5229\u94c2\u4e3a\u57fa\u7840\u7684\u5316\u7597\u8054\u5408\u5c3c\u6c83\u5362\u5355\u6297\u2014\u2014METIMMOX\u968f\u673a\u8bd5\u9a8c\u3002   <em>\u300a\u82f1\u56fd\u764c\u75c7\u6742\u5fd7\u300b\u3002<\/em><br\/><a href=\"https:\/\/www.nature.com\/articles\/s41416-024-02696-6\" target=\"_blank\" rel=\"noreferrer noopener\">\u70b9\u51fb\u6b64\u5904\u9605\u8bfb\u5168\u6587<\/a><\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u60a3\u8005\u63d0\u793a\uff1a<\/strong> <em>\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u62db\u52df\u5de5\u4f5c\u5df2\u7ed3\u675f\uff0c\u4f46\u5982\u679c\u60a8\u5c5e\u4e8eMSS\u4e9a\u578b\u4e14\u6b63\u5728\u8003\u8651\u63a5\u53d7\u514d\u75ab\u6cbb\u7597\uff0c\u60a8\u7684\u80bf\u7624\u79d1\u533b\u751f\u53ef\u80fd\u4f1a\u6839\u636e\u8be5\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u4e3a\u60a8\u5236\u5b9a\u7c7b\u4f3c\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/em><\/p>\n\n<p class=\"wp-block-paragraph\"><strong><em>\u514d\u8d23\u58f0\u660e\uff1a\u672c\u5217\u8868\u4e2d\u7684\u5185\u5bb9\u5e76\u4e0d\u610f\u5473\u7740\u5bf9\u76f8\u5173\u9879\u76ee\u7684\u8ba4\u53ef\u6216\u4fdd\u8bc1\u5176\u6709\u6548\u6027\u3002\u8bf7\u52a1\u5fc5\u54a8\u8be2\u60a8\u7684\u533b\u7597\u4fdd\u5065\u63d0\u4f9b\u8005\uff0c\u4ee5\u786e\u5b9a\u67d0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5426\u9002\u5408\u60a8\u3002 <\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7531Fight CRC\u533b\u7597\u987e\u95ee\u59d4\u5458\u4f1a\u53ca\u7814\u7a76\u5021\u5bfc\u57f9\u8bad\u4e0e\u652f\u6301\uff08RATS\uff09\u56e2\u961f\u7cbe\u5fc3\u7b56\u5212\u3002 \u672c\u6708\u7efc\u8ff0\u91cd\u70b9\u4ecb\u7ecd\u4e86MSS\u514d\u75ab [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":213427,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[650],"tags":[642,644,646,688,641],"class_list":["post-213470","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials","tag-crc","tag-fight-crc","tag-646","tag-cancer-prevention","tag-colorectal-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u5173\u6ce8\u7126\u70b9\uff1a2025\u5e7412\u6708\u4e34\u5e8a\u8bd5\u9a8c\u7efc\u8ff0 - Fight Colorectal Cancer<\/title>\n<meta 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