{"id":213563,"date":"2025-04-15T12:57:31","date_gmt":"2025-04-15T16:57:31","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/%e5%be%ae%e5%b0%8f%e6%ae%8b%e7%95%99%e7%97%85%ef%bc%88mrd%ef%bc%89%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c\/"},"modified":"2026-06-17T19:16:47","modified_gmt":"2026-06-17T23:16:47","slug":"%e5%be%ae%e5%b0%8f%e6%ae%8b%e7%95%99%e7%97%85%ef%bc%88mrd%ef%bc%89%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/%e5%be%ae%e5%b0%8f%e6%ae%8b%e7%95%99%e7%97%85%ef%bc%88mrd%ef%bc%89%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c\/","title":{"rendered":"\u5fae\u5c0f\u6b8b\u7559\u75c5\uff08MRD\uff09\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n<p>\u5728\u672c\u7bc7\u535a\u5ba2\u4e2d\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u4ecb\u7ecd\u4e94\u9879\u6b63\u5728\u62db\u52df\u53d7\u8bd5\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u9762\u5411\u63a5\u53d7\u8fc7\u6839\u6cbb\u6027\u6cbb\u7597\u540e\u4ecd\u5b58\u5728\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u6240\u8c13\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\uff0c\u662f\u6307\u5728\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\u6b8b\u7559\u5728\u4f53\u5185\u7684\u6781\u5c11\u91cf\u764c\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u65e0\u6cd5\u901a\u8fc7\u4f20\u7edf\u7684\u626b\u63cf\u6216\u5f71\u50cf\u5b66\u68c0\u67e5\u68c0\u6d4b\u5230\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">\u4eae\u70b9<\/h3>\n\n<ul class=\"wp-block-list\">\n<li>\u672c\u535a\u5ba2\u4ecb\u7ecd\u4e86\u4e94\u9879\u6b63\u5728\u62db\u52df\u60a3\u6709\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff09\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u63d0\u4f9b\u4e86\u60a3\u8005\u5021\u5bfc\u8005\u4e3a\u6b63\u5728\u5bfb\u627eMRD\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4eba\u58eb\u63d0\u4f9b\u7684\u5efa\u8bae\u3002<\/li>\n\n\n\n<li>\u6211\u4eec\u91cd\u70b9\u4ecb\u7ecd\u4e86\u6bcf\u9879\u8bd5\u9a8c\u7684\u5165\u9009\u6807\u51c6\u3001\u7814\u7a76\u76ee\u6807\u3001\u7814\u7a76\u8bbe\u8ba1\u548c\u4e3b\u8981\u7ec8\u70b9\u3002<\/li>\n\n\n\n<li>MRD \u662f\u6307\u5728\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\u6b8b\u7559\u5728\u4f53\u5185\u7684\u6781\u5c11\u91cf\u764c\u7ec6\u80de\uff0c\u8fd9\u4e9b\u7ec6\u80de\u65e0\u6cd5\u901a\u8fc7\u4f20\u7edf\u7684\u626b\u63cf\u6216\u5f71\u50cf\u5b66\u68c0\u67e5\u68c0\u6d4b\u5230\u3002<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\">\u8d44\u6e90<\/h3>\n\n<p>\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u4e8e\u5bfb\u627e\u7ed3\u76f4\u80a0\u764c\u7684\u6cbb\u6108\u65b9\u6cd5\u81f3\u5173\u91cd\u8981\u3002\u4f5c\u4e3a\u4e00\u5bb6\u81f4\u529b\u4e8e\u652f\u6301\u5e76\u8d4b\u80fd\u60a3\u8005\u3001\u62a4\u7406\u4eba\u5458\u53ca\u5bb6\u5c5e\u7fa4\u4f53\u7684\u5021\u5bfc\u7ec4\u7ec7\uff0c\u201cFight CRC\u201d\u5df2\u4e0eCOLONTOWN\u5408\u4f5c\uff0c\u63a8\u51fa\u4e00\u7cfb\u5217\u6708\u5ea6\u535a\u5ba2\uff0c\u91cd\u70b9\u4ecb\u7ecd\u60a3\u8005\u9700\u8981\u4e86\u89e3\u7684\u6709\u5173\u4e34\u5e8a\u8bd5\u9a8c\u4ee5\u53ca\u73b0\u6709\u6700\u4f73\u6cbb\u7597\u65b9\u6848\u7684\u6240\u6709\u4fe1\u606f\u3002 <\/p>\n\n<p><strong>\u66f4\u591a\u201cFight CRC\u201d\u8d44\u6e90\uff1a<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/\">\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/surgery\/\">\u5916\u79d1\u624b\u672f<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/biomarkers\/ctdna\/\">CtDNA<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/trial-finder\/\">\u4e34\u5e8a\u8bd5\u9a8c\u641c\u7d22\u5de5\u5177<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/blog\/\">\u4e34\u5e8a\u8bd5\u9a8c\u535a\u5ba2<\/a><\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"Introduction\">\u5f15\u8a00<\/h2>\n\n<p>\u672c\u6708\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u4ecb\u7ecd\u9488\u5bf9\u7ecf\u6839\u6cbb\u6027\u6cbb\u7597\u540e\u4ecd\u5b58\u5728\u5fae\u5c0f\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002MRD\u6307\u7684\u662f\u663e\u5fae\u955c\u4e0b\u53ef\u89c1\u7684\u6b8b\u7559\u75c5\u7076\uff0c\u5373\u5728\u6cbb\u7597\u671f\u95f4\u6216\u6cbb\u7597\u540e\uff0c\u4f53\u5185\u53ef\u80fd\u4ecd\u6b8b\u7559\u6781\u5c11\u91cf\u764c\u7ec6\u80de\u3002 \u4f20\u7edf\u626b\u63cf\u548c\u6210\u50cf\u6280\u672f\uff08\u5982CT\u626b\u63cf\u3001PET\u626b\u63cf\u6216MRI\uff09\u65e0\u6cd5\u68c0\u6d4b\u5230MRD\u3002\u8981\u68c0\u6d4bMRD\uff0c\u9700\u8981\u91c7\u7528\u9ad8\u7075\u654f\u5ea6\u7684\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u65b9\u6cd5\u3002\u901a\u8fc7\u68c0\u6d4b\u8840\u6db2\u6837\u672c\u4e2d\u662f\u5426\u5b58\u5728\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u2014\u2014\u5373\u80bf\u7624\u7ec6\u80de\u91ca\u653e\u5230\u8840\u6db2\u4e2d\u7684\u5fae\u5c0fDNA\u7247\u6bb5\u2014\u2014\u53ef\u4ee5\u8bc6\u522bMRD\u3002    <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"colon\">\u57fa\u4e8e\u6b8b\u7559\u75c5\u7076\u8bc4\u4f30\u7684\u7ed3\u80a0\u764c\u8f85\u52a9\u5316\u7597\uff08CIRCULATE-\u5317\u7f8e\uff09<\/h2>\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05174169\">NCT05174169<\/a><\/p>\n\n<p>CIRCULATE-North America\uff08\u5728\u7f8e\u56fd\u548c\u52a0\u62ff\u5927\u5f00\u5c55\uff09\u662f\u4e00\u9879\u9488\u5bf9\u975e\u8f6c\u79fb\u6027\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u3001\u6b63\u5728\u79ef\u6781\u62db\u52df\u53d7\u8bd5\u8005\uff08\u5df2\u62db\u52df714\u4f8b\uff0c\u51711912\u4e2a\u540d\u989d\uff09\u7684\u591a\u4e2d\u5fc3II\/III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n<p><strong>\u54ea\u4e9b\u4eba\u7b26\u5408\u6761\u4ef6\uff1f<\/strong>  \u60a3\u8005\u5fc5\u987b\u60a3\u6709IIB\/C\u671f\u6216III\u671f\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u7ed3\u80a0\u764c\uff0c\u4e14\u539f\u53d1\u80bf\u7624\u5df2\u901a\u8fc7\u624b\u672f\u6210\u529f\u5207\u9664\uff0c\u5207\u7f18\u6e05\u6670\u3002<\/p>\n\n<p><strong>\u672c\u7814\u7a76\u7684\u76ee\u6807\u662f\u4ec0\u4e48\uff1f<\/strong>  \u8be5\u8bd5\u9a8c\u65e8\u5728\u786e\u5b9a\u672f\u540ectDNA\u72b6\u6001\u662f\u5426\u53ef\u7528\u4e8e\u6307\u5bfcII\u671f\/III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u8f85\u52a9\u5316\u7597\u51b3\u7b56\u3002<\/p>\n\n<p>\u4f8b\u5982\uff0c\u63a5\u53d7\u6839\u6cbb\u6027\u624b\u672f\u540e\u672a\u68c0\u6d4b\u5230ctDNA\uff08ctDNA\u9634\u6027\uff09\u7684\u65e0\u8f6c\u79fb\u6027\u7ed3\u80a0\u764c\u60a3\u8005\uff0c\u5176\u590d\u53d1\u98ce\u9669\u8f83\u4f4e\uff0c\u53ef\u80fd\u65e0\u9700\u8f85\u52a9\u5316\u7597\uff1b\u800c\u68c0\u6d4b\u5230ctDNA \uff08ctDNA\u9633\u6027\uff09\u7684\u60a3\u8005\u590d\u53d1\u98ce\u9669\u8f83\u9ad8\uff0c\u53ef\u80fd\u9700\u8981\u66f4\u79ef\u6781\u7684\u8f85\u52a9\u6cbb\u7597\u3002\u672c\u8bd5\u9a8c\u65e8\u5728\u9a8c\u8bc1\u8fd9\u4e9b\u5047\u8bbe\uff0c\u5e76\u5c06\u6bd4\u8f83\u8bd5\u9a8c\u4e2d\u4e0d\u540c\u7ec4\u522b\u7684\u6cbb\u7597\u7ed3\u679c\u3002 <\/p>\n\n<p><strong>\u60a3\u8005\u53ef\u4ee5\u671f\u5f85\u4ec0\u4e48\uff1f<\/strong>  \u60a3\u8005\u5c06\u63a5\u53d7Signatera\u2122\u68c0\u6d4b\u2014\u2014\u4e00\u79cd\u57fa\u4e8e\u80bf\u7624\u4fe1\u606f\u7684\uff08\u4e2a\u6027\u5316\uff09\u8840\u6db2\u68c0\u6d4b\uff0c\u4ee5\u786e\u5b9a\u5176\u672f\u540ectDNA\u72b6\u6001\uff08\u9633\u6027\u6216\u9634\u6027\uff09\u3002<\/p>\n\n<p><strong>ctDNA \u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\u7684<\/strong>\u60a3\u8005<strong>\uff08A \u7ec4\uff09<\/strong>\u88ab\u968f\u673a\u5206\u914d\u81f3\u4ee5\u4e0b\u4efb\u4e00\u7ec4\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li>6\u81f312\u4e2a\u5468\u671f\u7684FOLFOX\u65b9\u6848\u62164\u4e2a\u5468\u671f\u7684CAPOX\u65b9\u6848\uff08\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff09<\/li>\n\n\n\n<li>\u672a\u8fdb\u884c\u8f85\u52a9\u5316\u7597\u7684\u8840\u6e05ctDNA\u8fde\u7eed\u76d1\u6d4b\uff08\u5b9e\u9a8c\u6027\uff09<\/li>\n<\/ul>\n\n<p>\u5c5e\u4e8eA\u7ec4\uff08ctDNA\u9634\u6027\uff09\u7684\u60a3\u8005\uff0c\u82e5\u5728\u4efb\u4f55\u65f6\u95f4\u70b9ctDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\uff0c\u5219\u5141\u8bb8\u8f6c\u5165B\u7ec4\uff08ctDNA\u9633\u6027\uff09\u3002<\/p>\n\n<p><strong>ctDNA\u9633\u6027\u7684<\/strong>\u60a3\u8005<strong>\uff08B\u7ec4\uff09<\/strong>\u88ab\u968f\u673a\u5206\u914d\u81f3\u4ee5\u4e0b\u7ec4\u522b\u4e4b\u4e00\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li>12\u4e2a\u5468\u671f\u7684FOLFOX\u62168\u4e2a\u5468\u671f\u7684CAPOX\uff08\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff09<\/li>\n\n\n\n<li>12\u4e2a\u5468\u671f\u7684FOLFIRINOX\uff08\u8bd5\u9a8c\u6027\uff09<\/li>\n<\/ul>\n\n<p><strong>\u6d4b\u91cf\u7684\u662f\u4ec0\u4e48\uff1f<\/strong>  \u4e3b\u8981\u7ec8\u70b9\u6307\u6807\u4e3actDNA\u68c0\u6d4b\u8f6c\u9633\u65f6\u95f4\uff08TTpos\uff09\u548c\u65e0\u75c5\u751f\u5b58\u671f\u3002<\/p>\n\n<p>\u9884\u8ba1\u8be5\u8bd5\u9a8c\u5c06\u5728\u672a\u6765\u51e0\u5e74\u5185\u5b8c\u6210\u53d7\u8bd5\u8005\u62db\u52df\uff0c\u5e76\u5728\u968f\u8bbf\u7ed3\u675f\u540e\u516c\u5e03\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u5c06\u786e\u5b9a\u5176\u201c\u4e34\u5e8a\u5b9e\u7528\u6027\u201d\u2014\u2014\u5373ctDNA\u72b6\u6001\u662f\u5426\u53ef\u7528\u4e8e\u5b89\u5168\u5730\u8c03\u6574\u8f85\u52a9\u5316\u7597\u7684\u5f3a\u5ea6\uff08\u589e\u52a0\u6216\u51cf\u5c11\uff09\u3002 \u8fd9\u6837\u4e00\u6765\uff0c\u53ea\u6709\u80fd\u4ece\u8f85\u52a9\u5316\u7597\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\u624d\u9700\u8981\u63a5\u53d7\u6cbb\u7597\uff0c\u4ece\u800c\u4f7f\u5176\u4ed6\u60a3\u8005\u514d\u53d7\u5316\u7597\u526f\u4f5c\u7528\u7684\u5f71\u54cd\u3002\u800cctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u4e14\u53ef\u80fd\u9700\u8981\u66f4\u5f3a\u6548\u5316\u7597\u7684\u60a3\u8005\uff0c\u4e5f\u5c06\u80fd\u591f\u83b7\u5f97\u76f8\u5e94\u7684\u6cbb\u7597\u3002   <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"Micrometastatic\">III\u671f\u7ed3\u80a0\u764c\u4e2d\u5fae\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u8bc6\u522b\u4e0e\u6cbb\u7597\uff08ACT3\uff09<\/h2>\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03803553\">NCT03803553<\/a><\/p>\n\n<p>\u201cStand Up To Cancer ACT3\u201d\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u9879\u9488\u5bf9III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u3001\u76ee\u524d\u6b63\u5728\u79ef\u6781\u62db\u52df\u53d7\u8bd5\u8005\u7684\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u8bd5\u9a8c\u76ee\u524d\u5df2\u5728\u9a6c\u8428\u8bf8\u585e\u5dde\u603b\u533b\u9662\u3001\u65af\u9686-\u51ef\u7279\u7433\u7eaa\u5ff5\u764c\u75c7\u4e2d\u5fc3\u548c\u5eb7\u5948\u5c14\u5927\u5b66\u5f00\u5c55\u3002 <\/p>\n\n<p><strong>\u54ea\u4e9b\u4eba\u7b26\u5408\u6761\u4ef6\uff1f<\/strong>  \u5df2\u5b8c\u6210\u624b\u672f\u548c\u8f85\u52a9\u5316\u7597\u7684III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u3002<\/p>\n\n<p><strong>\u672c\u7814\u7a76\u7684\u76ee\u6807\u662f\u4ec0\u4e48\uff1f<\/strong>  \u624b\u672f\u548c\u8f85\u52a9\u5316\u7597\u540e\uff0c\u60a3\u8005\u901a\u5e38\u4f1a\u8fdb\u5165\u79ef\u6781\u76d1\u6d4b\u9636\u6bb5\uff0c\u8fd9\u662f\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u672c\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\uff0c\u5bf9\u4e8e\u624b\u672f\u53ca\u521d\u59cb\u8f85\u52a9\u5316\u7597\u540ectDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u7684\u60a3\u8005\uff0c\u76f8\u6bd4\u79ef\u6781\u76d1\u6d4b\uff0c\u8ffd\u52a0\u6cbb\u7597\uff08FOLFIRI\u65b9\u6848\u6216\u57fa\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u7684\u9776\u5411\u6cbb\u7597\uff09\u80fd\u5426\u964d\u4f4e\u590d\u53d1\u7387\u3002 <\/p>\n\n<p><strong>\u60a3\u8005\u53ef\u4ee5\u671f\u5f85\u4ec0\u4e48\uff1f<\/strong>  \u53d7\u8bd5\u8005\u5c06\u63a5\u53d7Guardant Reveal\u8840\u6db2\uff08ctDNA MRD\uff09\u68c0\u6d4b\uff0c\u4ee5\u786e\u5b9a\u5176ctDNA\u72b6\u6001\uff08\u9633\u6027\u6216\u9634\u6027\uff09\u3002<\/p>\n\n<p><strong>ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\u7684<\/strong>\u60a3\u8005\u5c06\u63a5\u53d7\u79ef\u6781\u968f\u8bbf\uff0c\u5305\u62ec\u901a\u8fc7\u5f71\u50cf\u5b66\u68c0\u67e5\u3001\u80bf\u7624\u6807\u5fd7\u7269\u68c0\u6d4b\u53ca\u7cfb\u5217ctDNA\u76d1\u6d4b\u8fdb\u884c\u89c2\u5bdf\u548c\u968f\u8bbf\u3002\u82e5\u5728\u7b2c\u4e00\u5e74\u5185ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u5219\u5c06\u5176\u968f\u673a\u5206\u914d\u81f3\u4e0b\u6587\u6240\u8ff0\u7684\u5176\u4e2d\u4e00\u4e2a\u6cbb\u7597\u7ec4\u3002 <\/p>\n\n<p><strong>ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u4e14\u5177\u6709\u5176\u4e2d\u4e00\u79cd\u80bf\u7624\u751f\u7269\u6807\u5fd7\u7269\u7684<\/strong>\u60a3\u8005\u5c06\u88ab\u5206\u914d\u81f3\u4ee5\u4e0b\u6cbb\u7597\u7ec4\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>HER2\u8fc7\u8868\u8fbe\/\u6269\u589e\uff1a<\/strong>\u66f2\u59a5\u73e0\u5355\u6297 + \u5e15\u59a5\u73e0\u5355\u6297\uff08\u6700\u591a8\u4e2a\u7597\u7a0b\uff09<\/li>\n\n\n\n<li><strong>BRAF V600E\uff1a<\/strong>\u6069\u79d1\u62c9\u975e\u5c3c\/\u6bd4\u5c3c\u7f8e\u66ff\u5c3c\/\u897f\u59a5\u6614\u5355\u6297\uff08\u6700\u591a12\u4e2a\u7597\u7a0b\uff09<\/li>\n\n\n\n<li><strong>MSI-H\/dMMR\uff1a<\/strong>\u5c3c\u6c83\u5362\u5355\u6297\uff08\u6700\u591a12\u4e2a\u7597\u7a0b\uff09<\/li>\n<\/ul>\n\n<p>\u6240\u6709\u5176\u4ed6ctDNA<strong>\u9633\u6027\u7684<\/strong>\u60a3\u8005\u5747\u88ab\u968f\u673a\u5206\u914d\u81f3\u4ee5\u4e0b\u7ec4\u522b\u4e4b\u4e00\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li>\u79ef\u6781\u76d1\u6d4b\uff08\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff09<\/li>\n\n\n\n<li>FOLFIRI\uff08\u6700\u591a\u5341\u4e8c\u4e2a\u7597\u7a0b\uff09<\/li>\n<\/ul>\n\n<p><strong>\u6d4b\u91cf\u7684\u662f\u4ec0\u4e48\uff1f<\/strong>  \u672c\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u75c5\u751f\u5b58\u671f\uff0c\u4ee5\u53ca\u63a5\u53d7\u79ef\u6781\u76d1\u6d4b\u7684ctDNA\u9633\u6027\u60a3\u8005\u4e0e\u63a5\u53d7FOLFIRI\u6cbb\u7597\u7684\u60a3\u8005\u4e4b\u95f4\u7684ctDNA\u6e05\u9664\u7387\u3002<\/p>\n\n<p>\u8fd9\u662f\u4e00\u9879\u65b0\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u7ed3\u679c\u5c06\u6709\u52a9\u4e8e\u8be5\u9886\u57df\u4e86\u89e3ctDNA\u68c0\u6d4b\u7684\u4e34\u5e8a\u4ef7\u503c\uff0c\u4ee5\u53ca\u5bf9\u4e8e\u5b8c\u6210\u8f85\u52a9\u6cbb\u7597\u540ectDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\u7684\u60a3\u8005\uff0c\u54ea\u4e9b\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u6709\u76ca\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"AMB-05X\">\u9488\u5bf9\u7ecf\u6839\u6cbb\u6027\u6cbb\u7597\u540ectDNA\u9633\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684AMB-05X\u4e34\u5e8a\u8bd5\u9a8c<\/h2>\n\n<p>\u8fd9\u662f\u4e00\u9879\u89c4\u6a21\u8f83\u5c0f\uff0815\u540d\u53d7\u8bd5\u8005\uff09\u3001\u6b63\u5728\u79ef\u6781\u62db\u52df\u53d7\u8bd5\u8005\u7684II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8be5\u8bd5\u9a8c\u4ec5\u5728\u5fb7\u514b\u8428\u65af\u5dde\u4f11\u65af\u987f\u7684MD\u5b89\u5fb7\u68ee\u764c\u75c7\u4e2d\u5fc3\u5f00\u5c55\u3002 <\/p>\n\n<p><strong>\u54ea\u4e9b\u4eba\u7b26\u5408\u6761\u4ef6\uff1f<\/strong>  \u4efb\u4f55\u671f\u7ed3\u80a0\u764c\u6216\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5df2\u5b8c\u6210\u4ee5\u6cbb\u6108\u4e3a\u76ee\u7684\u7684\u6cbb\u7597\uff08\u5305\u62ec\u8f85\u52a9\u6cbb\u7597\uff09\uff0c\u4e14ctDNA\u68c0\u6d4b\u5448\u9633\u6027\uff0c\u4f46\u65e0\u4e34\u5e8a\u53ef\u68c0\u6d4b\u5230\u7684\u75be\u75c5\u3002<\/p>\n\n<p><strong>\u672c\u7814\u7a76\u7684\u76ee\u6807\u662f\u4ec0\u4e48\uff1f<\/strong>  \u672c\u7814\u7a76\u65e8\u5728\u8bc4\u4f30AMB-05X\u5bf9\u5b58\u5728\u5fae\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff0c\u5b9a\u4e49\u4e3actDNA\u68c0\u6d4b\u9633\u6027\u4e14\u65e0\u4e34\u5e8a\u53ef\u68c0\u6d4b\u75c5\u7076\uff09\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n\n<p><strong>\u60a3\u8005\u53ef\u4ee5\u671f\u5f85\u4ec0\u4e48\uff1f<\/strong>  \u8fd9\u662f\u4e00\u9879\u5355\u81c2\u8bd5\u9a8c\uff0c\u8fd9\u610f\u5473\u7740\u6240\u6709\u53d7\u8bd5\u8005\u5747\u63a5\u53d7\u76f8\u540c\u7684\u6cbb\u7597\u3002\u6240\u6709\u53d7\u8bd5\u8005\u90fd\u5c06\u63a5\u53d7AMB-05X\uff08\u4e00\u79cd\u6297CSF1R\u5355\u514b\u9686\u6297\u4f53\uff09\u7684\u9759\u8109\u6ce8\u5c04\u6cbb\u7597\u3002 <\/p>\n\n<p><strong>\u6d4b\u91cf\u7684\u662f\u4ec0\u4e48\uff1f<\/strong>  \u4e3b\u8981\u7ed3\u5c40\u6307\u6807\u662f\u5b89\u5168\u6027\u53ca\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n\n<p>\u6297CSF1R\u5355\u514b\u9686\u6297\u4f53AMB-05X\u53ef\u589e\u5f3aT\u7ec6\u80de\u6d78\u6da6\u548c\u6297\u80bf\u7624T\u7ec6\u80de\u514d\u75ab\u5e94\u7b54\uff0c\u6709\u671b\u6e05\u9664\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4f53\u5185\u90a3\u4e9b\u770b\u4f3c\u5df2\u65e0\u764c\u8ff9\u8c61\u4f46\u5b9e\u9645\u4e0a\u4ecd\u5b58\u5728\u7684\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684\u764c\u7ec6\u80de\u3002\u8fd9\u53ef\u80fd\u964d\u4f4e\u764c\u75c7\u590d\u53d1\u7684\u98ce\u9669\uff0c\u4f7f\u60a3\u8005\u66f4\u6709\u673a\u4f1a\u957f\u671f\u4fdd\u6301\u5065\u5eb7\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"RO7198457\">\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u6bd4\u8f83RO7198457\u4e0e\u5bc6\u5207\u968f\u8bbf\u5728ctDNA\u9633\u6027\u3001\u5df2\u5207\u9664\u7684II\u671f\uff08\u9ad8\u5371\uff09\u548cIII\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548<\/h2>\n\n<p><em>\uff08\u9488\u5bf9\u672f\u540e\u809d\u8f6c\u79fb\u5904\u4e8e\u65e0\u75be\u75c5\u8bc1\u636e\uff08NED\uff09\u72b6\u6001\u7684IV\u671f\u60a3\u8005\uff0c\u65b0\u589e\u4e00\u7ec4\u7814\u7a76\u5bf9\u8c61\uff09<\/em><\/p>\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04486378\">NCT04486378<\/a><\/p>\n\n<p>\u8fd9\u662f\u4e00\u9879\u9488\u5bf9\u66fe\u63a5\u53d7\u8fc7\u9ad8\u5371\u2161\u671f\u6216\u2162\u671f\u7ed3\u76f4\u80a0\u764c\u624b\u672f\u6cbb\u7597\u7684\u60a3\u8005\u3001\u76ee\u524d\u6b63\u5728\u79ef\u6781\u62db\u52df\u53d7\u8bd5\u8005\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5171\u8bbe\u6709118\u4e2a\u8bd5\u9a8c\u70b9\u3002 <\/p>\n\n<p><strong>\u54ea\u4e9b\u4eba\u7b26\u5408\u6761\u4ef6\uff1f<\/strong>  II\u671f\u6216III\u671f\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u76f4\u80a0\u764c\u6216\u7ed3\u80a0\u764c\u60a3\u8005\uff0c\u5728\u80bf\u7624\u5b8c\u5168\u5207\u9664\u540ectDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\uff0c\u4e14\u5df2\u5b8c\u6210\u81f3\u5c11\u4e09\u4e2a\u6708\u7684\u8f85\u52a9\u5316\u7597\u3002\u6b64\u5916\uff0c\u8fd8\u8bbe\u6709\u4e00\u4e2a\u751f\u7269\u6807\u5fd7\u7269\u961f\u5217\uff0c\u7eb3\u5165\u7684\u60a3\u8005\u4e0d\u8003\u8651\u672f\u540ectDNA\u72b6\u6001\uff08\u9633\u6027\u6216\u9634\u6027\uff09\u3002 <\/p>\n\n<p>\u622a\u81f32024\u5e7411\u6708\uff0c\u672c\u7814\u7a76\u8fd8\u7eb3\u5165\u4e86\u4ee5\u4e0b\u60a3\u8005\uff1aIV\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\uff0c\u5728\u539f\u53d1\u80bf\u7624\u5207\u9664\u53ca\u4e3a\u6cbb\u7597\u809d\u8f6c\u79fb\u800c\u8fdb\u884c\u7684\u4ee5\u6cbb\u6108\u4e3a\u76ee\u7684\u7684\u809d\u5207\u9664\u672f\u540e\uff0cctDNA\u68c0\u6d4b\u7ed3\u679c\u5448\u9633\u6027\uff0c\u4e14\u5df2\u5b8c\u6210\u8f85\u52a9\u5316\u7597\u3002<\/p>\n\n<p>\u6240\u6709\u53c2\u4e0e\u8005\u5fc5\u987b\u63a5\u53d7R0\u5207\u9664\u672f\uff0c\u5e76\u7ecf\u75c5\u7406\u62a5\u544a\u786e\u8ba4\uff0c\u5373\u80bf\u7624\u5df2\u88ab\u5b8c\u5168\u5207\u9664\uff0c\u4e14\u80bf\u7624\u90e8\u4f4d\u672a\u53d1\u73b0\u764c\u7ec6\u80de\u7684\u663e\u5fae\u955c\u4e0b\u8bc1\u636e\u3002<\/p>\n\n<p><strong>\u672c\u7814\u7a76\u7684\u76ee\u6807\u662f\u4ec0\u4e48\uff1f<\/strong>\u672c\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u4e2a\u6027\u5316mRNA\u65b0\u6297\u539f\u75ab\u82d7RO7198457\uff08autogene cevumeran\uff09\u5728\u9884\u9632\u764c\u75c7\u590d\u53d1\u65b9\u9762\u7684\u7597\u6548\uff0c\u5e76\u5c06\u5176\u4e0e\u89c2\u5bdf\u7b49\u5f85\uff08\u6807\u51c6\u6cbb\u7597\uff09\u8fdb\u884c\u6bd4\u8f83\u3002<\/p>\n\n<p><strong>\u60a3\u8005\u53ef\u4ee5\u671f\u5f85\u4ec0\u4e48\uff1f<\/strong>  \u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3\u4ee5\u4e0b\u4efb\u4e00\u7ec4\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li>RO7198457\uff0c\u4e00\u79cd\u57fa\u4e8emRNA\u7684\u4e2a\u6027\u5316\u75ab\u82d7\uff08\u572812\u4e2a\u6708\u5185\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\uff0c\u6700\u591a15\u5242\uff09<\/li>\n\n\n\n<li>\u89c2\u5bdf\u7b49\u5f85\uff0c\u4e5f\u79f0\u4e3a\u79ef\u6781\u76d1\u6d4b\uff08\u6807\u51c6\u6cbb\u7597\u65b9\u6848\uff09<\/li>\n<\/ul>\n\n<p>\u6b64\u524d\u4e00\u9879\u4f7f\u7528\u8be5\u75ab\u82d7\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u8be5\u75ab\u82d7\u786e\u5b9e\u80fd\u8bf1\u5bfc\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\uff1a\u5927\u591a\u6570\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u4e3a1-2\u7ea7\u3002 \u53d1\u751f\u7387\u226520%\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u8f93\u6ce8\u76f8\u5173\u53cd\u5e94\uff08IRR\uff09\/\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09\u3001\u75b2\u52b3\u3001\u6076\u5fc3\u548c\u8179\u6cfb\u3002IRR\/CRS\u4e3a\u4e00\u8fc7\u6027\u4e14\u53ef\u9006\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a1-2\u7ea7\u7684\u5bd2\u6218\u548c\u53d1\u70ed\u3002\u65e0\u60a3\u8005\u56e0\u4e0d\u826f\u4e8b\u4ef6\u800c\u4e2d\u6b62\u6cbb\u7597\u3002   <\/p>\n\n<p><strong>\u6d4b\u91cf\u7684\u662f\u4ec0\u4e48\uff1f<\/strong>  \u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u75c5\u751f\u5b58\u671f\u3002<\/p>\n\n<p>\u8be5\u8bd5\u9a8c\u751f\u7269\u6807\u5fd7\u7269\u961f\u5217\u6700\u8fd1\u516c\u5e03\u7684\u7ed3\u679c\uff082024\u5e746\u6708ESMO\u4f1a\u8bae\u6458\u898129P\uff09\u663e\u793a\uff0cRO7198457\uff08\u81ea\u4f53\u6e90\u6027\u585e\u6b66\u7f8e\u5170\uff09\u6210\u529f\u523a\u6fc0\u4e86\u8be5\u7ec411\u540d\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u4f7f\u5176\u4ea7\u751f\u80fd\u591f\u8bc6\u522b\u7279\u5b9a\u764c\u75c7\u6807\u5fd7\u7269\u7684T\u7ec6\u80de\u3002 \u5728\u63a5\u53d78\u5242\u6cbb\u7597\u540e\uff0c\u8fd9\u4e9bT\u7ec6\u80de\u5728\u60a3\u8005\u7684\u514d\u75ab\u7ec6\u80de\u4e2d\u5360\u636e\u4e86\u663e\u8457\u6bd4\u4f8b\uff0c\u5176\u4e2d8\u540d\u60a3\u8005\u7684\u5faa\u73afCD8+ T\u7ec6\u80de\u53d7\u4f53\u4e2d\uff0c\u591a\u8fbe42%\uff08\u4e2d\u4f4d\u6570\uff1a9%\uff0c\u8303\u56f4\uff1a3-42%\uff09\u4e3a\u75ab\u82d7\u7279\u5f02\u6027\u3002 \u5728\u968f\u8bbf\u4e2d\u4f4d\u6570\u4e3a640\u5929\uff08\u8303\u56f4\uff1a602\u2013779\u5929\uff09\u65f6\uff0c\u6240\u6709\u60a3\u8005\u5747\u672a\u51fa\u73b0\u75be\u75c5\u590d\u53d1\u3002<\/p>\n\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u9274\u4e8eII\u671f\u548cIII\u671f\u9ad8\u5371\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u7279\u6027\u2014\u2014\u5176\u590d\u53d1\u7387\u53ef\u80fd\u76f8\u5f53\u9ad8\u2014\u2014\u6240\u6709\u60a3\u8005\u5747\u4fdd\u6301\u65e0\u75be\u75c5\u8bc1\u636e\uff08NED\uff09\u72b6\u6001\u3002\u7136\u800c\uff0c\u7531\u4e8e\u8fd9\u662f\u751f\u7269\u6807\u5fd7\u7269\u961f\u5217\u7814\u7a76\uff0c\u56e0\u6b64\u65e0\u6cd5\u76f4\u63a5\u8bc1\u660e\u4e0e\u672a\u5e72\u9884\u7ec4\u76f8\u6bd4\uff0c\u8be5\u75ab\u82d7\u9884\u9632\u4e86\u590d\u53d1\u3002 \u4e3b\u8981\u8bd5\u9a8c\u4e2d\u8bbe\u6709\u4e00\u4e2a\u9488\u5bf9ctDNA\u9633\u6027\u60a3\u8005\u7684\u201c\u5bc6\u5207\u89c2\u5bdf\u201d\u5bf9\u7167\u7ec4\uff0c\u8be5\u8bd5\u9a8c\u5c06\u660e\u786e\u75ab\u82d7\u7684\u7597\u6548\u3002  <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"trop2\">\u9488\u5bf9\u5b58\u5728\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff09\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\uff0cTROP2 CAR\u5de5\u7a0b\u5316\u3001\u7ecfIL-15\u8f6c\u5bfc\u7684\u8110\u5e26\u8840\u6765\u6e90\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u7684\u5242\u91cf\u9012\u589e\u53ca\u60a3\u8005\u5165\u7ec4\u6269\u5c55\u7814\u7a76<\/h2>\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06358430\">NCT06358430<\/a><\/p>\n\n<p>\u8fd9\u9879\u5904\u4e8e\u7b2c1\u9636\u6bb5\u4e14\u6b63\u5728\u79ef\u6781\u62db\u52df\u53d7\u8bd5\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u63a2\u7d22\u4e00\u79cd\u9488\u5bf9\u63a5\u53d7\u624b\u672f\u548c\u6807\u51c6\u8f85\u52a9\u6cbb\u7597\u540e\u4ecd\u5b58\u5728\u5fae\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u7684\u5927\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n\n<p><strong>\u54ea\u4e9b\u4eba\u7b26\u5408\u6761\u4ef6\uff1f<\/strong>  \u7ecf\u5b8c\u5168\u5207\u9664\uff08\u624b\u672f\uff09\u548c\u8f85\u52a9\u6cbb\u7597\u540e\uff0c\u5b58\u5728\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff0c\u5b9a\u4e49\u4e3a\u5f71\u50cf\u5b66\u4e0a\u65e0\u75be\u75c5\u8ff9\u8c61\u4e14ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff09\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002<\/p>\n\n<p><strong>\u672c\u7814\u7a76\u7684\u76ee\u6807\u662f\u4ec0\u4e48\uff1f<\/strong>  \u672c\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76TROP2-CAR-NK\u7ec6\u80de\uff08\u5373\u7ecfTROP2\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u5de5\u7a0b\u5316\u6539\u9020\u5e76\u8f6c\u67d3IL-15\u7684\u8110\u5e26\u8840\u6765\u6e90\u81ea\u7136\u6740\u4f24\uff08NK\uff09\u7ec6\u80de\uff0c\u5c5e\u4e8e\u4e00\u79cd\u7ec6\u80de\u7597\u6cd5\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\uff08Erbitux\u00ae\uff09\u7684\u7597\u6548\u3002<\/p>\n\n<p>TROP2\u662f\u4e00\u79cd\u5728\u7ed3\u76f4\u80a0\u764c\u4e2d\u5e38\u5448\u8fc7\u8868\u8fbe\u7684\u86cb\u767d\u8d28\u3002\u8be5\u7597\u6cd5\u5229\u7528\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u6280\u672f\uff0c\u5bf9\u81ea\u7136\u5177\u5907\u6740\u4f24\u764c\u7ec6\u80de\u80fd\u529b\u7684\u514d\u75ab\u7ec6\u80de\u2014\u2014\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08NK\u7ec6\u80de\uff09\u8fdb\u884c\u57fa\u56e0\u6539\u9020\uff0c\u4f7f\u5176\u80fd\u591f\u7279\u5f02\u6027\u8bc6\u522b\u5e76\u653b\u51fb\u8868\u8fbeTROP2\u7684\u764c\u7ec6\u80de\u3002 \u8fd9\u4e9b\u81ea\u7136\u6740\u4f24\u7ec6\u80de\u7ecf\u8fc7IL-15\u4fee\u9970\uff0c\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u80fd\u589e\u5f3a\u5176\u5b58\u6d3b\u7387\u548c\u6548\u529b\uff0c\u4ece\u800c\u53ef\u80fd\u4f7f\u5176\u5728\u5bf9\u6297\u6b8b\u7559\u764c\u7ec6\u80de\u65b9\u9762\u66f4\u5177\u4f18\u52bf\u3002\u8054\u5408\u4f7f\u7528\u9488\u5bf9EGFR\uff08\u53e6\u4e00\u79cd\u4e0e\u7ed3\u76f4\u80a0\u764c\u76f8\u5173\u7684\u86cb\u767d\u8d28\uff09\u7684\u6807\u51c6\u6cbb\u7597\u836f\u7269\u897f\u59a5\u6614\u5355\u6297\uff0c\u53ef\u80fd\u8fdb\u4e00\u6b65\u589e\u5f3a\u8be5\u7597\u6cd5\u7684\u6548\u679c\u3002   <\/p>\n\n<p>\u8be5\u7814\u7a76\u65e8\u5728\u786e\u5b9aTROP2-CAR-NK\u7ec6\u80de\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u6700\u9ad8\u5242\u91cf\u548c\/\u6216\u63a8\u8350\u5242\u91cf\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u65e8\u5728\u8bc4\u4f30\u8be5\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002 <\/p>\n\n<p><strong>\u60a3\u8005\u53ef\u4ee5\u671f\u5f85\u4ec0\u4e48\uff1f<\/strong>  \u8fd9\u662f\u4e00\u9879\u5355\u81c2\u8bd5\u9a8c\uff0c\u8fd9\u610f\u5473\u7740\u6240\u6709\u53d7\u8bd5\u8005\u90fd\u5c06\u63a5\u53d7TROP2-CAR-NK\u7ec6\u80de\u4e0e\u897f\u59a5\u6614\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\uff0c\u4e24\u8005\u5747\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u7ed9\u836f\u3002<\/p>\n\n<p><strong>\u6d4b\u91cf\u7684\u662f\u4ec0\u4e48\uff1f<\/strong>  \u7814\u7a76\u4e3b\u8981\u5173\u6ce8\u5b89\u5168\u6027\u53ca\u4e0d\u826f\u4e8b\u4ef6\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u5c06\u6d4b\u91cf3\u4e2a\u6708\u65f6\u7684\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u6e05\u9664\u60c5\u51b5\uff0c\u4f5c\u4e3a\u6cbb\u7597\u6548\u679c\u7684\u6307\u6807\u3002 <\/p>\n\n<p>\u5982\u679c\u8fd9\u79cd\u7597\u6cd5\u80fd\u591f\u6e05\u9664\u6f5c\u4f0f\u7684\u764c\u7ec6\u80de\uff0c\u5c31\u6709\u53ef\u80fd\u964d\u4f4e\u75be\u75c5\u590d\u53d1\u7684\u98ce\u9669\uff0c\u4ece\u800c\u4e3a\u60a3\u8005\u63d0\u4f9b\u66f4\u9ad8\u7684\u957f\u671f\u751f\u5b58\u51e0\u7387\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"Advice\">\u60a3\u8005\u6743\u76ca\u5021\u5bfc\u8005\u7ed9\u6b63\u5728\u8003\u8651\u53c2\u52a0MRD\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4eba\u7684\u4e00\u4e9b\u5efa\u8bae\uff1a<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5c3d\u65e9\u5f00\u59cb\u641c\u7d22\u3002<\/strong>  \u641c\u7d22\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u786e\u5b9a\u6700\u9002\u5408\u60a8\u7684\u8bd5\u9a8c\u53ef\u80fd\u9700\u8981\u4e00\u4e9b\u65f6\u95f4\u3002 \u5bf9\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff09\u4e34\u5e8a\u8bd5\u9a8c\u611f\u5174\u8da3\u7684\u60a3\u8005\uff0c\u5e94\u8003\u8651\u5728\u63a5\u53d7\u6839\u6cbb\u6027\u6cbb\u7597\u671f\u95f4\u5c31\u5f00\u59cb\u5bfb\u627e\u76f8\u5173\u8bd5\u9a8c\uff0c\u8fd9\u6837\u5982\u679c\u6cbb\u7597\u540e\u68c0\u6d4b\u51fa\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u9633\u6027\uff0c\u4fbf\u80fd\u53ca\u65f6\u5165\u7ec4MRD\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5bf9\u4e8ectDNA\u9634\u6027\u7684\u60a3\u8005\uff0c\u4e5f\u53ef\u80fd\u6709\u673a\u4f1a\u5165\u7ec4\u4e34\u5e8a\u8bd5\u9a8c\u3002  <\/li>\n\n\n\n<li><strong>\u4ee5\u809d\u810fMRI\u4e3a\u4f8b\u3002<\/strong>  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