{"id":213616,"date":"2025-03-06T04:24:40","date_gmt":"2025-03-06T09:24:40","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/gi-asco-%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81\/"},"modified":"2026-06-17T19:17:12","modified_gmt":"2026-06-17T23:17:12","slug":"gi-asco-%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/gi-asco-%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81\/","title":{"rendered":"GI ASCO \u6700\u65b0\u52a8\u6001"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n<p class=\"wp-block-paragraph\">\u60a8\u662f\u5426\u5bf9\u5728\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u80c3\u80a0\u9053\uff08GI\uff09\u764c\u75c7\u7814\u8ba8\u4f1a\u4e0a\u53d1\u5e03\u7684\u6700\u65b0\u79d1\u7814\u6210\u679c\u611f\u5230\u597d\u5947\uff1f\u6bcf\u5e74\uff0c\u60a3\u8005\u6743\u76ca\u5021\u5bfc\u8005\u739b\u96c5\u548c\u66fc\u6731\u90fd\u4f1a\u4e3a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7fa4\u4f53\u68b3\u7406\u76f8\u5173\u7814\u7a76\u53ca\u503c\u5f97\u5173\u6ce8\u7684\u8fdb\u5c55\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">GI ASCO\u4f1a\u8bae\u4eae\u70b9<\/h3>\n\n<ul class=\"wp-block-list\">\n<li>\u6bcf\u5e74\uff0c\u4e13\u6ce8\u4e8e\u80c3\u80a0\u9053\uff08GI\uff09\u764c\u75c7\uff08\u5305\u62ec\u7ed3\u76f4\u80a0\u764c\uff09\u7684\u7814\u7a76\u4eba\u5458\u90fd\u4f1a\u5728GI ASCO\u4f1a\u8bae\u4e0a\u5c55\u793a\u4ed6\u4eec\u7684\u7814\u7a76\u6210\u679c\u548c\u6700\u65b0\u53d1\u73b0\u3002<\/li>\n\n\n\n<li>\u201cFight CRC\u201d\u7814\u7a76\u5021\u5bfc\u8005\u4eec\u51fa\u5e2d\u4e86\u6b64\u6b21\u4f1a\u8bae\uff0c\u4ee5\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u5e76\u5c06\u6240\u83b7\u4fe1\u606f\u53cd\u9988\u7ed9\u793e\u533a\uff0c\u540c\u65f6\u5206\u4eab\u4ed6\u4eec\u7684\u89c1\u89e3\u3002<\/li>\n\n\n\n<li>\u201cFight CRC\u201d\u901a\u8fc7\u535a\u5ba2\u6587\u7ae0\u548c\u7f51\u7edc\u7814\u8ba8\u4f1a\u53d1\u5e03\u5e74\u5ea6\u4f1a\u8bae\u7684\u4eae\u70b9\u5185\u5bb9\uff0c\u5411\u516c\u4f17\u4ecb\u7ecd\u4e13\u6ce8\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\u7684\u3001\u524d\u666f\u826f\u597d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\">\u66f4\u591a\u201cFight CRC\u201d\u8d44\u6e90<\/h3>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/\">\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/blog\/\">\u4e34\u5e8a\u8bd5\u9a8c\u535a\u5ba2<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/biomarkers\/\">\u751f\u7269\u6807\u5fd7\u7269<\/a><\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"2025\">2025<\/h2>\n\n<h3 class=\"wp-block-heading\">\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408\u6216\u4e0d\u8054\u5408\u5316\u7597\u6cbb\u7597\u53f3\u4fa7\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff1aOrigAMI-1\u7814\u7a76\uff08\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u76841b\/2\u671f\u7814\u7a76\uff09\u7684\u6700\u65b0\u7ed3\u679c\u3002<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 197<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">OrigAMI-1 \u8bd5\u9a8c (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05379595\">NCT05379595<\/a>) \u662f\u4e00\u9879 I \u671fb\/II \u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u963f\u7c73\u4e07\u5854\u5355\u6297\uff08\u4e00\u79cd\u9488\u5bf9 EGFR \u548c MET \u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff09\u5355\u836f\uff08\u5355\u7597\u6cd5\uff09\u4ee5\u53ca\u4e0e FOLFOX \u6216 FOLFIRI \u8054\u5408\u4f7f\u7528\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u7597\u6548\u3002 \u7814\u7a76\u62a5\u544a\u4e86\u53f3\u4fa7\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u7ed3\u679c\uff0c\u5305\u62ec\u76f2\u80a0\u3001\u5347\u7ed3\u80a0\u3001\u809d\u66f2\u548c\u6a2a\u7ed3\u80a0\u7684\u539f\u53d1\u80bf\u7624\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u5165\u7ec4\u5bf9\u8c61\uff1a<\/strong>\u672c\u8bd5\u9a8c\u7eb3\u5165\u4e86KRAS\u3001NRAS\u3001BRAF\u548cEGFR\u80de\u5916\u57df\u4e3a\u91ce\u751f\u578b\u3001\u4e14\u65e0HER2\u6269\u589e\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u3002 \u8be5\u8bd5\u9a8c\u540c\u65f6\u7eb3\u5165\u4e86\u5de6\u4fa7\u548c\u53f3\u4fa7\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002\u7136\u800c\uff0c\u62a5\u544a\u4e2d\u4ec5\u5217\u51fa\u4e86C\u3001D\u548cE\u7ec4\u4e2d\u53f3\u4fa7\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u7ed3\u679c\uff0c\u5305\u62ec\u4ee5\u4e0b\u5185\u5bb9\uff1a  <\/p>\n\n<ul class=\"wp-block-list\">\n<li>C\u7ec4\uff1a23\u4f8b\u53f3\u4fa7\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u6b64\u524d\u63a5\u53d7\u8fc72\u62163\u7ebf\u6cbb\u7597\uff08\u5141\u8bb8\u6b64\u524d\u63a5\u53d7\u8fc7EGFR\u6291\u5236\u5242\u6cbb\u7597\uff09<\/li>\n\n\n\n<li>D\u7ec4\uff084\u540d\u60a3\u8005\uff09\u548cE\u7ec4\uff083\u540d\u60a3\u8005\uff09\u4e3a\u53f3\u4fa7mCRC\u60a3\u8005\uff0c\u6b64\u524d\u63a5\u53d7\u8fc71\u7ebf\u6cbb\u7597\uff0c\u4f46\u672a\u66fe\u63a5\u53d7\u8fc7EGFR\u6291\u5236\u5242\u6cbb\u7597<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u60a3\u8005\u63a5\u53d7\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6cbb\u7597\uff08C\u7ec4\uff09\uff0c\u6216\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408FOLFOX\u65b9\u6848\uff08D\u7ec4\uff09\u6216FOLFIRI\u65b9\u6848\uff08E\u7ec4\uff09\u6cbb\u7597\u3002   <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\uff1a<\/strong>\u5728\u4e09\u7ebf\u53ca\u4ee5\u4e0a\uff083L+\uff09\u6cbb\u7597\u80cc\u666f\u4e0b\u63a5\u53d7\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6cbb\u7597\uff08C\u7ec4\uff09\u7684\u60a3\u8005\uff0c\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a22%\uff085\/23\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a78% \uff0818\/23\uff09\uff0c\u5176\u4e2d1\u4f8b\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\uff0c3\u4f8b\u60a3\u8005\u7f13\u89e3\u72b6\u6001\u6301\u7eed\u3002\u5728\u4e8c\u7ebf\uff082L\uff09\u6cbb\u7597\u4e2d\u63a5\u53d7\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408FOLFOX \uff08D\u7ec4\uff09\u6216FOLFIRI\uff08E\u7ec4\uff09\u8054\u5408\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5176\u603b\u4f53\u7f13\u89e3\u7387\u4e3a43%\uff083\/7\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a86%\uff086\/7\uff09\uff0c\u5176\u4e2d1\u540d\u60a3\u8005\u6301\u7eed\u7f13\u89e3\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\uff1a<\/strong>\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u9884\u671f\u4e00\u81f4\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5728\u8be5\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u5355\u836f\u6cbb\u7597\u4ee5\u53ca\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u8054\u5408FOLFOX\u6216FOLFIRI\u6cbb\u7597\u5747\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u7684\u963f\u7c73\u4e07\u5854\u9a6c\u5e03III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5305\u62ec\uff1a <\/p>\n\n<ul class=\"wp-block-list\">\n<li><strong>OrigAMI-2<\/strong>\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u4e0e\u897f\u59a5\u6614\u5355\u6297\uff08\u5747\u8054\u5408 FOLFOX \u6216 FOLFIRI\uff09\u4f5c\u4e3a\u4e00\u7ebf\uff081L\uff09\u6cbb\u7597\u7684\u7597\u6548\u3002<\/li>\n\n\n\n<li><strong>OrigAMI-3<\/strong>\u7814\u7a76\u65e8\u5728\u6bd4\u8f83\u963f\u7c73\u4e07\u5854\u9a6c\u5e03\u4e0e\u897f\u59a5\u6614\u5355\u6297\u6216\u8d1d\u4f10\u73e0\u5355\u6297\uff08\u5747\u8054\u5408 FOLFIRI \u65b9\u6848\uff09\u4f5c\u4e3a\u4e8c\u7ebf\uff082L\uff09\u6cbb\u7597\u7684\u7597\u6548\u3002<\/li>\n<\/ul>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">BREAKWATER\uff1a\u9488\u5bf9BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e00\u7ebf\u6069\u79d1\u62c9\u975e\u5c3c+\u897f\u59a5\u6614\u5355\u6297+\u5316\u7597\u65b9\u6848\u5206\u6790<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 16<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">BREAKWATER\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\">NCT04607421<\/a>\uff09\u662f\u4e00\u9879\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f83\u4e00\u7ebf \uff081L\uff09\u6069\u79d1\u62c9\u975e\u5c3c\uff08\u4e00\u79cdBRAF\u6291\u5236\u5242\uff09\u4e0e\u897f\u59a5\u6614\u5355\u6297\uff08\u4e00\u79cdEGFR\u6291\u5236\u5242\uff09\u2014\u2014\u5408\u79f0EC\u65b9\u6848\u2014\u2014\u4e0eFOLFOX\u65b9\u6848\uff0c\u4ee5\u53ca\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u5728BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002 \u672c\u7814\u7a76\u7684\u4e3b\u8981\u7ec8\u70b9\u5305\u62ec\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u5bf9\u8c61\uff1a<\/strong>\u672c\u7814\u7a76\u5165\u7ec4\u4e86479\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff08EC+FOLFOX\u7ec4=236\u4f8b\uff1b\u6807\u51c6\u6cbb\u7597\u7ec4=243\u4f8b\uff09\u3002\u4e24\u7ec4\u60a3\u8005\u7684\u4eba\u53e3\u7edf\u8ba1\u5b66\u7279\u5f81\u76f8\u5f53\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u8be5\u8bd5\u9a8c\u6700\u521d\u63091:1:1\u7684\u6bd4\u4f8b\u5c06\u53d7\u8bd5\u8005\u5206\u914d\u81f3\u4e09\u4e2a\u7ec4\u522b\uff1aEC\u7ec4\u3001EC+FOLFOX\u7ec4\u548c\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u7ec4\u3002\u4f46\u968f\u540e\u5bf9\u8bd5\u9a8c\u65b9\u6848\u8fdb\u884c\u4e86\u4fee\u8ba2\uff0c\u6539\u4e3a\u63091:1\u7684\u6bd4\u4f8b\u5c06\u53d7\u8bd5\u8005\u5206\u914d\u81f3\u4e24\u4e2a\u7ec4\u522b\uff1aEC+FOLFOX\u7ec4\u548c\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u7ec4\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\uff1a<\/strong>\u62a5\u544a\u4e86\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u7684\u4e3b\u8981\u5206\u6790\uff08\u57fa\u4e8e\u968f\u673a\u5206\u914d\u81f3\u5404\u7ec4\u7684\u524d110\u4f8b\u60a3\u8005\uff09\u4ee5\u53ca\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u5b89\u5168\u6027\u306e\u4e2d\u671f\u5206\u6790\u3002 EC + FOLFOX\u7ec4\u7684ORR\u4e3a60.9%\uff083\u4f8b\u5b8c\u5168\u7f13\u89e3\u548c64\u4f8b\u90e8\u5206\u7f13\u89e3\uff09\uff0c\u800c\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09\u7ec4\u4e3a40%\uff082\u4f8b\u5b8c\u5168\u7f13\u89e3\u548c42\u4f8b\u90e8\u5206\u7f13\u89e3\uff09\u3002EC + FOLFOX\u7ec4 \uff08n=67\u540d\u60a3\u8005\uff09\u7684\u4f30\u8ba1\u4e2d\u4f4d\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u4e3a13.9\u4e2a\u6708\uff08\u800c\u6807\u51c6\u6cbb\u7597\u7ec4\u4e3a11.1\u4e2a\u6708\uff0c[n=44 patients] \uff09\uff0c\u4e14\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u226512\u4e2a\u6708\u7684\u60a3\u8005\u4eba\u6570\u662f\u6807\u51c6\u6cbb\u7597\u7ec4\u7684\u4e24\u500d\uff08\u5206\u522b\u4e3a15\u540d\u548c5\u540d\uff09\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\uff1a<\/strong>\u4e24\u7ec4\u7684\u4e0d\u826f\u4e8b\u4ef6\u5747\u5728\u9884\u671f\u8303\u56f4\u5185\u3002<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u57fa\u4e8e\u8fd9\u4e9b\u7ed3\u679c\uff0cEC + FOLFOX \u65b9\u6848\u83b7\u5f97\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u9488\u5bf9 BRAF V600E \u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u7684\u52a0\u901f\u6279\u51c6\uff0c\u5e76\u88ab\u89c6\u4e3a\u8be5\u4eba\u7fa4\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u65b9\u6848\u3002<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u53ef\u5207\u9664\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\uff08pMMR\uff09\u548c\u7f3a\u5931\uff08dMMR\uff09\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\uff08\u535a\u6ed5\u897f\u5229\u5355\u6297[BOT]\u8054\u5408\u5df4\u65af\u5229\u5355\u6297[BAL]\uff09\uff1aNEST\u4e34\u5e8a\u8bd5\u9a8c\u6700\u65b0\u8fdb\u5c55<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 207<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">NEST\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05571293\">NCT05571293<\/a>\uff09\u662f\u4e00\u9879II\u671f\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u65b0\u8f85\u52a9\uff08\u672f\u524d\u7ed9\u836f\uff09\u535a\u7279\u897f\u5229\u5355\u6297\uff08\u4e00\u79cdFc\u589e\u5f3a\u578b\u65b0\u4e00\u4ee3CTLA-4\u6291\u5236\u5242\uff09\u8054\u5408\u5df4\u65af\u5229\u5355\u6297\uff08\u4e00\u79cdPD-1\u6291\u5236\u5242\uff09 \uff08BOT\/BAL\uff09\u65b9\u6848\u5728\u53ef\u5207\u9664pMMR\/MSS\u548cdMMR\/MSI-H\uff08CRC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u4e3b\u8981\u75c5\u7406\u53cd\u5e94\uff08MPR\uff09\u7387\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u5bf9\u8c61\uff1a<\/strong>\u672c\u7814\u7a76\u7eb3\u5165\u4e8624\u4f8b\u53ef\u5207\u9664\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5176\u4e2d20\u4f8b\u4e3apMMR\/MSS\u578b\uff0c4\u4f8b\u4e3adMMR\/MSI-H\u578b\u3002<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u8fd9\u662f\u4e00\u9879\u4e24\u7ec4\u7814\u7a76\uff1a<\/p>\n\n<ul class=\"wp-block-list\">\n<li>NEST-1\u7ec4\uff0810\u540d\u60a3\u8005\uff1a7\u4f8bMSS\uff0c3\u4f8bMSI-H\uff09\u63a5\u53d7\u4e861\u5242\u535a\u7279\u897f\u5229\u5355\u6297\u548c2\u5242\u5df4\u5c14\u65af\u5229\u5355\u6297\uff0c\u4e24\u5242\u7ed9\u836f\u95f4\u9694\u4e24\u5468\u3002<\/li>\n\n\n\n<li>NEST-2\u7ec4\uff0814\u540d\u60a3\u8005\uff1a13\u4f8bMSS\u548c1\u4f8bMSI-H\uff09\u63a5\u53d7\u4e861\u5242\u535a\u7279\u897f\u5229\u5355\u6297\uff0c\u4ee5\u53ca\u6700\u591a4\u5242\u5df4\u5c14\u897f\u5229\u5355\u6297\uff0c\u4e24\u5242\u4e4b\u95f4\u95f4\u9694\u4e24\u5468\u3002<\/li>\n<\/ul>\n\n<p class=\"wp-block-paragraph\">\u5728\u4e24\u7ec4\u4e2d\uff0cBOT\/BAL\u6cbb\u7597\u540e\u5747\u8fdb\u884c\u4e86\u624b\u672f\u5e72\u9884\u3002<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\uff1a<\/strong>\u5728MSS\u578b\u548cMSI-H\u578b\u7ed3\u76f4\u80a0\u764c\u4e2d\u5747\u89c2\u5bdf\u5230\u8f83\u9ad8\u7684MPR\u7387\u3002MPR\u5b9a\u4e49\u4e3a\u226590%\u7684\u75c5\u7406\u53cd\u5e94\uff08\u80bf\u7624\u9000\u7f29\uff09\u3002 \u5728NEST-1\u7ec4\u4e2d\uff0cMSS\u60a3\u8005\u7684MPR\u7387\u4e3a29%\uff082\/7\uff09\uff0c\u800c\u5728NEST-2\u7ec4\u91c7\u7528\u5ef6\u957f\u7ed9\u836f\u65b9\u6848\u540e\uff0c\u8be5\u6bd4\u4f8b\u4e0a\u5347\u81f347%\uff087\/14\uff09\u3002 \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cMSI-H\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684MPR\u7387\u9ad8\u8fbe100%\uff084\/4\uff09\u3002\u672a\u62a5\u544a\u590d\u53d1\u75c5\u4f8b\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\/\u526f\u4f5c\u7528\uff1a<\/strong>\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u7ed3\u80a0\u708e\u3001\u8179\u6cfb\u548c\u53d1\u70ed\uff1b\u4f46\u672a\u51fa\u73b04\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u6216\u672a\u89e3\u51b3\u7684\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u4e8b\u4ef6\u3002NEST-2\u7ec4\u4e2d\u67097\u540d\u60a3\u8005\u672a\u5b8c\u6210\u5df4\u65af\u66ff\u5229\u5355\u6297\u7684\u6cbb\u7597\u65b9\u6848\u3002\u672a\u56e0\u514d\u75ab\u4ecb\u5bfc\u6027\u4e0d\u826f\u4e8b\u4ef6\u5bfc\u81f4\u624b\u672f\u63a8\u8fdf\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u8be5\u8bd5\u9a8c\u8868\u660e\uff0cBOT\/BAL\u514d\u75ab\u7597\u6cd5\u7684\u8054\u5408\u5e94\u7528\u662f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u65b0\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\uff0c\u5c24\u5176\u5728\u5b9e\u73b0\u9ad8MPR\u7387\u7684\u540c\u65f6\uff0c\u672a\u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3002 \u8fd9\u4e9b\u53d1\u73b0\u53ef\u80fd\u9884\u793a\u7740\u7ed3\u76f4\u80a0\u764c\u672f\u524d\u6cbb\u7597\u7b56\u7565\u5c06\u53d1\u751f\u91cd\u5927\u8f6c\u53d8\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u96be\u4ee5\u6cbb\u7597\u7684pMMR\/MSS\u548cdMMR\/MSI-H\u60a3\u8005\u800c\u8a00\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u53e6\u4e00\u9879\u9488\u5bf9\u65e0\u809d\u8f6c\u79fb\u7684\u8f6c\u79fb\u6027MSS\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7814\u7a76BOT\/BAL\u8054\u5408\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05608044\">NCT05608044<\/a>\uff09\u5728\u672c\u6b21ASCO GI 2025\u4f1a\u8bae\u4e0a\u62a5\u544a\u4e86\u7814\u7a76\u7ed3\u679c\uff08\u6458\u898123\uff09\u3002 \u60a8\u53ef\u901a\u8fc7\u4e0b\u65b9Fight CRC\u7ec4\u7ec7\u7684\u201cASCO GI\u4f1a\u8bae\u4eae\u70b9\u201d\u7f51\u7edc\u7814\u8ba8\u4f1a\u4e86\u89e3\u66f4\u591a\u76f8\u5173\u4fe1\u606f\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u5728\u63a5\u53d7\u585e\u6765\u6614\u5e03\u6cbb\u7597\u7684III\u671f\u7ed3\u80a0\u764c\u4e2d\u7684\u9884\u540e\u548c\u9884\u6d4b\u4f5c\u7528\uff1a\u6765\u81eaCALGB\uff08\u8054\u76df\uff09\/SWOG 80702\u7814\u7a76\u7684\u7ed3\u679c<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 LBA14<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">CALGB\/SWOG 80702 (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT01150045\">NCT01150045<\/a>) \u8bd5\u9a8c\u662f\u4e00\u9879\u5927\u578b III \u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30\u585e\u6765\u6614\u5e03\uff08\u4e00\u79cd\u975e\u753e\u4f53\u6297\u708e\u836f\uff08NSAID\uff09\uff09\u8054\u5408 FOLFOX \u5316\u7597\u5728 III \u671f\u7ed3\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002 \u6b64\u524d\u8be5\u7814\u7a76\u62a5\u544a\u79f0\uff0c\u52a0\u7528\u585e\u6765\u6614\u5e03\u5e76\u672a\u663e\u8457\u6539\u5584\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u3002\u672c\u6b21\u4e9a\u7ec4\u5206\u6790\u65e8\u5728\u63a2\u8ba8\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u72b6\u6001\u80fd\u5426\u901a\u8fc7\u8bc6\u522b\u54ea\u4e9b\u60a3\u8005\u53ef\u80fd\u4ece\u585e\u6765\u6614\u5e03\u4e2d\u83b7\u76ca\uff0c\u4ece\u800c\u6307\u5bfc\u8f85\u52a9\u6cbb\u7597\u51b3\u7b56\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u5bf9\u8c61\uff1a<\/strong>\u5171\u7eb3\u51652,524\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc7\u624b\u672f\u6cbb\u7597\u7684III\u671f\u7ed3\u80a0\u817a\u764c\u60a3\u8005\u3002 \u5728\u672c\u6b21\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c\u5bf9940\u540d\u60a3\u8005\u5728\u672f\u540e\u4f46\u8f85\u52a9\u6cbb\u7597\u5f00\u59cb\u524d\u6d4b\u5b9a\u4e86ctDNA\u3002\u5176\u4e2d\uff0c18.4%\u7684\u60a3\u8005ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c81.6%\u7684\u60a3\u8005\u4e3a\u9634\u6027\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3\u585e\u6765\u6614\u5e03\u7ec4\u6216\u5b89\u6170\u5242\u7ec4\uff0c\u540c\u65f6\u63a5\u53d7FOLFOX\u5316\u7597\uff0c\u7597\u7a0b\u6700\u957f\u4e3a\u4e09\u5e74\u3002\u8fd9\u4e9b\u7ed3\u679c\u6765\u81ea\u4e00\u9879\u4e8b\u540e\u5206\u6790\uff08\u5728\u7814\u7a76\u5b8c\u6210\u540e\u8fdb\u884c\uff09\uff0c\u8be5\u5206\u6790\u8bc4\u4f30\u4e86\u672f\u540ectDNA\u4f5c\u4e3a\u9884\u6d4b\u6cbb\u7597\u7597\u6548\u7684\u751f\u7269\u6807\u5fd7\u7269\u7684\u4ef7\u503c\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\uff1a<\/strong>\u5728ctDNA\u9634\u6027\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u4f30\u8ba1\u76845\u5e74\u603b\u751f\u5b58\u7387\uff08OS\uff09\u4e3a91.5%\uff0c\u800c\u5728ctDNA\u9633\u6027\u60a3\u8005\u7fa4\u4f53\u4e2d\u4e3a52.6%\uff0c\u8fd9\u4e0e\u5176\u4ed6\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u4e00\u81f4\u3002 \u585e\u6765\u8003\u6614\u4e3actDNA\u9633\u6027\u60a3\u8005\u5e26\u6765\u4e86\u663e\u8457\u7684\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u83b7\u76ca\uff0c\u585e\u6765\u8003\u6614\u7ec43\u5e74DFS\u7387\u4e3a41.0%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a22.6%\u3002 \u76f8\u6bd4\u4e4b\u4e0b\uff0c\u65e0\u8bba\u63a5\u53d7\u585e\u6765\u6614\u5e03\u8fd8\u662f\u5b89\u6170\u5242\u6cbb\u7597\uff0cctDNA\u9634\u6027\u60a3\u8005\u7684DFS\u7ed3\u679c\u5747\u76f8\u4f3c\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\uff1a<\/strong>\u7814\u7a76\u53d1\u73b0\uff0c\u585e\u6765\u6614\u5e03\u4f5c\u4e3a\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u662f\u53ef\u884c\u4e14\u8010\u53d7\u6027\u826f\u597d\u7684\uff0c\u5176\u4e0d\u826f\u7ed3\u5c40\u53d1\u751f\u7387\u8f83\u5b89\u6170\u5242\u7ec4\u672a\u51fa\u73b0\u663e\u8457\u589e\u52a0\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u5f3a\u8c03\u4e86ctDNA\u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\u5728\u66f4\u6709\u6548\u5730\u5236\u5b9a\u4e2a\u6027\u5316\u8f85\u52a9\u6cbb\u7597\u65b9\u6848\u65b9\u9762\u7684\u6f5c\u529b\u3002\u5229\u7528ctDNA\u8bc6\u522b\u53ef\u80fd\u4ece\u5728\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u4e2d\u6dfb\u52a0\u585e\u6765\u6614\u5e03\u4e2d\u83b7\u76ca\u7684\u60a3\u8005\uff0c\u6709\u671b\u5728\u67d0\u4e9b\u7ed3\u80a0\u764c\u75c5\u4f8b\u4e2d\u6539\u5584\u4e2a\u6027\u5316\u6cbb\u7597\u6548\u679c\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u6d41\u884c\u75c5\u5b66\u3001\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u63d0\u4f9b\u7684\u8bc1\u636e\u8868\u660e\uff0c\u50cf\u585e\u6765\u6614\u5e03\u8fd9\u6837\u7684\u975e\u753e\u4f53\u6297\u708e\u836f\uff08NSAIDs\uff09\u5728\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u5316\u5b66\u9884\u9632\u4e2d\u53d1\u6325\u7740\u79ef\u6781\u4f5c\u7528\uff0c\u5e76\u53ef\u80fd\u5bf9\u6cbb\u7597\u6709\u76ca\u3002ALASCCA\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02647099\">NCT02647099<\/a>\uff09\u7684\u4e09\u5e74\u968f\u8bbf\u7ed3\u679c\uff0c \u57282025\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u80c3\u80a0\u764c\u7814\u8ba8\u4f1a\u4e0a\uff08LBA125\uff09\u516c\u5e03\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8ePI3K\u901a\u8def\u5b58\u5728\u7a81\u53d8\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u4f7f\u7528\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\uff08\u4e00\u79cd\u975e\u753e\u4f53\u6297\u708e\u836f\uff09\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u663e\u8457\u964d\u4f4e\u4e86\u590d\u53d1\u7387\u3002 \u6b32\u4e86\u89e3\u66f4\u591a\u8be6\u60c5\uff0c\u8bf7\u89c2\u770b\u4e0b\u65b9\u201cFight CRC\u201d\u7ec4\u7ec7\u7684\u201c2025\u5e74ASCO\u80c3\u80a0\u764c\u7814\u8ba8\u4f1a\u4eae\u70b9\u201d\u7f51\u7edc\u7814\u8ba8\u4f1a\u3002  <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">CheckMate 8HW \u7814\u7a76\u4e2d\uff0c\u5c3c\u6c83\u5362\u5355\u6297\uff08NIVO\uff09\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\uff08IPI\uff09\u4e0e NIVO \u5355\u836f\u6cbb\u7597\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\/\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08MSI-H\/dMMR\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u521d\u6b65\u7ed3\u679c<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 LBA143<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">III\u671fCheckMate 8HW\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04008030\">NCT04008030<\/a>\uff09\u4e34\u5e8a\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u514d\u75ab\u7597\u6cd5\u5c3c\u6c83\u5362\u5355\u6297\uff08\u4e00\u79cd\u6297PD-1\u7597\u6cd5\uff09\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297 \uff08\u4e00\u79cdCTLA-4\u6291\u5236\u5242\uff09\u8054\u5408\u6cbb\u7597\u65b9\u6848\uff0c\u4e0e\u5c3c\u6c83\u5362\u5355\u6297\u5355\u836f\u6cbb\u7597\uff08\u6216\u5355\u72ec\u4f7f\u7528\uff09\u5728\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u6216\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08MSI-H\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002 \u8be5\u7814\u7a76\u65e8\u5728\u8bc4\u4f30\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u53ca\u5176\u4ed6\u5173\u952e\u7ec8\u70b9\u6307\u6807\uff0c\u4ee5\u786e\u7acb\u9488\u5bf9\u6b64\u7c7b\u60a3\u8005\u7684\u6709\u6548\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u5165\u7ec4\u5bf9\u8c61\uff1a<\/strong>\u8be5\u8bd5\u9a8c\u5165\u7ec4\u4e86703\u4f8b\u7ecf\u75c5\u7406\u5b66\u786e\u8bca\u4e3a\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001MSI-H\/dMMR\u9633\u6027\uff0c\u4e14\u4e1c\u90e8\u80bf\u7624\u534f\u4f5c\u7ec4\uff08ECOG\uff09\u4f53\u80fd\u72b6\u6001\u8bc4\u5206\u4e3a0\u62161\u7684\u60a3\u8005\u3002<\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u4e3a\u4e24\u7ec4\uff1a\u4e00\u7ec4\u63a5\u53d7\u5c3c\u6c83\u5362\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u6cbb\u7597\uff0c\u53e6\u4e00\u7ec4\u63a5\u53d7\u5c3c\u6c83\u5362\u5355\u6297\u5355\u836f\u6cbb\u7597\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\uff0c\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u4e0e\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\uff08HRQOL\uff09\u548c\u5b89\u5168\u6027\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u7ed3\u679c\uff1a<\/strong>\u4e0e\u5355\u7528\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u4e0e\u4f0a\u5339\u6728\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u663e\u8457\u5ef6\u957f\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u4ece\u800c\u786e\u7acb\u4e86\u8be5\u65b9\u6848\u4f5c\u4e3a\u8be5\u60a3\u8005\u7fa4\u4f53\u65b0\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u7684\u5730\u4f4d\u3002 \u8054\u5408\u6cbb\u7597\u7ec4\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u663e\u8457\u66f4\u9ad8\uff0c\u8fbe\u523071%\uff0c\u800c\u5355\u836f\u6cbb\u7597\u7ec4\u4e3a58%\u3002\u8054\u5408\u6cbb\u7597\u7ec4\u5728\u751f\u6d3b\u8d28\u91cf\uff08HRQOL\uff09\u65b9\u9762\u4e5f\u89c2\u5bdf\u5230\u6539\u5584\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u4e0d\u826f\u4e8b\u4ef6\uff1a<\/strong>\u8054\u5408\u6cbb\u7597\u4e2d\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\u53d1\u751f\u7387\u66f4\u9ad8\uff0c\u536081%\u7684\u60a3\u8005\uff0c\u800c\u5355\u836f\u6cbb\u7597\u7ec4\u4e3a71%\u3002\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u7619\u75d2\u3001\u8179\u6cfb\u548c\u7532\u72b6\u817a\u529f\u80fd\u51cf\u9000\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u901a\u8fc7\u6ee1\u8db3MSI-H\/dMMR\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u5bf9\u6709\u6548\u4e00\u7ebf\u6cbb\u7597\u7684\u9700\u6c42\uff0c\u4e3a\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u9886\u57df\u5e26\u6765\u4e86\u4e00\u9879\u6781\u5177\u524d\u666f\u7684\u8fdb\u5c55\u3002\u5c3c\u6c83\u5362\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7684\u6cbb\u7597\u65b9\u6848\u53ef\u80fd\u5e26\u6765\u6301\u4e45\u7684\u7597\u6548\u5e76\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u8fd9\u6807\u5fd7\u7740\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u6b63\u671d\u7740\u66f4\u4e2a\u6027\u5316\u3001\u66f4\u6709\u6548\u7684\u65b9\u5411\u53d1\u751f\u5173\u952e\u6027\u8f6c\u53d8\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u4e86\u89e3\u66f4\u591a\u201cASCO GI\u4f1a\u8bae\u4eae\u70b9\u201d<\/h3>\n\n<p class=\"wp-block-paragraph\">\u89c2\u770b\u6211\u4eec\u8fd1\u671f\u4e0e\u80bf\u7624\u5b66\u5bb6\u963f\u5c14\u00b7\u672c\u68ee\u4e09\u4e16\u535a\u58eb\uff08\u897f\u5317\u5927\u5b66\uff09\u4ee5\u53ca\u201cFight CRC\u201d\u7814\u7a76\u5021\u5bfc\u8005\u8fc8\u514b\u5c14\u00b7\u970d\u5c14\u8328\u5171\u540c\u4e3e\u529e\u7684\u7f51\u7edc\u7814\u8ba8\u4f1a\u5f55\u50cf\uff0c\u4e86\u89e3\u66f4\u591a\u201cASCO GI\u5927\u4f1a\u4eae\u70b9\u201d\uff01\u7f51\u7edc\u7814\u8ba8\u4f1a\u4e2d\u8ba8\u8bba\u7684\u51e0\u4e2a\u8981\u70b9\u5305\u62ec\uff1a <\/p>\n\n<ul class=\"wp-block-list\">\n<li>\u5e15\u6885\u62c9\u00b7\u6606\u8328\u535a\u58eb\u5728\u9898\u4e3a\u300a\u98a0\u8986\u80c3\u80a0\u9053\u80bf\u7624\u5b66\uff1a\u4ee5\u5305\u5bb9\u6027\u79d1\u5b66\u6253\u7834\u58c1\u5792\u300b\u7684\u4e3b\u9898\u6f14\u8bb2\u4e2d\u63d0\u51fa\u7684\u603b\u4f53\u4e3b\u9898\uff0c\u91cd\u70b9\u5f3a\u8c03\u4e86\u5305\u5bb9\u6027\u79d1\u5b66\u548c\u5065\u5eb7\u516c\u5e73\u3002<\/li>\n\n\n\n<li>\u4ee5\u4e0b\u4e94\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\uff1a\n<ul class=\"wp-block-list\">\n<li><strong>BESPOKE CRC<\/strong>\u8bc4\u4f30\u4e86\u4e00\u9879 ctDNA \u68c0\u6d4b\u5728\u6307\u5bfc II\/III \u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u6cbb\u7597\u51b3\u7b56\u65b9\u9762\u7684\u4f5c\u7528\u3002<\/li>\n\n\n\n<li><strong>\u5728CALGB\/SWOG 80702\u7814\u7a76\u4e2d<\/strong>\uff0c\u7814\u7a76\u4eba\u5458\u8bc4\u4f30\u4e86\u672f\u540ectDNA\u72b6\u6001\u662f\u5426\u53ef\u7528\u4e8e\u786e\u5b9a\u54ea\u4e9bIII\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u53ef\u80fd\u4ece\u8f85\u52a9\u6cbb\u7597\u4e2d\u4f7f\u7528\u585e\u6765\u6614\u5e03\u83b7\u76ca\u3002<\/li>\n\n\n\n<li><strong>ALASCCA<\/strong>\u7814\u7a76\u63a2\u8ba8\u4e86\u4f4e\u5242\u91cf\u963f\u53f8\u5339\u6797\u5bf9 PI3K \u901a\u8def\u53d1\u751f\u6539\u53d8\u7684\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u590d\u53d1\u7387\u7684\u5f71\u54cd\u3002<\/li>\n\n\n\n<li><strong>BREAKWATER<\/strong>\u7814\u7a76\u8bc4\u4f30\u4e86\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u52a0\u5316\u7597\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u5728 BRAF V600E \u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002<\/li>\n\n\n\n<li>\u4e00\u9879\u8bc4\u4f30\u535a\u6ed5\u897f\u5229\u5355\u6297\uff08BOT\uff09\u8054\u5408\u6216\u4e0d\u8054\u5408\u5df4\u5c14\u65af\u5229\u5355\u6297\uff08BAL\uff09\u6cbb\u7597\u65e0\u809d\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u7684\u7814\u7a76\u3002<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Highlights from ASCO GI\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/bMLLqwyJRKI?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n<h2 class=\"wp-block-heading\" id=\"2024\">2024<\/h2>\n\n<p class=\"wp-block-paragraph\"><em>Maia\uff1a\u5728\u672c\u6b21\u4f1a\u8bae\u4e0a\uff0c\u6211\u4eec\u5bf9\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u68c0\u6d4b\u5728\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u6709\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u3002 \u6211\u5f88\u671f\u5f85\u66fc\u6731\u5bf9\u6b64\u7684\u89c1\u89e3\u3002\u5c31\u6211\u4e2a\u4eba\u800c\u8a00\uff0c\u6211\u60f3\u91cd\u70b9\u4ecb\u7ecd\u56db\u7bc7\u6765\u81ea2024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u5206\u4f1a\uff08GI ASCO 2024\uff09\u7684\u7814\u7a76\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6458\u8981\uff0c\u8fd9\u4e9b\u5185\u5bb9\u5bf9\u60a3\u8005\u7fa4\u4f53\u4e5f\u81f3\u5173\u91cd\u8981\u3002  <\/em><\/p>\n\n<h3 class=\"wp-block-heading\">NEST-1\uff1a\u53ef\u5207\u9664\u7684\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\u548c\u7f3a\u5931\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63a5\u53d7\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u535a\u7279\u897f\u5229\u5355\u6297\u8054\u5408\u5df4\u65af\u5229\u5355\u6297<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 117\uff0c\u6d77\u62a5\u5c55\u677f H2\uff1b\u5e15\u4ec0\u56fe\u4eba\u7a46\u5c14\u5854\u624e\u00b7\u5361\u897f\uff0c\u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">NEST-1 \u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05571293\">NCT05571293<\/a>\uff09\u9488\u5bf9\u53ef\u624b\u672f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u6d4b\u8bd5\u4e86\u4e00\u79cd\u65b0\u7684\u836f\u7269\u8054\u5408\u65b9\u6848\uff1a \u514d\u75ab\u7597\u6cd5\u836f\u7269\u535a\u6ed5\u897f\u5229\u5355\u6297\uff08\u4e00\u79cdFc\u589e\u5f3a\u578b\u65b0\u4e00\u4ee3CTLA-4\u6291\u5236\u5242\uff09\u4e0e\u5df4\u5c14\u65af\u5229\u5355\u6297\uff08\u4e00\u79cdPD-1\u6291\u5236\u5242\uff09\u3002\u8be5\u8054\u5408\u65b9\u6848\u4e5f\u88ab\u6635\u79f0\u4e3a\u201cBOT\/BAL\u201d\u3002 \u8be5\u8bd5\u9a8c\u7eb3\u5165\u4e8612\u4f8b\u60a3\u6709\u4e24\u79cd\u7c7b\u578b\u7ed3\u76f4\u80a0\u764c\u7684\u60a3\u8005\uff1a\u5176\u4e2d9\u4f8b\u4e3a\u9519\u914d\u4fee\u590d\u529f\u80fd\u6b63\u5e38\/\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08pMMR\/MSS\uff09\uff0c3\u4f8b\u4e3a\u9519\u914d\u4fee\u590d\u7f3a\u9677\/\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\u578b\uff08dMMR\/MSI-H\uff09\u7ed3\u76f4\u80a0\u764c\u3002 \u8fd9\u4e9b\u60a3\u8005\u5148\u63a5\u53d7\u4e86\u4e00\u6b21\u56fa\u5b9a\u5242\u91cf\u7684\u535a\u6ed5\u897f\u5229\u5355\u6297\uff0c\u968f\u540e\u95f4\u9694\u4e24\u5468\u63a5\u53d7\u4e86\u4e24\u6b21\u56fa\u5b9a\u5242\u91cf\u7684\u5df4\u5c14\u65af\u5229\u5355\u6297\u3002\u5728\u7b2c\u4e8c\u6b21\u5df4\u5c14\u65af\u5229\u5355\u6297\u7ed9\u836f\u540e\uff0c\u7ecf\u8fc71\u81f36\u5468\u7684\u89c2\u5bdf\u671f\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u624b\u672f\u5207\u9664\u80bf\u7624\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u4eba\u5458\u62a5\u544a\u79f0\uff0c\u535a\u6ed5\u897f\u5229\u5355\u6297\u4e0e\u5df4\u65af\u5229\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u5b89\u5168\u4e14\u5927\u591a\u6570\u60a3\u8005\u8010\u53d7\u6027\u826f\u597d\uff0c\u4ec5\u51fa\u73b0\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u526f\u4f5c\u7528\uff08\u8179\u6cfb\u3001\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u5934\u75db\u3001\u75b2\u52b3\u548c\u76ae\u75b9\uff09\u3002 \u8be5\u8054\u5408\u7597\u6cd5\u5728pMMR\/MSS\u548cdMMR\/MSI-H\u764c\u75c7\u4e2d\u5747\u663e\u793a\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7597\u6548\uff0c\u80bf\u7624\u7f29\u5c0f\u7387\u548c\u6d88\u5931\u7387\u5747\u8f83\u9ad8\u3002\u5728MSS\u60a3\u8005\u4e2d\uff0c\u5171\u670967%\uff089\u540d\u60a3\u8005\u4e2d\u76846\u540d\uff09\u51fa\u73b0\u4e86\u75c5\u7406\u53cd\u5e94\uff08\u5b9a\u4e49\u4e3a\u80bf\u7624\u7f29\u5c0f\u81f3\u5c1150%\uff09\uff0c \u800cMSI-H\u7ec4\u60a3\u8005100%\uff083\u540d\u4e2d\u76843\u540d\uff09\u5b9e\u73b0\u4e86\u4e3b\u8981\u75c5\u7406\u53cd\u5e94\uff08\u5b9a\u4e49\u4e3a\u80bf\u7624\u7f29\u5c0f\u81f3\u5c1190%\uff09\u3002 \u7814\u7a76\u4eba\u5458\u8fd8\u6d4b\u5b9a\u4e86\u6cbb\u7597\u524d\u540e\u8840\u6db2\u4e2d\u7684ctDNA\u6c34\u5e73\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u6cbb\u7597\u524d\u5b58\u5728ctDNA\u7684\u60a3\u8005\u5728\u6cbb\u7597\u540e\u8f6c\u4e3a\u9634\u6027\uff0c\u8fd9\u8868\u660e\u8be5\u8054\u5408\u7597\u6cd5\u6d88\u706d\u4e86\u4f53\u5185\u5927\u90e8\u5206\u764c\u7ec6\u80de\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\">\u603b\u4e4b\uff0c\u65b0\u8f85\u52a9\u6cbb\u7597\u4e2d\u535a\u7279\u897f\u5229\u5355\u6297\u4e0e\u5df4\u65af\u5229\u5355\u6297\u7684\u8054\u5408\u65b9\u6848\u5bf9\u4e8e\u53ef\u5207\u9664\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u800c\u8a00\u662f\u4e00\u79cd\u6781\u5177\u524d\u666f\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u7279\u522b\u662f\u5bf9\u4e8edMMR\/MSI-H\u80bf\u7624\u60a3\u8005\u3002 \u7814\u7a76\u4eba\u5458\u8fd8\u6307\u51fa\uff0c\u8be5\u8bd5\u9a8c\u8868\u660e\uff0c\u514d\u75ab\u7597\u6cd5\u5728pMMR\/MSS\u80bf\u7624\u4e2d\u540c\u6837\u6709\u6548\u2014\u2014\u8fd9\u7c7b\u80bf\u7624\u901a\u5e38\u5bf9\u8fd9\u79cd\u6cbb\u7597\u65b9\u5f0f\u5177\u6709\u8010\u836f\u6027\uff0c\u4f46\u81f3\u5c11\u5728\u8be5\u6cbb\u7597\u573a\u666f\uff08\u65b0\u8f85\u52a9\u6cbb\u7597\uff0c\u5373\u672f\u524d\uff09\u4e2d\uff0c\u514d\u75ab\u7597\u6cd5\u4ecd\u80fd\u53d1\u6325\u4f5c\u7528\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u76ee\u524d\u8fd8\u6709\u5176\u4ed6\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u6d4b\u8bd5\u8fd9\u79cd\u8054\u5408\u7597\u6cd5\uff1b\u60a8\u53ef\u4ee5\u5728<a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/trial-finder\/\">\u201cFight CRC\u201d\u7ec4\u7ec7\u7684\u201c\u8bd5\u9a8c\u67e5\u627e\u5668<\/a>\u201d\u4e2d\u8fdb\u884c\u641c\u7d22\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">CheckMate 8HW\uff1a \u5c3c\u6c83\u5362\u5355\u6297\uff08NIVO\uff09\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\uff08IPI\uff09\u4e0e\u5316\u7597\uff08chemo\uff09\u4f5c\u4e3a\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\/\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08MSI-H\/dMMR\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u4e00\u7ebf\uff081L\uff09\u6cbb\u7597<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 LBA768\uff1b\u8482\u57c3\u91cc\u00b7\u5b89\u5fb7\u70c8\uff0c\u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">CheckMate 8HW \u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04008030\">NCT04008030<\/a>\uff09\u5bf9\u6bd4\u4e86\u9488\u5bf9 MSI-H \u60a3\u8005\u7684\u4e24\u79cd\u4e0d\u540c\u6cbb\u7597\u65b9\u6848\u3002MSI-H \u662f\u4e00\u79cd DNA \u7a81\u53d8\u8f83\u591a\u7684\u665a\u671f\u7ed3\u76f4\u80a0\u764c\uff0c\u6b64\u7c7b\u764c\u75c7\u7684\u764c\u7ec6\u80de\u66f4\u5bb9\u6613\u88ab\u514d\u75ab\u7cfb\u7edf\u8bc6\u522b\uff0c\u4e14\u5bf9\u67d0\u4e9b\u836f\u7269\u66f4\u5177\u8010\u836f\u6027\u3002 \u8be5\u7814\u7a76\u5c06\u9488\u5bf9\u8f6c\u79fb\u6027\u75be\u75c5\u7684\u4e00\u7ebf\u6cbb\u7597\u65b9\u6848\u2014\u2014\u5c3c\u6c83\u5362\u5355\u6297\uff08OPDIVO\u00ae\uff09\u4e0e\u4f0a\u5339\u6728\u5355\u6297\uff08YERVOY\u00ae\uff09\u7684\u8054\u5408\u7597\u6cd5\uff08\u8fd9\u4e24\u79cd\u514d\u75ab\u7597\u6cd5\u5206\u522b\u9776\u5411PD-1\u548cCTLA-4\uff09\u2014\u2014\u4e0e\u5316\u7597\u8fdb\u884c\u4e86\u5bf9\u6bd4\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u663e\u8457\u6539\u5584\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u8054\u5408\u4f0a\u5339\u6728\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dPFS\u5c1a\u672a\u8fbe\u5230\uff0c\u800c\u5316\u7597\u7ec4\u4e3a5.9\u4e2a\u6708\u3002 \u8fd9\u8868\u660e\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e\u4e8679%\u3002\u8fd9\u4e00PFS\u83b7\u76ca\u5728\u6240\u6709\u9884\u5148\u6307\u5b9a\u7684\u4e9a\u7ec4\u4e2d\u5747\u4e00\u81f4\uff0c\u5305\u62ec\u643a\u5e26KRAS\u6216NRAS\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u5728\u8bd5\u9a8c\u5f00\u59cb\u65f6\u5b58\u5728\u809d\u3001\u80ba\u6216\u8179\u819c\u8f6c\u79fb\u7684\u60a3\u8005\u3002   <\/p>\n\n<p class=\"wp-block-paragraph\">\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b89\u5168\u6027\u7279\u5f81\u4e0e\u5148\u524d\u62a5\u544a\u7684\u6570\u636e\u4e00\u81f4\u3002 \u8be5\u514d\u75ab\u7597\u6cd5\u8054\u5408\u65b9\u6848\u53ef\u901a\u8fc7\u65e2\u5b9a\u65b9\u6848\u8fdb\u884c\u7ba1\u7406\uff0c\u4e14\u672a\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u53f7\u3002\u7136\u800c\uff0cPD-1\/CTLA-4\u6291\u5236\u5242\u8054\u5408\u6cbb\u7597\u7684\u6bd2\u6027\u663e\u8457\uff081%\uff0c\u5c3c\u6c83\u5362\u5355\u6297\u548c\u4f0a\u5339\u6728\u5355\u6297\u7ec4\u62a5\u544a\u4e862\u4f8b\u6cbb\u7597\u76f8\u5173\u6b7b\u4ea1\uff09\uff0c\u5728\u8003\u8651\u8be5\u65b9\u6848\u65f6\u5e94\u4e88\u4ee5\u8ba8\u8bba\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\"><strong>\u6838\u5fc3\u7ed3\u8bba\uff1a<\/strong>\u5bf9\u4e8e\u672a\u66fe\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684dMMR\/MSI-H\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u514d\u75ab\u6cbb\u7597\u8054\u5408\u65b9\u6848\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u663e\u8457\u964d\u4f4e\u4e86\u75be\u75c5\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u6b63\u5982\u83ab\u91cc\u65af\u535a\u58eb\u5728\u201cFight CRC 2024 GI ASCO\u201d\u4f1a\u8bae\u56de\u987e\u7f51\u7edc\u7814\u8ba8\u4f1a\u4e0a\u6240\u8a00\uff0c\u76ee\u524d\u5c1a\u65e0\u6cd5\u786e\u5b9a\u8fd9\u79cd\u6297PD-1\/CTLA-4\u8054\u5408\u7597\u6cd5\u662f\u5426\u4f18\u4e8e\u6297PD-1\u5355\u836f\u6cbb\u7597\uff1b\u6211\u4eec\u5c06\u7b49\u5f85CheckMate 8HW\u7814\u7a76\u7684\u8fdb\u4e00\u6b65\u8fdb\u5c55\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u76f4\u80a0\u764c\u4e2d\u7684\u5668\u5b98\u4fdd\u7559\uff1a\u5728\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7684\u60c5\u51b5\u4e0b\u91c7\u53d6\u201c\u89c2\u5bdf\u7b49\u5f85\u201d\u7b56\u7565\u5b58\u5728\u54ea\u4e9b\u98ce\u9669\uff1f<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 7\uff1b\u52b3\u62c9\u00b7M\u00b7\u8d39\u5c14\u5357\u5fb7\u65af\uff0c\u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u5728\u67d0\u4e9b\u63a5\u53d7\u8fc7\u65b0\u8f85\u52a9\u6cbb\u7597\u7684\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\u75c5\u4f8b\u4e2d\uff0c\u4fdd\u7559\u53d7\u7d2f\u5668\u5b98\u53ef\u4f5c\u4e3a\u5168\u76f4\u80a0\u7cfb\u819c\u5207\u9664\u672f\uff08TME\uff09\u7684\u4e00\u79cd\u53ef\u884c\u66ff\u4ee3\u65b9\u6848\u3002 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\u6240\u91c7\u7528\u7684ctDNA\u68c0\u6d4b\u4e3a\u4e2a\u6027\u5316\u68c0\u6d4b\uff0c\u5e76\u57fa\u4e8e\u80bf\u7624\u7279\u5f81\u8fdb\u884c\u5206\u6790\u3002\u5bf9\u4e8ectDNA\u6307\u5bfc\u6cbb\u7597\u7ec4\uff0c\u82e5\u672f\u540e\u7b2c4\u5468\u548c\/\u6216\u7b2c7\u5468ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff08ctDNA(+)\uff09\uff0c\u5219\u63a5\u53d7\u4e3a\u671f4\u4e2a\u6708\u7684\u5965\u6c99\u5229\u94c2\u62165-\u6c1f\u5c3f\u5627\u5576\uff085FU\uff09\u4e3a\u57fa\u7840\u7684\u5316\u7597\u3002 \u82e5ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\uff0c\u4e14\u65e0\u6dcb\u5df4\u7ed3\u8f6c\u79fb\uff0c\u60a3\u8005\u5219\u4e0d\u63a5\u53d7\u4efb\u4f55\u5316\u7597\uff1b\u82e5\u6dcb\u5df4\u7ed3\u9633\u6027\uff0c\u5219\u63a5\u53d7\u4e34\u5e8a\u533b\u751f\u9009\u62e9\u7684\u5316\u7597\u65b9\u6848\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u8f85\u52a9\u5316\u7597\u7684\u4f7f\u7528\u60c5\u51b5\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8e\u65b0\u51a0\u75ab\u60c5\u4ee5\u53ca\u5168\u9762\u65b0\u8f85\u52a9\u6cbb\u7597\uff08TNT\uff09\u7684\u91c7\u7528\uff0c\u8be5\u7814\u7a76\u63d0\u524d\u7ec8\u6b62\u3002\u57282024\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u80c3\u80a0\u764c\u4f1a\u8bae\u4e0a\u516c\u5e03\u7684\u7ed3\u679c\u57fa\u4e8e230\u540d\u5165\u7ec4\u60a3\u8005\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a37\u4e2a\u6708\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u5728\u63a5\u53d7ctDNA\u6307\u5bfc\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c97%\u7684\u60a3\u8005ctDNA\u5206\u6790\u7ed3\u679c\u6210\u529f\uff0c\u5176\u4e2d28%\u88ab\u68c0\u6d4b\u51factDNA\u9633\u6027\u3002\u4e0e\u6807\u51c6\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0cctDNA\u6307\u5bfc\u7ec4\u4e2d\u8f85\u52a9\u5316\u7597\u7684\u4f7f\u7528\u7387\u660e\u663e\u8f83\u4f4e\uff0c\u4ec5\u670946%\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u8f85\u52a9\u5316\u7597\u3002 ctDNA\u6307\u5bfc\u6cbb\u7597\u7ec4\u7684\u4e09\u5e74\u65e0\u590d\u53d1\u751f\u5b58\u7387\u4e3a76%\uff0c\u6807\u51c6\u6cbb\u7597\u7ec4\u4e3a82%\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u4f5c\u8005\u5f97\u51fa\u7ed3\u8bba\uff1a\u5728\u65b0\u8f85\u52a9\u5316\u7597\u653e\u7597\u548c\u624b\u672f\u540e\u91c7\u7528ctDNA\u6307\u5bfc\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4e0e\u5316\u7597\u7528\u836f\u91cf\u7684\u51cf\u5c11\u76f8\u5173\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">BESPOKE CRC \u7814\u7a76\uff1a\u5229\u7528\u5faa\u73af\u80bf\u7624 DNA\uff08ctDNA\uff09\u6307\u5bfc II\/III \u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u8f85\u52a9\u5316\u7597\uff08ACT\uff09<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 9\uff1b\u5e15\u4ec0\u56fe\u4eba\u7a46\u5c14\u5854\u624e\u00b7\u5361\u897f\uff0c\u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u662fBESPOKE CRC\u89c2\u5bdf\u6027\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04264702\">NCT04264702<\/a>\uff09\uff08N=350\uff09\u7684\u9996\u6279\u7ed3\u679c\uff0c\u8be5\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\u57fa\u4e8e\u80bf\u7624\u4fe1\u606f\u7684ctDNA\u68c0\u6d4b\uff08Signatera\u2122\uff09\u5728\u6307\u5bfcII\u671f\/III\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u8f85\u52a9\u5316\u7597\u6cbb\u7597\u51b3\u7b56\u65b9\u9762\u7684\u4f5c\u7528\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u7ed3\u679c\u6765\u81ea\u9996\u6279\u63a5\u53d7Signatera\u2122\u5fae\u5c0f\u6b8b\u7559\u75c5\u53d8\uff08MRD\uff09ctDNA\u68c0\u6d4b\u7684154\u4f8bII\u671f\u548c196\u4f8bIII\u671f\u60a3\u8005\uff0c\u5176\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a24.8\u4e2a\u6708\u3002 \u6839\u6cbb\u6027\u624b\u672f\u540e\uff0c232\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u8f85\u52a9\u5316\u7597\uff0c118\u540d\u60a3\u8005\u672a\u63a5\u53d7\u5316\u7597\uff0c\u4ec5\u8fdb\u884c\u89c2\u5bdf\u3002 295 \u540d\u60a3\u8005\u63d0\u4f9b\u4e86\u672f\u540e MRD \u65f6\u95f4\u70b9\u7684 ctDNA \u7ed3\u679c\uff1b\u5176\u4e2d 15.6% \u4e3a ctDNA(+)\uff0c\u5305\u62ec 6.9% \u7684 II \u671f\u60a3\u8005\u548c 22.4% \u7684 III \u671f\u60a3\u8005\u3002 ctDNA(+)\u60a3\u8005\u7684\u75be\u75c5\u590d\u53d1\u7387\u66f4\u9ad8\uff0c\u8fd9\u4f53\u73b0\u5728\u5176\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u4e2d\u4f4d\u6570\u663e\u8457\u8f83\u4f4e\u3002\u5728MRD ctDNA(+)\u7ec4\u4e2d\uff0c\u8f85\u52a9\u5316\u7597\u53ef\u964d\u4f4e\u590d\u53d1\u7387\uff0c\u4f46\u5728ctDNA(-)\u60a3\u8005\u4e2d\u672a\u89c1\u76ca\u5904\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\">\u4ece\u60a3\u8005\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u53c2\u4e0e\u672c\u7814\u7a76\u7684\u60a3\u8005\u5bf9ctDNA\u68c0\u6d4b\u8868\u793a\u6b22\u8fce\uff1a73%\u7684\u60a3\u8005\u8868\u793a\uff0cctDNA\u68c0\u6d4b\u7ed3\u679c\u51cf\u8f7b\u4e86\u4ed6\u4eec\u5bf9\u590d\u53d1\u7684\u7126\u8651\uff0c\u800c87%\u7684\u60a3\u8005\u8868\u793a\uff0c\u5728\u4e86\u89e3ctDNA\u68c0\u6d4b\u7ed3\u679c\u540e\uff0c\u4ed6\u4eec\u8ba4\u4e3a\u81ea\u5df1\u6b63\u5728\u63a5\u53d7\u6b63\u786e\u7684\u6cbb\u7597\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">GALAXY\u7814\u7a76\uff1a\u5b58\u5728\u5206\u5b50\u6b8b\u7559\u75c5\u53d8\u7684\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4e2d\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u7684\u52a8\u6001\u53d8\u5316<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 6\uff1b Yukami Hiroki \u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u672c\u6458\u8981\u4ecb\u7ecd\u4e86GALAXY\u7814\u7a76\u4e2d\uff0c\u9488\u5bf9\u63a5\u53d7\u6839\u6cbb\u6027\u624b\u672f\u7684II-IV\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u5bf9\u5176ctDNA\u52a8\u6001\u53d8\u5316\u4e0e\u9884\u540e\u4e4b\u95f4\u7684\u5206\u6790\u53ca\u76f8\u5173\u6027\u7814\u7a76\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">Signatera\u2122 \u68c0\u6d4b\u6cd5\u5bf9\u672f\u540e\u7b2c 1\u30013\u30016\u30019\u300112\u300118 \u548c 24 \u4e2a\u6708\u76f4\u81f3\u590d\u53d1\u671f\u95f4\u91c7\u96c6\u7684\u7cfb\u5217\u8840\u6d46\u6837\u672c\u4e2d\u7684ctDNA\u8fdb\u884c\u4e86\u68c0\u6d4b\u548c\u5b9a\u91cf\u5206\u6790\u3002 \u5728\u4ee5\u6cbb\u6108\u4e3a\u76ee\u7684\u7684\u624b\u672f\u540e\uff0c\u60a3\u8005\u63a5\u53d7\u4e86\u8f85\u52a9\u5316\u7597\uff08N=1,000\uff09\u6216\u89c2\u5bdf\uff08N=1,518\uff09\u3002\u4e3b\u8981\u7ec8\u70b9\u4e3a\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u5728GALAXY\u7814\u7a76\u5165\u7ec4\u76843,034\u4f8b\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4e2d\uff0c\u67092,518\u4f8b\u7b26\u5408\u7eb3\u5165\u6807\u51c6\uff0c\u5e76\u88ab\u7eb3\u5165\u672c\u5b50\u7814\u7a76\u7684\u5206\u6790\u3002 \u672f\u540e\uff0c309\u540d\uff0814.8%\uff09\u60a3\u8005ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u5176\u4e2d181\u540d\u63a5\u53d7\u4e86\u8f85\u52a9\u5316\u7597\uff0c72.9%\uff08132\/181\uff09\u5b9e\u73b0\u4e86ctDNA\u6e05\u9664\u3002 \u7ea654%\u7684\u60a3\u8005\u5b9e\u73b0\u4e86\u6301\u7eed\u6027ctDNA\u6e05\u9664\uff0c\u800c46%\u7684\u60a3\u8005\u6700\u7ec8\u518d\u6b21\u68c0\u6d4b\u51factDNA\u9633\u6027\u3002\u4e0ectDNA\u6682\u65f6\u6e05\u9664\u7684\u60a3\u8005\u76f8\u6bd4\uff0c\u5b9e\u73b0\u6301\u7eed\u6027\u6e05\u9664\u7684\u60a3\u8005\u9884\u540e\u663e\u8457\u66f4\u597d\u3002   <\/p>\n\n<p class=\"wp-block-paragraph\">BESPOKE \u548c GALAXY \u4e24\u9879\u7814\u7a76\u7684\u7ed3\u679c\u5747\u8868\u660e\uff0cctDNA \u5fae\u6b8b\u7559\u75c5\u7076\uff08MRD\uff09\u68c0\u6d4b\u7ed3\u679c\u4ee5\u53ca\u60a3\u8005\u5bf9\u8f85\u52a9\u5316\u7597\u7684 ctDNA \u52a8\u6001\u53d8\u5316\uff0c\u5bf9\u9884\u540e\u5177\u6709\u6781\u9ad8\u7684\u9884\u6d4b\u4ef7\u503c\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">NRG-GI005\uff08COBRA\uff09\u2161\/\u2162\u671f\u7814\u7a76\uff1a\u5faa\u73af\u80bf\u7624DNA\u4f5c\u4e3a\u2161\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u8f85\u52a9\u5316\u7597\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u7269\u7684\u2161\u671f\u7814\u7a76\u7ed3\u679c<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981 5\uff1b\u8303\u00b7\u83ab\u91cc\u65af\uff0c\u533b\u5b66\u535a\u58eb<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">COBRA\u8bd5\u9a8c\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04068103\">NCT04068103<\/a>\uff09\u9488\u5bf9\u4f4e\u98ce\u9669\u2161\u671f\u7ed3\u80a0\u764c\uff0c\u65e8\u5728\u8bc6\u522bctDNA\u9633\u6027\u7684\u60a3\u8005\uff0c\u5e76\u63a2\u8ba8\u4ed6\u4eec\u662f\u5426\u53ef\u80fd\u4ece\u8f85\u52a9\u5316\u7597\u4e2d\u83b7\u76ca\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5728\u8fd9\u9879\u524d\u77bb\u6027\u2161\/\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7ecf\u4e3b\u6cbb\u80bf\u7624\u79d1\u533b\u751f\u5224\u5b9a\u65e0\u9700\u8f85\u52a9\u5316\u7597\u7684\u4f4e\u5371\u2161\u671f\u7ed3\u80a0\u764c\u60a3\u8005\uff0c\u63091:1\u7684\u6bd4\u4f8b\u968f\u673a\u5206\u914d\u81f3\u4e24\u4e2a\u7ec4\u522b\u3002A\u7ec4\u4e3a\u6807\u51c6\u6cbb\u7597\/\u89c2\u5bdf\u7ec4\uff0cB\u7ec4\u4e3a\u57fa\u4e8ectDNA\u7684\u9776\u5411\u6cbb\u7597\u7ec4\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u672f\u540e\u91c7\u7528Guardant LUNAR\u68c0\u6d4b\u6cd5\u5bf9\u8840\u6db2\u8fdb\u884cctDNA\u5206\u6790\uff0c\u8be5\u68c0\u6d4b\u6cd5\u662f\u4e00\u79cd\u4e0d\u57fa\u4e8e\u80bf\u7624\u4fe1\u606f\u7684\u68c0\u6d4b\u65b9\u6cd5\uff0c\u6db5\u76d6\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u9057\u4f20\u6807\u5fd7\u7269\u3002B\u7ec4\u4e2dctDNA\u9633\u6027\u7684\u60a3\u8005\u63a5\u53d7\u4e86\u4e3a\u671f6\u4e2a\u6708\u7684\u8f85\u52a9\u6027CAPOX\u6216FOLFOX\u6cbb\u7597\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">635\u540d\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3A\u7ec4\uff08318\u540d\uff09\u548cB\u7ec4\uff08317\u540d\uff09\u3002 \u5728\u524d16\u4f8bctDNA(+)\u60a3\u8005\u4e2d\uff0c\u672a\u63a5\u53d7\u8f85\u52a9\u5316\u7597\u7684\u5bf9\u7167\u7ec4\u4e2d\uff0c7\u540d\u60a3\u8005\u4e2d\u67093\u540d\uff0843%\uff09\u57286\u4e2a\u6708\u540e\u89c2\u5bdf\u5230ctDNA\u6e05\u9664\uff1b\u800c\u63a5\u53d7\u8f85\u52a9\u5316\u7597\u7684\u5b9e\u9a8c\u7ec4\u4e2d\uff0c9\u540d\u60a3\u8005\u4e2d\u67091\u540d\uff0811%\uff09\u89c2\u5bdf\u5230ctDNA\u6e05\u9664\u3002 \u8fd9\u4e00\u7ed3\u679c\u51fa\u4e4e\u610f\u6599\uff0c\u56e0\u6b64\u7814\u7a76\u63d0\u524d\u7ec8\u6b62\u3002\u63a5\u53d7\u5316\u7597\u7684\u60a3\u8005\u4e2d\u672a\u51fa\u73b0\u4efb\u4f55\u610f\u5916\u6bd2\u6027\u53cd\u5e94\u3002   <\/p>\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"GI ASCO 2024 Recap\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/95_N50DgBnY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n<h2 class=\"wp-block-heading\" id=\"2023\">2023<\/h2>\n\n<p class=\"wp-block-paragraph\"><em>\u739b\u96c5\uff1a<\/em><\/p>\n\n<h3 class=\"wp-block-heading\">\u4e00\u9879\u9488\u5bf9\u65b0\u578b\u5148\u5929\/\u9002\u5e94\u6027\u514d\u75ab\u6fc0\u6d3b\u5242\u535a\u6ed5\u897f\u5229\u5355\u6297\uff08BOT\uff09\u8054\u5408\u5df4\u65af\u5229\u5355\u6297\uff08BAL\uff1b\u6297PD-1\u6297\u4f53\uff09\u6cbb\u7597\u8f6c\u79fb\u6027\u3001\u7ecf\u591a\u6b21\u524d\u671f\u6cbb\u7597\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\u76841a\/1b\u671f\u7814\u7a76\u7ed3\u679c<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 #LBA8\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 #A1\uff1b\u5b89\u4e1c\u5c3c\u00b7B\u00b7\u57c3\u5c14-\u5e93\u57c3\u91cc<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u4eca\u5e74\u7684\u4f1a\u8bae\u4e3a\u6211\u4eec\u7684\u533b\u5b66\u754c\u5e26\u6765\u4e86\u5173\u4e8e\u4e24\u79cd\u514d\u75ab\u6cbb\u7597\u836f\u7269\u8054\u5408\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u7ed3\u76f4\u80a0\u764c\uff08MSS CRC\uff09\u7684\u4ee4\u4eba\u9f13\u821e\u7684\u6d88\u606f\u3002 \u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c\u5171\u670970\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u535a\u6ed5\u897f\u5229\u5355\u6297\uff08botensilimab\uff09\u4e0e\u5df4\u5c14\u65af\u5229\u5355\u6297\uff08balstilimab\uff09\u7684\u8054\u5408\u6cbb\u7597\uff08BOT + BAL\uff09\u3002\u535a\u6ed5\u897f\u5229\u5355\u6297\u662f\u4e00\u79cd\u65b0\u4e00\u4ee3Fc\u589e\u5f3a\u578bCTLA-4\u6291\u5236\u5242\uff0c\u800c\u5df4\u5c14\u65af\u5229\u5355\u6297\u5219\u662f\u4e00\u79cdPD-1\u6291\u5236\u5242\uff1b\u4e5f\u5c31\u662f\u8bf4\uff0c\u5b83\u4eec\u5c5e\u4e8e\u4e24\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u514d\u75ab\u7597\u6cd5\u3002 \u4f7f\u7528\u8fd9\u4e24\u79cd\u514d\u75ab\u7597\u6cd5\u540e\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a23%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u4e3a76%\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a4.1\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5c1a\u672a\u8fbe\u5230\u3002 \u4f30\u8ba1\u768412\u4e2a\u6708\u603b\u751f\u5b58\u7387\u4e3a63%\uff0c\u4f18\u4e8e\u5f53\u524d\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002    <\/p>\n\n<p class=\"wp-block-paragraph\">\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u8fd9\u4e9b\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u8fc7\u7684\u4e2d\u4f4d\u6570\u4e3a4\u7ebf\u6cbb\u7597\uff0c\u5176\u4e2d59%\u7684\u60a3\u8005\u5b58\u5728RAS\u7a81\u53d8\u3002\u8be5\u8bd5\u9a8c\u5141\u8bb8\u60a3\u8005\u6b64\u524d\u63a5\u53d7\u8fc7\u514d\u75ab\u6cbb\u7597\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u5927\u591a\u6570\u60a3\u8005\uff0891%\uff09\u62a5\u544a\u4e86\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\u3002 \u5176\u4e2d\u6700\u5e38\u89c1\u7684\u662f\u8179\u6cfb\/\u7ed3\u80a0\u708e\uff0843%\uff09\u548c\u75b2\u52b3\uff0834%\uff09\u3002\u6700\u5e38\u89c1\u76843\u7ea7\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\u5305\u62ec\u8179\u6cfb\/\u7ed3\u80a0\u708e\uff0820%\uff09\u3001\u75b2\u52b3\uff084%\uff09\u548c\u53d1\u70ed\uff08\u4f53\u6e29\u5347\u9ad8\uff09\uff084%\uff09\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u8fd9\u4e9b\u662f\u6269\u5c55\u76841a\/1b\u671f\u7814\u7a76\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03860272\">NCT03860272<\/a>\uff09\u7684\u7ed3\u679c\uff1b\u76ee\u524d\uff0c\u9488\u5bf9\u8be5\u8054\u5408\u7597\u6cd5\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u62db\u52df\u60a3\u8005\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05608044\">NCT05608044<\/a>\uff09\uff0c\u5e76\u8ba1\u5212\u5f00\u5c553\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">BREAKWATER \u5b89\u5168\u6027\u5148\u5bfc\u7814\u7a76\uff08SLI\uff09\uff1a\u6069\u79d1\u62c9\u975e\u5c3c\uff08E\uff09+ \u897f\u59a5\u6614\u5355\u6297\uff08C\uff09+ \u5316\u7597\u7528\u4e8e\u6cbb\u7597 BRAFV600E \u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 119\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 F16\uff1b\u65af\u79d1\u7279\u00b7\u79d1\u4f69\u8328<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u5173\u4e8eBRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u6cbb\u7597\uff0c \u6765\u81eaIII\u671fBREAKWATER\u7814\u7a76\u5b89\u5168\u6027\u5bfc\u5165\uff08SLI\uff09\u90e8\u5206\u7684\u6570\u636e\u8868\u660e\uff0c\u6069\u79d1\u62c9\u975e\u5c3c\uff08Braftovi\u00ae\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\uff08Erbitux\u00ae\uff09\u548c\u5316\u7597\u7684\u65b9\u6848\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e14\u5728\u63a5\u53d7\u8be5\u8054\u5408\u65b9\u6848\u4f5c\u4e3a\u65e9\u671f\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u4e86\u6297\u80bf\u7624\u53cd\u5e94\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u57fa\u4e8eBEACON III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\uff0c\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u7684\u65b9\u6848\u81ea2021\u5e74\u8d77\u5df2\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u63a5\u53d7\u8fc7\u5176\u4ed6\u6cbb\u7597\u7684BRAF\u9633\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u3002 \u8fd9\u9879\u540d\u4e3aBREAKWATER\u7684III\u671f\u7814\u7a76\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04607421\">NCT04607421<\/a>\uff09\u65e8\u5728\u786e\u5b9a\u5bf9\u4e8e\u5c1a\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684BRAF\u9633\u6027\u3001\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u54ea\u79cd\u6cbb\u7597\u65b9\u6848\u66f4\u6709\u6548\uff1a\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\uff1b\u6069\u79d1\u62c9\u975e\u5c3c\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u52a0\u5316\u7597\uff1b\u8fd8\u662f\u5355\u7528\u5316\u7597\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u4e24\u79cd\u8054\u5408\u65b9\u6848\uff08\u6069\u79d1\u62c9\u975e\u5c3c\/\u897f\u59a5\u6614\u5355\u6297\u8054\u5408FOLFOX\u6216FOLFIRI\uff09\u7684\u7ed3\u679c\uff0c \u9488\u5bf9\u4e24\u7ec4\u60a3\u8005\uff08\u4e00\u7ebf\u6216\u4e8c\u7ebf\u6cbb\u7597\uff09\u5747\u663e\u793a\u51fa\u8f83\u9ad8\u7684\u7597\u6548\uff0c\u4e14\u4e0e\u65e2\u5f80\u9488\u5bf9BRAF V600E\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u7684\u6570\u636e\u76f8\u6bd4\u8868\u73b0\u66f4\u4f73\u2014\u2014\u8be5\u7c7b\u60a3\u8005\u63a5\u53d7\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u65f6\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u901a\u5e38\u8f83\u4f4e\u3002 FOLFIRI\u65b9\u6848\u7684\u526f\u4f5c\u7528\u5c11\u4e8eFOLFOX\u65b9\u6848\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">SUNLIGHT\uff1a\u4e09\u6c1f\u5c3f\u5627\u5576\/\u66ff\u5339\u62c9\u897f\u5c14\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7528\u4e8e\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u4e09\u7ebf\u6cbb\u7597<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7b2c4\u53f7\uff1b\u53e3\u5934\u62a5\u544a\u73af\u8282\uff1b\u4f55\u585e\u666e\u00b7\u5854\u4f2f\u5185\u7f57<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">III\u671f\u968f\u673aSUNLIGHT\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04737187\">NCT04737187<\/a>\uff09\u7814\u7a76\u8bc4\u4f30\u4e86\u4e09\u6c1f\u80f8\u82f7\/\u66ff\u5339\u62c9\u897f\uff08Lonsurf\u00ae\uff0c TAS-102\uff09\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff08Avastin\u00ae\uff09\u6cbb\u7597\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u7684\u4e09\u7ebf\u65b9\u6848\uff0c\u5e76\u4e0e\u4ec5\u4f7f\u7528Lonsurf\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u8fdb\u884c\u4e86\u5bf9\u6bd4\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u7ed3\u679c\u663e\u793a\uff0c\u5728\u4e09\u6c1f\u5c3f\u5627\u5576\/\u66ff\u5339\u62c9\u897f\uff08FTD\/TPI\uff09\u65b9\u6848\u4e2d\u52a0\u7528\u8d1d\u4f10\u73e0\u5355\u6297\uff08BEV\uff09\u540e\uff0c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u548c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u5747\u53d6\u5f97\u4e86\u201c\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u4e14\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u201d\u7684\u6539\u5584\uff1a 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\u6240\u6709\u4e9a\u7ec4\u5747\u4ece\u6dfb\u52a0\u8d1d\u4f10\u73e0\u5355\u6297\u4e2d\u83b7\u76ca\uff1b\u5176\u4e2d\uff0c\u6b64\u524d\u672a\u63a5\u53d7\u8fc7\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4ece\u8be5\u8054\u5408\u6cbb\u7597\u4e2d\u83b7\u76ca\u66f4\u4e3a\u663e\u8457\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u5728\u751f\u6d3b\u8d28\u91cf\u6307\u6807\u65b9\u9762\uff0c\u6cbb\u7597\u7ec4\u4e2d\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u6076\u5316\u65f6\u95f4\u7684\u4e2d\u4f4d\u6570\u4e3a\uff1a\u5b9e\u9a8c\u7ec4\u4e3a8.5\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a4.7\u4e2a\u6708\u3002  <strong>\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u5c06\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\uff0cTAS-102\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u8054\u5408\u7528\u836f\u53ef\u80fd\u4e3a\u63a5\u53d7\u8fc7\u4e24\u7ebf\u6cbb\u7597\u540e\u75be\u75c5\u4ecd\u8fdb\u5c55\u7684\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u63d0\u4f9b\u4e00\u79cd\u65b0\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">CV301\u3001N-803\u3001bintrafusp alfa \u548c M9241 \u8054\u5408\u514d\u75ab\u7597\u6cd5\u5728\u665a\u671f\u5c0f\u80a0\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684 II \u671f\u8bc4\u4f30<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 #116\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 #F13\uff1b\u4e39\u59ae\u5c14\u00b7M\u00b7\u5e15\u65af\u7279<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u57282023\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u80c3\u80a0\u75c5\u5b66\u4f1a\u8bae\u4e0a\uff0c\u6211\u4eec\u8fd8\u4e86\u89e3\u5230\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u4e00\u9879\u6b63\u5728\u8fdb\u884c\u7684\u7814\u7a76\u53d6\u5f97\u4e86\u4e00\u4e9b\u521d\u6b65\u4f46\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u3002 \u8fd9\u662f\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u9488\u5bf9\u665a\u671f\u5c0f\u80a0\u548c\u7ed3\u76f4\u80a0MSS\u60a3\u8005\u7684\u8054\u5408\u514d\u75ab\u6cbb\u7597\u65b9\u6848\uff0c\u8be5\u65b9\u6848\u5305\u542bCV301\uff08\u4e00\u79cd\u6cbb\u7597\u6027\u75ab\u82d7\uff09\u3001N-803\uff08IL-15\uff1b\u4e00\u79cd\u8d85\u7ea7\u6fc0\u52a8\u5242\uff09\u3001bintrafusp alfa\uff08M7824\uff1b \u4e00\u79cdPD-L1\u548cTGF-\u03b2\u6355\u83b7\u5242\u201c\u53cc\u529f\u80fd\u836f\u7269\u201d\uff09\u4ee5\u53caM9241\uff08NHS-IL12\uff1b\u4e00\u79cd\u9776\u5411\u80bf\u7624\u7684\u514d\u75ab\u7ec6\u80de\u56e0\u5b50\uff09\u7684\u8054\u5408\u514d\u75ab\u7597\u6cd5\uff0c\u9002\u7528\u4e8e\u665a\u671f\u5c0f\u80a0\u548c\u7ed3\u76f4\u80a0MSS\u764c\u75c7\u60a3\u8005\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04491955\">NCT04491955<\/a>\uff09\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u5171\u670930\u540d\u60a3\u8005\uff08\u5176\u4e2d2\u4f8b\u4e3a\u5c0f\u80a0\u764c\u300117\u4f8b\u4e3a\u7ed3\u80a0\u764c\u300111\u4f8b\u4e3a\u76f4\u80a0\u764c\uff09\u63a5\u53d7\u4e86\u6cbb\u7597\u3002\u5728\u8fd9\u9879\u8bd5\u9a8c\u4e2d\uff0c\u5176\u4e2d12\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u5176\u4e2d3\u79cd\u514d\u75ab\u7597\u6cd5\u7684\u6cbb\u7597\uff0c\u53e6\u670918\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u5168\u90e84\u79cd\u836f\u7269\u7684\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u5728\u53c2\u52a0\u8bd5\u9a8c\u524d\u5747\u5df2\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e24\u7ebf\u6cbb\u7597\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u4e09\u8054\u7597\u6cd5\u4f7f\u4e24\u540d\u60a3\u8005\u7684\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\uff1b\u56db\u8054\u7597\u6cd5\u4f7f\u4e24\u540d\u60a3\u8005\u7684\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u3002 \u4e09\u8054\u7597\u6cd5\u548c\u56db\u8054\u7597\u6cd5\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c12\u4e2a\u6708\u751f\u5b58\u7387\u5206\u522b\u4e3a66.7%\uff08\u4e09\u8054\u7597\u6cd5\uff09\u548c77.2%\uff08\u56db\u8054\u7597\u6cd5\uff09\u3002 8\u540d\u60a3\u8005\uff0826.7%\uff09\u51fa\u73b0\u4e863\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u53cd\u5e94\uff08TRAE\uff09\uff1b\u672a\u51fa\u73b04\u7ea7\u62165\u7ea7TRAE\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u8fd9\u610f\u5473\u7740\uff0c\u5728\u63a5\u53d7\u8fd9\u4e9b\u836f\u7269\u6cbb\u7597\u7684\u665a\u671fMSS\/pMMR\u5c0f\u80a0\u764c\u6216\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0c\u89c2\u5bdf\u5230\u4e86\u521d\u6b65\u7684\u4e34\u5e8a\u7597\u6548\uff0c\u4e14\u8fd9\u4e9b\u836f\u7269\u7684\u5b89\u5168\u6027\u7279\u5f81\u5728\u53ef\u63a7\u8303\u56f4\u5185\u3002\u4e0e\u63a5\u53d7\u591a\u7ebf\u6cbb\u7597\u540e6\u81f37\u4e2a\u6708\u7684\u5386\u53f2\u4e2d\u4f4d\u751f\u5b58\u671f\u76f8\u6bd4\uff0c\u5176\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u8868\u73b0\u4ee4\u4eba\u9f13\u821e\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u5176\u4ed6\u503c\u5f97\u5173\u6ce8\u7684\u8bd5\u9a8c<\/h3>\n\n<p class=\"wp-block-paragraph\">\u6211\u4eec\u957f\u671f\u5173\u6ce8\u7684\u4e24\u9879\u4e34\u5e8a\u8bd5\u9a8c\u516c\u5e03\u4e86\u7ed3\u679c\uff0c\u5373\u4f7f\u672a\u89c2\u5bdf\u5230\u80bf\u7624\u53cd\u5e94\uff0c\u4e86\u89e3\u8fd9\u4e9b\u7ed3\u679c\u4f9d\u7136\u5f88\u91cd\u8981\u3002<\/p>\n\n<h4 class=\"wp-block-heading\">ILOC\uff1a\u5bf9\u60a3\u6709\u4e0d\u53ef\u5207\u9664\u809d\u8f6c\u79fb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u91c7\u7528\u5ea6\u4f10\u5229\u5c24\u5355\u6297\u548c\u7279\u96f7\u7f8e\u5229\u5c24\u5355\u6297\u8054\u5408\u5c40\u90e8\u80bf\u7624\u6d88\u878d\u6cbb\u7597<\/h4>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 #141\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 #G19\uff1b\u73cd\u59ae\u00b7\u585e\u5229\u683c\u66fc<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u201c\u514d\u75ab\u8c03\u8282\u4e0e\u80bf\u7624\u6d88\u878d\u534f\u540c\u6cbb\u7597\uff08ILOC\uff09\u201d\u662f\u4e00\u9879\u73b0\u5df2\u5b8c\u6210\u7684\u6b27\u6d32\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c \uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03101475\">NCT03101475<\/a>\uff09\uff0c\u8be5\u8bd5\u9a8c\u9488\u5bf9\u4e0d\u53ef\u5207\u9664\u809d\u8f6c\u79fb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u5c06\u514d\u75ab\u7597\u6cd5\u5ea6\u4f10\u5229\u5c24\u5355\u6297\uff08durvalumab\uff09\u548c\u7279\u96f7\u7c73\u5229\u5c24\u5355\u6297\uff08tremelimumab\uff09\u4e0e\u5c40\u90e8\u80bf\u7624\u6d88\u878d\uff08\u5c04\u9891\u6d88\u878d\uff08RFA\uff09\u6216\u7acb\u4f53\u5b9a\u5411\u4f53\u90e8\u653e\u5c04\u6cbb\u7597\uff08SBRT\uff09\uff09\u76f8\u7ed3\u5408\u3002 \u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u9664\u7ecf\u5c40\u90e8\u6d88\u878d\uff08RFA\u6216SBRT\uff09\u6cbb\u7597\u7684\u75c5\u7076\u5916\uff0c\u6dfb\u52a0\u514d\u75ab\u7597\u6cd5\u5e76\u672a\u5728\u5176\u4ed6\u75c5\u7076\u4e2d\u4ea7\u751f\u7597\u6548\u3002\u8fd9\u610f\u5473\u7740\u9700\u8981\u8fdb\u4e00\u6b65\u7684\u7b56\u7565\u6765\u6539\u5584\u6b64\u7c7b\u75c5\u4f8b\u5bf9\u514d\u75ab\u7597\u6cd5\u7684\u53cd\u5e94\u3002  <\/p>\n\n<h4 class=\"wp-block-heading\">OBERTO-201\uff1aPolyPEPI1018\u75ab\u82d7\u4f5c\u4e3aTAS-102\u7684\u8f85\u52a9\u514d\u75ab\u7597\u6cd5<\/h4>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 147\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 H6\uff1b\u4e54\u7433\u00b7M\u00b7\u54c8\u4f2f\u5fb7<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">OBERTO-201\uff08<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05130060\">NCT05130060<\/a>\uff09\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\u5728\u665a\u671f\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\uff0c\u5c06\u4e00\u79cd\u764c\u75c7\u75ab\u82d7\uff08PolyPEPI1018\uff09\u4e0eLonsurf\u00ae\uff08TAS-102\uff09\u8054\u5408\u4f7f\u7528\u7684\u7597\u6548\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u8054\u5408\u7597\u6cd5\u8010\u53d7\u6027\u826f\u597d\uff0c\u9664Lonsurf\u5355\u836f\u6cbb\u7597\u9884\u671f\u8303\u56f4\u5185\u76843\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u5916\uff0c\u672a\u51fa\u73b0\u5176\u4ed63\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5373\u4f7f\u672a\u80fd\u68c0\u6d4b\u5230\u5ba2\u89c2\u7684\u80bf\u7624\u53cd\u5e94\uff0cPolyPEPI1018\u75ab\u82d7\u4ecd\u5728\u5916\u5468\u548c\u80bf\u7624\u4e24\u7ea7\u8bf1\u5bfc\u4e86\u514d\u75ab\u5e94\u7b54\uff1b\u6cbb\u7597\u540e\u7684\u68c0\u6d4b\u663e\u793a\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u66f4\u957f\u7684\u60a3\u8005\u5bf9\u8be5\u75ab\u82d7\u8868\u73b0\u51fa\u5f3a\u70c8\u7684\u75ab\u82d7\u7279\u5f02\u6027T\u7ec6\u80de\u5e94\u7b54\u3002<\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<p class=\"wp-block-paragraph\"><em>\u66fc\u6731\uff1a<\/em><\/p>\n\n<h3 class=\"wp-block-heading\">\u76f4\u80a0\u764c\u7684\u5668\u5b98\u4fdd\u7559\u4e0e\u5168\u5957\u65b0\u8f85\u52a9\u6cbb\u7597\uff1a\u957f\u7597\u7a0b\u5316\u653e\u7597\u4e0e\u77ed\u7597\u7a0b\u653e\u7597\u7684\u6bd4\u8f83\u7814\u7a76<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7b2c10\u53f7\uff1b\u5feb\u901f\u6d77\u62a5\u6458\u8981\u73af\u8282\uff1b\u4fdd\u7f57\u00b7\u4f2f\u7eb3\u5fb7\u00b7\u7f57\u6885\u745f<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u63a2\u8ba8\u4e86\u5728\u5c40\u90e8\u665a\u671f\u76f4\u80a0\u764c\uff08\u75be\u75c5\u5df2\u6269\u6563\u81f3\u90bb\u8fd1\u6dcb\u5df4\u7ed3\uff09\u7684\u5168\u9762\u65b0\u8f85\u52a9\u6cbb\u7597\uff08TNT\uff09\u4e2d\uff0c\u4f5c\u4e3a\u77ed\u671f\u653e\u7597\uff08SCRT\uff09\u4e0e\u957f\u671f\u5316\u653e\u7597\uff08LCRT\uff09\u4e4b\u95f4\u73af\u8282\u7684\u5668\u5b98\u4fdd\u7559\u65b9\u6848\u7684\u53ef\u884c\u6027\u3002 \u8fd9\u662f\u4e00\u9879\u56de\u987e\u6027\u7814\u7a76\uff0c\u7eb3\u5165\u4e86563\u4f8b\u63a5\u53d7TNT\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5176\u4e2d76\u4f8b\u63a5\u53d7SCRT\u6cbb\u7597\uff0c256\u4f8b\u63a5\u53d7LCRT\u6cbb\u7597\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u4e24\u7ec4\u7684\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7387\u5747\u4e3a46%\uff0c\u4f46LCRT\u7ec4\u7684\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u66f4\u957f\u3002\u5c3d\u7ba1\u6574\u4e2a\u7814\u7a76\u961f\u5217\u4e2d\u4e24\u7ec4\u7684\u4e34\u5e8a\u5b8c\u5168\u7f13\u89e3\u7387\u76f8\u540c\uff0c\u4f46SCRT\u7ec4\u7684\u4e24\u5e74\u5668\u5b98\u4fdd\u7559\u7387\u4e3a29%\uff0c\u800cLCRT\u7ec4\u4e3a40%\u3002 \u6b64\u5916\uff0c\u5728\u91c7\u53d6\u201c\u89c2\u5bdf\u7b49\u5f85\u201d\u7b56\u7565\u7684\u60a3\u8005\u4e2d\uff0cLCRT\u7ec4\u7684\u4e24\u5e74\u5668\u5b98\u4fdd\u7559\u7387\u4e3a88%\uff0c\u800cSCRT\u7ec4\u4e3a67%\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u56e0\u6b64\uff0c\u603b\u4f53\u800c\u8a00\uff0c\u5982\u679c\u76ee\u6807\u662f\u4fdd\u62a4\u5668\u5b98\uff0cLCRT\u4f3c\u4e4e\u662f\u6700\u4f73\u9009\u62e9\u3002\u800c\u5982\u679c\u4fdd\u62a4\u5668\u5b98\u5e76\u975e\u76ee\u6807\uff0c\u4e14\u60a3\u8005\u9700\u8981\u63a5\u53d7\u624b\u672f\uff0c\u90a3\u4e48\u4e0eLCRT\u76f8\u6bd4\uff0c\u77ed\u671f\u653e\u7597\u5728\u80bf\u7624\u5b66\u7597\u6548\u65b9\u9762\u8868\u73b0\u76f8\u5f53\uff0c\u56e0\u6b64\u53ef\u80fd\u66f4\u5177\u5438\u5f15\u529b\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u5206\u6790\u505c\u75285-\u6c1f\u5c3f\u5627\u5576 bolus \u7ed9\u836f\u5bf9\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u5f71\u54cd<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 #59\uff1b\u6d77\u62a5\u5c55\u677f #C14\uff1b\u5f6d\u6210\u4f1f<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u5728IV\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7684\u6cbb\u7597\u4e2d\uff0c\u901a\u5e38\u91c7\u75285-FU\u5148\u8fdb\u884c bolus \u7ed9\u836f\uff0c\u968f\u540e\u8fdb\u884c\u6301\u7eed\u8f93\u6ce8\u7684\u65b9\u6848\u3002bolus \u7ed9\u836f\u4f1a\u589e\u52a0\u526f\u4f5c\u7528\uff0c\u56e0\u6b64\u901a\u5e38\u4e0d\u9002\u7528\u4e8e\u529f\u80fd\u72b6\u6001\u8f83\u5dee\u6216\u60a3\u6709\u5176\u4ed6\u4e25\u91cd\u5065\u5eb7\u95ee\u9898\u7684\u60a3\u8005\uff0c\u4f46\u5176\u5bf9\u6cbb\u7597\u7ed3\u679c\u7684\u5f71\u54cd\u5c1a\u4e0d\u660e\u786e\u3002 <\/p>\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\u4e0d\u7ed9\u4e885-FU bolus\u662f\u5426\u4e0e\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5b58\u5728\u5dee\u5f02\u3002\u5728\u8fd9\u9879\u9488\u5bf99741\u4f8b\u63a5\u53d75-FU\u4e3a\u57fa\u7840\u7684\u4e00\u7ebf\u5316\u7597\u7684IV\u671f\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u56de\u987e\u6027\u7814\u7a76\u4e2d\uff1a \u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u4e865-FU\u6301\u7eed\u8f93\u6ce8\uff0c\u5176\u4e2d81%\u7684\u60a3\u8005\u8fd8\u63a5\u53d7\u4e865-FU bolus\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a19\u4e2a\u6708\u3002\u5728\u4e0d\u540c\u7684\u5206\u6790\uff08\u5355\u53d8\u91cf\u548c\u591a\u53d8\u91cf\uff09\u4e2d\uff0c5-FU bolus\u7684\u4f7f\u7528\u4e0e\u603b\u751f\u5b58\u671f\u5747\u65e0\u76f8\u5173\u6027\u3002   <\/p>\n\n<p class=\"wp-block-paragraph\">\u8fd9\u9879\u5927\u578b\u591a\u4e2d\u5fc3\u961f\u5217\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0c\u5728\u8c03\u6574\u4e86\u60a3\u8005\u548c\u6cbb\u7597\u56e0\u7d20\u540e\uff0c\u5bf9\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u800c\u8a00\uff0c5-\u6c1f\u5c3f\u5627\u5576\uff085-FU\uff09 bolus \u7ed9\u836f\u5e76\u672a\u5e26\u6765\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u83b7\u76ca\u3002\u8fd9\u8868\u660e\uff0c\u5728\u5305\u542b\u9759\u8109\u6ef4\u6ce8 5-FU \u7684\u5316\u7597\u65b9\u6848\u4e2d\u52a0\u5165 5-FU bolus \u7ed9\u836f\uff0c\u4f3c\u4e4e\u5e76\u4e0d\u80fd\u63d0\u9ad8\u7597\u6548\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">PARADIGM \u751f\u7269\u6807\u5fd7\u7269\u7814\u7a76\uff1aRAS \u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u63a5\u53d7\u5e15\u5c3c\u5355\u6297\u6cbb\u7597\u7684\u8d1f\u5411\u8d85\u9009\u62e9<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 11\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 A4\uff1b\u4e0b\u7530\u6d69\u5e73<\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">III\u671fPARADIGM\u7814\u7a76\u7ed3\u679c\u79ef\u6781\uff0c\u663e\u793a\u5728mFOLFOX6\u65b9\u6848\u4e2d\u8054\u5408\u4e00\u7ebfEGFR\u6291\u5236\u5242\uff08\u5e15\u5c3c\u5355\u6297\uff09\u7684\u7597\u6548\u66f4\u4f18\uff08\u4e2d\u4f4d\u603b\u751f\u5b58\u671f \uff08OS\uff0937.9\u4e2a\u6708 vs 34.3\u4e2a\u6708\uff09\u4f18\u4e8emFOLFOX6\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u65b9\u6848\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u5728\u672a\u68c0\u6d4b\u5230\u76ee\u6807\u57fa\u56e0\u7a81\u53d8\u7684\u4e25\u683c\u7b5b\u9009\u4eba\u7fa4\u4e2d\uff0c\u603b\u4f53\u800c\u8a00\uff0c\u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u76f8\u6bd4\uff0c\u5e15\u5c3c\u5355\u6297\u7ec4\u7684\u603b\u751f\u5b58\u671f\u66f4\u957f\uff0841.3\u4e2a\u6708 vs 34.4\u4e2a\u6708\uff09\u3002\u800c\u5728\u68c0\u6d4b\u5230\u76ee\u6807\u57fa\u56e0\u7a81\u53d8\u7684\u53f3\u4fa7\u548c\u5de6\u4fa7\u60a3\u8005\u7fa4\u4f53\u4e2d\uff0c\u8054\u5408\u4f7f\u7528\u8d1d\u4f10\u73e0\u5355\u6297\u4f3c\u4e4e\u80fd\u5e26\u6765\u66f4\u957f\u7684\u603b\u751f\u5b58\u671f\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u96f7\u6208\u62c9\u975e\u5c3c\u3001\u4f0a\u5339\u6728\u5355\u6297\u548c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08RIN\uff09\u5728\u5316\u7597\u8010\u836f\u7684MSS\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u4e2d\u7684\u5e94\u7528<\/h3>\n\n<p class=\"wp-block-paragraph\"><strong>\u6458\u8981\u7f16\u53f7 #110\uff1b\u6d77\u62a5\u5c55\u677f\u7f16\u53f7 #F7\uff1b\u9a6c\u5c14\u4e07\u00b7\u6cd5\u57fa\u8d6b <\/strong><\/p>\n\n<p class=\"wp-block-paragraph\">\u8be5\u6d77\u62a5\u5c55\u793a\u4e86\u96f7\u6208\u62c9\u975e\u5c3c\uff08R\uff09\u3001\u4f0a\u5339\u6728\u5355\u6297\uff08I\uff09\u548c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08N\uff09\uff08RIN\uff09\u5728\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\uff0c\u91c7\u7528\u63a8\u8350\u7684II\u671f\u5242\u91cf\uff08RP2D\uff09\u65f6\u7684\u7597\u6548\u6570\u636e\u3002<\/p>\n\n<p class=\"wp-block-paragraph\">\u5171\u5165\u7ec439\u540d\u60a3\u8005\u2014\u2014\u5176\u4e2d29\u540d\u63a5\u53d7RP2D\u5242\u91cf\uff087\u540d\u6709\u809d\u8f6c\u79fb\uff09\uff0c10\u540d\uff083\u540d\u6709\u809d\u8f6c\u79fb\uff09\u63a5\u53d7\u8c03\u6574\u540e\u768440 mg\u81f380 mg\u5242\u91cf\u7ec4\u6cbb\u7597\u3002 \u5728\u6709\u809d\u8f6c\u79fb\u7684\u60a3\u8005\u4e2d\u672a\u89c2\u5bdf\u5230\u663e\u8457\u7684\u4e34\u5e8a\u7597\u6548\uff08\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09= 0%\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09= 2\u4e2a\u6708\uff09\u3002\u65e0\u809d\u8f6c\u79fb\u60a3\u8005\u7684ORR\u4e3a36%\uff0cmPFS\u4e3a5\u4e2a\u6708\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">RIN\uff0880\/1\/240\uff09\u5bf9\u65e0\u809d\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u7a33\u5b9a\u578b\uff08MSS\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u5177\u6709\u663e\u8457\u7597\u6548\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\uff0c\u96f7\u6208\u62c9\u975e\u5c3c80 mg\u7684\u8d77\u59cb\u5242\u91cf\u5bf9\u4e8e\u8bf1\u5bfc\u5bf9RIN\u7684\u514d\u75ab\u5e94\u7b54\u81f3\u5173\u91cd\u8981\u3002 \u5efa\u8bae\u5728\u65e0\u809d\u8f6c\u79fb\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u4e2d\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76 80\/1\/240 mg \u7684\u63a8\u8350\u6700\u5927\u8010\u53d7\u5242\u91cf\uff08RP2D\uff09\u3002  <\/p>\n\n<p class=\"wp-block-paragraph\">\u4e34\u5e8a\u8bd5\u9a8c\u4fe1\u606f\uff1a<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04362839\">NCT04362839<\/a>\u3002<\/p>\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"2023 GI ASCO Recap with Dr. Cathy Eng\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/UvcQia-LUKk?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n<h2 class=\"wp-block-heading\" id=\"staytuned\">\u656c\u8bf7\u671f\u5f85<\/h2>\n\n<p class=\"wp-block-paragraph\">\u6bcf\u6708\u4e00\u6b21\uff0cMaia Walker \u548c Manju George \u4f1a\u82b1\u65f6\u95f4\u4e3a\u6211\u4eec\u7684\u793e\u533a\u6df1\u5165\u89e3\u8bfb\u91cd\u8981\u7684\u4e34\u5e8a\u7814\u7a76\u3001\u5b9e\u7528\u6280\u5de7\u548c\u5efa\u8bae\u3002\u8bf7\u52a1\u5fc5\u8ba2\u9605 Fight CRC \u5e76\u52a0\u5165 COLONTOWN \u7684\u5728\u7ebf\u793e\u533a\uff0c\u4ee5\u4fbf\u6301\u7eed\u83b7\u53d6\u7ed3\u76f4\u80a0\u764c\u9886\u57df\u6700\u76f8\u5173\u7684\u6700\u65b0\u8d44\u8baf\uff01 \u60a8\u8fd8\u53ef\u4ee5\u5173\u6ce8\u739b\u96c5\uff08<a href=\"https:\/\/twitter.com\/sassycell\">@sassycell<\/a>\uff09\u548c\u66fc\u6731\uff08<a href=\"https:\/\/twitter.com\/manjuggm\">@manjuggm<\/a>\uff09\uff0c\u53ca\u65f6\u4e86\u89e3\u7814\u7a76\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6700\u65b0\u52a8\u6001\uff0c\u5e76\u8bbf\u95ee<a href=\"https:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/a>\u6216<a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/trial-finder\/\">Fight CRC \u7684\u201c\u4e34\u5e8a\u8bd5\u9a8c\u641c\u7d22\u5de5\u5177<\/a>\u201d\uff0c\u83b7\u53d6\u66f4\u591a\u5173\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4fe1\u606f\u3002  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u672c\u6b21\u4f1a\u8bae\u4e0a\uff0c\u6211\u4eec\u5bf9\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u68c0\u6d4b\u5728\u7ed3\u76f4\u80a0\u764c\u6cbb\u7597\u4e2d\u7684\u4f5c\u7528\u6709\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\u3002\u6211\u5f88\u671f\u5f85Manju\u5bf9\u6b64\u7684\u89c1\u89e3\u3002\u5c31\u6211\u4e2a\u4eba\u800c\u8a00\uff0c\u6211\u60f3\u91cd\u70b9\u4ecb\u7ecd\u56db\u7bc7\u5173\u4e8e  <\/p>\n","protected":false},"author":3,"featured_media":213427,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[650],"tags":[],"class_list":["post-213616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-trials"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GI ASCO \u6700\u65b0\u52a8\u6001 - Fight Colorectal Cancer<\/title>\n<meta name=\"description\" content=\"\u83b7\u53d6 FightCRC \u7684 GI ASCO \u6700\u65b0\u52a8\u6001\uff1a\u5173\u4e8e\u6700\u65b0\u7ed3\u76f4\u80a0\u764c\u4e34\u5e8a\u8bd5\u9a8c\u3001\u514d\u75ab\u7597\u6cd5\u7814\u7a76\u3001ctDNA 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