{"id":213618,"date":"2024-10-23T19:42:56","date_gmt":"2024-10-23T23:42:56","guid":{"rendered":"https:\/\/fightcolorectalcancer.org\/esmo%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81\/"},"modified":"2026-06-17T19:17:12","modified_gmt":"2026-06-17T23:17:12","slug":"esmo%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81","status":"publish","type":"post","link":"https:\/\/fightcolorectalcancer.org\/zh-hans\/esmo%e6%9c%80%e6%96%b0%e5%8a%a8%e6%80%81\/","title":{"rendered":"ESMO\u6700\u65b0\u52a8\u6001"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">\u6982\u8ff0<\/h3>\n\n<p>\u60a8\u662f\u5426\u5bf9\u6b27\u6d32\u533b\u5b66\u80bf\u7624\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e0a\u53d1\u5e03\u7684\u6700\u65b0\u79d1\u7814\u6210\u679c\u611f\u5230\u597d\u5947\uff1f\u6bcf\u5e74\uff0c\u60a3\u8005\u6743\u76ca\u5021\u5bfc\u8005\u739b\u96c5\u548c\u66fc\u6731\u90fd\u4f1a\u4e3a\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7fa4\u4f53\u68b3\u7406\u76f8\u5173\u7814\u7a76\u53ca\u503c\u5f97\u5173\u6ce8\u7684\u8fdb\u5c55\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">ESMO\u80c3\u80a0\u75c5\u5b66\u5927\u4f1a\u4eae\u70b9<\/h3>\n\n<ul class=\"wp-block-list\">\n<li><strong>\u65f6\u95f4\uff1a<\/strong>\u5c06\u4e8e7\u6708\u4e3e\u884c<\/li>\n\n\n\n<li><strong>\u5730\u70b9\uff1a<\/strong>\u5df4\u585e\u7f57\u90a3<\/li>\n\n\n\n<li><strong>\u53c2\u4e0e\u8005\uff1a<\/strong>\u6765\u81ea\u4e16\u754c\u5404\u5730\u4e13\u6ce8\u4e8e\u80c3\u80a0\u9053\u764c\u75c7\u7684\u7814\u7a76\u4eba\u5458\u5c06\u4ecb\u7ecd\u4ed6\u4eec\u7684\u7814\u7a76\u6210\u679c\u548c\u6700\u65b0\u53d1\u73b0\u3002<\/li>\n\n\n\n<li><strong>\u5185\u5bb9\uff1a<\/strong>Fight CRC \u53d1\u5e03\u66f4\u65b0\uff0c\u5411\u793e\u533a\u4ecb\u7ecd\u6709\u5173\u7ed3\u76f4\u80a0\u764c\u7684\u5177\u6709\u524d\u666f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/li>\n<\/ul>\n\n<h3 class=\"wp-block-heading\">\u8d44\u6e90<\/h3>\n\n<p><strong>\u66f4\u591a\u201cFight CRC\u201d\u8d44\u6e90\uff1a<\/strong><\/p>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/fightcolorectalcancer.org\/for-patients\/treatment\/clinical-trials\/\">\u5173\u4e8e\u4e34\u5e8a\u8bd5\u9a8c<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/colontown.org\/clinical-trial-university\/\">COLONTOWN \u4e34\u5e8a\u8bd5\u9a8c\u5927\u5b66<\/a><\/li>\n<\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"2024-trials\">2024<\/h2>\n\n<h3 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<\/p>\n\n<p><strong>\u7ed3\u679c\uff1a<\/strong>26%\u7684\u60a3\u8005\u5728\u63a5\u53d7TNT\u6cbb\u7597\u540e\u8fbe\u5230\u5b8c\u5168\u7ec6\u80de\u5b66\u7f13\u89e3\uff08cCR\uff09\uff0c\u5e76\u8f6c\u4e3a\u975e\u624b\u672f\u6cbb\u7597\u300230\u4e2a\u6708\u65f6\u7684\u8fdc\u5904\u65e0\u590d\u53d1\u751f\u5b58\u7387\uff08DRFS\uff09\u5728\u975e\u624b\u672f\u6cbb\u7597\u7ec4\uff08NOM\uff09\u4e3a96%\uff0c\u5728\u76f4\u80a0\u624b\u672f\u7ec4\u4e3a74%\u3002 \u975e\u624b\u672f\u6cbb\u7597\u7ec4\u4e2d\u670915%\u7684\u60a3\u8005\u51fa\u73b0\u5c40\u90e8\u590d\u53d1\uff0c\u624b\u672f\u7ec4\u4e2d\u67099%\u7684\u60a3\u8005\u51fa\u73b0\u5c40\u90e8\u590d\u53d1\uff1b\u6240\u6709\u5c40\u90e8\u590d\u53d1\u60a3\u8005\u5747\u63a5\u53d7\u4e86\u633d\u6551\u6027\u624b\u672f\uff0c\u5176\u4e2d42%\uff083\/7\uff09\u7684\u75c5\u4f8b\u4e3a\u4fdd\u62ec\u7ea6\u808c\u624b\u672f\u3002 TNT\u6cbb\u7597\u540e\uff0cctDNA\u9633\u6027\uff08ctDNA+\uff09\u4e0e\u4e0d\u5b8c\u5168\u7f13\u89e3\u53ca\u8f83\u5dee\u7684DRFS\u663e\u8457\u76f8\u5173\u3002\u624b\u672f\u540e\uff0cctDNA+\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u5c55\u98ce\u9669\u663e\u8457\u589e\u52a0\u3002    <\/p>\n\n<p><strong>\u5b89\u5168\u6027\uff1a<\/strong>\u5b89\u5168\u6027\u7279\u5f81\u7b26\u5408\u5bf9TNT\u7684\u9884\u671f\uff0c\u526f\u4f5c\u7528\u5728\u53ef\u63a7\u8303\u56f4\u5185\u3002\u90e8\u5206\u60a3\u8005\u51fa\u73b0\u5c40\u90e8\u590d\u53d1\uff0c\u4f46\u8fd9\u4e9b\u75c5\u4f8b\u901a\u8fc7\u540e\u7eed\u6cbb\u7597\u5f97\u5230\u4e86\u6709\u6548\u63a7\u5236\u3002\u5171\u62a5\u544a12\u4f8b\u6b7b\u4ea1\uff08\u5176\u4e2d1\u4f8b\u4e0e\u4e0d\u826f\u4e8b\u4ef6\u76f8\u5173\uff0c9\u4f8b\u4e0e\u80bf\u7624\u76f8\u5173\uff0c2\u4f8b\u4e0e\u5176\u4ed6\u539f\u56e0\u76f8\u5173\uff09\u3002  <\/p>\n\n<p>\u6b63\u5982\u672c\u9879\u8bd5\u9a8c\u4ee5\u53ca\u7f8e\u56fd\u5f00\u5c55\u7684\u968f\u673a\u2161\u671fOPRA\u8bd5\u9a8c\u6240\u793a\uff0c\u5bf9\u4e8eTNT\u68c0\u6d4b\u5448cCR\u7684MSS\/pMMR LARC\u60a3\u8005\uff0c\u5728cCR\u540e\u91c7\u53d6\u975e\u624b\u672f\u6cbb\u7597\u5e76\u672a\u589e\u52a0\u8fdc\u5904\u590d\u53d1\u7684\u98ce\u9669\uff0c\u4e14\u6709\u5229\u4e8e\u5668\u5b98\u4fdd\u7559\u3002\u8fd9\u4e9b\u7ed3\u679c\u53ef\u80fd\u5bf9\u8be5\u60a3\u8005\u7fa4\u4f53\u7684\u672a\u6765\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">MSS\/pMMR\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597<\/h3>\n\n<p><strong>\u521d\u6b65\u7ed3\u679c\u8868\u660e\uff0c\u5bf9\u4e8e\u90e8\u5206MSS\/pMMR\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u8054\u5408\u514d\u75ab\u6cbb\u7597\u53ef\u80fd\u6709\u6548\u3002<\/strong><\/p>\n\n<p>\u514d\u75ab\u6cbb\u7597\u901a\u5e38\u88ab\u8ba4\u4e3a\u5bf9MSS\/pMMR\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u65e0\u6548\u3002\u4e0b\u6587\u4ecb\u7ecd\u7684\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u7814\u7a76\uff0c\u5728\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u4e2d\u8054\u5408\u514d\u75ab\u6cbb\u7597\u662f\u5426\u80fd\u6539\u5584\u90e8\u5206\u60a3\u8005\u7684\u9884\u540e\u3002 <\/p>\n\n<h4 class=\"wp-block-heading\">\u6458\u8981 5020\uff1a\u5fae\u536b\u661f\u7a33\u5b9a\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e14\u514d\u75ab\u6d78\u6da6\u7a0b\u5ea6\u9ad8\u7684\u60a3\u8005\u63a5\u53d7\u6d3e\u59c6\u5355\u6297\u8054\u5408CAPOX\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\uff1aFFCD 1703 POCHI\u8bd5\u9a8c\u7684\u521d\u6b65\u7ed3\u679c<\/h4>\n\n<p><strong>\u6458\u8981\uff1a<\/strong>POCHI\u662f\u4e00\u9879II\u671f\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u6cbb\u7597\u5f00\u59cb\u540e10\u4e2a\u6708\u65f6\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002<\/p>\n\n<p><strong>\u5165\u7ec4\u5bf9\u8c61\uff1a<\/strong>30\u4f8b\u65e2\u5f80\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684IV\u671f\uff08\u8f6c\u79fb\u6027\uff09MSS\/pMMR\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u7ecfImmunoscore\u00ae\u548c\/\u6216TuLIS\u8bc4\u5206\u786e\u5b9a\u5176\u80bf\u7624\u5177\u6709\u9ad8\u514d\u75ab\u6d78\u6da6\uff08\u80bf\u7624\u5185\u514d\u75ab\u7ec6\u80de\u6570\u91cf\u8f83\u9ad8\uff09\u3002<\/p>\n\n<p><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u60a3\u8005\u6bcf3\u5468\u63a5\u53d7\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408CAPOX\u548c\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\u3002\u6cbb\u7597\u7684\u4e2d\u4f4d\u6301\u7eed\u65f6\u95f4\u4e3a9.5\u4e2a\u6708\u3002 <\/p>\n\n<p><strong>\u7ed3\u679c\uff1a<\/strong>\u5728\u4e2d\u671f\u5206\u6790\u65f6\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a100%\uff0c\u603b\u4f53\u53cd\u5e94\u7387\uff08ORR\uff09\u4e3a74%\uff0c\u5176\u4e2d17%\uff085\/30\uff09\u7684\u60a3\u8005\u8fbe\u5230\u5b8c\u5168\u7f13\u89e3\u3002 12\u4e2a\u6708\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\uff08PFS\uff09\u4e3a51%\uff0c2\u5e74\u603b\u751f\u5b58\u7387\uff08OS\uff09\u4e3a80%\u3002 <\/p>\n\n<p><strong>\u5b89\u5168\u6027\uff1a<\/strong>\u8fd9\u4e9b\u836f\u7269\u7684\u526f\u4f5c\u7528\u60c5\u51b5\u4e0e\u9884\u671f\u4e00\u81f4\u300270%\u7684\u60a3\u8005\u81f3\u5c11\u51fa\u73b0\u4e86\u4e00\u6b213\u7ea7\u53ca\u4ee5\u4e0a\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">EGFR\u6291\u5236\u5242\u7684\u518d\u6b21\u6cbb\u7597<\/h3>\n\n<p><strong>RAS\u3001BRAF \u548c EGFR \u7a81\u53d8\u68c0\u6d4b\u7ed3\u679c\u5747\u4e3a\u9634\u6027\u7684\u60a3\u8005\uff0c\u53ef\u80fd\u4ece\u518d\u6b21\u4f7f\u7528 EGFR \u6291\u5236\u5242\u4e2d\u83b7\u76ca\u3002<\/strong><\/p>\n\n<p>RAS\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u5728\u4e00\u7ebf\u6cbb\u7597\u4e2d\u901a\u5e38\u63a5\u53d7\u5316\u7597\u8054\u5408EGFR\u6291\u5236\u5242\u7684\u6cbb\u7597\u3002\u6709\u521d\u6b65\u8bc1\u636e\u8868\u660e\uff0c\u75c5\u60c5\u8fdb\u5c55\u7684\u60a3\u8005\u5728\u540e\u7eed\u6cbb\u7597\u4e2d\u91cd\u65b0\u4f7f\u7528\uff08\u91cd\u65b0\u5f15\u5165\uff09EGFR\u6291\u5236\u5242\u53ef\u80fd\u83b7\u76ca\u3002 <\/p>\n\n<h4 class=\"wp-block-heading\">\u6458\u8981 511MO\uff1a\u9488\u5bf9\u7ecf\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u7b5b\u9009\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u91c7\u7528\u897f\u59a5\u6614\u5355\u6297\uff08Cet\uff09\u548c\u4f0a\u7acb\u66ff\u5eb7\u8fdb\u884c\u7b2c\u4e09\u7ebf\u518d\u6311\u6218\u6cbb\u7597\uff1aCITRIC\u968f\u673a\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/h4>\n\n<p><strong>\u6458\u8981\uff1a<\/strong>CITRIC\u8bd5\u9a8c\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u7684II\u671f\u7814\u7a76\u3002<\/p>\n\n<p><strong>\u5165\u7ec4\u6807\u51c6\uff1a<\/strong>\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\u7684MSS\u578b\u3001RAS\u91ce\u751f\u578b\uff08\u65e0\u7a81\u53d8\uff09\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\u53ef\u5165\u7ec4<strong>\uff1a<\/strong>\u5728\u4e00\u7ebf\uff081L\uff09\u6cbb\u7597\u4e2d\u4eceEGFR\u6291\u5236\u5242\uff08\u5982\u897f\u59a5\u6614\u5355\u6297\uff09\u83b7\u76ca\uff0c\u4f46\u5728\u4e8c\u7ebf\uff082L\uff09\u5316\u7597\uff08\u672a\u4f7f\u7528EGFR\u6291\u5236\u5242\uff09\u671f\u95f4\u75c5\u60c5\u8fdb\u5c55\u3002 \u7ecf\u6db2\u4f53\u6d3b\u68c0\u68c0\u6d4b\uff0c58\u540d\u7b26\u5408\u6761\u4ef6\u7684\u60a3\u8005RAS\u3001BRAF V600E\u53caEGFR\u7ec6\u80de\u5916\u57df\uff08ECD\uff09\u7a81\u53d8\u5747\u4e3a\u9634\u6027\uff0c\u5e76\u88ab\u7eb3\u5165\u7814\u7a76\u3002 <\/p>\n\n<p><strong>\u7814\u7a76\u8bbe\u8ba1\uff1a<\/strong>\u5165\u7ec4\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u81f3\u897f\u59a5\u6614\u5355\u6297\uff08\u4e00\u79cdEGFR\u6291\u5236\u5242\uff09\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\uff08\u5316\u7597\uff09\u7ec4\uff0c\u6216\u7814\u7a76\u8005\u9009\u62e9\u7684\u6cbb\u7597\u65b9\u6848\u7ec4\uff08\u4e0d\u5305\u62ecEGFR\u6291\u5236\u5242\uff09\uff0c\u4f5c\u4e3a\u4e09\u7ebf\uff083L\uff09\u6cbb\u7597\u3002<\/p>\n\n<p><strong>\u7ed3\u679c\uff1a<\/strong>\u91cd\u65b0\u63a5\u53d7EGFR\u6291\u5236\u5242\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u4f0a\u7acb\u66ff\u5eb7\u6cbb\u7597\u7684\u60a3\u8005\uff0c\u5176\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u66f4\u9ad8\uff0812% vs 0%\uff0c\u7814\u7a76\u8005\u9009\u62e9\u7ec4\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e5f\u66f4\u9ad8\uff0874% vs 44%\uff0c\u7814\u7a76\u8005\u9009\u62e9\u7ec4\uff09\u3002 \u91cd\u65b0\u6311\u6218\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a4.4\u4e2a\u6708\uff0c\u800c\u7814\u7a76\u8005\u9009\u62e9\u7ec4\u4e3a2.2\u4e2a\u6708\u3002 <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"2023-trials\">2023<\/h2>\n\n<p><em>\u53ef\u901a\u8fc7\u5728ESMO 2023\u4e2d\u641c\u7d22\u6458\u8981\u7f16\u53f7\u6216\u8bd5\u9a8c\u540d\u79f0\u6765\u67e5\u627e\u4e0a\u8ff0\u6458\u8981\u3002<\/em><\/p>\n\n<h3 class=\"wp-block-heading\">PEGASUS<\/h3>\n\n<p>II\u671fPEGASUS\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u8868\u660e\uff0c\u5229\u7528Guardant Reveal ctDNA\u8840\u6db2\u68c0\u6d4b\u6307\u5bfc\u9ad8\u5371II\u671f\u6216III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\uff0c\u53ef\u964d\u4f4e\u5316\u7597\u7684\u6bd2\u6027\uff0c\u5e76\u63d0\u9ad8\u5bf9\u6807\u51c6\u5316\u7597\u65b9\u6848\u7684\u5e94\u7b54\u7387\u3002<\/p>\n\n<p>\u5728\u8fd9\u9879\u7eb3\u5165\u9ad8\u5371\u2161\u671f\u548c\u2162\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u82e5ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff08ctDNA+\uff09\uff0c\u672f\u540e\u6cbb\u7597\u65b9\u6848\u4e3a\u5361\u57f9\u4ed6\u6ee8\u8054\u5408\u5965\u6c99\u5229\u94c2\u6cbb\u75973\u4e2a\u6708\uff1b\u82e5ctDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9634\u6027\uff08ctDNA-\uff09\uff0c\u5219\u4ec5\u63a5\u53d7\u5361\u57f9\u4ed6\u6ee8\u5355\u836f\u6cbb\u75976\u4e2a\u6708\u3002 \u5bf9\u4e8e\u63a5\u53d7\u8fc7\u8f85\u52a9\u5316\u7597\u7684\u60a3\u8005\uff0c\u82e5ctDNA\u9633\u6027\uff0c\u5219\u63a5\u53d7\u53f6\u9178-5-\u6c1f\u5c3f\u5627\u5576-\u4f0a\u7acb\u66ff\u5eb7\uff08FOLFIRI\uff09\u65b9\u6848\uff1b \u82e5\u5361\u57f9\u4ed6\u6ee8\u6cbb\u7597\u540ectDNA\uff08\u2013\uff09\uff0c\u5219\u51cf\u91cf\u81f3\u5361\u57f9\u4ed6\u6ee8\uff1b\u82e5ctDNA\uff08+\uff09\uff0c\u5219\u52a0\u91cf\u81f3\u5361\u57f9\u4ed6\u6ee8\u8054\u5408\u5965\u6c99\u5229\u94c2\u3002 <\/p>\n\n<p>\u5728\u7eb3\u5165\u65b9\u6848\u7b26\u5408\u6027\u5206\u6790\u4eba\u7fa4\u7684135\u540d\u60a3\u8005\u4e2d\uff0c\u670935\u540d\uff0826%\uff09\u60a3\u8005\u672f\u540ectDNA\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\u3002 \u7ecf\u8fc73\u4e2a\u6708\u7684\u5361\u57f9\u4ed6\u6ee8\u8054\u5408\u5965\u6c99\u5229\u94c2\u6cbb\u7597\u540e\uff0c35\u540d\u60a3\u8005\u4e2d\u670911\u540d\uff0831%\uff09\u8f6c\u4e3actDNA\uff08\u2013\uff09\uff0c\u4f46\u5176\u4e2d8\u540d\uff0873%\uff09\u6700\u7ec8\u590d\u53d1\u6216\u518d\u6b21\u8f6c\u4e3actDNA\uff08+\uff09\u3002 \u5728\u63a5\u53d7\u5361\u57f9\u4ed6\u6ee8\u8054\u5408\u5965\u6c99\u5229\u94c2\u6cbb\u7597\u540e\u63a5\u53d7 FOLFIRI \u65b9\u6848\u7684 24 \u540d\u60a3\u8005\u4e2d\uff0c \u5176\u4e2d13\u540d\uff0854%\uff09\u60a3\u8005ctDNA\u4ecd\u5448\u9633\u6027\uff08\u5176\u4e2d6\u540d\u51fa\u73b0\u590d\u53d1\uff09\uff0c\u5176\u4f5911\u540d\uff0846%\uff09\u60a3\u8005\u8f6c\u4e3actDNA\u9634\u6027\uff0c\u5e76\u5728\u5206\u6790\u65f6\u4ecd\u672a\u590d\u53d1\uff08\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f421.2\u4e2a\u6708\uff09\u3002  <\/p>\n\n<p>\u8be5\u7814\u7a76\u9610\u660e\u4e86ctDNA\u6307\u5bfc\u6cbb\u7597\u7684\u4f18\u52bf\uff0c\u5e76\u8868\u660e\u5bf9\u4e8e\u8f85\u52a9\u6cbb\u7597\u540ectDNA\u9633\u6027\u7684\u60a3\u8005\uff0c\u91c7\u7528FOLFIRI\u65b9\u6848\u8fdb\u884c\u6cbb\u7597\u53ef\u80fd\u6709\u6548\u3002  <strong>\uff08\u6458\u8981 LBA28\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">GALAXY\/CIRCULATE-\u65e5\u672c<\/h3>\n\n<p>\u5728\u4e00\u9879\u9488\u5bf92280\u4f8b\u7ecf\u624b\u672f\u5207\u9664\u7684I-IV\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u7684\u524d\u77bb\u6027\u5206\u6790\u4e2d\uff0c\u672f\u540e\u7b2c4\u5468ctDNA\u9633\u6027\u7684\u60a3\u8005\u4e0ectDNA\u9634\u6027\u60a3\u8005\u76f8\u6bd4\uff0c\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u663e\u8457\u8f83\u5dee\uff0824\u4e2a\u6708DFS\uff1a89% vs. 31%\uff1b HR 16.9\uff0cp&lt;.0001&gt;&lt;\/.0001&gt;<\/p>\n\n<p>\u8f85\u52a9\u5316\u7597\u4f3c\u4e4e\u5bf9ctDNA\uff08\u2013\uff09\u60a3\u8005\u65e0\u76ca\uff08\u5316\u7597\u7ec4\u4e0e\u672a\u5316\u7597\u7ec4\u768424\u4e2a\u6708\u65e0\u75c5\u751f\u5b58\u7387\u5206\u522b\u4e3a88%\u548c90%\uff1bHR 1.39\uff0cp=0.2\uff09\u3002 \u5728ctDNA\u9633\u6027\u60a3\u8005\u4e2d\uff0c\u8f85\u52a9\u5316\u7597\u7684\u83b7\u76ca\u5341\u5206\u660e\u663e\uff0824\u4e2a\u6708\u65e0\u75c5\u751f\u5b58\u7387\uff1a39% vs 16%\uff1bHR 3.29\uff0cp &lt; 0.0001\uff09\uff0c\u5c24\u5176\u662f\u63a5\u53d76\u4e2a\u6708\u6cbb\u7597\u7684\u60a3\u8005\u3002 <\/p>\n\n<p>\u7b2c4\u81f312\u5468\u671f\u95f4ctDNA\u7684\u52a8\u6001\u53d8\u5316\u5f71\u54cd\u4e86\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\uff1a\u5176\u4e2d\uff0cctDNA\u6301\u7eed\u9634\u6027\uff08\u2013\uff09\u7684\u60a3\u8005\u9884\u540e\u6700\u4f73\uff0c\u5176\u6b21\u662fctDNA\u6e05\u9664\uff08\u7531\u9633\u6027\u8f6c\u4e3a\u9634\u6027\uff09\u7684\u60a3\u8005\uff0c\u518d\u5176\u6b21\u662fctDNA\u518d\u73b0\uff08\u7531\u9634\u6027\u8f6c\u4e3a\u9633\u6027\uff09\u7684\u60a3\u8005\uff0c\u800cctDNA\u6301\u7eed\u9633\u6027\uff08+\uff09\u7684\u60a3\u8005\u9884\u540e\u6700\u5dee\u3002  <strong>\uff08\u6458\u8981 558MO\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">NICHE-3<\/h3>\n\n<p>\u5728\u53ef\u5207\u9664\u7684dMMR\/MSI-H\u7ed3\u80a0\u764c\uff08II-III\u671f\uff09\u60a3\u8005\u4e2d\uff0c\u672f\u524d\uff08\u5373\u624b\u672f\u524d\uff09\u7ed9\u4e88\u4e24\u5242\u5c3c\u6c83\u5362\u5355\u6297+\u96f7\u62c9\u66ff\u5355\u6297\uff08\u6297LAG3\uff09\u6cbb\u7597\uff0c\u5b9e\u73b0\u4e8679%\uff0815\/19\uff09\u7684\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\u7387\uff08pCR\uff09\u3002 \u6240\u6709\u63a5\u53d7\u6cbb\u7597\u7684\u60a3\u8005\u5747\u89c2\u5bdf\u5230\u75c5\u7406\u5b66\u53cd\u5e94\u3002 <\/p>\n\n<p>NICHE-3\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u6b64\u524dNICHE\u7cfb\u5217\u8bd5\u9a8c\u4e2d\u89c2\u5bdf\u5230\u7684\u7ed3\u679c\uff1a\u514d\u75ab\u7597\u6cd5\u5bf9\u65e9\u671fMSI-H\u7ed3\u80a0\u764c\u7597\u6548\u663e\u8457\u3002  <strong>\uff08\u6458\u8981 LBA31\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u4ee5KRAS G12C\u6291\u5236\u5242\u4e3a\u4e2d\u5fc3\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/h3>\n\n<p><strong>\u4e24\u9879\u5173\u4e8eKRAS G12C\u6291\u5236\u5242\u8054\u5408\u6297EGFR\u6297\u4f53\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u8be5\u65b9\u6848\u5bf9KRAS G12C\u7a81\u53d8\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u5177\u6709\u7597\u6548\u3002<\/strong><\/p>\n\n<h4 class=\"wp-block-heading\">CodeBreak 300<\/h4>\n\n<p>\u5728\u4e00\u9879III\u671f\u968f\u673a\u7814\u7a76\u4e2d\uff0c\u9488\u5bf9KRAS G12C\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u60a3\u8005\uff0c\u5c06\u7d22\u6258\u62c9\u897f\u5e03\u8054\u5408\u5e15\u5c3c\u5355\u6297\uff08\u7d22\u6258\u62c9\u897f\u5e03\uff1a\u6bcf\u65e5960 mg\u6216240 mg\uff09\u4e0e\u4e09\u6c1f\u5c3f\u5627\u5576\/\u66ff\u5339\u62c9\u897f\u6216\u96f7\u6208\u62c9\u975e\u5c3c\uff08\u6807\u51c6\u6cbb\u7597\uff0c\u5bf9\u7167\u7ec4\uff09\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002 \u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u4e24\u7ec4\u7d22\u6258\u62c9\u897f\u5e03\u8054\u5408\u5e15\u5c3c\u5355\u6297\u6cbb\u7597\u5747\u6539\u5584\u4e86\u4e3b\u8981\u7ec8\u70b9\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u3002 \u7d22\u6258\u62c9\u897f\u5e03\u548c\u5e15\u5c3c\u5355\u6297\u7684\u8054\u5408\u6cbb\u7597\u663e\u8457\u6539\u5584\u4e86PFS\uff08960 mg\u7d22\u6258\u62c9\u897f\u5e03+\u5e15\u5c3c\u5355\u6297\u7ec4\u4e3a5.6\u4e2a\u6708\uff0c\u5bf9\u7167\u7ec4\u4e3a2.2\u4e2a\u6708\uff09\uff0c\u5b9e\u9a8c\u7ec4\u7684ORR\u4e5f\u6709\u6240\u63d0\u9ad8\uff0c\u9ad8\u5242\u91cf\u7ec4\u8fbe\u523026%\u3002 \u603b\u751f\u5b58\u671f\uff08OS\uff09\u65e0\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u5206\u6790\u5c1a\u4e0d\u6210\u719f\u3002     <strong>\uff08\u6458\u8981 LBA10\uff09<\/strong><\/p>\n\n<h4 class=\"wp-block-heading\">KRYSTAL-1 \u6700\u65b0\u52a8\u6001<\/h4>\n\n<p>\u963f\u8fbe\u683c\u62c9\u897f\u5e03\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e2d\u4f4d\u6570\u4e3a6.9\u4e2a\u6708\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a46%\u3002  <strong>\uff08\u6458\u8981 549O\uff09<\/strong><\/p>\n\n<p>\u6709\u8da3\u7684\u662f\uff0c\u5c3d\u7ba1\u7d22\u6258\u62c9\u897f\u5e03\u548c\u963f\u8fbe\u683c\u62c9\u897f\u5e03\u90fd\u662fG12C\u6291\u5236\u5242\uff0c \u4f46\u963f\u8fbe\u683c\u62c9\u897f\u5e03\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u5728\u5ba2\u89c2\u7f13\u89e3\u7387\uff0846% \u5bf9\u6bd4\u7d22\u6258\u62c9\u897f\u5e03\u8054\u5408\u5e15\u5c3c\u5355\u6297\u7684 26%\uff09\u4ee5\u53ca\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff0c\u963f\u8fbe\u683c\u62c9\u897f\u5e03\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u4e3a 6.9 \u4e2a\u6708\uff0c\u7d22\u6258\u62c9\u897f\u5e03\u8054\u5408\u5e15\u5c3c\u5355\u6297\u4e3a 5.6 \u4e2a\u6708\uff09\u65b9\u9762\u5747\u8868\u73b0\u66f4\u4f73\u3002 \u4ee4\u4eba\u7a0d\u611f\u5931\u671b\u7684\u662f\uff0c\u5373\u4f7f\u540c\u65f6\u6291\u5236\u4e86KRAS G12C\u548cEGFR\uff0c\u5176\u5ba2\u89c2\u7f13\u89e3\u7387\u548c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4ecd\u672a\u8fbe\u5230\u60a3\u8005\u7684\u671f\u671b\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5f00\u53d1\u66f4\u591a\u836f\u7269\u7ec4\u5408\u4ecd\u52bf\u5728\u5fc5\u884c\uff0c\u4efb\u4f55\u80fd\u4e3a\u66f4\u591a\u60a3\u8005\u4e89\u53d6\u66f4\u591a\u65f6\u95f4\u7684\u65b9\u6848\u90fd\u5c06\u53d7\u5230\u70ed\u70c8\u6b22\u8fce\u3002  <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">\u5f00\u7f57 5<\/h3>\n\n<p><strong>\u5bf9\u4e8e\u53f3\u4fa7\/RAS\/RAF\u7a81\u53d8\u578b\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u91c7\u7528CTx\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u4e09\u8054\u7597\u6cd5\uff1b\u5bf9\u4e8e\u5de6\u4fa7RAS\/RAF\u91ce\u751f\u578b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\uff0c\u91c7\u7528\u53cc\u8054\u7597\u6cd5\u8054\u5408\u6297EGFR\u6cbb\u7597\uff0c\u5747\u672a\u80fd\u6539\u5584\u603b\u751f\u5b58\u671f\u3002<\/strong><\/p>\n\n<p>\u5728\u968f\u673aIII\u671f\u4e34\u5e8a\u8bd5\u9a8cCAIRO5\u4e2d\uff0c\u521d\u59cb\u4e0d\u53ef\u5207\u9664\u7684\u7ed3\u76f4\u80a0\u764c\u809d\u8f6c\u79fb\u60a3\u8005\u63a5\u53d7\u4e86\u8d1d\u4f10\u73e0\u5355\u6297\u8054\u5408FOLFOXIRI\u6216FOLFOX\/FOLFIRI\uff08\u82e5\u4e3a\u53f3\u4fa7\u75c5\u7076\u548c\/\u6216RAS\/BRAF V600E\u7a81\u53d8\u2014\u2014\u7b2c1\u7ec4\uff09\uff0c\u6216\u63a5\u53d7FOLFOX\/FOLFIRI\u8054\u5408\u5e15\u5c3c\u5355\u6297\u6216\u8d1d\u4f10\u73e0\u5355\u6297\u6cbb\u7597\uff08\u82e5\u4e3a\u53f3\u4fa7\u809d\u8f6c\u79fb\u4e14RAS\/BRAF V600E\u4e3a\u91ce\u751f\u578b\u2014\u2014\u7b2c2\u7ec4\uff09\u3002<\/p>\n\n<p>\u5728\u7b2c1\u7ec4\u4e2d\uff0c\u5c3d\u7ba1\u6b64\u524d\u6709\u62a5\u9053\u79f0\uff0c\u4e0e\u53cc\u836f\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u76f8\u6bd4\uff0c\u4e09\u836f\u5316\u7597\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u548c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u65b9\u9762\u66f4\u5177\u4f18\u52bf\uff0c\u4f46\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5e76\u672a\u5f97\u5230\u6539\u5584\uff08\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a23.6 \u4e2a\u6708 vs 24.1 \u4e2a\u6708\uff1b HR 0.92\uff0c95% CI 0.70-1.20\uff0cp=0.52\uff09\u3002<\/p>\n\n<p>\u5728\u7b2c2\u7ec4\u4e2d\uff0c\u4e0e\u5148\u524d\u62a5\u9053\u7684\u7ed3\u679c\u4e00\u81f4\uff0c\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u672a\u89c1\u6539\u5584\uff08HR 1.11\uff0c95% CI 0.48-1.48\uff0c p = 0.46\uff09\uff0cFOLFOX\/FOLFIRI \u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u4e0e FOLFOX\/FOLFIRI \u8054\u5408\u5e15\u5c3c\u5355\u6297\u7ec4\u5728\u603b\u751f\u5b58\u671f\uff08OS\uff09\u65b9\u9762\u65e0\u663e\u8457\u5dee\u5f02\uff08\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff1a\u5206\u522b\u4e3a 40.4 \u4e2a\u6708 vs 38.2 \u4e2a\u6708\uff1b HR 1.02\uff0c95% CI 0.72-1.46\uff0cp=0.89\uff09\u3002 \u4e0e\u8d1d\u4f10\u73e0\u5355\u6297\u76f8\u6bd4\uff0c\u5e15\u5c3c\u5355\u6297\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u66f4\u9ad8\uff0880% vs 53%\uff09\uff0c\u4f46R0\/1\u5207\u9664\u7387\u76f8\u4f3c\uff0858% vs 58%\uff09\u3002 <\/p>\n\n<p>\u4e0d\u540c\u6cbb\u7597\u65b9\u6848\u4e4b\u95f4\u7684\u603b\u751f\u5b58\u7387\u672a\u89c1\u663e\u8457\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u53ef\u9009\u62e9\u6bd2\u6027\u6700\u5c0f\u7684\u5168\u8eab\u6cbb\u7597\u65b9\u6848\u3002   <strong>\uff08\u6458\u8981 LBA27\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">IDEA\/ACCENT<\/h3>\n\n<p><strong>\u5728IDEA\/ACCENT\u6c47\u603b\u5206\u6790\u4e2d\uff0c\u7814\u7a76\u4e86KRAS\/BRAF\u7a81\u53d8\u5728\u65e9\u671f\u7ed3\u80a0\u764c\u4e2d\u7684\u4f5c\u7528\u3002<\/strong><\/p>\n\n<p>\u5728\u4e00\u9879\u9488\u5bf97\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6c47\u603b\u5206\u6790\u4e2d\uff0c\u8fd9\u4e9b\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30III\u671f\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u5207\u9664\u672f\u540e\u8f85\u52a9\u5316\u7597\u7684\u6301\u7eed\u65f6\u95f4\uff0c\u5e76\u8003\u5bdf\u4e86MMR\u72b6\u6001\u4ee5\u53caKRAS\u548cBRAF V600E\u7a81\u53d8\u5bf9\u9884\u540e\u7684\u5f71\u54cd\u3002 MSS\/pMMR\u578b\u7ed3\u76f4\u80a0\u764c\u76845\u5e74\u590d\u53d1\u7387\u4e3a29%\uff0c\u800cMSI\/dMMR\u578b\u7ed3\u76f4\u80a0\u764c\u76845\u5e74\u590d\u53d1\u7387\u4e3a21%\u3002 <\/p>\n\n<p>\u5728MSS\/pMMR\u80bf\u7624\u4e2d\uff0c\u4e0e\u91ce\u751f\u578b\u80bf\u7624\u76f8\u6bd4\uff0cKRAS\uff08\u5305\u62ec\u7b2c12\u548c13\u5bc6\u7801\u5b50\uff09\u548cBRAF\u7a81\u53d8\u5747\u5bf9\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u4ea7\u751f\u4e86\u8d1f\u9762\u5f71\u54cd\uff08HR\u5206\u522b\u4e3a1.41\u548c1.58\uff09\uff0c \u65e0\u75c5\u751f\u5b58\u671f\uff08HR\u5206\u522b\u4e3a1.35\u548c2.06\uff09\u4ee5\u53ca\u590d\u53d1\u540e\u751f\u5b58\u671f\uff08HR\u5206\u522b\u4e3a1.25\u548c2.87\uff09\u3002<\/p>\n\n<p>\u5728MSI\/dMMR\u80bf\u7624\u4e2d\uff0c\u672a\u89c2\u5bdf\u5230KRAS\u6216BRAF\u7a81\u53d8\u5bf9\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u4ea7\u751f\u5f71\u54cd\uff08HR\u5206\u522b\u4e3a0.99\u548c0.98\uff09\uff0c\u4f46BRAF\u7a81\u53d8\u5bf9\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4ea7\u751f\u4e86\u8d1f\u9762\u5f71\u54cd\uff08HR\u4e3a1.36\uff09\uff0c \u4e14KRAS\u548cBRAF\u7a81\u53d8\u5747\u4f1a\u6076\u5316\u590d\u53d1\u540e\u7684\u751f\u5b58\u60c5\u51b5\uff08HR\u5206\u522b\u4e3a1.52\u548c1.99\uff09\u3002  <strong>\uff08\u6458\u8981 553O\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h3 class=\"wp-block-heading\">ASCOLT<\/h3>\n\n<p>\u675c\u514b\u5206\u7ea7C\u671f\uff08III\u671f\uff09\u548c\u9ad8\u5371\u675c\u514b\u5206\u7ea7B\u671f\uff08\u9ad8\u5371II\u671f\uff09\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u5728\u624b\u672f\u53ca\u5b8c\u6210\u6807\u51c6\u8f85\u52a9\u6cbb\u7597\u540e\uff0c\u88ab\u968f\u673a\u5206\u914d\u81f3\u6bcf\u65e5\u670d\u7528200\u6beb\u514b\u963f\u53f8\u5339\u6797\u6216\u5b89\u6170\u5242\u7ec4\uff0c\u7597\u7a0b\u4e3a3\u5e74\u3002  <\/p>\n\n<p>\u963f\u53f8\u5339\u6797\u5e76\u672a\u6539\u5584\u65e0\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u8fd9\u4e00\u4e3b\u8981\u7ec8\u70b9\uff08HR 0.91\uff1b95% CI 0.73-1.13\uff0cp=0.38\uff09\u3002 \u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u7ed3\u679c\u4e5f\u76f8\u4f3c\uff08HR 0.75\uff0c95% CI 0.53-1.07\uff0cp = 0.11\uff09\u3002\u963f\u53f8\u5339\u6797\u7684\u8f85\u52a9\u6cbb\u7597\u4f5c\u7528\u4f3c\u4e4e\u6709\u9650\u3002    <strong>\uff08\u6458\u8981 LBA29\uff09<\/strong><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h2 class=\"wp-block-heading\" id=\"2022-trials\">2022<\/h2>\n\n<p><em>\u6211\u4eec\u91c7\u8bbf\u4e86\u201cFight CRC RATS\u201d\u5fd7\u613f\u8005\u4e4b\u4e00\u5b89\u59ae\uff0c\u4ee5\u5e2e\u52a9\u5927\u5bb6\u6df1\u5165\u4e86\u89e3\u6700\u8fd1\u5728ESMO\u4f1a\u8bae\u4e0a\u53d1\u8868\u7684\u3001\u5bf9\u6211\u4eec\u7684\u793e\u533a\u800c\u8a00\u6700\u91cd\u8981\u7684\u7814\u7a76\u6210\u679c\u3002<\/em><\/p>\n\n<h3 class=\"wp-block-heading\">ESMO 2022 \u7814\u7a76\u52a8\u6001<\/h3>\n\n<h4 class=\"wp-block-heading\">MSI\u578b\u7ed3\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597<\/h4>\n\n<p><strong>\u95ee\uff1a\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\uff0c\u5728ASCO\u5e74\u4f1a\u4e0a\uff0c\u6211\u4eec\u4e86\u89e3\u5230\u514d\u75ab\u7597\u6cd5\uff08\u6297PD-1\uff09\u5bf9\u90e8\u5206\u76f4\u80a0\u764c\u60a3\u8005\u2014\u2014\u5373II\u671f\u548cIII\u671f\u3001\u9519\u914d\u4fee\u590d\u7f3a\u9677\/\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\u6027\u9ad8\uff08dMMR\/MSI-H\uff09\u7684\u76f4\u80a0\u764c\u60a3\u8005\u2014\u2014\u53d6\u5f97\u4e86\u663e\u8457\u7597\u6548\u3002 \u800c\u5728ESMO\u5e74\u4f1a\u4e0a\uff0c\u9488\u5bf9MSI\u578b\u7ed3\u80a0\u764c\u4e9a\u7ec4\u60a3\u8005\uff0c\u91c7\u7528\u514d\u75ab\u7597\u6cd5\u8054\u5408\u6cbb\u7597\u7684\u65b9\u6848\u4e5f\u5e26\u6765\u4e86\u66f4\u591a\u597d\u6d88\u606f\u3002\u60a8\u80fd\u5c31\u6b64\u8be6\u7ec6\u4ecb\u7ecd\u4e00\u4e0b\u5417\uff1f  <\/strong><\/p>\n\n<p>NICHE-2\u7814\u7a76\u57282022\u5e74ESMO\u5e74\u4f1a\u4e0a\u8d62\u5f97\u4e86\u5168\u573a\u8d77\u7acb\u9f13\u638c\u3002 \u6765\u81ea\u8377\u5170\u7684\u7c73\u91cc\u4e9a\u59c6\u00b7\u67e5\u62c9\u6bd4\uff08Myriam Chalabi\uff09\u535a\u58eb\u516c\u5e03\u4e86\u9488\u5bf9MSI\u578bIII\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u5355\u6b21\u514d\u75ab\u6cbb\u7597\u7684\u7597\u6548\u6570\u636e\u3002\u8be5\u8bd5\u9a8c\u663e\u793a\uff0c95%\u7684\u60a3\u8005\u5b9e\u73b0\u4e86\u4e3b\u8981\u75c5\u7406\u53cd\u5e94\uff08\u5176\u4e2d67%\u4e3a\u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff0c\u5373\u201cpCR\u201d\uff09\u3002  <\/p>\n\n<p>\u4e00\u9879\u9c9c\u4e3a\u4eba\u77e5\u7684\u7ed3\u679c\uff1a\u8be5\u7814\u7a76\u8fd8\u663e\u793a\uff0c\u6797\u5947\u7efc\u5408\u5f81\u60a3\u8005\u7684\u6cbb\u7597\u53cd\u5e94\u7387\u6709\u6240\u63d0\u9ad8\uff08pCR\u7387\u4e3a78%\uff0c\u800c\u5bf9\u7167\u7ec4\u4e3a58%\uff09\u3002<\/p>\n\n<p>\u6240\u6709\u7ed3\u76f4\u80a0\u764c\u4e2d\u670915%\u5c5e\u4e8eMSI\u4e9a\u578b\uff08\u7ea6\u5360III\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u768410%\uff09\u3002 \u76ee\u524d\uff0c\u5728\u514d\u75ab\u6cbb\u7597\u65b9\u6848\u65b9\u9762\uff0c\u6709ATOMIC\u8bd5\u9a8c\uff08\u5316\u7597\u540e\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\uff09\u548cStandUp2Cancer\u8bd5\u9a8c\uff08\u82e5\u5faa\u73af\u80bf\u7624DNA\uff08ctDNA\uff09\u68c0\u6d4b\u7ed3\u679c\u4e3a\u9633\u6027\uff0c\u5219\u5728\u5316\u7597\u540e\u8fdb\u884c\u514d\u75ab\u6cbb\u7597\uff09\u3002 \u5965\u6c99\u5229\u94c2\u5316\u7597\u53ef\u80fd\u5f15\u53d1\u795e\u7ecf\u75c5\u53d8\u526f\u4f5c\u7528\uff08\u8fd9\u53ef\u80fd\u5f71\u54cd\u8bb8\u591a\u804c\u4e1a\u7684\u5de5\u4f5c\u80fd\u529b\uff0c\u6216\u589e\u52a0\u8001\u5e74\u60a3\u8005\u8dcc\u5012\u7684\u98ce\u9669\uff09\u3002 \u5bf9\u4e8eIII\u671f\u7ed3\u80a0\u764c\u60a3\u8005\u800c\u8a00\uff0c\u867d\u7136\u624b\u672f\u7684\u526f\u4f5c\u7528\u5c1a\u5728\u53ef\u63a7\u8303\u56f4\u5185\uff0c\u4f46\u5e76\u975e\u5fae\u4e0d\u8db3\u9053\uff08\u5982\u80a0\u9053\u95ee\u9898\uff09\u3002\u82e5\u80fd\u53c2\u4e0e\u4e00\u9879\u53ef\u907f\u514d\u624b\u672f\u6216\u5316\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5bf9\u60a3\u8005\u800c\u8a00\u5c06\u662f\u4e00\u4e2a\u4ee4\u4eba\u632f\u594b\u7684\u9009\u62e9\uff0c\u503c\u5f97\u4e0e\u4e13\u4e1a\u80bf\u7624\u79d1\u533b\u751f\u8fdb\u884c\u63a2\u8ba8\u3002    <\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<h4 class=\"wp-block-heading\">FRESCO-2 \u8bd5\u9a8c\uff1a\u5f17\u9c81\u6606\u66ff\u5c3c<\/h4>\n\n<p><strong>\u95ee\uff1a\u5bf9\u4e8e\u6240\u6709\uff08\u7ed3\u80a0\u764c\u6216\u76f4\u80a0\u764c\uff09\u60a3\u8005\u2014\u2014\u65e0\u8bba\u5176\u57fa\u56e0\u7a81\u53d8\u60c5\u51b5\u6216\u5fae\u536b\u661f\u72b6\u6001\u5982\u4f55\u2014\u2014\u6709\u4ec0\u4e48\u65b0\u6d88\u606f\u5417\uff1f\u6211\u4eec\u4e00\u76f4\u5173\u6ce8\u53ef\u80fd\u4fc3\u6210\u65b0\u7597\u6cd5\u83b7\u6279\u3001\u8fdb\u800c\u6539\u53d8\u4e34\u5e8a\u5b9e\u8df5\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002 <\/strong><\/p>\n\n<p>\u5bf9\u4e8e\u63a5\u53d7\u5316\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u7684IV\u671f\u60a3\u8005\u800c\u8a00\uff0c\u540e\u7eed\u6cbb\u7597\u65b9\u6848\u7684\u9009\u62e9\u5341\u5206\u6709\u9650\u3002\u56e0\u6b64\uff0c\u65e8\u5728\u8bc4\u4f30\u5f17\u9c81\u6606\u66ff\u5c3c\uff082018\u5e74\u5728\u4e2d\u56fd\u83b7\u6279\uff09\u7684III\u671fFRESCO-2\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u9a8c\u8bc1\u5176\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002 \u8be5\u836f\u7269\u6709\u671b\u5728\u672a\u6765\u6570\u6708\u5185\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\uff08\u5df2\u4e8e2020\u5e746\u6708\u88ab\u7eb3\u5165\u5feb\u901f\u901a\u9053\uff09\u3002\u8be5\u8bd5\u9a8c\u8bc1\u5b9e\u4e86\u8be5\u6cbb\u7597\u5bf9\u60a3\u8005\u7684\u83b7\u76ca\uff0c\u4e14\u5176\u526f\u4f5c\u7528\u5728\u53ef\u8010\u53d7\u8303\u56f4\u5185\u3002   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