A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer (BREAKWATER)
计划状态
活跃，非招募阶段
第三阶段允许先接受免疫治疗
没有CRC 指导的试验
是药物
5-FU, Bevacizumab, capecitabine, cetuximab, encorafenib, Irinotecan, Leucovorin, oxaliplatin标签
MSS/ MMRp评论
Phase III BREAKWATER trial. Only for patients with BRAF V600E–mutated, stage IV (metastatic) CRC, who are about to the receive their FIRST LINE of treatment, in the metastatic setting. Trial compares:
1. encorafenib (Braftovi) plus cetuximab (Erbitux) vs.
2. encorafenib (Braftovi) plus cetuximab (Erbitux) plus standard-of-care (SOC) chemotherapy vs.
3. chemotherapy alone
| 地点 | 位置状态 |
|---|---|
| 美国 | |
|
Mayo Clinic Hospital 亚利桑那州凤凰城 85054 |
活跃，非招募 |
|
Mayo Clinic in Arizona - Scottsdale Scottsdale, Arizona 85259 |
活跃，非招募 |
|
Keck Hospital of USC 加利福尼亚州洛杉矶 90033 |
活跃，非招募 |
|
LAC & USC Medical Center 加利福尼亚州洛杉矶 90033 |
活跃，非招募 |
|
USC / Norris Comprehensive Cancer Center 加利福尼亚州洛杉矶 90033 |
活跃，非招募 |
|
USC/Norris Comprehensive Cancer Center 加利福尼亚州洛杉矶 90033 |
活跃，非招募 |
|
Keck Hospital of USC Pasadena Pasadena, California 91105 |
活跃，非招募 |
|
Mount Sinai Comprehensive Cancer Center, Aventura Aventura, Florida 33180 |
活跃，非招募 |
|
西奈山综合癌症中心 佛罗里达州迈阿密海滩 33140 |
活跃，非招募 |
|
Mount Sinai Medical Center 佛罗里达州迈阿密海滩 33140 |
活跃，非招募 |
|
BRCR Global Plantation, Florida 33322 |
活跃，非招募 |
|
BRCR Medical Center Inc. Plantation, Florida 33322 |
活跃，非招募 |
|
UChicago Medicine - River East 伊利诺伊州芝加哥 60611 |
活跃，非招募 |
|
University of Chicago Medical Center 伊利诺伊州芝加哥 60637 |
活跃，非招募 |
|
UChicago Medicine at Ingalls - Flossmoor Flossmoor, Illinois 60422 |
活跃，非招募 |
|
UChicago Medicine Ingalls Memorial Harvey, Illinois 60426 |
活跃，非招募 |
|
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital New Lenox, Illinois 60451 |
活跃，非招募 |
|
The University of Chicago Medicine Center for Advanced Care Orland Park Orland Park, Illinois 60462 |
活跃，非招募 |
|
UChicago Medicine at Ingalls - Tinley Park Tinley Park, Illinois 60477 |
活跃，非招募 |
|
Ochsner Clinic Foundation Research Pharmacy New Orleans, Louisiana 70121 |
活跃，非招募 |
|
Ochsner Clinic Foundation New Orleans, Louisiana 70121 |
活跃，非招募 |
|
Mayo Clinic Rochester 明尼苏达州罗切斯特 55905 |
活跃，非招募 |
|
Siteman Cancer Center - West County 密苏里州克里夫科尔 63141 |
活跃，非招募 |
|
Siteman Cancer Center - North County Florissant, Missouri 63031 |
活跃，非招募 |
|
Barnes- Jewish Hospital 密苏里州圣路易斯 63110 |
活跃，非招募 |
|
华盛顿大学医学院 密苏里州圣路易斯 63110 |
活跃，非招募 |
|
Siteman Cancer Center - South County 密苏里州圣路易斯 63129 |
活跃，非招募 |
|
Siteman Cancer Center - St Peters 密苏里州圣彼得斯 63376 |
活跃，非招募 |
|
Oncology Hematology West PC dba Nebraska Cancer Specialists 内布拉斯加州奥马哈 68114 |
活跃，非招募 |
|
Oncology Hematology West PC dba Nebraska Cancer Specialists Omaha, Nebraska 68124 |
活跃，非招募 |
|
Oncology Hematology West PC dba Nebraska Cancer Specialists 内布拉斯加州奥马哈 68130 |
活跃，非招募 |
|
Oncology Hematology West, PC dba Nebraska Cancer Specialists - IP Storage 内布拉斯加州奥马哈 68130 |
活跃，非招募 |
|
Oncology Hematology West PC dba Nebraska Cancer Specialists Papillion, Nebraska 68046 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center - Basking Ridge 新泽西州巴斯汀里奇 07920 |
活跃，非招募 |
|
Summit Medical Group Florham Park, New Jersey 07932 |
活跃，非招募 |
|
纪念斯隆-凯特琳癌症中心-蒙莫斯 新泽西州米德尔敦 07748 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center- Bergen 新泽西州蒙特维尔 07645 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center Commack 纽约州康马克 11725 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center - Westchester 纽约州哈里森 10604 |
活跃，非招募 |
|
纪念斯隆-凯特琳癌症中心 New York, New York 10022 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center - Main Campus 纽约州纽约市 10065 |
活跃，非招募 |
|
Memorial Sloan Kettering Cancer Center- Nassau 纽约州尤尼恩代尔 11553 |
活跃，非招募 |
|
Cleveland Clinic Taussig Cancer Center Investigational Pharmacy 俄亥俄州克利夫兰 44195 |
活跃，非招募 |
|
Cleveland Clinic 俄亥俄州克利夫兰 44195 |
活跃，非招募 |
|
The Ohio State University James Cancer Hospital and Solove Research Institute 俄亥俄州哥伦布市 43210 |
活跃，非招募 |
|
Stefanie Spielman Comprehensive Breast Cancer 俄亥俄州哥伦布市 43212 |
活跃，非招募 |
|
Martha Morehouse Medical Plaza 俄亥俄州哥伦布市 43221 |
活跃，非招募 |
|
The James Outpatient Care West Campus 俄亥俄州哥伦布市 43221 |
活跃，非招募 |
|
University of Oklahoma Health Sciences Center, OU Health Stephenson Cancer Center 俄克拉荷马州俄克拉荷马城 73104 |
活跃，非招募 |
|
Providence Cancer Institute Franz Clinic 俄勒冈州波特兰 97213 |
活跃，非招募 |
|
普罗维登斯波特兰医疗中心 俄勒冈州波特兰 97213 |
活跃，非招募 |
|
Providence Onc and Heme Care Clinic - Westside Portland, Oregon 97225 |
活跃，非招募 |
|
Providence St Vincent Medical Center Portland, Oregon 97225 |
活跃，非招募 |
|
UPMC Hillman Cancer Center Investigational Drug Service 宾夕法尼亚州匹兹堡 15232 |
活跃，非招募 |
|
UPMC 希尔曼癌症中心 宾夕法尼亚州匹兹堡 15232 |
活跃，非招募 |
|
The West Clinic. PLLC. dba West Cancer Center 田纳西州日耳曼敦 38138 |
活跃，非招募 |
|
Henry-Joyce Cancer Center 田纳西州纳什维尔 37232 |
活跃，非招募 |
|
Vanderbilt Oncology IDS Pharmacy 田纳西州纳什维尔 37232 |
活跃，非招募 |
|
Vanderbilt-Ingram Cancer Center 田纳西州纳什维尔 37232 |
活跃，非招募 |
|
得克萨斯大学 MD 安德森癌症中心 德克萨斯州休斯顿 77030 |
活跃，非招募 |
|
VCU Health - Adult Outpatient Pavilion (AOP) Investigational Drug Services Richmond, Virginia 23219 |
活跃，非招募 |
|
Virginia Commonwealth University Richmond, Virginia 23219 |
活跃，非招募 |
|
Seattle Cancer Care Alliance 华盛顿州西雅图 98109 |
活跃，非招募 |
|
University of Washington Medical Center 华盛顿州西雅图 98195 |
活跃，非招募 |
|
University of Wisconsin Clinical Science Center 威斯康星州麦迪逊 53792 |
活跃，非招募 |
| 阿根廷 | |
|
Centro Medico San Roque San Miguel De Tucumán, Tucumán 4000 |
活跃，非招募 |
|
Instituto Médico Especializado Alexander Fleming Ciudad Autónoma de Buenos Aires 1426 |
活跃，非招募 |
|
Clinica Universitaria Reina Fabiola Cordoba X5004FHP |
活跃，非招募 |
|
Hospital Privado Centro Médico de Córdoba Cordoba X5016KEH |
活跃，非招募 |
| 澳大利亚 | |
|
Chris O'Brien Lifehouse 新南威尔士州坎珀当 2050 |
活跃，非招募 |
|
Liverpool Hospital Liverpool, New South Wales 2170 |
活跃，非招募 |
|
GenesisCare - North Shore 新南威尔士州圣莱昂纳兹 2065 |
活跃，非招募 |
|
GenesisCare North Shore 新南威尔士州圣莱昂纳兹 2065 |
活跃，非招募 |
|
Royal Brisbane & Women's Hospital Herston, Queensland 4029 |
活跃，非招募 |
|
亚历山德拉公主医院 昆士兰州伍尔隆阿巴 4102 |
活跃，非招募 |
|
伊丽莎白医院 Adelaide, South Australia 5011 |
活跃，非招募 |
|
Monash Health Clayton, Victoria 3168 |
活跃，非招募 |
|
Austin Health 维多利亚州海德堡 3084 |
活跃，非招募 |
|
彼得-麦克卡勒姆癌症中心 墨尔本，维多利亚 3000 |
活跃，非招募 |
|
Alfred Health 墨尔本，维多利亚州 3004 |
活跃，非招募 |
| 比利时 | |
|
Université Libre de Bruxelles - Hôpital Erasme Brussels, Bruxelles-capitale, Région DE 1070 |
活跃，非招募 |
|
Cliniques universitaires Saint-Luc Brussels, Bruxelles-capitale, Région DE 1200 |
活跃，非招募 |
|
Grand Hôpital de Charleroi Charleroi, Hainaut 6060 |
活跃，非招募 |
|
AZ Groeninge Campus Kennedylaan Kortrijk, West-vlaanderen 8500 |
活跃，非招募 |
|
ZNA Middelheim Antwerpen 2020 |
活跃，非招募 |
|
鲁汶工程大学 鲁汶 3000 |
活跃，非招募 |
|
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman Liège 4000 |
活跃，非招募 |
|
GZA Hospitals Campus Sint Augustinus Wilrijk 2610 |
活跃，非招募 |
| 巴西 | |
|
Hospital de Clinicas de Porto Alegre Porto Alegre, RIO Grande DO SUL 90035-903 |
活跃，非招募 |
|
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA Rio de Janeiro, RJ 20230-130 |
活跃，非招募 |
|
Reichow - Centro de Ensino e Pesquisa Blumenau, Santa Catarina 89010-340 |
活跃，非招募 |
|
Clínica de Neoplasias Litoral Itajaí, Santa Catarina 88301-220 |
活跃，非招募 |
|
FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC - Centro de Estudos e Pesquisas de Hematologia e Onco Santo Andre, SP 09060-870 |
活跃，非招募 |
|
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Faculdade de Medicina do ABC Santo André, SP 09060-650 |
活跃，非招募 |
|
Fundação Pio XII - Hospital de Câncer de Barretos Barretos, SÃO Paulo 14784400 |
活跃，非招募 |
|
Fundação Faculdade Regional de Medicina de São José do Rio Preto São José do Rio Preto, SÃO Paulo 15090000 |
活跃，非招募 |
| Bulgaria | |
|
MHAT Uni Hospital OOD Panagyurishte, Pazardzhik 4500 |
活跃，非招募 |
|
MHAT "Dr. Tota Venkova" AD Gabrovo 5300 |
活跃，非招募 |
|
MHAT Central Onco Hospital OOD Plovdiv 4000 |
活跃，非招募 |
|
Complex Oncology Center - Plovdiv EOOD Plovdiv 4004 |
活跃，非招募 |
|
Medical Center Nadezhda Clinical EOOD Sofia 1303 |
活跃，非招募 |
|
Acibadem City Clinic MHAT Tokuda Sofia 1407 |
活跃，非招募 |
|
University Multiprofile Hospital for Active Treatment Sofiamed Sofia 1750 |
活跃，非招募 |
| 加拿大 | |
|
Arthur J.E. Child Comprehensive Cancer Centre Calgary, Alberta T3N 4N1 |
活跃，非招募 |
|
Cross Cancer Institute 艾伯塔省埃德蒙顿 T6G 1Z2 |
活跃，非招募 |
|
London Regional Cancer Program, London Health Sciences Centre 安大略省伦敦 N6A 5W9 |
活跃，非招募 |
|
Sunnybrook Health Sciences Centre Toronto, Ontario M4N 3M5 |
活跃，非招募 |
|
Jewish General Hospital 魁北克蒙特利尔 H3T 1E2 |
活跃，非招募 |
| 中国 | |
|
Cancer Hospital Chinese Academy of Medical Science 北京，北京 100021 |
活跃，非招募 |
|
Beijing Cancer hospital 北京, 北京 100142 |
活跃，非招募 |
|
Beijing Hospital 北京, 北京 100730 |
活跃，非招募 |
|
Chongqing University Cancer Hospital Chongqing, Chongqing 400030 |
活跃，非招募 |
|
Fujian Medical University Union Hospital Fuzhou, Fujian 350001 |
活跃，非招募 |
|
The Sixth Affiliated Hospital of Sun Yat-sen University 广东广州 510655 |
活跃，非招募 |
|
Affiliated Tumor Hospital of Guangxi Medical University Nanning, Guangxi 530021 |
活跃，非招募 |
|
Affiliated Tumor Hospital of Guangxi Medical University Nanning, Guangxi 530200 |
活跃，非招募 |
|
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology 湖北武汉 430030 |
活跃，非招募 |
|
The Second Xiangya Hospital of Central South University 湖南长沙 410011 |
活跃，非招募 |
|
The Third Xiangya Hospital of Central South University 湖南长沙 410013 |
活跃，非招募 |
|
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School 江苏南京 210008 |
活跃，非招募 |
|
Shengjing Hospital Of China Medical University Shenyang, Liaoning 110022 |
活跃，非招募 |
|
Shandong province cancer hospital Jinan, Shandong 250117 |
活跃，非招募 |
|
Shanghai Jiaotong University School of Medicine Ruijin Hospital Shanghai, Shanghai 200025 |
活跃，非招募 |
|
Shanghai General Hospital Shanghai, Shanghai 200080 |
活跃，非招募 |
|
Sichuan Province Cancer Hospital Chengdu, Sichuan 610041 |
活跃，非招募 |
|
Yunnan Cancer Hospital(The Third Affiliated Hospital of Kunming Medical University) Kunming, Yunnan 650118 |
活跃，非招募 |
|
The second Affiliated Hospital of College of Medicine, Zhejiang University 浙江杭州 310000 |
活跃，非招募 |
|
Peking University First Hospital Beijing 100034 |
活跃，非招募 |
|
复旦大学上海肿瘤防治中心 Shanghai 201321 |
活跃，非招募 |
|
Tianjin Union Medical Center Tianjin 300000 |
活跃，非招募 |
| Czechia | |
|
Fakultní nemocnice Brno Bohunice Brno, Brno-město 625 00 |
活跃，非招募 |
|
Fakultni nemocnice Hradec Kralove Hradec Kralove, Hradec Králové 500 05 |
活跃，非招募 |
|
Fakultni Thomayerova nemocnice Prague, Praha 4 14059 |
活跃，非招募 |
|
Fakultni nemocnice Olomouc Olomouc 779 00 |
活跃，非招募 |
|
Fakultni nemocnice Bulovka Praha 8 180 81 |
活跃，非招募 |
| 丹麦 | |
|
Aalborg Universitetshospital, Syd Aalborg, Nordjylland 9000 |
活跃，非招募 |
|
Vejle Hospital-Sygehus Lillebaelt Vejle, Syddanmark 7100 |
活跃，非招募 |
|
Vejle Sygehus Vejle, Syddanmark 7100 |
活跃，非招募 |
|
医院 Copenhagen 2100 |
活跃，非招募 |
|
Herlev and Gentofte Hospital Herlev 2730 |
活跃，非招募 |
|
Odense University Hospital Odense C 5000 |
活跃，非招募 |
| Finland | |
|
Docrates Syöpäsairaala Helsinki, Nyland 00180 |
活跃，非招募 |
|
Helsinki University Central Hospital Helsinki 00029 |
活跃，非招募 |
|
Oulu University Hospital Oulu 90220 |
活跃，非招募 |
|
Satakunnan Keskussairaala Pori 28500 |
活跃，非招募 |
|
Tampereen yliopistollinen sairaala Tampere 33520 |
活跃，非招募 |
|
Turku University Hospital Turku 20520 |
活跃，非招募 |
| 德国 | |
|
Muenchen Klinik Neuperlach, Klinik fuer Haematologie und Onkologie Muenchen, Bayern 81737 |
活跃，非招募 |
|
Institut für Klinisch Onkologische Forschung Frankfurt, Hessen 60488 |
活跃，非招募 |
|
Medizinische Hochschule Hannover Hannover, Lower Saxony 30625 |
活跃，非招募 |
|
Medizinische Hochschule Hannover Hannover, Niedersachsen 30625 |
活跃，非招募 |
|
Universitätsklinikum Leipzig Leipzig, Sachsen 04103 |
活跃，非招募 |
|
Radiologie Berlin Berlin - Charlottenburg 10719 |
活跃，非招募 |
|
Onkologische Schwerpunktpraxis Kurfuerstendamm Berlin 10707 |
活跃，非招募 |
|
Waage Apotheke Berlin 10709 |
活跃，非招募 |
|
HELIOS Klinikum Berlin Buch GmbH Berlin 13125 |
活跃，非招募 |
|
Technische Universität Dresden, Medizinische Fakultät Carl Gustav Carus 德累斯顿 01307 |
活跃，非招募 |
|
Universitätsklinikum Carl Gustav Carus Dresden 德累斯顿 01307 |
活跃，非招募 |
|
Facharztzentrum Eppendorf Hamburg 20249 |
活跃，非招募 |
|
ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld Hamburg 22045 |
活跃，非招募 |
|
Radiologie im Israelitischen Krankenhaus Hamburg 22297 |
活跃，非招募 |
| India | |
|
Rajiv Gandhi Cancer Institute And Research Centre New Delhi, Delhi 110085 |
活跃，非招募 |
|
Tata Memorial Hospital Mumbai, Maharashtra 400012 |
活跃，非招募 |
|
Deenanath Mangeshkar Hospital & Research Centre Pune, Maharashtra 411 004 |
活跃，非招募 |
|
Sahyadri Speciality Hospital Pune, Maharashtra 411 004 |
活跃，非招募 |
|
Bhakti Vedanta Hospital and Research Institute Thane, Maharashtra 401107 |
活跃，非招募 |
|
R K Birla Cancer Center, SMS Hospital Jaipur, Rajasthan 302004 |
活跃，非招募 |
|
Sawai Man Singh Medical College Hospital (SMS Hospital) Jaipur, Rajasthan 302004 |
活跃，非招募 |
| 意大利 | |
|
Azienda Ospedaliera Universitaria di Cagliari - Presidio Policlinico Universitario "D.Casula" Monserrato (CA), Cagliari 09042 |
活跃，非招募 |
|
IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo, Foggia 71013 |
活跃，非招募 |
|
ASST Grande Ospedale Metropolitano Niguarda Milan, Milano 20162 |
活跃，非招募 |
|
Fondazione del Piemonte per l'Oncologia - Istituto di Candiolo IRCCS Candiolo, Torino 10060 |
活跃，非招募 |
|
Azienda Ospedaliero Universitaria San Luigi Gonzaga Orbassano, Torino 10043 |
活跃，非招募 |
|
Fondazione Poliambulanza Istituto Ospedaliero 布雷西亚 25124 |
活跃，非招募 |
|
Istituto Europeo di Oncologia IRCCS Milano 20141 |
活跃，非招募 |
|
Azienda Ospedaliera Universitaria dell'Università "Luigi Vanvitelli" di Napoli 那不勒斯 80131 |
活跃，非招募 |
|
IRCCS Istituto Oncologico Veneto (IOV) 帕多瓦 35128 |
活跃，非招募 |
|
Azienda USL - IRCCS di Reggio Emilia - Arcispedale Santa Maria Nuova Reggio Emilia 42123 |
活跃，非招募 |
| 日本 | |
|
Chiba cancer center 千叶县千叶市 260-8717 |
活跃，非招募 |
|
国家癌症中心东区医院 Kashiwa, Chiba 277-8577 |
活跃，非招募 |
|
北海道大学医院 北海道札幌市 060-8648 |
活跃，非招募 |
|
Kanazawa University Hospital Kanazawa, Ishikawa 920-8641 |
活跃，非招募 |
|
St. Marianna University Hospital Kawasaki, Kanagawa 216-8511 |
活跃，非招募 |
|
Kanagawa cancer center Yokohama, Kanagawa 2418515 |
活跃，非招募 |
|
Aichi Cancer Center Hospital Nagoya, Nagoya, Aichi 464-8681 |
活跃，非招募 |
|
Osaka Prefectural Hospital Organization Osaka International Cancer Institute Osaka-shi, Osaka 5418567 |
活跃，非招募 |
|
金台大学医院 Osakasayama, Osaka 589-8511 |
活跃，非招募 |
|
大阪大学医院 Suita, Osaka 565-0871 |
活跃，非招募 |
|
Osaka Medical and Pharmaceutical University Hospital Takatsuki, Osaka 569-8686 |
活跃，非招募 |
|
Saitama Medical University International Medical Center Hidaka-city, Saitama 350-1298 |
活跃，非招募 |
|
Saitama Prefectural Cancer Center Ina-machi, Saitama 362-0806 |
活跃，非招募 |
|
静冈癌症中心 Nagaizumi, Shizuoka 411-8777 |
活跃，非招募 |
|
国家癌症中心医院 104-0045 东京都中央区 |
活跃，非招募 |
|
Japanese Foundation for Cancer Research 东京都江东区 135-8550 |
活跃，非招募 |
|
国立医院组织 九州癌症中心 Fukuoka 811-1395 |
活跃，非招募 |
|
National Hospital Organization - Osaka National Hospital - Institute For Clinical Research Osaka 540-0006 |
活跃，非招募 |
|
Keio university hospital Tokyo 1600035 |
活跃，非招募 |
| 大韩民国 | |
|
National Cancer Center Goyang-si, Gyeonggi-do 10408 |
活跃，非招募 |
|
Kyungpook National University Hospital Daegu, Taegu-kwangyǒkshi 41404 |
活跃，非招募 |
|
Dong-A University Hospital Busan 49201 |
活跃，非招募 |
|
Kyungpook National University Chilgok Hospital Daegu 41404 |
活跃，非招募 |
|
Gachon University Gil Medical Center 仁川 21565 |
活跃，非招募 |
|
Korea University Anam Hospital Seoul 02841 |
活跃，非招募 |
|
首尔大学医院 首尔 03080 |
活跃，非招募 |
|
延世大学医疗系统 Severance 医院 首尔 03722 |
活跃，非招募 |
|
牙山医疗中心 首尔 05505 |
活跃，非招募 |
|
三星医疗中心 首尔 06351 |
活跃，非招募 |
| 墨西哥 | |
|
Accelerium, S. de R.L. de C.V. Monterrey, Nuevo LEON 64000 |
活跃，非招募 |
|
Centro de Investigacion Clinica de Oaxaca Oaxaca 68020 |
活跃，非招募 |
| 荷兰 | |
|
Catharina Ziekenhuis Eindhoven, Noord-brabant 5623 EJ |
活跃，非招募 |
|
Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL) Amsterdam, Noord-holland 1066 CX |
活跃，非招募 |
|
Universitair Medisch Centrum Utrecht Utrecht 3584 CX |
活跃，非招募 |
| 新西兰 | |
|
Auckland City Hospital 奥克兰 1023 |
活跃，非招募 |
| 挪威 | |
|
St. Olavs hospital Trondheim, Sør-trøndelag 7030 |
活跃，非招募 |
|
Sørlandet Sykehus Kristiansand Kristiansand, Vest-agder N-4615 |
活跃，非招募 |
|
Oslo universitetssykehus, Radiumhospitalet Oslo 0379 |
活跃，非招募 |
|
Oslo Universitetssykehus Ullevål Oslo 0450 |
活跃，非招募 |
| 波兰 | |
|
Przychodnia Lekarska KOMED Konin, Wielkopolskie 62-500 |
活跃，非招募 |
|
Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza Brzozow 36-200 |
活跃，非招募 |
|
Wojewodzki Szpital Specjalistyczny Nr 4 w Bytomiu Oddzial Onkologii Bytom 41-902 |
活跃，非招募 |
|
COPERNICUS PL sp. z. o. o. Wojewodzkie Centrum Onkologii w Gdansku Ambulatoryjna Gdansk 80-219 |
活跃，非招募 |
|
COPERNICUS Podmiot Leczniczy Sp. z o.o. Wojewodzkie Centrum Onkologii Gdansk 80-219 |
活跃，非招募 |
| Russian Federation | |
|
Private Medical Institution "Euromedservice" Pushkin, Saint-petersburg 196603 |
活跃，非招募 |
|
GBUZ Chelyabinsk 454087 |
活跃，非招募 |
|
Kaluga Regional Clinical Oncology Center Kaluga 248007 |
活跃，非招募 |
|
FSAEI HE I.M Sechenov First MSMU MoH Russia (Sechenovskiy University), Moscow 119991 |
活跃，非招募 |
|
BHI of Omsk Region "Clinical Oncology Dispensary" Omsk 644013 |
活跃，非招募 |
|
BHI of Omsk Region "Clinical Oncology Dispensary" Omsk 644046 |
活跃，非招募 |
|
LLC "EuroCityClinic" Saint Petersburg 197022 |
活跃，非招募 |
|
LLC "Medicina Severnoy Stolitsy" Saint-Petersburg 191025 |
活跃，非招募 |
|
LLC "Severo-Zapadny Medical Center" Saint-Petersburg 192007 |
活跃，非招募 |
|
Private Healthcare Institution "Clinical Hospital "RZD-Medicine" of St. Petersburg Saint-Petersburg 195271 |
活跃，非招募 |
|
FSBI "Russian Scientific Center For Radiology and Surgical Technologies n.a. Academician A.M. Granov St. Petersburg 197758 |
活跃，非招募 |
|
SHI YR Regional Clinical Oncology Hospital Yaroslavl 150054 |
活跃，非招募 |
| Slovakia | |
|
Narodny Onkologicky Ustav Bratislava 833 10 |
活跃，非招募 |
|
Vychodoslovensky onkologicky ustav, a.s. Kosice 04191 |
活跃，非招募 |
| 南非 | |
|
Cancercare Rondebosch Oncology Rondebosch, Cape Town 7700 |
活跃，非招募 |
|
Cancercare Langenhoven Drive Oncology Centre Port Elizabeth, Eastern CAPE 6045 |
活跃，非招募 |
|
Wits Health Consortium (Pty) Ltd Johannesburg 2193 |
活跃，非招募 |
| 西班牙 | |
|
Complejo Hospitalario Universitario Santiago de Compostela Santiago de Compostela, A Coruña 15706 |
活跃，非招募 |
|
埃尔切大学总医院 Elche, Alicante 03203 |
活跃，非招募 |
|
ICO L'Hospitalet (Hospital Duran i Reynals) Hospitalet de Llobregat, Barcelona 08908 |
活跃，非招募 |
|
瓦尔德希伯伦大学医院 巴塞罗那 08035 |
活跃，非招募 |
|
Hospital Clinic Barcelona Barcelona 08036 |
活跃，非招募 |
|
Hospital General Universitario Gregorio Marañon Madrid 28007 |
活跃，非招募 |
|
Hospital Universitario Ramon Y Cajal 马德里 28034 |
活跃，非招募 |
|
Hospital Universitario 12 de octubre 马德里 28041 |
活跃，非招募 |
|
Hospital Universitario Virgen Del Rocio 塞维利亚 41013 |
活跃，非招募 |
|
Hospital Clinico Universitario de Valencia 巴伦西亚 46010 |
活跃，非招募 |
|
巴伦西亚大学总医院 Valencia 46014 |
活跃，非招募 |
|
米格尔-塞尔维特大学医院 Zaragoza 50009 |
活跃，非招募 |
| 瑞典 | |
|
Karolinska Universitetssjukhuset Solna Solna, Stockholms LÄN [se-01] 171 64 |
活跃，非招募 |
|
Akademiska sjukhuset Uppsala, Uppsala LÄN [se-03] 751 85 |
活跃，非招募 |
|
Norrlands universitetssjukhus Umeå, Västerbottens LÄN [se-24] 90185 |
活跃，非招募 |
|
Sahlgrenska Universitetssjukhuset Göteborg, Västra Götalands LÄN [se14] 413 45 |
活跃，非招募 |
| 台湾 | |
|
高雄医学大学中和纪念医院 Kaohsiung 807 |
活跃，非招募 |
|
China Medical University Hospital Taichung 404 |
活跃，非招募 |
|
National Cheng-Kung University Hospital Tainan 704 |
活跃，非招募 |
|
Chi Mei Hospital, Liouying Tainan 73657 |
活跃，非招募 |
|
台湾大学医院 Taipei 100 |
活跃，非招募 |
|
Taipei Medical University Hospital Taipei 11031 |
活跃，非招募 |
|
台北荣民总医院 Taipei 112 |
活跃，非招募 |
|
Chang Gung Medical Foundation-Linkou Branch Taoyuan 333 |
活跃，非招募 |
| Ukraine | |
|
Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council Dnipro 49102 |
活跃，非招募 |
|
Ivano-Frankivsk National Medical University Ivano-Frankivsk 76018 |
活跃，非招募 |
|
MNPE "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Regional Council" Ivano-Frankivsk 76018 |
活跃，非招募 |
|
Communal enterprise "Kryvyi Rih Oncology Dispensary" of Dnipropetrovsk Regional Council Kryvyi Rih 50048 |
活跃，非招募 |
| 英国 | |
|
Freeman Hospital Newcastle upon Tyne, HIGH Heaton NE7 7DN |
活跃，非招募 |
|
Royal Marsden NHS Foundation Trust 萨顿，萨里 SM2 5PT |
活跃，非招募 |
|
Heartlands Hospital Birmingham B9 5SS |
活跃，非招募 |
|
Hammersmith Hospital, Imperial College Healthcare NHS Trust London W12 0HS |
活跃，非招募 |
|
Hammersmith Hospital London W6 8RF |
活跃，非招募 |
|
Churchill Hospital - Oncology Oxford OX3 7LE |
活跃，非招募 |
纳入标准
纳入标准
* Safety Lead-In = Male/female ≥ 18 years old
* Phase 3 and Cohort 3: Male/female ≥ 16 years old (where permitted locally)
* Histologically or cytologically confirmed Stage IV CRC that contains BRAF V600E mutation
* Prior systemic treatment in metastatic setting: 0-1 regimens for Safety Lead In; none for Phase 3 and Cohort 3. (Note: Prior adjuvant or neoadjuvant therapy considered metastatic treatment if relapse/metastasis < 6 month from end of adj/neoadjuvant treatment )
* Measurable disease (Phase 3 and Cohort 3)/ Measurable or evaluable disease (Safety Lead-in)
* ECOG PS 0-1
* 适当的器官功能
排除标准
排除标准：
* Tumors that are locally confirmed or unknown MSI-H or dMMR unless participant is ineligible to receive immune checkpoint inhibitors due to a pre-existing medical condition
* Active bacterial or viral infections in 2 weeks prior to starting dosing
* Symptomatic brain metastases
